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( Alpaslan Akyol ),( Memet Simsek ),( Ozlem Ucer ) 대한산부인과학회 2016 Obstetrics & Gynecology Science Vol.59 No.6
Invasive mole is a benign gestational trophoblastic disease that arises from the myometrial invasion of any gestational event via direct extension through tissue or vascular structures. Invasive mole (and other gestational trophoblastic diseases) may present with life-threatening complications including uterine perforation, excessive bleeding, acute hemoperitoneum, and abdominal pain. We report a case of invasive mole presenting as abdominal distention in a 51-year-old perimenopausal woman (gravida 12, para 12, abortion 0). The patient was admitted to the gynecology clinic with a giant uterine mass filling the pelvic and abdominal cavity. To our knowledge, this is the first case in the literature of a gestational trophoblastic neoplasia presenting with uterine mass of 28 weeks` gestational size in this age group. Interestingly, complications such as uterine rupture or invasion of the adjacent structures (such as parametrial tissues or blood vessels) had not developed in our patient despite the considerable enlargement of the uterus.
Sedat Alpaslan Tuncel,Bekir Çaglı,Aslan Tekatas¸,Mehmet Yadigar Kırıcı,Ercüment Ünlü,Hakan Gençhellaç 대한영상의학회 2015 Korean Journal of Radiology Vol.16 No.4
The aim of the present study was to determine the prevalence and reporting rate of incidental findings (IF) in adult outpatients undergoing lumbar magnetic resonance imaging (MRI). Re-evaluation of a total of 1278 lumbar MRI images (collected from patients with a mean age of 50.5 years, range 16–91 years) captured between August 2010–August 2011 was done by a neuroradiologist and a musculoskeletal radiologist. IFs were classified according to organ or system (liver, gallbladder, kidney, bladder, uterus, ovary, lymph node, intestine and aorta). The rate of reporting of a range of IF was examined. The outcome of each patient’s treatment was evaluated based on review of hospital records and by telephone interviews. A total of 253 IFs were found in 241 patients (18.8% of 1278). Among these, clinically significant IFs (n = 34) included: 2 renal masses (0.15%), 2 aortic aneurysms (0.15%), 2 cases of hydronephrosis (0.15%), 11 adrenal masses (0.86%), 7 lymphadenopathies (0.55%), 6 cases of endometrial or cervical thickening (0.47%), 1 liver hemangioma (0.08%), 1 pelvic fluid (0.08%) and 2 ovarian dermoid cysts (0.15%). Overall, 28% (71/253) of IFs were included in the clinical reports, while clinically significant findings were reported in 41% (14/34) of cases. Extraspinal IFs are commonly detected during a routine lumbar MRI, and many of these findings are not clinically significant. However, IFs including clinically important findings are occasionally omitted from formal radiological reports.
Clinicopathological Features and Survival of Young Turkish Patients with Testicular Germ Cell Tumors
Ozgun, Alpaslan,Karagoz, Bulent,Tuncel, Tolga,Emirzeoglu, Levent,Celik, Serkan,Bilgi, Oguz Asian Pacific Journal of Cancer Prevention 2013 Asian Pacific journal of cancer prevention Vol.14 No.11
Background: Testicular germ cell tumors (TGCTs) are a relatively common malignancy in young men. The aim of this study was to investigate the clinicopathological features and survival of young Turkish patients with TGCT. Materials and Methods: In this retrospective study, the clinical and pathological characteristics of young Turkish patients with TGCT who were monitored by the Department of Medical Oncology of a military hospital between 2008 and 2013 were investigated. Overall survival data were analyzed. Results: Ninety-six patients were included in the study. The mean age was 26.4 years. Among the patients, 17.7% had seminoma and 43.8% had mixed non-seminomatous germ cell tumors. Some 46.9% were Stage I, 30.2% were Stage II, and 22.9 were Stage III. Of the patients, 83.3% received chemotherapy, 25% underwent retroperitoneal lymph node dissection (RPLND), 3.1% received radiotherapy, and 12.5% were followed-up without treatment. In addition, 18.8% of the patients were administered salvage chemotherapy due to relapse or progression. The 5-year overall survival rate was 90.2% for all patients. The 2-year overall survival rate was 100% for Stage I patients, 94% for Stage II patients, and 70.2% for Stage III patients. The difference between the survival curves of stages was statistically significant (p=0.029). Conclusions: In young Turkish patients with TGCT, good results were obtained with appropriate treatment, most receiving chemotherapy. The prognosis of the disease was good even in the advanced stage.
