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( Sang Hoon Ahn ),( Won Hyeok Choe ),( Yoon Jun Kim ),( Jeong Heo ),( Dorota Latarska-smuga ),( Jiho Kang ),( Seung Woon Paik ) 대한간학회 2017 춘·추계 학술대회 (KASL) Vol.2017 No.1
Aims: Chronic Hepatitis C Virus (HCV) infection increases the risk for progressive liver disease, hepatocellular carcinoma and negatively impacts the patient’s quality of life. HCV treatment is evolving with direct acting antivirals but IFN based therapy has been the standard of care for many years and remains available in some countries. The MOSAIC study aims to characterize patients with chronic HCV infection and assess the impact of IFN-containing treatment on health-related quality of life, work related productivity and health care utilization. Methods: MOSAIC is an international prospective multicenter observational study that has been conducted in 20 countries. Consecutive patients with chronic HCV infection were enrolled and those who initiated an IFN based regimen were prospectively followed for 48 weeks. We report results from the Korean cohort Results: 100 patients were enrolled: 86 were treatment naïve and 14 were treatment experienced. 33 patients initiated an IFN based regimen: 6 patients started IFN + RBV, 26 patients started Peg-IFN + RBV, none started Peg-IFN + RBV + DAA and 1 patient received other treatment. Among the treated cohort, demographic and disease characteristics were the following: the mean age was 54.5 years; 14 patients were male. 14 had minimal or no fibrosis, 2 portal fibrosis, 3 bridging fibrosis and 6 patients suffered from cirrhosis. HCV Genotype distribution was as follows: genotype 1: 11; genotype 2: 19 and genotype 3: 3. Table 1 describes the results at baseline and changes over 4, 12 and 48 weeks and end-of-treatment (EOT) for the quality of life and work productivity outcome measures (EQ-5D-5L, HCV-PRO and WPAI). Conclusions: Results from the Korean cohort of the MOSAIC study show a moderate trend for deterioration of health-related quality of life and work productivity associated with IFN based treatment for patients with chronic HCV infection during treatment period. Acknowledgements: The design, study conduct, analysis, and financial support of MOSAIC study were provided by AbbVie. AbbVie participated in the interpretation of data, review, and approval of the content of the abstract. All authors had access to all relevant data and participated in writing, review, and approval of this abstract. Medical writing support was provided by Olivier Van de Steen of Medeor-consulting, funded by AbbVie. Disclosures: Sang Hoon Ahn: served as an advisor and lecturer for Bristol-Myers Squibb, Gilead Sciences, F.Hoffmann-La Roche, Merck, AbbVie, and has received unrestricted grants from Bristol-Myers Squibb, Gilead Sciences, and F. Hoffmann-La Roche for investigator- initiated trials Won Hyeok Choe: Nothing to disclosure Yoon Jun Kim: Nothing to disclosure Jeong Heo: received a grant from GSK; Research support from BMS, and Roche; Advisor for Abbvie, BMS, Gilead Sciences, Pharma Essentia, SillaJen, and Johnson & Johnson. Dorota Latarska-Smuga, Jiho Kang: are employees of AbbVie, Inc. and may hold stock or stock options. Seung Woon Paik: received grant and research support from AbbVie, BMS, Gilead, GSK, Merck, Novartis, and Roche
A Case of Eosinophilic Esophagitis With Food Hypersensitivity
( Sang Hoon Kim ),( Seong Hwan Kim ),( Young Sook Park ),( Byoung Kwan Son ),( Nam In Kim ),( Sang Bong Ahn ),( Yunju Jo ),( Jong Eun Ju ) 대한소화관운동학회 2010 Journal of Neurogastroenterology and Motility (JNM Vol.16 No.3
Eosinophilic esophagitis (EoE) is a disorder characterized by isolated eosinophilic infiltration of the esophagus with esophageal symptoms. Although some patients with EoE are related to food hypersensitivity, it is hard to identify causative foods. This re port describes a case of EoE with dysphagia. A 28-year-old man presented with dysphagia and substernal discomfort for 15days. He had taken a protein complex for 2 months. Endoscopy showed several linear furrows and multiple mucosal nod-ularities on the lower and mid esophagus, and the biopsies of esophagus revealed marked eosinophil infiltration in the mucosa. The skin testing for the protein complex was positive. The patient was successfully treated with withholding treatment.
