Analysis Natrium Iodide Symporter Expression in Breast Cancer Subtypes for Radioiodine Therapy Response

Aisyah Elliyanti,Dewi Rusnita,Nita Afriani,Yayi Dwina Billianti Susanto,Veronica Y. Susilo,Sri Setiyowati,Wirsma Arif Harahap 대한핵의학회 2020 핵의학 분자영상 Vol.54 No.1

Purpose This study investigates natrium iodide symporter (NIS) expression in three breast cancer subtypes to predict radioiodine response. Materials and Methods Frozen breast tissues from triple negative (TN), human epidermal receptor 2 (HER2+), and luminal A cancers were used in this research. NIS protein expression in each subtype was analyzed using immunohistochemistry (IHC) and western blot (WB). Secondary data such as age, subtypes, and Ki 67 index were drawn from the surgical oncologist database. Breast cancer cell lines were used to investigate the effect of radioiodine by measuring cell proliferation. Results The forty-one breast cancer samples were analyzed consisted of the following subtypes: TN, HER2+, and luminal Awere 58%, 22%, and 20%respectively. The stages of disease were 2A to 4A. Most of samples were at 3B. Ki 67 index of TN, HER2+, and luminalAwere 21 ± 12, 19 ± 5, and 7 ± 3 respectively. The NIS expressionwas detected in 95%of samples in cytoplasmand/ or cell membrane; 93% of samples were invasive breast carcinomas. Only 20% of the samples showed NIS expression at cell membrane; four samples were HER2+, and other four were TN subtypes. NIS membrane score was significantly positively correlated with Ki67 index, p = 0.04. NIS protein expression was detected at sizes 88 kDa, 50 kDa, and 27 kDa. Cell proliferation rate means of MDA-MB 231, SKBR3, and MCF7 cells were 81.6 ± 4, 10.6 ± 5, and 15.4 ± 13 respectively (p = 0.009). Conclusion NIS protein expression is detectable in breast cancer cells to varying degrees. HER2+ is the most likely to express NIS in the cell membrane followed by TN subtypes. This indicates that radioiodine could be used as a novel adjuvant treatment in breast cancer.

Design of Self-Evaluation Model for Smart City in Bandung

Aisyah Nuraeni,Yiyi Supendi,Daniel Rohmatulloh 한국정보통신학회 2022 2016 INTERNATIONAL CONFERENCE Vol.13 No.1

An Ensemble Classification of Mental Health in Malaysia related to the Covid-19 Pandemic using Social Media Sentiment Analysis

Nur ‘Aisyah Binti Zakaria Adli,Muneer Ahmad,Norjihan Abdul Ghani,Sri Devi Ravana,Azah Anir Norman 한국인터넷정보학회 2024 KSII Transactions on Internet and Information Syst Vol.18 No.2

COVID-19 was declared a pandemic by theWorld Health Organization (WHO) on 30 January 2020. The lifestyle of people all over the world has changed since. In most cases, the pandemic has appeared to create severe mental disorders, anxieties, and depression among people. Mostly, the researchers have been conducting surveys to identify the impacts of the pandemic on the mental health of people. Despite the better quality, tailored, and more specific data that can be generated by surveys, social media offers great insights into revealing the impact of the pandemic on mental health. Since people feel connected on social media, thus, this study aims to get the people’s sentiments about the pandemic related to mental issues. Word Cloud was used to visualize and identify the most frequent keywords related to COVID-19 and mental health disorders. This study employs Majority Voting Ensemble (MVE) classification and individual classifiers such as Naïve Bayes (NB), Support Vector Machine (SVM), and Logistic Regression (LR) to classify the sentiment through tweets. The tweets were classified into either positive, neutral, or negative using the Valence Aware Dictionary or sEntiment Reasoner (VADER). Confusion matrix and classification reports bestow the precision, recall, and F1-score in identifying the best algorithm for classifying the sentiments.

