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Are Macrophages in Tumors Good Targets for Novel Therapeutic Approaches?
Alahari, Samthosh V.,Dong, Shengli,Alahari, Suresh K. Korean Society for Molecular and Cellular Biology 2015 Molecules and cells Vol.38 No.2
The development of cancer has been an extensively researched topic over the past few decades. Although great strides have been made in cancer prevention, diagnosis, and treatment, there is still much to be learned about cancer's micro-environmental mechanisms that contribute to cancer formation and aggressiveness. Macrophages, lymphocytes which originate from monocytes, are involved in the inflammatory response and often dispersed to areas of infection to fight harmful antigens and mutated cells in tissues. Macrophages have a plethora of roles including tissue development and repair, immune system functions, and inflammation. We discuss various pathways by which macrophages get activated, various approaches that can regulate the function of macrophages, and how these approaches can be helpful in developing new cancer therapies.
Are Macrophages in Tumors Good Targets for Novel Therapeutic Approaches?
Suresh K. Alahari,Samthosh V. Alahari,Shengli Dong 한국분자세포생물학회 2015 Molecules and cells Vol.38 No.2
The development of cancer has been an extensively researched topic over the past few decades. Although great strides have been made in cancer prevention, diagnosis, and treatment, there is still much to be learned about cancer’s micro-environmental mechanisms that contribute to cancer formation and aggressiveness. Macrophages, lymphocytes which originate from monocytes, are involved in the inflammatory response and often dispersed to areas of infection to fight harmful antigens and mutated cells in tissues. Macrophages have a plethora of roles including tissue development and repair, immune system functions, and inflammation. We discuss various pathways by which macrophages get activated, various approaches that can regulate the function of macrophages, and how these approaches can be helpful in developing new cancer therapies.
Microwave Assisted One-pot Synthesis of Novel α-Aminophosphonates and Their Biological Activity
Alahari Janardhan Rao,Pasupuleti Visweswara Rao,Valsani Koteswara Rao,Challamchalla Mohan,Chamarthi Naga Raju,Cirandur Suresh Reddy 대한화학회 2010 Bulletin of the Korean Chemical Society Vol.31 No.7
A simple and efficient synthesis of various α-aminophosphonates (3a-l) by the reaction of substituted aromatic/heterocyclic aldehydes, 2-amino-6-methoxy-benzothiazole and dibutyl/diphenyl phosphites under microwave irradiation without catalyst was accomplished. The phosphonates were characterized by elemental analysis, IR, 1H, 13C- and 31PNMR spectra. They showed promising antimicrobial, anti-oxidant activities depending on the nature of bioactive groups at the α-carbon.
Microwave Assisted One-pot Synthesis of Novel α-Aminophosphonates and heir Biological Activity
Rao, Alahari Janardhan,Rao, Pasupuleti Visweswara,Rao, Valsani Koteswara,Mohan, Challamchalla,Raju, Chamarthi Naga,Reddy, Cirandur Suresh Korean Chemical Society 2010 Bulletin of the Korean Chemical Society Vol.31 No.7
A simple and efficient synthesis of various $\alpha$-aminophosphonates (3a-l) by the reaction of substituted aromatic/heterocyclic aldehydes, 2-amino-6-methoxy-benzothiazole and dibutyl/diphenyl phosphites under microwave irradiation without catalyst was accomplished. The phosphonates were characterized by elemental analysis, IR, $^1H$, $^{13}C$- and $^{31}PNMR$ spectra. They showed promising antimicrobial, anti-oxidant activities depending on the nature of bioactive groups at the $\alpha$-carbon.