Update in the Mechanisms of Allergen-Specific Immunotheraphy

Tunc Akkoc,Mübeccel Akdis,Cezmi A. Akdis 대한천식알레르기학회 2011 Allergy, Asthma & Immunology Research Vol.3 No.1

Allergic diseases represent a complex innate and adoptive immune response to natural environmental allergens with Th2-type T cells and allergenspecific IgE predominance. Allergen-specific immunotherapy is the most effective therapeutic approach for disregulated immune response towards allergens by enhancing immune tolerance mechanisms. The main aim of immunotherapy is the generation of allergen nonresponsive or tolerant T cells in sensitized patients and downregulation of predominant T cell- and IgE-mediated immune responses. During allergen-specific immunotherapy,T regulatory cells are generated, which secrete IL-10 and induce allergen-specific B cells for the production of IgG4 antibodies. These mechanisms induce tolerance to antigens that reduces allergic symptoms. Although current knowledge highlights the role of T regulatory cell-mediated immunetolerance,definite mechanisms that lead to a successful clinical outcomes of allergen-specific immunotherapy still remains an open area of research.

Oxytocin Ameliorates Remote Liver Injury Induced by Renal Ischemia- Reperfusion in Rats

Hasan Akkoc 대한약리학회 2013 The Korean Journal of Physiology & Pharmacology Vol.17 No.2

Renal ischemia-reperfusion (IR) causes remote liver damage. Oxytocin has anti-inflammatory and antioxidant effects. The main purpose of this study was to evaluate the protective function of oxytocin (OT) in remote liver damage triggered by renal IR in rats. Twenty four rats were randomly divided into four different groups, each containing 8 rats. The groups were as follows: (1) Sham operated group;(2) Sham operated+OT group (3) Renal IR group; (4) Renal IR+OT group. OT (500μ g/kg) was administered subcutaneously 12 and 24 hours before and immediately after ischemia. At the end of experimental procedure, the rats were sacrificed, and liver specimens were taken for histological assessment or determination of malondialdehyde (MDA), total oxidant status (TOS), total antioxidant status (TAS), paraoxonase (PON-1) activity and nitric oxide (NO). The results showed that renal IR injury constituted a notable elevation in MDA, TOS, Oxidative stress index (OSI) and significantly decreased TAS, PON-1 actvity and NO in liver tissue (p< 0.05). Additionally renal IR provoked significant augmentation in hepatic microscopic damage scores. However, alterations in these biochemical and histopathological indices due to IR injury were attenuated by OT treatment (p<0.05). These findings show that OT ameliorates remote liver damage triggered by renal ischemia-reperfusion and this preservation involves suppression of inflammation and regulation of oxidant-antioxidant status.

Energy-Efficient RL-Based Aerial Network Deployment Testbed for Disaster Areas

Ariman, Mehmet,Akkoc, Mertkan,Talip Sari, Tolga,Erol, Muhammed Rasit,Seçinti, Gökhan,Canberk, Berk 한국통신학회 2023 Journal of communications and networks Vol.25 No.1

Rapid deployment of wireless devices with 5G andbeyond enabled a connected world. However, an immediatedemand increase right after a disaster paralyzes network in-frastructure temporarily. The continuous flow of information iscrucial during disaster times to coordinate rescue operations andidentify the survivors. Communication infrastructures built for users of disaster areasshould satisfy rapid deployment, increased coverage, and avail-ability. Unmanned air vehicles (UAV) provide a potential solutionfor rapid deployment as they are not affected by traffic jamsand physical road damage during a disaster. In addition, ad-hocWiFi communication allows the generation of broadcast domainswithin a clear channel which eases one-to-many communications. Moreover, using reinforcement learning (RL) helps reduce thecomputational cost and increases the accuracy of the NP-hardproblem of aerial network deployment. To this end, a novel flying WiFi ad-hoc network managementmodel is proposed in this paper. The model utilizes deep-Q-learning to maintain quality-of-service (QoS), increase userequipment (UE) coverage, and optimize power efficiency. Fur-thermore, a testbed is deployed on Istanbul Technical Univer-sity (ITU) campus to train the developed model. Training resultsof the model using testbed accumulates over 90% packet deliveryratio as QoS, over 97% coverage for the users in flow tables, and0.28 KJ/Bit average power consumption.

Effects of pain catastrophizing and anxiety on analgesic use after surgical removal of impacted mandibular third molars

Altan, Ahmet,Akkoc, Sumeyra,Erdil, Aras,Colak, Sefa,Demir, Osman,Altan, Halenur The Korean Dental Society of Anesthsiology 2019 Journal of Dental Anesthesia and Pain Medicine Vol.19 No.6