Atomisation and vacuum drying studies on Malaysian honey encapsulation

Nurul Aisyah Rosli,Boon-Beng Lee,Khairul Farihan Kasim,Sharifah Robiah Mohamad 한국식품저장유통학회 2023 한국식품저장유통학회지 Vol.30 No.4

Malaysian honey is rich in nutrients and bioactive compounds, which can be a healthy alternative to refined sugar in food production. However, liquid honey’s viscous and sticky nature makes it unpreferable in industrial handling. This study, an atomization system coupled with vacuum drying to produce honey powders to overcome the problem. Three types of Malaysian honey, namely Acacia, Gelam, and Tualang, were encapsulated in Ca-alginate gel beads using the atomization system. The density viscosity, and surface tension of the honey-alginate solutions were measured, and the concentration of honey and alginate influenced the physical properties of the solutions. Honey-encapsulated gel beads in the size range of 2.16-2.92 mm were produced using the atomization system with the air-liquid mass flow rate ratios of 0.22-0.31, Weber number (We) of 112-545, and Ohnersorges number (Oh) of 0.35-10.46. Gel bead diameter can be predicted using a simple mathematical model. After vacuum drying, the honey gel powder produced was in the size range of 1.50-1.79 mm. Results showed that honey gel powders with good encapsulation efficiency and high honey loading could be produced using the atomization system and vacuum drying.

Semantic Differential Applied to the Evaluation of Customers’Preferences for a Coffee Shop

Siti Aisyah binti Muhammad,이성필 한국인더스트리얼디자인학회 2014 산업디자인학연구 Vol.8 No.4

Nowadays, coffee shops born in Korean culture are not only because of the taste of the coffee to enjoy but the atmosphere offered inside the coffee shops, such as themed café and also gallery. Rust and Oliver (1994) stated reliability is based on the customer’s evaluation of the physical service factors such as design. The aim of this study is to grasp the preferences factor that influenced the selection of a coffee shop to the customers. For this study, semantic differential (SD) method was employed to examine the relationship between the subjects' evaluation of coffee shop in form design elements. Two coffee shops were chose as a case study. The results from the factor analysis and hierarchial cluster analysis of both coffee shops suggest that the main components to consider in a coffee shop are six; Ambience, Emotion, Gesture, Impression, Spatial Layout, and Mood. This can be useful fundamental data enabling designers to understand factor of preferences easily and to establish concepts for their coffee shop designs.

Biomimetic hydrophobic membrane: A review of anti-wetting properties as a potential factor in membrane development for membrane distillation (MD)

Wan Aisyah Fadilah Wae AbdulKadir,ABDUL LATIF AHMAD,Ooi Boon Seng,Nuur Fahanis Che Lah 한국공업화학회 2020 Journal of Industrial and Engineering Chemistry Vol.91 No.-

The development of superhydrophobic membranes had inspired by superhydrophobic surfaces ofbiomimetic nature. Among the superhydrophobic nature surface, ‘lotus effect’ with a contact angle of150 has been widely explored for membrane distillation. In a recent development, membranedistillation highlighting the new interest of different separation approaches such as removal of metals,antibiotics, and ammonia from wastewater. This development has attracted researchers to produce adesired superhydrophobic membrane with excellent anti-wetting properties to ensure the efficiency ofthe membrane distillation process. In this review, the authors emphasize a few studies from variousresearchers regarding the superhydrophobic membrane surfaces by the different approaches ofmaterials, methods, and membrane configurations in achieving desired anti-wetting properties. Theliterature showed that the incorporation of the modified nanoparticle byfluoroalkyl silane (FAS) andelectrospinning membrane configuration has high potential properties to produce a novel anti-wettingmembrane for a unique requirement of the membrane distillation process. Factors of the significantimprovement in membrane performances have also proposed for large-scale demand. The versatility ofthe desired anti-wetting membrane has proved to use in the vast areas of applications.

Simultaneously enhanced optical, electrical, and mechanical properties of highly stretchable transparent silver nanowire electrodes using organic surface modifier

Entifar, Siti Aisyah Nurmaulia,Han, Joo Won,Lee, Dong Jin,Ramadhan, Zeno Rizqi,Hong, Juhee,Kang, Moon Hee,Kim, Soyeon,Lim, Dongchan,Yun, Changhun,Kim, Yong Hyun TaylorFrancis 2019 Science and technology of advanced materials Vol.20 No.1

