Evaluation of Biochemical Recurrence-free Survival after Radical Prostatectomy by Cancer of the Prostate Risk Assessment Post-Surgical (CAPRA-S) Score

Aktas, Binhan Kagan,Ozden, Cuneyt,Bulut, Suleyman,Tagci, Suleyman,Erbay, Guven,Gokkaya, Cevdet Serkan,Baykam, Mehmet Murat,Memis, Ali Asian Pacific Journal of Cancer Prevention 2015 Asian Pacific journal of cancer prevention Vol.16 No.6

Background: The cancer of the prostate risk assessment (CAPRA) score has been defined to predict prostate cancer recurrence based on the pre-clinical data, then pathological data have also been incorporated. Thus, CAPRA post-surgical (CAPRA-S) score has been developed based on six criteria (prostate specific antigen (PSA) at diagnosis, pathological Gleason score, and information on surgical margin, seminal vesicle invasion, extracapsular extension and lymph node involvement) for the prediction of post-surgical recurrences. In the present study, biochemical recurrence (BCR)-free probabilities after open retropubic radical prostatectomy (RP) were evaluated by the CAPRA-S scoring system and its three-risk level model. Materials and Methods: CAPRA-S scores (0-12) of our 240 radical prostatectomies performed between January 2000-May 2011 were calculated. Patients were distributed into CAPRA-S score groups and also into three-risk groups as low, intermediate and high. BCR-free probabilities were assessed and compared using Kaplan-Meier analysis and Cox proportional hazards regression. Ability of CAPRA-S in BCR detection was evaluated by concordance index (c-index). Results: BCR was present in 41 of total 240 patients (17.1%) and the mean follow-up time was $51.7{\pm}33.0$ months. Mean BCR-free survival time was 98.3 months (95% CI: 92.3-104.2). Of the patients in low, intermediate and high risk groups, 5.4%, 22.0% and 58.8% had BCR, respectively and the difference among the three groups was significant (P = 0.0001). C-indices of CAPRA-S score and three-risk groups for detecting BCR-free probabilities in 5-yr were 0.87 and 0.81, respectively. Conclusions: Both CAPRA-S score and its three-risk level model well predicted BCR after RP with high c-index levels in our center. Therefore, it is a clinically reliable post-operative risk stratifier and disease recurrence predictor for prostate cancer.

BOUNDS FOR RADII OF CONVEXITY OF SOME q-BESSEL FUNCTIONS

Aktas, Ibrahim,Orhan, Halit Korean Mathematical Society 2020 대한수학회보 Vol.57 No.2

In the present investigation, by applying two different normalizations of the Jackson's second and third q-Bessel functions tight lower and upper bounds for the radii of convexity of the same functions are obtained. In addition, it was shown that these radii obtained are solutions of some transcendental equations. The known Euler-Rayleigh inequalities are intensively used in the proof of main results. Also, the Laguerre-Pólya class of real entire functions plays an important role in this work.

ON PARTIAL SUMS OF NORMALIZED q-BESSEL FUNCTIONS

Aktas, Ibrahim,Orhan, Halit Korean Mathematical Society 2018 대한수학회논문집 Vol.33 No.2

In the present investigation our main aim is to give lower bounds for the ratio of some normalized q-Bessel functions and their sequences of partial sums. Especially, we consider Jackson's second and third q-Bessel functions and we apply one normalization for each of them.

On Interpretation of Hyperbolic Angle

Aktas, Busra,Gundogan, Halit,Durmaz, Olgun Department of Mathematics 2020 Kyungpook mathematical journal Vol.60 No.2

Minkowski spaces have long been investigated with respect to certain properties and substructues such as hyperbolic curves, hyperbolic angles and hyperbolic arc length. In 2009, based on these properties, Chung et al. [3] defined the basic concepts of special relativity, and thus; they interpreted the geometry of the Minkowski spaces. Then, in 2017, E. Nesovic [6] showed the geometric meaning of pseudo angles by interpreting the angle among the unit timelike, spacelike and null vectors on the Minkowski plane. In this study, we show that hyperbolic angle depends on time, t. Moreover, using this fact, we investigate the angles between the unit timelike and spacelike vectors.

Resistance to Macrolide, Lincosamide and Streptogramin Antibiotics in Staphylococci Isolated in Istanbul, Turkey

Aktas, Zerrin,Aridogan, Aslihan,Kayacan, Cigdem Bal,Aydin, Derya The Microbiological Society of Korea 2007 The journal of microbiology Vol.45 No.4

The purpose of this study was to investigate the prevalence and genetic mechanisms of erythromycin resistance in staphylococci. A total of 102 erythromycin resistant non-duplicate clinical isolates of staphylococci [78. coagulase negative stapylococci (CNS), 24 Staphylococcus aureus] were collected between October 2003 and August 2004 in Istanbul Faculty of Medicine in Turkey. The majority of the isolates were from blood and urine specimens. Antimicrobial susceptibilities were determined by the agar dilution procedure and the resistance phenotypes by the double disk induction test. A multiplex PCR was performed, using primers specific for erm(A), erm(B), erm(C), and msrA genes.. Among the 78 CNS isolates, 57.8% expressed the $MLS_{B}-constitutive$, 20.6% the $MLS_{B}-inducible$, and 21.6% the $MS_B$ phenotypes. By PCR, 78.2% of these isolates harbored the erm(C) gene, 8.9% erm(A), 6.4% erm(B), and 11.5% msrA genes. In S. aureus, the constitutive $MLS_B$ (58.3 %) was more common than the inducible phenotype (20.8%). erm(A) was detected in 50% and erm(C) in 62.5% of the isolates, while 37.5% contained both erm(A) and erm(C). erm(C)-associated macrolide resistance was the most prevalent in CNS, while ermC) and erm(A, C) was the most prevalent in S. aureus.

