Disorders Center, Fujieda Heisei Memorial Hospital, Fujieda, Shizuoka, Japan

Turgut Akgül,Kerim Sarıyılmaz,Murat Korkmaz,Okan Özkunt,Özcan Kaya,Fatih Dikici 대한척추외과학회 2018 Asian Spine Journal Vol.12 No.1

Study Design: Retrospective analysis of adolescent idiopathic scoliosis. Purpose: This study aimed to investigate the influence of distinct distal fusion levels on spinopelvic parameters in patients with adolescent idiopathic scoliosis (AIS) who underwent posterior instrumentation and fusion surgery. Overview of Literature: The distal fusion level selection in treatment of AIS is the one of milestone to effect on surgical outcome. Most of the paper focused on the coronal deformity correction and balance. The literature have lack of knowledge about spinopelvic changing after surgical treatment and the relation with distal fusion level. We evaluate the spinopelvic and pelvic parameter alteration after fusion surgery in treatment of AIS. Methods: A total of 100 patients with AIS (88 females and 12 males) were retrospectively reviewed. Patients were assigned into the following three groups according to the distal fusion level: lumbar 2 (L2), lumbar 3 (L3), and lumbar 4 (L4). Using a lateral plane radiograph of the whole spine, spinopelvic angular parameters such as thoracic kyphosis (TK), lumbar lordosis (LL), pelvic incidence (PI), sacral slope (SS), and pelvic tilt (PT) were radiologically assessed. Results: The mean age was 15±2.4 years, and the mean follow-up period was 24.27±11.69 months. Regarding the lowest instrumented vertebra, patients were categorized as follows: 30 patients in L2 (group 1), 40 patients in L3 (group 2), and 30 patients in L4 (group 3). TK decreased from 36.60±13.30 degrees preoperatively to 26.00±7.3 degrees postoperatively in each group (p =0.001). LL decreased from 52.8±9.4 degrees preoperatively to 44.30±7.50 degrees postoperatively (p =0.001). Although PI showed no difference preoperatively among the groups, it was statistically higher postoperatively in group 3 than in the other groups (p <0.05). In addition, in group 2, PI decreased from 50.60±8.74 degrees preoperatively to 48.00±6.84 degrees postoperatively (p =0.027). SS decreased from 35.20±6.40 degrees preoperatively to 33.40±5.80 degrees postoperatively (p =0.08, p >0.05). However, mean SS was significantly higher in group 3 (p =0.042, p <0.05). PT decreased from 15.50±7.90 degrees preoperatively to 15.2±7.10 degrees postoperatively. The positive relationship (28.5%) between LL and PI measurements was statistically significant (r =0.285; p =0.004, p <0.01). Furthermore, the positive relationship (36.5%) between LL and SS measurements was statistically significant (r =0.365; p =0.001, p <0.01). Conclusions: When the distal instrumentation level in AIS surgery is below L3, a significant change in PT and SS (pelvic parameters) is anticipated.

Palliative Posterior Instrumentation versus Corpectomy with Cage Reconstruction Treatment for Thoracolumbar Pathological Fracture

Serkan Bayram,Turgut Akgül,Murat Altan,Tuna Pehlivanoğlu,Özcan Kaya,Mustafa Abdullah Özdemir,Cüneyt Şar 대한척추외과학회 2019 Asian Spine Journal Vol.13 No.2

Study Design: Single-center, retrospective cohort study. Purpose: We aimed to evaluate and compare the clinical outcomes in patients who underwent palliative posterior instrumentation (PPI) versus those who underwent corpectomy with cage reconstruction (CCR) for thoracolumbar pathological fracture. Overview of Literature: The requirement for anterior support after corpectomy has been emphasized in the treatment of pathological fractures of the vertebrae. However, for patients with a relatively short life expectancy, anterior reconstruction may not be required and posterior instrumentation alone may provide adequate stabilization. Methods: A total of 43 patients with metastases of the thoracolumbar spine underwent surgery in the department of orthopaedic and traumatology of Istanbul University Faculty of Medicine from 2003 to 2016. Surgical outcomes were assessed on the basis of survival status, pre- and postoperative pain, complication rate, and operation time. Results: PPI was performed for 22 patients and CCR was performed for 21 patients. In the PPI group, the follow-up period of the five surviving patients was 32 months. The remaining 17 patients died with a mean survival duration of 12.3 months postoperatively. In the CCR group, the five surviving patients were followed up for an average of 14.1 months. The remaining 16 patients died with a mean survival duration of 18.7 months postoperatively. No statistically significant difference (p=0.812) was noted in the survival duration. The Visual Analog Scale scores of the patients were significantly reduced after both procedures, with no significant difference noted on the basis of the type of surgical intervention (p>0.05). The complication rate in the CCR group (33.3%) was higher compared with that in the PPI group (22.7%); however, this difference was not noted to be statistically significant (p=0.379). The average operation time in the PPI group (149 minutes) was significantly shorter (p=0.04) than that in the CCR group (192 minutes). Conclusions: The PPI technique can decompress the tumor for functional improvement and can stabilize the spinal structure to provide pain relief.