<P><B>ABSTRACT</B></P><P>We report on a new surface modifier which simultaneously improves electrical, optical, and mechanical properties of silver nanowire-based stretchable transparent electrodes. The transparent electrodes treated with 11-aminoundecanoic acid achieve a low sheet resistance of 26.0 ohm/sq and a high transmittance of 90% with an excellent stretchability. These improvements are attributed to the effective formation of a strong chemical bond between silver nanowire networks and elastomeric substrates by 11-aminoundecanoic acid treatment. The resistance change of the optimized silver nanowire/poly(3,4-ethylenedioxythiophene):poly(styrenesulfonate) (PEDOT:PSS) thin-films is only about 10% when the film is stretched by 120%. In addition, the chemical stability of stretchable silver nanowire films is significantly improved by the introduction of conductive PEDOT:PSS overcoat film. The optimized electrodes are utilized as high-performance stretchable transparent heaters, successfully illustrating its feasibility for future wearable electronics.</P>

Stretchable Transparent Conductive Electrodes Based on Silver Nanowires-Polymer Composites for Stretchable Electronic Devices

( Entifar Siti Aisyah Nurmaulia ),김용현 한국공업화학회 2018 한국공업화학회 연구논문 초록집 Vol.2018 No.0

Recently, silver nanowires (AgNWs) have received a great interest as a transparent conducting material for various optoelectronic devices. Here, high performance stretchable transparent electrodes based on AgNWs and conductive polymer PEDOT:PSS on an elastomeric polydimethylsiloxane (PDMS) has been investigated. The surface modifier introduced in this study significantly improves the hydrophilicity of the PDMS surface and enhances the bonding between AgNWs and PDMS. The resulting hybrid transparent electrodes show a low sheet resistance of 25 Ω/sq and high transmittance of 82%, which are comparable to the performance of indium tin oxide (ITO) reference electrodes. In addition, the hybrid transparent electrodes show a remarkably small resistance change below 10 % up to the strain of 100 %. Furthermore, the hybrid electrodes are employed into stretchable heater devices.

Flavonoid Compounds from the Leaves of Kalanchoe prolifera and Their Cytotoxic Activity against P-388 Murine Leukimia Cells

Lilis Siti Aisyah,Yenny Febriani Yun,Tati Herlina,Euis Julaeha,Achmad Zainuddin,Ida Nurfarida,Ace Tatang Hidayat,Unang Supratman,Yoshihito Shiono 한국생약학회 2017 Natural Product Sciences Vol.23 No.2

Seven flavonoid compounds, kaempferol (1), quercetin (2), quercetin-3-O-b-D-glucopyranoside (3), kaempferol-3-O-b-D-glucopyranoside (4), kaempferol-3-O-a-L-rhamnoside (5), quercetin-3-O-sophoroside (6) and quercetin-3-O-rutinoside (7), were isolated from the methanolic extract of leaves of Kalanchoe prolifera. Compounds 1-7 were isolated for first time from this plant. These compounds were evaluated their cytotoxic activity against P-388 murine leukimia cells in vitro. Among those compounds kaempferol (1) and quercetin (2) showed strongest cytotoxic activity with IC50 values of 4.45 ? 0.05 and 6.28 ? 0.02 mg/mL, respectively.

THE INSTAGRAM’S STRATEGY IN ENGAGING THE CUSTOMER’S LOYALITY IN RIA MIRANDA’S BRAND

Siti Dewi Aisyah 글로벌지식마케팅경영학회 2017 Global Fashion Management Conference Vol.2017 No.07

