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이애님,박주성 조선대학교 사범대학 부설 교과교육연구소 2002 敎科敎育硏究 Vol.23 No.1
This study was aimed to see the effects of the relationship between the educational belief of kindergarten teachers and the self-concept of infants. The study was assumed to be able to estimate the effects of influence of the belief, actions, and types of kindergarten teachers to forming character, feeling, and human nature of infants. Characters formed at the time of kindergarten education will influence continuously to their lives to the future in the process of growth and development. To achieve the research goals the following research questions were established. First, is there any difference in the educational belief among teachers? Second, is there any difference in the self-concepts among infants? Third, is there any difference in the degree of self-concept of infants according to that of educational belief of the teachers? To examine the research questions questionnaires were distributed to 125 kindergarten teachers and 1,875 infants (15 infants to each teacher) in Kwangju area, Out of the collected data, questionnaires of 106 teachers and 1590 infants were selected and analyzed for this study. The results from the analysis are as follows : First, Although kindergarten teachers generally have suitable educational belief, they do not practice their educational belief for their teaching properly. Second, the self-concept level of infants was found as a medium level, and the perceptions of self-concept influences mostly to the self-concept of infants in the lower level. Third, the level of self-concept of infants taught by the teachers with suitable educational belief showed higher than that of self-concept of infants taught by the teacher with unsuitable educational belief. Difference were found at the level of p<0.05. For each lower level, it showed p<0.05 in perceiving self, and p<0.01 in social self and physical self. Fourth, the self-concept level of infants taught by teachers with suitable educational practice showed higher than that of unsuitable educational practice according to the level of teachers educational practice. There was a meaningful at the level of p<0.05. For each lower level, it showed p<0.01 in the perceiving self, and p<0.05 in feeling self, social self, and physical self. Fifth, the self-concept level of infants who taught by the teachers with practical applications and suitable educational belief showed higher than that of unsuitable teachers. Difference were found at the level of p<0.05. For each lower level, it showed p<0.05 in social self and physical self. From the results, we can conclude that the educational belief of teachers influence to the level of concept of infants. In addition, it was found that the educational belief played the most important role among various factors of teachers.
Novel Serotonin Antagonist/Serotonin Reuptake Inhibitors (SARI) as Potential Antidepressants
Pae, Ae Nim 이화여자대학교 세포신호전달연구센터 2009 고사리 세포신호전달 심포지움 Vol. No.11
Serotonin(5-HT), a major neurotransmitter found in the central nervous system(CNS), is also present in many peripheral tissues. Its numerous biological functions are mediated by variety of serotonin receptors. The interaction with these different serotonin receptors constitutes the mechanism of action of many drugs. In particular, type 2 serotonin receptors(5-HT2) mediate the actions of several drugs used in treating diseases such as schizophrenia, feeding disorders, perception, depression, migraines, hypertension, anxiety, hallucinations and gastrointestinal dysfunctions. A dual serotonin antagonist/serotonin reuptake inhibitor(SARI) is attractive strategy to improve pharmaceutical profile of selective serotonin reuptake inhibitor(SSRI). Sequential virtual screening approach using combined models of pharmacophore and recursive partitioning method applied for identification of novel scaffolds resulted in highly active SARI(1.8~80nM for each receptor). Design, synthesis and biological evaluation were performed for developing antagonists active on 5-HT2a and 5-HT2c receptors with high activity on serotonin transporter at the same time. Small molecule libraries having phthalazinone, isoxazole and oxazole moieties were constructed and evaluted in 5-HT2a, 5-HT2c, and SERT. The hits were evaluted in vivo depression animal model. Some of compounds showed good antidepressive efficacy. The further structural optimizations are in progress.
교사의 교육신념에 따른 유치원과 어린이집 유아의 자아개념 차이 연구
이애님(Lee, Ae-nim) 조선대학교 교과교육연구소 2004 敎科敎育硏究 Vol.25 No.2
The goal of this study is to find relationship between kindergarten teachers and nursery school teachers educational belief and reality and their students self concept. Conclusions are as follows: First, after reviewing and comparing a kindergarten and a nursery school in relation with educational belief and educational reality, kindergarten teachers seemed to have more belief congruent for development of children than nursery school teachers in light of educational belief. However, from the viewpoint of educational reality, kindergarten teachers and nursery school teachers seemed to have equal distribution in reality congruent or incongruent for development of children. Second, regarding the self concept of children in kindergartens and nursery schools kindergarten children gained significantly higher scoren all aspects of self concept and subordinate sectors such as cognitive self, emotional self, social self, physical self than nursery school children. Third, kindergarten seemed to have higher scores in light of self concept and subordinate sectors and nursery school children when the teacher s educational belief is necessary to development of children compared with belief incongruent for development of children. If the teacher s educational belief is a congruent belief for development of children, kindergarten children have gained higher score, compared to nursery school children, in self concept and cognitive self and physical self. Even if it is not a congruent belief for development of children, kindergarten children have attained higher score, compared to nursery school children, in light of self concept and subordinate sectors. In addition, when the teacher s application of educational reality is congruent reality for development of children, kindergarten and nursery school children gained higher score in all fields of self concept and subordinate sectors when the teacher s application of educational reality is not a congruent reality for development of children. Whether it is a congruent reality for development or not, kindergarten children got higher scores in all fields of self concept and subordinate sectors than nursery school children. In conclusion, the educational belief and reality of teachers congruent for development of children affected self concept development of children in a positive manner, and accordingly it is reasonable that kindergarten children educated by the teachers with more educational belief and reality have higher self concept development than nursery school children.
