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Semra Gürsoy,Tuba Koçkar,Sezen Ugan Atik,Zerrin Önal,Hasan Önal,Erdal Adal 대한소아청소년과학회 2018 Clinical and Experimental Pediatrics (CEP) Vol.61 No.7
Purpose: Type 1 diabetes mellitus (T1DM) is a chronic and immune-mediated disease, which is characterized by the progressive destruction of pancreatic beta cells. T1DM precipitates in genetically susceptible individuals through environmental factors. In this study, we aimed to evaluate the impact of autoimmunity and intestinal colonization of Candida albicans on the development of T1DM. Methods: Forty-two patients newly diagnosed with T1DM and 42 healthy subjects were included in this monocentric study. The basic and clinical characteristics of the patients were recorded. T1DM-, thyroid-, and celiac-associated antibodies were evaluated. Stool cultures for C. albicans were performed to assess whether or not gut integrity was impaired in patients with T1DM. Results: The evaluation of T1DM- and thyroid-associated antibodies showed that the prevalences of islet cell antibodies and antithyroperoxidase positivity were higher in the study patients than in the patients in the control group. Furthermore, the direct examination and culture of fresh stool samples revealed that 50% of the patients with T1DM and 23.8% of the control subjects had fungi (C. albicans). Conclusion: Through this study, we suggest that the presence of intestinal C. albicans colonization at the time of the diagnosis of T1DM may indicate impairment of normal intestinal microbiota. We also suggest that there may be a tendency of T1DM in patients with a high prevalence of intestinal C. albicans.
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Gursoy, Semra,Kockar, Tuba,Atik, Sezen Ugan,Onal, Zerrin,Onal, Hasan,Adal, Erdal The Korean Pediatric Society 2018 Clinical and Experimental Pediatrics (CEP) Vol.61 No.7
Purpose: Type 1 diabetes mellitus (T1DM) is a chronic and immune-mediated disease, which is characterized by the progressive destruction of pancreatic beta cells. T1DM precipitates in genetically susceptible individuals through environmental factors. In this study, we aimed to evaluate the impact of autoimmunity and intestinal colonization of Candida albicans on the development of T1DM. Methods: Forty-two patients newly diagnosed with T1DM and 42 healthy subjects were included in this monocentric study. The basic and clinical characteristics of the patients were recorded. T1DM-, thyroid-, and celiac-associated antibodies were evaluated. Stool cultures for C. albicans were performed to assess whether or not gut integrity was impaired in patients with T1DM. Results: The evaluation of T1DM- and thyroid-associated antibodies showed that the prevalences of islet cell antibodies and antithyroperoxidase positivity were higher in the study patients than in the patients in the control group. Furthermore, the direct examination and culture of fresh stool samples revealed that 50% of the patients with T1DM and 23.8% of the control subjects had fungi (C. albicans). Conclusion: Through this study, we suggest that the presence of intestinal C. albicans colonization at the time of the diagnosis of T1DM may indicate impairment of normal intestinal microbiota. We also suggest that there may be a tendency of T1DM in patients with a high prevalence of intestinal C. albicans.
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Effects of Rhinophototherapy on Quality of Life in Persistant Allergic Rhinitis
Emel Çadalli Tatar,Hakan Korkmaz,Ünzile Akpinar Sürenoğlu,Güleser Saylam,Ali Özdek 대한이비인후과학회 2013 Clinical and Experimental Otorhinolaryngology Vol.6 No.2
Objectives. To investigate the effect of rhinophototherapy with medical therapy on quality of life in persistent allergic rhinitis. Methods. A prospective, randomized study was being performed between December 2009 and March 2010. The study included65 patients with persistent allergic rhinitis. The diagnosis was confirmed with positive skin tests. All of the patientshad house dust mite allergies. We divided the patients into two groups. First group (n=33) was given topicalmometasone furoate 200 mcg/day and levocetirizine 5 mg/day for a month. Rhinophototherapy was applied withthe same medical therapy to the second group (n=32), twice a week for three weeks continuously. Rhinophototherapyincluded visible light, ultraviolet A and ultraviolet B. We evaluated patients before the treatment, at the first monthand at the third month after treatment with rhinoconjunctivitis quality of life questionnaire, nasal symptom scoresand visual analogue scale (VAS) scores. Results. Improvements of all variables of the quality of life questionnaire, nasal symptom scores and VAS were statisticallysignificant in the second group both on the first and the third months when compared with the first group. Conclusion. Allergic rhinitis is a social problem and impairs quality of life. Rhinophototherapy with medical therapy improvesthe quality of life in allergic rhinitis.
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