The phenomena of fashionable hijabi - headscarf-wearing women - who crowded social media has been seen in the past three years. Social media is progressively penetrating daily media using (Hinton & Hjort, 2013). Indonesian hijabis also use social media to show her creativity in styling their outfit and hijab and share it to others thus like-minded people are inspired to do the same thing too, to combine the fashion and faith. Indonesia, as the largest Muslim majority country has benefited this booming of hijab fashion in articulating the Muslim lifestyle. This trend is triggered by 30 young Muslim women who then formed Hijabers Community. One of them was Ria Miranda, who is known as one of hijab fashion movers in Indonesia, is then now a prominent Muslim fashion designer in Indonesia. Ria Miranda is actively using social media for her marketing strategy from the booming of blog, Facebook, Twitter then now Instagram and the newest one is YouTube. Her team is using many forms of social media to engange with customers. She has her own Instagram under the name @riamiranda which has more than 500.000 followers as for personal branding including her daily activities, her family story which is considered now as family goals and also her designer life. Her husband under the name @pandurosadi serves as her co-branding which sometimes tell a behind-the-scene of her designer wife's activities, his family and his romantic words to her wife. She also has an instagram as for the information about her brand named @inforiamiranda which has more than 80.000 followers. She builds a very good relationship with her customers who then claimed to be Ria Miranda Loyal Customer or RMLC. These customers are die-hard fans who always hunt her products and they also sometimes serve as word-of-mouth on their social media platform especially on Instagram. They always wear Ria Miranda’s products and post their photos under the hashtags that of Ria also uses, they also put their biodata as “Ria Miranda Loyal Customers” which becomes a pride for them. Ria Miranda uses a several hashtag to differentiate her timeline feeds and the most used ones are #riamirandastyle, #RMLC and #riamirandasale. These hashtags are also used by unofficial sellers of her products because her producst are not easy to get thus there are many people who sell their items to others. Apart from only selling her fashion products, Ria tells a story, she tells her lifestyles as her digital strategy engagement. That is what Indonesian people are looking for, a role model. Her product was once only women’s clothes but now it also ranges to accessories such as eyeglasses, necklaces, shoes and bags. It is not only designed for women but also kids and the newest one is for men. So it is a family-package brand. In 2016, she makes several activations including private preview collection show to several big cities around Indonesia that has its store branches and this program also included to invite her customers to travel together and it ended up with fashion show and bazaar. No need to explain, her products were all sold out in minutes. Other events are Ria Miranda Trend Show which is an annual event, this year is the forth time. It was held on December for two days, not only about fashion show but also talkshows about trend in fashion, beauty, e-commerce, lifestyle, music and family. Before this main event, it held several pre-events about Beauty and Make Up class and talkshows about Fashionpreneur that were also crowded by her customers. The most interesting was that it also made a challenge in Instagram called #30dailychallenges that has been used for more than 5.000 posts in Instagram. This program was about a challenge to post our photos on Instagram with several thematic topic such as about the style, hijab outfit of the day that mostly knonw as #HOTD and other daily activities related to Ria’s products and other products that are collaborated with her such as cosmetics and e-commerce. Ria can be said as a good designer in Indonesia. I have a high curiosity about how she can make her customers loyal to her and always want to buy more and more. Besides that she made a good and high quality product, her clothes are not cheap but her customers are always willing to buy and even compete to have her products. They have created many words that are only understood among them, we need a dictionary to know the meaning of them such as #PPCi, #RMLCii, #RMTSiii. I want to analyze them too. This research will employ a qualitative research method which will use more words than numbers (Stokes, 2003) with non-participants observation and visual semiotics analysis. Semiotics is the study of signs that is useful to interpreting the text (Berger, 2014; Howells, 2003; Jensen & Jankowski, 1991; Stoke, 2003). In here I will analyze the Instagram's photographs, captions and also the hashtags that contain meaning behind their usings. Globally, Instagram has reached 500 million users and Indonesia is ranked as the third countries with most users after Japan and Brazil. 89% of instagram users are between 18 – 34 years old and dominated by women with a portion of 63% (Edwin, 2016). Instagram helps designers to show their product freely and got global exposure as long as they can provide a good quality of photos. Fashion and technology are the most popular products among Indonesian Instagram users and they must have ever made a shopping experience from their Instagram’s brands they follow. Apart from that, Indonesians use instagram to find inspiration, share their travel experience and to find information about new trends. I also use in-depth interview to understand more about this brand. I have been able to interview her husband who serves as Business Development and who creates the strategy behind this brand. I want to know deeper about the digital strategy of Ria Miranda brand as it is actively using social media to engange with customers and how it creates consumer culture for fashionable hijabi. Consumer culture is simply the tendency of people who consume what is available on the market through different types of shopping platforms such as on the Internet, retail and shopping malls (Lury, 2011). This research’s goals are to examine the digital strategy of Ria Miranda and team that has been used on Instagram. I hope that this research will contribute to the way how we use social media to make a profit, share positive things and to know more about the new digital strategy. The future work will be possible to analyze about YouTube video that Ria Miranda has newly engaged with.