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Long-Term Tropical Residency Diminishes Central Sudomotor Sensitivities in Male Subjects
이정범,배준상,신영오,강종철,Takaaki Matsumoto,Aliopva Aziza Toktasynovna,Alipov Gabit Kaimovich,김완종,민영기,양훈모 대한약리학회 2007 The Korean Journal of Physiology & Pharmacology Vol.11 No.6
Tropical natives (TROP) are capable of tolerating tropical heat because of their long-term adaptation to tropical environments. When exposed to heat stress, these natives tend to respond with lower sweat output, which is generally thought to be the result of heat acclimatization. The main objective of this study was to clarify central mechanisms inherent to suppressed thermal sweating in tropical natives (Malaysians) by comparing their sweating responses to those of temperate native (TEMP) (Koreans). This experiment was conducted in a thermoneutral climatic chamber (24±0.5oC, 40±3% relative humidity). Heat loads were applied to each subject by the immersion of their lower legs in a hot water bath (43oC for 30 min). Sweat onset-time and sweat volume were compared between TROP and TEMP. The sweat onset-times on four selected points on the body ranged from 10.25 to 13.47 min in TEMP subjects, and from 16.24 to 17.83 min in TROP subjects (p<0.001). The local sweat volumes at the same sites ranged from 4.30 to 9.74 mg/cm2 in TEMP subjects, and from between 1.80 to 4.40 mg/cm2 in TROP subjects (p<0.001). These results demonstrated a significant difference between TROP and TEMP subjects with regard to the manner in which they regulate their body temperatures when exposed to heat loads, and verified that long-term thermal adaptation blunts sweating sensitivities.
Long-Term Tropical Residency Diminishes Central Sudomotor Sensitivities in Male Subjects
Lee, Jeong-Beom,Bae, Jun-Sang,Shin, Young-Oh,Kang, Jong-Chul,Matsumoto, Takaaki,Toktasynovna, Aliopva Aziza,Kaimovich, Alipov Gabit,Kim, Wan-Jong,Min, Young-Ki,Yang, Hun-Mo The Korean Society of Pharmacology 2007 The Korean Journal of Physiology & Pharmacology Vol.11 No.6
Tropical natives (TROP) are capable of tolerating tropical heat because of their long-term adaptation to tropical environments. When exposed to heat stress, these natives tend to respond with lower sweat output, which is generally thought to be the result of heat acclimatization. The main objective of this study was to clarify central mechanisms inherent to suppressed thermal sweating in tropical natives (Malaysians) by comparing their sweating responses to those of temperate native (TEMP) (Koreans). This experiment was conducted in a thermoneutral climatic chamber ($24{\pm}0.5^{\circ}C,\;40{\pm}3%$ relative humidity). Heat loads were applied to each subject by the immersion of their lower legs in a hot water bath ($43^{\circ}C$ for 30 min). Sweat onset-time and sweat volume were compared between TROP and TEMP. The sweat onset-times on four selected points on the body ranged from 10.25 to 13.47 min in TEMP subjects, and from 16.24 to 17.83 min in TROP subjects (p<0.001). The local sweat volumes at the same sites ranged from 4.30 to $9.74 mg/cm^2$ in TEMP subjects, and from between 1.80 to $4.40mg/cm^2$ in TROP subjects (p<0.001). These results demonstrated a significant difference between TROP and TEMP subjects with regard to the manner in which they regulate their body temperatures when exposed to heat loads, and verified that long-term thermal adaptation blunts sweating sensitivities.
The Influence of Alpha-fetoprotein on Natural Suppressor Cell Activity and Ehrlich Carcinoma Growth
Nikolai Nikolaevich Belyaev,Andrei-Yurievich Bogdanov,Philipp-Georgievich Savvulidi,Vladimir- Konstantinovich Krasnoshtanov,Raikhan-Tleulievna Tleulieva,Gabit-Kaimovich Alipov,Ichiro Sekine,Jun-Sang B 대한생리학회-대한약리학회 2008 The Korean Journal of Physiology & Pharmacology Vol.12 No.4
The influence of alpha-fetoprotein (AFP) on the bone marrow (BM) natural suppressor (NS) cells of intact Ehrlich carcinoma -bearing CBA mice was studied. Bone marrow NS cells were fractionated into three fractions by isopycnic centrifugation on percoll gradients: NS1 (Ց=1.080 g/ml), NS2 (Ց=1.090 g/ml) and NS3 (1.100>Ց>1.090 g/ml). These fractions were highly different in their sensitivity to known NS cell inductors (interleukin (IL)-2, IL-3 or histamine). None of the NS fractions isolated from the intact mice spontaneously produced antiproliferative activity, however, they showed a high level of NS (antiproliferative and natural killer cell inhibitory) activity under the influence of AFP. A single injection of AFP to intact mice led to an increase of spontaneous NS activity and the inhibition of natural killer cell activity. NS activity, especially NS2, was increased in when tumor cells were subcutaneously inoculated three days after AFP injection. In the AFP-treated mice, the tumor mass at 14 days was 60% larger than that in the untreated mice. Our data confirmed that AFP is a tumor marker that can inhibit cancer immunity and plays a role in cancer pathogenesis.
