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Mate Intake and Risk of Breast Cancer in Uruguay: a Case-Control Study
Ronco, Alvaro L,De Stefani, Eduardo,Mendoza, Beatriz,Deneo-Pellegrini, Hugo,Vazquez, Alvaro,Abbona, Estela Asian Pacific Journal of Cancer Prevention 2016 Asian Pacific journal of cancer prevention Vol.17 No.3
Regarding 'mate' intake (infusion of Ilex paraguariensis herb, a staple beverage in temperate South American regions), most epidemiologic studies showed positive associations with risk of some cancers, (e.g. upper aerodigestive tract), but evidence on breast cancer (BC) risk is limited to a previous multi-site study, which reported a non significant odds ratio [OR]=0.85, 95% confidence interval [95% CI] 0.67-1.09, p for trend=0.31) for the highest quartile of intake. The present study was conducted in order to further assess associations of 'mate' intake with BC risk. We combined two databases of women belonging to public and private healthcare hospitals. The sample included 572 BC incident cases and 889 controls interviewed with a specific questionnaire featured by socio-demographic, reproductive and lifestyle variables, and a food frequency questionnaire of 64 items, also analyzing 'mate' intake (consumer status, daily intake, age at start, age at quit, duration of habit, intensity of intake). ORs and their 95%CI were calculated through unconditional logistic regression, adjusting for relevant potential confounders. The highest quartile of 'mate' intake was inversely associated with BC risk (OR=0.40, 95%CI 0.26-0.57, p for trend <0.001). Stratified analyses also displayed strong significant inverse associations for 'mate' in frequent tea drinkers (OR=0.22), high energy intake (OR=0.23), high body mass index (OR=0.29) and in postmenopausal women (OR=0.36), among other results. As conclusions, we found evidence of a significant inverse association for 'mate' intake and BC risk.
Mate and Tea Intake, Dietary Antioxidants and Risk of Breast Cancer: a Case-Control Study
Ronco, Alvaro L,Stefani, Eduardo De,Mendoza, Beatriz,Vazquez, Alvaro,Abbona, Estela,Sanchez, Gustavo,Rosa, Alejandro De Asian Pacific Journal of Cancer Prevention 2016 Asian Pacific journal of cancer prevention Vol.17 No.6
Recently, we reported an inverse association between high 'mate' intake (infusion of Ilex paraguariensis herb, a staple beverage in temperate South America) and breast cancer (BC) risk. Stronger inverse associations were found in high strata of tea, vegetable, fruit and energy intakes, and in overweight/obese women, suggesting possible roles for 'mate' mainly from its antioxidant contribution. The present study attempted to thoroughly explore possible associations among 'mate' and tea intake, dietary antioxidants and BC risk. Combining two databases of previous studies, 572 BC incident cases and 889 controls were interviewed with a specific questionnaire featuring socio-demographic, reproductive and lifestyle variables, and a food frequency questionnaire (64 items), focusing on 'mate' intake (consumer status, daily intake, age at start, age at quit, duration of habit). Food-derived nutrients were calculated from available databases. Odds ratios (OR) and their 95% confidence intervals were calculated through unconditional logistic regression, adjusting for relevant potential confounders. The highest 'mate' intake was significantly inversely associated with BC risk for both low and high carotenoids (OR=0.40 vs. 0.41), vitamin C (OR=0.33 vs. 0.50), vitamin E (OR=0.37 vs. 0.45), flavonols (OR=0.38 vs. 0.48) and reduced glutathione (OR=0.48 vs. 0.46) strata. High tea intake showed significant inverse risk associations only with high carotenoids (OR=0.41), vitamin E (OR=0.48) and reduced glutathione (OR=0.43) strata. In conclusion, a strong and inverse association for 'mate' intake and BC was found, independent of dietary antioxidant levels. Also strong inverse associations with tea intake were more evident only at high levels of certain dietary antioxidants.
CASE REPORT : Congenital Tuberculosis as a Result of Disseminated Maternal Disease: Case Report
( Alvaro Hoyos Orrego ),( Monica Trujillo Honeysberg ),( Lucy Diazgranados Cuenca ) 대한결핵 및 호흡기학회 2015 Tuberculosis and Respiratory Diseases Vol.78 No.4
Although tuberculosis is highly prevalent worldwide, congenital tuberculosis is one of the least common manifestations of the disease. The diagnosis is usually difficult because of the non-specific clinical presentation and the lack of awareness of maternal disease prior to pregnancy and delivery. We present the case of a preterm neonate with congenital tuberculosis, born to a previously healthy mother who had developed severe disseminated tuberculosis during her pregnancy. Once the diagnosis was confirmed in the mother, the congenital infection was confirmed by isolation of Mycobacterium tuberculosis in gastric aspirates, and positive polymerase chain reaction in a cerebrospinal fluid examination. Treatment for tuberculosis with a four-drug regimen resulted in an adequate clinical response in both the mother and infant.