Female body, femininity and authority in Bollywood: The “new” woman in Dangal and Queen

Waseem Ahad,Selma Koç Akgül 이화여자대학교 아시아여성학센터 2020 Asian Journal of Women's Studies(AJWS) Vol.26 No.1

Bollywood’s departure from its earlier constructions of women as sex objects, victims of male violence, dependent, obedient and peripheral, is partly due to global/transnational cultural and economic flows that have influence in Indian society. What needs to be charted out is how patriarchal anxieties continue to emerge in recent Bollywood movies where women otherwise appear to assume assertive screen presence and play dominant roles. This study seeks to disentangle notions of “national” and “local,” in particular, because the former does not explain India’s family or local community settings that exercise substantial control over women. Through an analysis of two films, Dangal (2016) and Queen (2014), this study shows how present-day Bollywood appropriates opposing ideals of Hinduism and liberal ideology; therefore, the stories remain rooted in contemporary social discourse. It will be seen that the somewhat masculine woman in Dangal, who is divested of erotic and reproductive attributes, bears the double-burden of subordination by a family patriarch and becoming a national symbol. Through its scrutiny of Queen, the study also demonstrates how a new Indian femininity, “assertive” and “confident,” is mediated by the dominant male cultural gaze. The films offer useful models for comparison of varying forms of femininities.

Pure Uterine Lipoma, a Very Rare Benign Tumor

Elif Ülker Akyildiz,Sema Ozuysal,Akgül Arici,Mehmet Aral Atalay 대한병리학회 2010 Journal of Pathology and Translational Medicine Vol.44 No.6

Pure lipomas of the uterus are very rare tumors that may be misdiagnosed on radiological examination due to their rarity and fat content. We present here the case of a 57-year-old postmenopausal woman who presented to the hospital with lower abdominal pain. Abdominal hysterectomy and bilateral salpingo-oophorectomy were performed under the prediagnoses of benign cystic ovarian teratoma or leiomyoma. On the histopathological examination of tissue samples, the tumor was composed of mature fat cells. There were a few smooth muscle cells confined to the periphery. Pure uterine lipoma may be asymptomatic or it may have symptoms similar to those of leiomyoma such as vaginal bleeding or pelvic pain. A pure lipoma should be diagnosed only if smooth muscle cells are confined to the periphery.

Methacryloylamidohistidine in Affinity Ligands for Immobilized Metal-ion Affinity Chromatography of Ferritin

Deniz Akta Uygun,Nevra Öztürk,Sinan Akgöl,Adil Denizli 한국생물공학회 2011 Biotechnology and Bioprocess Engineering Vol.16 No.1

A new metal-chelate adsorbent utilizing 2-methacryloylamidohistidine (MAH) was prepared as a metalchelating ligand. MAH was synthesized using methacryloly chloride and histidine. Monosize nanospheres with an average diameter of 450 nm were produced by emulsion polymerization of 2-hydroxyetylmethacrylate (HEMA) and MAH. Then, Fe^(3+) ions were chelated directly onto the monosize nanospheres. Mon-poly(HEMA-MAH) nanospheres were characterized by Fourier transform infrared spectroscopy,scanning electron microscopy, and elemental analysis. Fe^(3+) chelated monosize nanospheres were used in ferritin adsorption from an aqueous solution. The maximum ferritin adsorption capacity of Fe^(3+)-chelated mon-poly(HEMAMAH)nanospheres was 202 mg/g at pH 4.0 in acetate buffer. The non-specific ferritin adsorption on the monpoly(HEMA-MAH) nanospheres was 20 mg/g. The adsorption behavior of ferritin could be modeled using both Langmuir and Freundlich isotherms. The adsorption capacity decreased with increasing ionic strength of the binding buffer. High desorption ratios (> 95% of the adsorbed ferritin) were achieved with 1.0 M NaCl at pH 7.0. Ferritin could be repeatedly adsorbed and desorbed with the Fe^(3+)-chelated mon-poly(HEMA-MAH) nanospheres without significant loss of adsorption capacity.