The Influence of Alpha-fetoprotein on Natural Suppressor Cell Activity and Ehrlich Carcinoma Growth
Belyaev, Nikolai Nikolaevich,Bogdanov, Andrei-Yurievich,Savvulidi, PhiIipp-Gorgievich,Krasnoshtanov, Vladimir-Konstantinovich,Tleulieva, Raikhan-Tleulievna,Alipov, Gabit-Kaimovich,Sekine, Ichiro,Bae, The Korean Society of Pharmacology 2008 The Korean Journal of Physiology & Pharmacology Vol.12 No.4
The influence of alpha-fetoprotein (AFP) on the bone marrow (BM) natural suppressor (NS) cells of intact Ehrlich carcinoma -bearing CBA mice was studied. Bone marrow NS cells were fractionated into three fractions by isopycnic centrifugation on percoll gradients: NS1 (${\rho}$=1.080 g/ml), NS2 (${\rho}$=1.090 g/ml) and NS3 (1.100> ${\rho}$ > 1.090 g/ml). These fractions were highly different in their sensitivity to known NS cell inductors (interleukin (IL)-2, IL-3 or histamine). None of the NS fractions isolated from the intact mice spontaneously produced antiproliferative activity, however, they showed a high level of NS (antiproliferative and natural killer cell inhibitory) activity under the influence of AFP. A single injection of AFP to intact mice led to an increase of spontaneous NS activity and the inhibition of natural killer cell activity. NS activity, especially NS2, was increased in when tumor cells were subcutaneously inoculated three days after AFP injection. In the AFP-treated mice, the tumor mass at 14 days was 60% larger than that in the untreated mice. Our data confirmed that AFP is a tumor marker that can inhibit cancer immunity and plays a role in cancer pathogenesis.
Long-Term Tropical Residency Diminishes Central Sudomotor Sensitivities in Male Subjects
Jeong-Beom Lee,Jun-Sang Bae,Young-Oh Shin,Jong-Chul Kang,Takaaki Matsumoto,Aliopva Aziza Toktasynovna,Alipov Gabit Kaimovich,Wan-Jong Kim,Young-Ki Min,Hun-Mo Yang 대한생리학회-대한약리학회 2007 The Korean Journal of Physiology & Pharmacology Vol.11 No.6
Tropical natives (TROP) are capable of tolerating tropical heat because of their long-term adaptation to tropical environments. When exposed to heat stress, these natives tend to respond with lower sweat output, which is generally thought to be the result of heat acclimatization. The main objective of this study was to clarify central mechanisms inherent to suppressed thermal sweating in tropical natives (Malaysians) by comparing their sweating responses to those of temperate native (TEMP) (Koreans). This experiment was conducted in a thermoneutral climatic chamber (24±0.5<SUP>o</SUP>C, 40±3% relative humidity). Heat loads were applied to each subject by the immersion of their lower legs in a hot water bath (43<SUP>o</SUP>C for 30 min). Sweat onset-time and sweat volume were compared between TROP and TEMP. The sweat onset-times on four selected points on the body ranged from 10.25 to 13.47 min in TEMP subjects, and from 16.24 to 17.83 min in TROP subjects (p<0.001). The local sweat volumes at the same sites ranged from 4.30 to 9.74 mg/cm<SUP>2</SUP> in TEMP subjects, and from between 1.80 to 4.40 mg/cm<SUP>2</SUP> in TROP subjects (p<0.001). These results demonstrated a significant difference between TROP and TEMP subjects with regard to the manner in which they regulate their body temperatures when exposed to heat loads, and verified that long-term thermal adaptation blunts sweating sensitivities.