Effect of Home Care Service on the Quality of Life in Patients with Gynecological Cancer

Aktas, Demet,Terzioglu, Fusun Asian Pacific Journal of Cancer Prevention 2015 Asian Pacific journal of cancer prevention Vol.16 No.9

The purpose of the research was to determine the effect of home care service on the quality of life in patients with gynecological cancer. This randomized case control study was carried out in a womans hospital between September 2011 and February 2012. Women undergoing gynecological cancer treatment were separated into intervention and control groups, of 35 patients each. The intervention group was provided with nursing care service through hospital and home visits ($1^{st}$, $12^{th}$ weeks) within the framework of a specifically developed nursing care plan. The control group was monitored without any intervention through the hospital routine protocols ($1^{st}$, $12^{th}$ weeks). Data were collected using An Interview Form, Home Visit Monitoring Form and Quality of Life Scale/Cancer Survivors. Effects of home care service on the quality of life in gynecological cancer patients were investigated using chi-square tests, McNemar's test, independent t-test and ANOVA. This study found that the intervention group receiving home care service had a moderately high quality of life (average mean: $6.01{\pm}0.64$), while the control group had comparatively lower quality (average mean: $4.35{\pm}0.79$) within the 12 week post-discharge period (p<0.05). This study found home care services to be efficient in improving the quality of life in patients with gynecological cancer.

Resistance to Macrolide, Lincosamide and Streptogramin Antibiotics in Staphylococci Isolated in Istanbul, Turkey

Zerrin Aktas,Aslihan Aridogan,Cigdem Bal Kayacan,Derya Aydin 한국미생물학회 2007 The journal of microbiology Vol.45 No.4

The purpose of this study was to investigate the prevalence and genetic mechanisms of erythromycin resistance in staphylococci. A total of 102 erythromycin resistant non-duplicate clinical isolates of staphylococci [78 coagulase negative stapylococci (CNS), 24 Staphylococcus aureus] were collected between October 2003 and August 2004 in Istanbul Faculty of Medicine in Turkey. The majority of the isolates were from blood and urine specimens. Antimicrobial susceptibilities were determined by the agar dilution procedure and the resistance phenotypes by the double disk induction test. A multiplex PCR was performed, using primers specific for erm(A), erm(B), erm(C), and msrA genes. Among the 78 CNS isolates, 57.8% expressed the MLSB-constitutive, 20.6% the MLSB-inducible, and 21.6% the MSB phenotypes. By PCR, 78.2% of these isolates harbored the erm(C) gene, 8.9% erm(A), 6.4% erm(B), and 11.5% msrA genes. In S. aureus, the constitutive MLSB (58.3%) was more common than the inducible phenotype (20.8%). erm(A) was detected in 50% and erm(C) in 62.5% of the isolates, while 37.5% contained both erm(A) and erm(C). erm(C)-associated macrolide resistance was the most prevalent in CNS, while erm(C) and erm(A, C) was the most prevalent in S. aureus.

Investigation of fresh concrete behavior under vibration using mass-spring model

Gultekin Aktas 국제구조공학회 2016 Structural Engineering and Mechanics, An Int'l Jou Vol.57 No.3

This paper deals with the behavior of fresh concrete that is under vibration using mass-spring model (MSM). To this end, behaviors of two different full scale precast concrete molds were investigated experimentally and theoretically. Experiments were performed under vibration with the use of a computerbased data acquisition system. Transducers were used to measure time-dependent lateral displacements at some points on mold while mold is empty and full of fresh concrete. Analytical modeling of molds used in experiments were prepared by three dimensional finite element method (3D FEM) using software. Modeling of full mold, using MSM, was made to solve the problem of dynamic interaction between fresh concrete and mold. Numerical displacement histories obtained from time history analysis were compared with experimental results. The comparisons show that the measured and computed results are compatible.

Bounds for radii of convexity of some q-Bessel functions

Ibrahim Aktas,Halit Orhan 대한수학회 2020 대한수학회보 Vol.57 No.2

In the present investigation, by applying two different normalizations of the Jackson's second and third $q$-Bessel functions tight lower and upper bounds for the radii of convexity of the same functions are obtained. In addition, it was shown that these radii obtained are solutions of some transcendental equations. The known Euler-Rayleigh inequalities are intensively used in the proof of main results. Also, the Laguerre-P\'olya class of real entire functions plays an important role in this work.

Prediction of behavior of fresh concrete exposed to vibration using artificial neural networks and regression model

Gultekin Aktas,Mehmet Sirac Ozerdem 국제구조공학회 2016 Structural Engineering and Mechanics, An Int'l Jou Vol.60 No.4

This paper aims to develop models to accurately predict the behavior of fresh concrete exposed to vibration using artificial neural networks (ANNs) model and regression model (RM). For this purpose, behavior of a full scale precast concrete mold was investigated experimentally and numerically. Experiment was performed under vibration with the use of a computer-based data acquisition system. Transducers were used to measure time-dependent lateral displacements at some points on mold while both mold is empty and full of fresh concrete. Modeling of empty and full mold was made using both ANNs and RM. For the modeling of ANNs: Experimental data were divided randomly into two parts. One of them was used for training of the ANNs and the remaining part was used for testing the ANNs. For the modeling of RM: Sinusoidal regression model equation was determined and the predicted data was compared with measured data. Finally, both models were compared with each other. The comparisons of both models show that the measured and testing results are compatible. Regression analysis is a traditional method that can be used for modeling with simple methods. However, this study also showed that ANN modeling can be used as an alternative method for behavior of fresh concrete exposed to vibration in precast concrete structures.