Fragility Analysis of Atmospheric Storage Tanks by Observational and Analytical Data

Fırat Bezir,Sezer Öztürk,Ali Sarı,Kayahan Akgül 한국강구조학회 2022 International Journal of Steel Structures Vol.22 No.1

In this research, seismic fragility analysis of storage tanks is carried out with a large damage database from past earthquakes and analytical studies. At the fragility analysis, a new damage state has been defi ned. Peak ground acceleration is employed as an intensity measure. Epistemic and aleatory uncertainties are considered. At the observational fragility analysis, logit, probit and cumulative lognormal model and maximum likelihood method are utilized. In this research, Finite Element Analysis is also performed. As a result, new seismic fragility curves for storage tanks obtained and compared with the existing tank fragility curves in the literature.

The Independent Relationship of Systemic Inflammation With Fragmented QRS Complexes in Patients With Acute Coronary Syndromes

Mustafa Çetin,Sinan Altan Kocaman,Turan Erdog˘ an,Aytun Çanga,Murtaza Emre Durakog˘ lugil,Ömer S¸atırog˘ lu,Özgür Akgül, MD,Tuncay Kırıs,Yüksel Çiçek,Barıs¸ Yaylak,Sıtkı Dog˘ an,smail S¸ahin,Mehmet Bo 대한심장학회 2012 Korean Circulation Journal Vol.42 No.7

Background and Objectives: QRS complex fragmentations are frequently seen on routine electrocardiograms with narrow or wide QRS complex. Fragmented QRS complex (fQRS) is associated with increased morbidity and mortality, sudden cardiac death and recurrent car-diovascular events. In this study, we aimed to interrogate the relationship of systemic inflammation with the presence of fQRS in patients with acute coronary syndromes (ACS). Subjects and Methods: Two-hundred and twenty eligible patients with ACS that underwent coronary angiography were enrolled con-secutively in this study. Patients with significant organic valve disease and those with any QRS morphology that had a QRS duration ≥120 ms as well as patients with permanent pacemakers were excluded from this study. Results: Patients with fQRS were of a higher age (p=0.02), had increased C-reactive protein (CRP) levels (p<0.001), prolonged QRS time (p<0.001), extent of coronary artery disease (CAD) (p<0.001), creatine kinase-MB (CK-MB) levels (p=0.006) and Q wave on admission elec-trocardiography (p<0.001) in comparison to patients with non-fragmented QRS. When we performed multiple logistic regression analysis,fQRS was found to be related to increased CRP levels {odds ratio (OR): 1.2, 95% confidence interval (CI): 1.045-1.316, p=0.007}, QRS du-ration (OR: 1.1, 95% CI: 1.033-1.098, p<0.001), extent of CAD (OR: 1.5, 95% CI: 1.023-2.144, p=0.037), Q wave (OR: 2.2, 95% CI: 1.084-4.598, p=0.03) and CK-MB levels (OR: 1.0, 95% CI: 1.001-1.037, p=0.04) independently. Conclusion: In our study, we found that fQRS was independently related to increased CRP. Fragmented QRS that may result as an end effect of inflammation at cellular level can represent increased cardiac risk by different causative mechanisms in patients with ACS. Background and Objectives: QRS complex fragmentations are frequently seen on routine electrocardiograms with narrow or wide QRS complex. Fragmented QRS complex (fQRS) is associated with increased morbidity and mortality, sudden cardiac death and recurrent car-diovascular events. In this study, we aimed to interrogate the relationship of systemic inflammation with the presence of fQRS in patients with acute coronary syndromes (ACS). Subjects and Methods: Two-hundred and twenty eligible patients with ACS that underwent coronary angiography were enrolled con-secutively in this study. Patients with significant organic valve disease and those with any QRS morphology that had a QRS duration ≥120 ms as well as patients with permanent pacemakers were excluded from this study. Results: Patients with fQRS were of a higher age (p=0.02), had increased C-reactive protein (CRP) levels (p<0.001), prolonged QRS time (p<0.001), extent of coronary artery disease (CAD) (p<0.001), creatine kinase-MB (CK-MB) levels (p=0.006) and Q wave on admission elec-trocardiography (p<0.001) in comparison to patients with non-fragmented QRS. When we performed multiple logistic regression analysis,fQRS was found to be related to increased CRP levels {odds ratio (OR): 1.2, 95% confidence interval (CI): 1.045-1.316, p=0.007}, QRS du-ration (OR: 1.1, 95% CI: 1.033-1.098, p<0.001), extent of CAD (OR: 1.5, 95% CI: 1.023-2.144, p=0.037), Q wave (OR: 2.2, 95% CI: 1.084-4.598, p=0.03) and CK-MB levels (OR: 1.0, 95% CI: 1.001-1.037, p=0.04) independently. Conclusion: In our study, we found that fQRS was independently related to increased CRP. Fragmented QRS that may result as an end effect of inflammation at cellular level can represent increased cardiac risk by different causative mechanisms in patients with ACS.