Background: In dentistry, pain is a factor that negatively affects treatments and drug use. The aim of this study was to evaluate the correlations of the postoperative analgesic use with pain catastrophizing and anxiety in patients who underwent removal of an impacted mandibular third molar. Methods: We recruited 92 patients who underwent the extraction of impacted mandibular third molar. In this study, the Pederson index was used to preoperatively determine the difficulty of surgical extraction. Patients were asked to note the number of analgesics used for 7 postoperative days. Patients were divided into two groups based on the Pain Catastrophizing Scale: low and high score groups. State-Trait Anxiety Inventory-trait and State-Trait Anxiety Inventory-state questionnaires were used to determine the anxiety levels of the patients. The obtained data were examined to evaluate the correlations of pain catastrophizing and anxiety with the postoperative analgesic use. Results: In this study, 92 patients, including 60 women and 32 men, were recruited. The analgesic use was higher in women than in men but with no significant difference (P > 0.05). Pain Catastrophizing Scale scores were higher in women than in men but with no significant difference (P > 0.05). The analgesic use was higher in patients with high pain catastrophizing than in those with low pain catastrophizing but with no significant difference (P > 0.05). State-Trait Anxiety Inventory-trait scores were higher in women than in men but with no significant difference. However, state-Trait Anxiety Inventory-state scores were significantly higher in women than in men (P < 0.05). Conclusion: The postoperative analgesic use may be higher in patients who catastrophize pain than in others. Knowing the patient's catastrophic characteristics preoperatively would contribute to successful pain management and appropriate drug selection.

Intracranial Dural Arteriovenous Fistula Draining into Spinal Perimedullary Veins: A Rare Cause of Myelopathy

Funda Atamaz,Ismail Oran,Yesim Akkoc,Berrin Durmaz 대한의학회 2006 Journal of Korean medical science Vol.21 No.5

Targeted surveillance to assess the presence of BSE in the age risk population of cattle slaughtered in Bursa, Turkey: preliminary results of an immunohistochemical detection study for the 2004-2005

M. Mufit Kahraman,M. Ozgur Ozygit,Ahmet Akkoc,Bulent Ediz,Deniz Misirlioglu,Gursel Sonmez,Aylin Alasonyalilar,Rahsan Yilmaz 대한수의학회 2007 JOURNAL OF VETERINARY SCIENCE Vol.8 No.2

Bovine spongiform encephalopathy (BSE), a member of the transmissible spongiform encepahlopathies, has been a notifiable disease in Turkey since 1997. In 2002, the BSE status of Turkey was assessed by the EU Scientific Steering Committee as “it is likely but not confirmed”.This study presents the results of a targeted surveillance study to assess the presence of BSE in the age risk population of Bursa, Turkey. In the assessment procedure, the immunohistochemical detection of protease-resistant prion protein (PrP-Sc) was aimed at and applied to 420 brain tissues of cattle slaughtered in Bursa at an age of 30-months and older. None of the samples were positive for BSE.

Oxytocin Ameliorates Remote Liver Injury Induced by Renal Ischemia-Reperfusion in Rats

Hekimoglu, Askin Tas,Toprak, Gulten,Akkoc, Hasan,Evliyaoglu, Osman,Ozekinci, Selver,Kelle, Ilker The Korean Society of Pharmacology 2013 The Korean Journal of Physiology & Pharmacology Vol.17 No.2

Renal ischemia-reperfusion (IR) causes remote liver damage. Oxytocin has anti-inflammatory and antioxidant effects. The main purpose of this study was to evaluate the protective function of oxytocin (OT) in remote liver damage triggered by renal IR in rats. Twenty four rats were randomly divided into four different groups, each containing 8 rats. The groups were as follows: (1) Sham operated group; (2) Sham operated+OT group (3) Renal IR group; (4) Renal IR+OT group. OT ($500{\mu}g/kg$) was administered subcutaneously 12 and 24 hours before and immediately after ischemia. At the end of experimental procedure, the rats were sacrificed, and liver specimens were taken for histological assessment or determination of malondialdehyde (MDA), total oxidant status (TOS), total antioxidant status (TAS), paraoxonase (PON-1) activity and nitric oxide (NO). The results showed that renal IR injury constituted a notable elevation in MDA, TOS, Oxidative stress index (OSI) and significantly decreased TAS, PON-1 actvity and NO in liver tissue (p<0.05). Additionally renal IR provoked significant augmentation in hepatic microscopic damage scores. However, alterations in these biochemical and histopathological indices due to IR injury were attenuated by OT treatment (p<0.05). These findings show that OT ameliorates remote liver damage triggered by renal ischemia-reperfusion and this preservation involves suppression of inflammation and regulation of oxidant-antioxidant status.

A Case of Adult-Onset Still’s Disease Complicated with Diffuse Alveolar Hemorrhage

Ismail Sari,Omer Binicier,Erkan Yilmaz,Merih Birlik,Servet Akar,Fatos Onen,Nurullah Akkoc 대한의학회 2009 Journal of Korean medical science Vol.24 No.1

Adult-onset Still’s disease (AOSD) is an inflammatory disease that presents with a variety of clinical symptoms. Pulmonary involvement is well-known in AOSD and is seen in up to 53% of AOSD cases, with the most common pulmonary diseases being pleural effusion and transient pulmonary infiltrates. We present the first case of chronic AOSD complicated with diffuse alveolar hemorrhage during the acute flare of the disease.