Ahn, Sung Hoon,Kim, Dong Jun,Chi, Won Seok,Kim, Jong Hak WILEY‐VCH Verlag 2013 ADVANCED MATERIALS Vol.25 No.35
<P><B>Hierarchical nanostructures of TiO<SUB>2</SUB> nanosheets</B> on SnO<SUB>2</SUB> nanotubes (SNT@TNS) are uniformly dispersed in an organized mesoporous (OM) TiO<SUB>2</SUB> film with large pores, high porosity, and good interconnectivity. The solid‐state dye sensitized solar cells (ssDSSCs) fabricated with 10 wt% SNT@TNS dispersed in a OM–TiO<SUB>2</SUB> film show an energy conversion efficiency of 7.7% at 100 mW cm<SUP>−2</SUP>, which is one of the highest values for N719‐based ssDSSCs and much larger than that of a randomly oriented TiO<SUB>2</SUB> nanoparticles‐based cell (4.0%).</P>
Epidemiological studies of Clonorchis sinensis in the coastal areas of Kyungpook, Korea
Ahn,Sung Hoon,Lee,Soo Hyeong,Joo,Chong Yoon 啓明大學校 醫科大學 1996 계명의대학술지 Vol.15 No.4
In order to determine the epidemiological patterns of the liver fluke, the infection rates for Clonorchis larvae in the snails and fish hosts, and the prevalence of C. sinensis among the residents in the coastal areas of Kyungpook Province were studied from April, 1992 to September, 1993. Four snail habitats were found in the river Hyungsan and come streams. One area had snails infected with Clonorchis cercaria, but the proportion of infected snails was very low, the average rates varying from zero to 0.081 percent. Of the 19 species of fish, 3 species were infected with the encysted larvae of C. sinensis. Infection rates varied greatly by the fish species, and ranged from 6.7 percent in P. herzi to 88.9 percent in G. artomaculatus. In the intensity of infection with C. sinensis, G. atromaculatus was the most heavily infected species, the average number of cysts per gram of the fish flesh being 72.2 followed by P. herzi with 53.0 cysts. The infection rate for C. sinensis among the residents was relatively high, being found to be 5.9 percent with a prevalence of 7.0 percent in males and 5.1percent in females. the difference in the rate of infection between males and females is found to be statistically significant(t>2). For the quantitative analysis of epidemiology of C. sinensis, a special type of simple catalytic model was applied to the sex and age infection rates revealed by stool examination for Clonorchis eggs. The simple catalytic curve for males was y=0.21(1-e-0.021t), and females was y=0.19(1-e-0.013t). From these equations the force of infection of 2.1 and 1.3 effective infections giving positive stool examination per 1,000 residents annually was suggested. And the asymptote is at about 21.0 percent of males and 19.0 percent of females, the estimated values of the limit of possible positive cases in the residents. For the analysis of the age prevalence patterns of Clonorchis positives applied the two-stage catalytic model, and the equation is y=0.511(e-0.0093t-e-0.0275t). for the analysis of the intensity of infection, the frequency distribution by the Clonorchis egg counts was calculated as well as the cumulative percentage to the total number of positive cases, and the regression equation is y=1.07+1.50 log X. This study indicate that endemic foci of C. sinensis exist in the coastal areas of Kyungpook Province and the prevalence of the liver fluke among the residents is still high, and that the infection rates with Clonorchis larvae in the fresh-water fish and snails varied greatly by the species of fish and its habitats.