Sargassum sp. Attenuates Oxidative Stress and Suppresses Lipid Accumulation in vitro
Jung-Ae Kim(김정애),Fatih Karadeniz,Byul-Nim Ahn(안별님),Myeong Sook Kwon(권명숙),Ok-Ju Mun(문옥주),Mihyang Kim(김미향),Sang-Hyeon Lee(이상현),Ki Hwan Yu(유기환),Yuck Yong Kim(김육용),Chang-Suk Kong(공창숙) 한국생명과학회 2014 생명과학회지 Vol.24 No.3
인간 생체 내 산화스트레스는 조직적 손상을 일으켜 당뇨병, 심장혈관계질환, 비만 등의 대사성 질환의 발병에 관여하는 것으로 알려져 있다. 본 연구에서는 질병예방용 천연 보조제 개발의 일환으로 모자반 3종류(Sargassum hemiphyllum, Sargassum thunbergii, Sargassum honeri)의 에탄올 추출물을 이용하여 항산화활성 및 지방생성억제효과를 비교 검토하였다. 항산화활성은 DPPH 라디칼 소거능, 세포 내 ROS 활성 및 NO 함량의 측정을 통해 검토하였다. 지방세포생성억제활성은 3T3L1세포를 이용하여 지방세포의 축적 정도와 PPARγ 유전자의 발현 정도를 각각 Oil-Red O 염색법과 RT-PCR로 측정하였다. DPPH 라디칼 소거능 결과, 모자반의 처리에 의해 농도 의존적으로 DPPH 라디칼이 줄어드는 경향을 보였으며, 모자반 중에서 S. hemiphyllum 처리군에서 가장 높은 소거 효과를 볼 수 있었다. MTT assay을 통해 모자반의 에탄올 추출물들이 RAW 264.7 cell에 대한 독성을 보이지 않는 농도에서 세포내 실험을 진행하였다. 세포 내 ROS 소거능의 측정 결과, 농도 의존적으로 DCF 형광도 값이 낮게 나왔으며, 시간이 지남에 따라 형광도 값이 일정하여 모자반의 에탄올 추출물에는 세포 내 ROS 생성을 억제하는 효과가 있음을 알 수 있었다. LPS 처리에 의해 증가한 NO 값은 모자반의 추출물들의 처리에 의해 유의적으로 감소하였으며, 감소 정도는 S. hemiphyllum과 S. thunbergii 처리 군에서 높게 나타났다. 모자반의 추출물들을 3T3-L1지방세포에 유도물질과 함께 처리한 결과 모자반 추출물 중 S. hemiphyllum과 S. thunbergii이 세포 내 지방 축적 및 PPAR γ 유전자의 발현을 유의적으로 감소시키는 것으로 나타났다. 이상의 결과로부터 모자반 추출물들 중 S. hemiphyllum과 S. thunbergii이 높은 항산화 활성과 지방세포 생성억제 효능을 보유하고 있는 천연소재임을 확인할 수 있었다. Oxidative stress causes tissue damage and facilitates the progression of metabolic diseases, including diabetes, cardiovascular heart diseases, and obesity. Lipid accumulation and obesity-related complications have been observed in the presence of extensive oxidative stress. As part of an ongoing study to develop therapeutic supplements, Sargassum sp. were tested for their ability to scavenge free radicals and intracellular reactive oxygen species (ROS), as well as to suppress lipid accumulation. Three species, S. hemiphyllum, S. thunbergii, and Sargassum horneri, were shown to scavenge free radicals in a di(phenyl)-(2,4,6-trinitrophenyl)iminoazanium (DPPH) assay. In addition, Sargassum sp. was shown to scavenge intracellular ROS and to decrease nitric oxide (NO) production in H₂O₂ and lipopolysaccharide (LPS)-induced in RAW264.7 mouse macrophages, respectively. Taken together, the results suggest that Sargassum sp. possess huge potential to relieve oxidative stress and related complications, as well as lipid-induced oxidation. They indicate that S. hemiphyllum, S. thunbergii, and S. horneri are potent functional supplements that can produce beneficial health effects through antioxidant and antiobesity activities, with S. hemiphyllum being the most potent among the Sargassum sp. tested. A potential mechanism for the effect of Sargassum sp. on the suppression of lipid accumulation in differentiating 3T3-L1 mouse preadipocytes through deactivation of the peroxisome proliferator-activated receptor γ (PPAR γ) is presented.
Ji Ae Park,Byung Kun Kim,Han Nim Choi,이원용 대한화학회 2010 Bulletin of the Korean Chemical Society Vol.31 No.11
A highly sensitive electrochemical detection method for dopamine (DA) has been developed by relying on a multiwalled carbon nanotube (CNT)-sol-gel titania-Nafion composite film modified glassy carbon (GC) electrode. The CNT-titania-Nafion/GC electrode exhibited excellent electrocatalytic activity towards DA. Therefore, the CNT-titania-Nafion/GC electrode showed improved voltammetric and amperometric responses for DA compared to those obtained with both titania-Nafion/GC and Nafion/GC electrodes. The CNT-titania-Nafion/GC electrode gave a linear response (R2 = 0.999) for DA from 0.5 μM to 0.5 mM with a detection limit (S/N = 3) of 0.1 μM and a good sensitivity of 150mA/M while other electrodes such as CNT-Nafion/GC, titania-Nafion/GC, and a bare GC gave a sensitivity of 89,39, and 36 mA/M, respectively. Besides, the CNT-titania-Nafion/GC electrode displayed very fast response time within 2 s. The modified electrode showed good selectivity against ascorbic acid. The modified electrode showed good stability and reproducibility. The CNT-titania-Nafion/GC electrode was applied to the determination of DA in urine and serum samples.