http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
A Hybrid Genetic Algorithm for the Location-Routing Problem with Simultaneous Pickup and Delivery
Karaoglan, Ismail,Altiparmak, Fulya Korean Institute of Industrial Engineers 2011 Industrial Engineeering & Management Systems Vol.10 No.1
In this paper, we consider the Location-Routing Problem with simultaneous pickup and delivery (LRPSPD) which is a general case of the location-routing problem. The LRPSPD is defined as finding locations of the depots and designing vehicle routes in such a way that pickup and delivery demands of each customer must be performed with same vehicle and the overall cost is minimized. Since the LRPSPD is an NP-hard problem, we propose a hybrid heuristic approach based on genetic algorithms (GA) and simulated annealing (SA) to solve the problem. To evaluate the performance of the proposed approach, we conduct an experimental study and compare its results with those obtained by a branch-and-cut algorithm on a set of instances derived from the literature. Computational results indicate that the proposed hybrid algorithm is able to find optimal or very good quality solutions in a reasonable computation time.
Dr. Mitsuo Gen, Editor-in-Chief, Ranked as Top Productive Authors in POM
Runwei Cheng,Fulya Altiparmak 대한산업공학회 2010 Industrial Engineeering & Management Systems Vol.9 No.4
Publishing a new research paper in academic and professional journals is very important to facilitate knowledge sharing among scientists and engineers, researchers and practitioners. Variouse measures and citation scores have been developed to evaluate and rank scientific publications in order to foster the progress of research and real world applications. Recently, Hsieh and Chang reported "An assessment of world-wide research productivity in production and operations management" in International Journal of Production Economics[1]. This report explores the global production and operations management (POM) research performance on papers published in 20 core POM journals in the past half century, which is based on the data of 1959-2008 from Thomson Reuters" Web of Science/Knowledge databases.
A Hybrid Genetic Algorithm for the Location-Routing Problem with Simultaneous Pickup and Delivery
Ismail Karaoglan,Fulya Altiparmak 대한산업공학회 2011 Industrial Engineeering & Management Systems Vol.10 No.1
In this paper, we consider the Location-Routing Problem with simultaneous pickup and delivery (LRPSPD) which is a general case of the location-routing problem. The LRPSPD is defined as finding locations of the depots and designing vehicle routes in such a way that pickup and delivery demands of each customer must be performed with same vehicle and the overall cost is minimized. Since the LRPSPD is an NP-hard problem, we propose a hybrid heuristic approach based on genetic algorithms (GA) and simulated annealing (SA) to solve the problem. To evaluate the performance of the proposed approach, we conduct an experimental study and compare its results with those obtained by a branch-and-cut algorithm on a set of instances derived from the literature. Computational results indicate that the proposed hybrid algorithm is able to find optimal or very good quality solutions in a reasonable computation time.
Association of Secondary Amyloidosis with Common Variable Immune Deficiency and Tuberculosis
Aykut Ferhat Celik,Mehmet Riza Altiparmak,Gulsum Emel Pamuk,Omer Nuri Pamuk,Fehmi Tabak 연세대학교의과대학 2005 Yonsei medical journal Vol.46 No.6
This paper describes the first case of common variable immunodeficiency (CVID) and AA amyloidosis. A recently treated tuberculosis, and chronic inflammation induced by frequent respiratory tract infections, were thought to be responsible for the amyloidosis. No other reason for this condition could be detected. Although T cell dysfunction in some CVID patients has been reported, pulmonary tuberculosis is quite rare with this condition. Bacterial or viral agents or evidence in favour of intestinal tuberculosis, which would explain this patient's recurrent diarrhea, were not found. In this case, the response of the attacks of diarrhea to metranidazole and the histologic observation of extensive intestinal amyloid deposition, which is known to decrease intestinal motility, made us conclude that the diarrhea was associated with bacterial overgrowth. In this report, we discuss the association of CVID and tuberculosis to secondary amyloidosis and recurrent diarrhea.
Yilmaz, Hayriye,Guzel, Yahya,Onal, Zulbiye,Altiparmak, Gokce,Kocakaya, Safak Ozhan Korean Chemical Society 2011 Bulletin of the Korean Chemical Society Vol.32 No.12
A four dimensional quantitative structure activity relationship analysis was applied to a series of 50 flavonoid inhibitors of $p56^{lck}$ protein tyrosine kinase by the molecular comparative electron topological method. It was found that the -log (IC50) values of the compounds were highly dependent on the topology, size and electrostatic character of the substituents at seven positions of the flavonoid scaffold in this study. Depending on the negative or positive charge of the groups correctly embedded in these substituents, three-dimensional bio-structure to increase or decrease -log (IC50) values in the training set of 39 compounds was predicted. The test set of 11 compounds was used to evaluate the predictivity of the model. To generate 4D-QSAR model, the defined function groups and pharmacophore used as topological descriptors in the calculation of activity were of sufficient statistical quality ($R^2$ = 0.72 and $Q^2$ = 0.69). Ligand docking approach by using Dock 6.0. These compounds include many flavonoid analogs, They were docked onto human families of p56lck PTKs retrieved from the Protein Data Bank, 1lkl.pdb.