Ahn, Jun Hyong,Lee, Sang Hyun,Kim, Sohee,Joo, Jungnam,Yoo, Heon,Lee, Seung Hoon,Shin, Sang Hoon,Gwak, Ho-Shin Journal of Neurosurgery Publishing Group 2012 Journal of Neurosurgery Vol.116 No.5
<B>Object</B><P>Surgical spillage has been one of the causative factors for the development of leptomeningeal seeding (LMS) after resection of brain metastases. In this paper, the authors' goal was to define the factors related to the development of LMS and to evaluate the difference according to tumor location.</P><B>Methods</B><P>The authors retrospectively analyzed 242 patients who had undergone resection for brain metastases. The factors investigated included tumor location with proximity to the CSF pathway (that is, contacting, involved with, or separated from the CSF pathway), the method of resection, and the use of the Cavitron Ultrasonic Surgical Aspirator (CUSA).</P><B>Results</B><P>A total of 39 patients (16%) developed LMS at a median of 6.0 months (range 1-42 months) after resection. The risk of developing LMS was significantly higher in patients whose tumors were resected piecemeal than in those whose tumors were removed en bloc, with a hazard ratio (HR) of 4.08 (p < 0.01). The incidence of LMS was significantly higher in patients in whom the CUSA was used, and the HR was 2.64 (p < 0.01). The proximity of tumor to the CSF pathway in the involved group conferred an increased risk of LMS compared with the separated group (HR 11.36, p < 0.01). The risk of piecemeal resection for LMS was significant only in involved lesions (p < 0.01), and the use of the CUSA in both contact and involved lesions increased the incidence of LMS (p < 0.01 and p < 0.03, respectively).</P><B>Conclusions</B><P>The authors suggest that piecemeal resection using the CUSA should be limited because of the risk of postsurgical LMS, especially when the tumor is in contact with the CSF pathway.</P>
A Literature Analysis on Medicinal Use and Research of Cannabis in the Meiji Era of Japan
Ahn, Byung-Soo,Kang, Seokhyun,Lee, Kyung Hoon,Kim, Seoyoon,Park, Jin Sung,Seo, Hyung-Sik KOREAN PHARMACOPUNCTURE INSTITUTE 2020 Journal of pharmacopuncture Vol.23 No.3
Cannabis is a historical plant which has been used as a medicine in East Asia. These days, there are active debates about using cannabis in clinical field. Collecting and comparing cannabis research articles which had been published in the Opening of Japan to spot the interactions between the traditional medicine of Japan, Rangaku which was established in Edo Period and the European medicine which is transferred after Perry Expedition is academically meaningful. This study searched publications, which were listed on Open-Access databases by Dec. 11<sup>th</sup>, 2019. We collected research articles which had been published from January 3<sup>rd</sup>, 1867 to July 30<sup>th</sup>, 1912 also known as Meiji era and uploaded on OpenAccess databases. Our searching databases were J-stage, CiNii (Scholarly and Academic Information Navigator), Tokyo Metropolitan Library, The National Diet Library, IRDB (Institutional Repositories DataBase) and KAKEN (Grant-in-Aid for Scientific Research Database). Searching keywords were cannabis, hemp and all their Japanese synonyms and available combinations. We selected final 15 studies which met every selection criteria in the 346,393 collected studies. Cannabis was prescribed in Meiji era of Japan to alleviate pain and cure the digestive, respiratory, urinary, and nervous system diseases such as indigestion, asthma, tuberculosis, gonorrhea and its complications, insomnia, and nervous prostration. Cannabis was medically used in Meiji era of Japan and the reporting and sharing of its clinical effect was published on the medical journals like present days. There were already Cannabis regulations in that era, but its medicinal use was more liberated than nowadays. It may be a chance to reconsider the current legal system, which strictly controls the use of Cannabis.
Toxic Fungi Protein Classification Using Task Specific BERT
Sung-Yoon Ahn,Sung-Hoon Kim,Ji-Soo Tak,Sang-Woong Lee 한국차세대컴퓨팅학회 2022 한국차세대컴퓨팅학회 학술대회 Vol.2022 No.10
From Covid-19 we have witnessed the destructive power of infectious diseases. To prevent such catastrophes from occurring, it is crucial to prevent an outbreak of any infectious disease. As it is well known for bacteria and viruses to cause such outbreaks, some fungal species also cause harmful reactions. In this paper, we attempt to classify toxic fungi protein sequences through the help of protBERT a BERT-based protein language model. Our experiment results reveal the effectiveness of our proposed approach as it shows 99% accuracy and F1 score of 0.9901 in the classification of toxic fungi protein sequences.