Advances in neoadjuvant therapy for resectable pancreatic cancer over the past two decades
Alvaro Gregorio Morales Taboad,Pablo Lozano Lominchar,Lorena Martin Roman,Pilar Garcia-Alfonso,Andres Jesus Munoz Martin,Jose Antonio Blanco Rodriguez,Jose Manuel Asencio Pascual 한국간담췌외과학회 2021 Annals of hepato-biliary-pancreatic surgery Vol.25 No.2
In the last two decades, pancreatic cancer has been undergoing important changes in its perioperative management due to the great interest in multidisciplinary management and preoperative multimodal therapy, which in numerous studies have shown promising clinical results. Although the standard of treatment for resectable pancreatic ductal adenocarcinoma (PDAC) today is surgery followed by adjuvant therapy, as it is a biologically aggressive disease, even with complete resection, it has high rates of local and distant relapse. Several retrospective and prospective phase I/II studies have opened the window for neoadjuvant therapy with chemotherapy (CT), chemoradiotherapy (CRT), or both, as an alternative treatment for resectable pancreatic cancer, with promising results. Neoadjuvant therapy could has some advantages, including early administration of systemic treatment, in vivo assessment of response to treatment, increase resectability rate in borderline patients, increase resection rate with negative margin and survival benefit. While it seems clear that even potentially resectable disease would benefit from preoperative multimodal therapy, the optimal neoadjuvant therapeutic strategy is still controversial and currently there are only recommendations for neoadjuvant treatment, in clinical guidelines such as the NCCN and ESMO, for borderline and/or locally advanced PDAC. This review provides an overview of recent studies available and how they relate to systemic treatment of resectable PDAC in the neoadjuvant setting.
( Alvaro March-rodriguez ),( Beatriz Bellosillo ),( Alberto Alvarez-larran ),( Carles Besses ),( Ramon M Pujol ),( Agusti Toll ) 대한피부과학회 2019 Annals of Dermatology Vol.31 No.2
Ruxolitinib is a Janus kinase (JAK)1 and JAK2 inhibitor approved for the treatment of myelofibrosis and for polycythemia patients who are resistant or intolerant to hydroxyurea. We report a 72 year-old man patient with polycythemia vera who developed multiple cutaneous squamous cell carcinomas (cSCCs) with keratoacanthoma-like histological features while on treatment with ruxolitinib. Similar lesions have been reported in an isolated patient who also received ruxolitinib. Our case confirms that ruxolitinib may induce eruptive cSCCs with characteristic clinical and histological features that differentiate them from conventional non-drug induced lesions. Moreover, we performed a mutational panel analysis of the tumors. The lack of specific mutations in these tumors suggests an impairment of immunosurveillance in the origin of the cutaneous lesions. Frequent and thorough dermatological examinations in patients receiving ruxolitinib with a history of photodamage, skin cancer and/or previous hydroxyurea intake is thus recommended. (Ann Dermatol 31(2) 204∼208, 2019)
Gesture-based Teleoperation using a Holonomic Robot
Alvaro Uribe,Byron Perez-Gutierrez,Silas Alves 제어로봇시스템학회 2012 제어로봇시스템학회 국제학술대회 논문집 Vol.2012 No.10
This work presents the development and integration of an user interface (UI) framework based on various current input devices that take advantage of our ergonomics. The purpose is to teleoperate a holonomic robot using upper member gestures and postures for studying the suitable of such interfaces when programming and interacting with a mobile robot. As performance vary from UI to UI the framework is focused to be used as a complementary industrial or didactic tool thus, changing how inexperience users tackle their first impressions when working with mobile robots while performing simple gesture-based teleoperation tasks.
Method of Excitation for an Ultra High-Speed 2-phase SRM Using Hall-Effect Sensor
Alvaro Amos Hadipranoto(아모스),Grace Firsta Lukman(그레이스),Jin-Woo Ahn(안진우) 대한전기학회 2021 대한전기학회 학술대회 논문집 Vol.2021 No.11
The performance of switched reluctance motors (SRM)s depends heavily on the excitation angle. Ultra high-speed application makes it impossible to implement general contact-type sensors to detect the rotor position. In this paper, a simple magnetic sensor that operates based on Hall-effect principle is used to detect the position of the rotor, such as found in brushless DC (BLDC) motors. The proposed excitation method uses the edges of the three signals from the sensor to turn on and off the phases. Moreover, current level comparison is also used to help excite the phase. This approach much reduces the computation burden, and can even be implemented by analog means which may reduce overall cost. Simulations were performed to verify the effectiveness of the proposed method.
Human Anthropomorphic Gripper as an Automation Tool
Alvaro Uribe,Edgar Diaz,Hernando Leon 제어로봇시스템학회 2012 제어로봇시스템학회 국제학술대회 논문집 Vol.2012 No.10
This paper presents the design, development and implementation of a 14 DOF human anthropomorphic pneumatic gripper as a tool for teaching automation basics using pneumatics and PLCs. The dexterity of the human hand allows several types of power and precision grasps for interacting with various scenarios, these features have inspired the development of robotics mimicking the human hand in applications such as collaborative robotics workcells, where each finger is an actuated mechanism with a specific task. Collaborative actions through pneumatic and PLC programming basics using this hand allows enhancing the user’s knowledge based on concepts and familiarity with the device. The pneumatic hand can be used on site, with the user directly operating it, and offline with a virtual reality tool for offering simultaneous accessible devices when multiple users need the hand. Robotics currently assists training surgical procedures, manipulation of elements in hazardous environments for us, kinematics, dynamics and path planning simulations for various industrial processes, or as didactic tools for inspiring school students for working with robotics. The pneumatic hand system is composed of an actuation, control and teleoperation subsystems, these interact for simulating the muscles, and the user’s inputs for executing the chosen tasks.