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Noor Alaudin Abdul Wahab,Suzaily Wahab,Abdul Hamid Abdul Rahman,Dinsuhaimi Sidek,Mohd. Normani Zakaria 대한신경정신의학회 2016 PSYCHIATRY INVESTIGATION Vol.13 No.1
ObjectiveaaElectrophysiological studies, which are mostly focused on afferent pathway, have proven that auditory processing deficits exist in patients with schizophrenia. Nevertheless, reports on the suppressive effect of efferent auditory pathway on cochlear outer hair cells among schizophrenia patients are limited. The present, case-control, study examined the contralateral suppression of transient evoked otoacoustic emissions (TEOAEs) in patients with schizophrenia. MethodsaaParticipants were twenty-three healthy controls and sixteen schizophrenia patients with normal hearing, middle ear and cochlear outer hair cells function. Absolute non-linear and linear TEOAEs were measured in both ears by delivering clicks stimuli at 80 dB SPL and 60 dB SPL respectively. Subsequently, contralateral suppression was determined by subtracting the absolute TEOAEs response obtained at 60 dBpe SPL during the absence and presence of contralateral white noise delivered at 65 dB HL. No attention tasks were conducted during measurements. ResultsaaWe found no significant difference in absolute TEOAEs responses at 80 dB SPL, in either diagnosis or ear groups (p>0.05). However, the overall contralateral suppression was significantly larger in schizophrenia patients (p<0.05). Specifically, patients with schizophrenia demonstrated significantly increased right ear contralateral suppression compared to healthy control (p<0.05). ConclusionaaThe present findings suggest increased inhibitory effect of efferent auditory pathway especially on the right cochlear outer hair cells. Further studies to investigate increased suppressive effects are crucial to expand the current understanding of auditory hallucination mechanisms in schizophrenia patients.
Noor Alaudin Abdul Wahab,Mohd. Normani Zakaria,Abdul Hamid Abdul Rahman,Dinsuhaimi Sidek,Suzaily Wahab 대한신경정신의학회 2017 PSYCHIATRY INVESTIGATION Vol.14 No.6
Objective: The present, case-control, study investigates binaural hearing performance in schizophrenia patients towards sentences presented in quiet and noise. Methods: Participants were twenty-one healthy controls and sixteen schizophrenia patients with normal peripheral auditory functions. The binaural hearing was examined in four listening conditions by using the Malay version of hearing in noise test. The syntactically and semantically correct sentences were presented via headphones to the randomly selected subjects. In each condition, the adaptively obtained reception thresholds for speech (RTS) were used to determine RTS noise composite and spatial release from masking. Results: Schizophrenia patients demonstrated significantly higher mean RTS value relative to healthy controls (p=0.018). The large effect size found in three listening conditions, i.e., in quiet (d=1.07), noise right (d=0.88) and noise composite (d=0.90) indicates statistically significant difference between the groups. However, noise front and noise left conditions show medium (d=0.61) and small (d=0.50) effect size respectively. No statistical difference between groups was noted in regards to spatial release from masking on right (p=0.305) and left (p=0.970) ear. Conclusion: The present findings suggest an abnormal unilateral auditory processing in central auditory pathway in schizophrenia patients. Future studies to explore the role of binaural and spatial auditory processing were recommended.
( Ayman A. El-saleh ),( Mahamod Ismail ),( Mohd Alaudin Mohd Ali ),( Israna H. Arka ) 한국인터넷정보학회 2010 KSII Transactions on Internet and Information Syst Vol.4 No.6
In cognitive radio networks, cooperative spectrum sensing schemes are proposed to improve the performance of detecting licensees by secondary users. Commonly, the cooperative sensing can be realized by means of hard decision fusion (HDF) or soft decision fusion (SDF) schemes. The SDF schemes are superior to the HDF ones in terms of the detection performance whereas the HDF schemes are outperforming the SDF ones when the traffic overhead is taken into account. In this paper, a hybrid SFD-HDF cluster-based approach is developed to jointly exploit the advantages of SFD and HDF schemes. Different SDF schemes have been proposed and compared within a given cluster whereas the OR-rule base HDF scheme is applied to combine the decisions reported by cluster headers to a common receiver or base station. The computer simulations show promising results as the performance of the proposed scenario of hybridizing soft and hard fusion schemes is significantly outperforming other different combinations of conventional SDF and HDF schemes while it noticeably reduces the network traffic overhead.
Tong Woei Yenn,Leong Chean Ring,Khairul Azly Zahan,Muhammad Sharir Abdul Rahman,Wen-Nee Tan,Bintul Jauza’ Shaik Alaudin 한국생약학회 2018 Natural Product Sciences Vol.24 No.1
Helminthostachys zeylanica is a rare plant grows in lightly shaded areas. The fern was traditionally used as antipyretic and antiphlogistic agents. This study was aimed to evaluate the antibacterial potential of H. zeylanica on foodborne Bacillus cereus. The chemical composition of its ethanolic extract was also determined. The plant samples were collected at Kampung Kebun Relong, Kedah, Malaysia. The ethanolic extract showed significant inhibitory activity on B. cereus with a sizeable clear zone detected on disc diffusion assay. On broth microdilution assay, the MIC of the extract on B. cereus was 6.25 mg/ml and the MBC was 12.5 mg/ml. The inhibitory activity of the extract on B. cereus was bactericidal. In the growth dynamic study, the antibacterial efficacy of the extract was concentration dependent, where a lower colony forming unit count was obtained with increased extract concentration. The SEM micrograph of extract treated B. cereus cells showed invaginations of cell wall. The bacterial cell structure collapsed after 24 h exposure to the extract. The GCMS analysis of the extract showed that the major constituents of the extract were phenol (36.26%) and quercetin (29.70%). This study is important as it shows the potential use of H. zeylanica as an effective agent to control B. cereus related infections.