Change of attitude toward culture: pre- and post- expatriation experiences of managers
Sumeyra Alpaslan Danisman 한국사회과학협의회 2014 Korean Social Science Journal Vol.41 No.2
Cultural adjustment and intercultural effectiveness strongly influence interna-tional managerial issues, such as organizational success in a local firm, assignment com-pletion, cost of expatriation, and repatriation. Therefore, employees assigned to work inanother country need to prepare by learning about that country’s culture before expatria-tion. Much research has been conducted in the last few decades on the role of culture inexpatriation. This study examines how the attitude of expatriate managers toward theimportance of culture changes between the pre- and post-expatriation periods. This study isstructured as a two-step investigation: (1) pre-expatriation cultural preparation and (2)thoughts on the importance of culture after expatriation. The research sample was SouthKorean expatriate managers working in Turkey or the US. All participants were reached bythe trace method, and the interview data were analyzed in QSR NVivo software withcontent analysis. The results showed that expatriate managers’ attitude toward theimportance of culture changed as a result of expatriation. Pre-expatriation, some partici-pants did not prepare for the new culture. However, after the expatriation experience, allagreed that an understanding of the host culture was important during the assignment. Anoverseas experience allowed participants to understand the significant role played byculture in their adjustment to the new environment.
Tanoglu, Alpaslan,Balta, Ahmet Ziya,Berber, Ufuk,Ozdemir, Yavuz,Emirzeoglu, Levent,Sayilir, Abdurrahim,Sucullu, Ilker Asian Pacific Journal of Cancer Prevention 2015 Asian Pacific journal of cancer prevention Vol.16 No.5
Background: There are increasing data about microRNAs (miRNA) in the literature, providing abundant evidence that they play important roles in pathogenesis and development of colorectal cancer. In this study, we aimed to investigate the miRNA expression profiles in surgically resected specimens of patients with recurrent and non-recurrent colorectal cancer. Materials and Methods: The study population included 40 patients with stage II colorectal cancer (20 patients with recurrent tumors, and 20 sex and age matched patients without recurrence), who underwent curative colectomy between 2004 and 2011 without adjuvant therapy. Expression of 16 miRNAs (miRNA-9, 21, 30d, 31, 106a, 127, 133a, 133b, 135b, 143, 145, 155, 182, 200a, 200c, 362) was verified by quantitative real-time polymerase chain reaction (qRT-PCR) in all resected colon cancer tissue samples and in corresponding normal colonic tissues. Data analyses were carried out using SPSS 15 software. Values were statistically significantly changed in 40 cancer tissues when compared to the corresponding 40 normal colonic tissues (p<0.001). MiR-30d, miR-133a, miR-143, miR-145 and miR-362 expression was statistically significantly downregulated in 40 resected colorectal cancer tissue samples (p<0.001). When we compared subgroups, miRNA expression profiles of 20 recurrent cancer tissues were similar to all 40 cancer tissues. However in 20 non-recurrent cancer tissues, miR-133a expression was not significantly downregulated, moreover miR-133b expression was significantly upregulated (p<0.05). Conclusions: Our study revealed dysregulation of expression of ten miRNAs in Turkish colon cancer patients. These miRNAs may be used as potential biomarkers for early detection, screening and surveillance of colorectal cancer, with functional effects on tumor cell behavior.
Response surface-based model updating to detect damage on reduced-scale masonry arch bridge
Emre Alpaslan,Zeki Karaca 국제구조공학회 2021 Structural Engineering and Mechanics, An Int'l Jou Vol.79 No.1
Response surface (RS) methods, a combination of mathematical and statistical techniques, have been widely used in design optimization, response prediction, and model validation in structural engineering systems. However, its usage in structural damage identification, especially for historic structures has not been quite common. For this purpose, this study attempts to investigate damage detection in a masonry arch bridge. Within the scope of this, a reduced-scale model of a one span historical masonry arch bridge was built in a laboratory environment. To determine the modal parameters of the reduced-scaled bridge model, operational modal analysis (OMA) was performed under ambient vibrations. Signals originated by sensitive accelerometers were collected to quantify the vibratory response of the reduced-scaled model bridge. The experimental natural frequencies, mode shapes, and damping ratios resulting from these measurements were figured out by using the Enhanced Frequency Domain Decomposition (EFDD) technique. The three-dimensional model of the reduced-scale bridge was created in the ANSYS finite element (FE) software program to expose the analytical dynamic characteristics of the bridge model. The results obtained in the experimental application were compared with those of the finite-element analysis of the bridge model. The calibration of the numeric model was utilized depending on the experimental modal analysis results of the reduced-scale bridge by using the RS method. Design of experiments was constructed by using central composite design, and the RS models were generated by performing the genetic aggregation approach. The optimum results between the experimental and numerical analyses were found by using the RS optimization. Then, regional damages created on the scaled model and the changes of dynamic properties of the damaged case were evaluated. The damage location was approximately identified by using the RS method in the calibrated finite-element model. The results demonstrated that the RS-based FE updating approach is an effective way for damage detection and localization in masonry type structures.