Mechanical and electrical stability of PEDOT:PTS and Au source/drain electrodes for bottom contact OTFTs on plastic films under bending conditions

Abdur, Rahim,Lee, Young Kyu,Jeong, Kyunghoon,Nam, Ho-Seok,Kim, Young-Ho,Kim, Jiyoung,Lee, Jaegab Elsevier 2015 Organic Electronics Vol.26 No.-

<P><B>Abstract</B></P> <P>Two types of source/drain (S/D) electrodes, formed of poly(3,4-ethylenedioxythiophene):<I>p</I>-toluenesulfonate (PEDOT:PTS) conducting polymer and Au, were fabricated and mounted on flexible pentacene transistors. Several properties of the S/D electrodes were investigated: the adhesion between electrode and pentacene, the failure induced by mechanical bending, the electrical properties including contact resistance, and the field-effect mobility. The measurement of adhesive force using a 90° peel tester revealed that the adhesive force of the pentacene–PEDOT:PTS interface was 200N/m, while that of Au–pentacene was too small to be measured. The poor adhesion between the Au and pentacene led to the local delamination of the Au film, starting at a strain of approximately 1% and with a rapid increase of delamination density with increasing strain. The strain-induced mechanical damage has a direct effect on contact resistance, which in turn degrades mobility. In contrast, no delamination is observed with the high adhesive force at the pentacene–PEDOT:PTS interface, which thus led to a slight increase of contact resistance and mobility with strain. Consequently, the pentacene–PEDOT:PTS contacts provide mechanical and electrical stability in flexible organic thin film transistors (OTFTs) under bending tests.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Mechanical and electrical stability of PEDOT:PTS and Au S/D OTFTs in flexible OTFTs under bending was studied. </LI> <LI> The poor adhesion between Au and pentacene led to the local delamination of the Au film. </LI> <LI> The straining-induced mechanical damage has a direct effect on contact resistance, which in turn degrades mobility. </LI> <LI> The pentacene–PEDOT:PTS contacts provide excellent mechanical and electrical stability in flexible OTFTs under bending tests. </LI> </UL> </P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>

Poster Session : PS 0474 ; Nephrology ; Clinical Utility of Reticulocyte Hemoglobin Equivalent in Management of Regular Haemodialysis Patients with Iron Defi ciency Anemia

( Naomi Niari Dalimunthe ),( Abdurrahim Rasyid Lubis ) 대한내과학회 2014 대한내과학회 추계학술대회 Vol.2014 No.1

Background: Reticulocyte Hemoglobin Equivalent (RET-HE) is a new parameter for evaluation of iron status. The aim of this study was to assess the accuracy of RET-HE in identifi cation of iron defi ciency in regular haemodialysis patients and to investigate RET-HE as a tool to monitor responses to intravenous iron supplementation. Methods: Seventy-two regular haemodialysis patients at Adam Malik Hospital, Medan, Indonesia were studied from April to May 2011. Hemoglobin (Hb), serum ferritin, serum transferrin saturation (TSAT) and RET-HE were measured. RET-HE was compared with conventional iron parameters (serum ferritin and TSAT) for identifi cation of iron defi ciency. fifteen patients with iron defi ciency anemia (Hb =10 g/dl with serum ferritin <100 ng/ml and/or TSAT <20%) were selected to receive 100 mg iron sucrose intravenous during every dialysis session (2x/weeks) for 4 weeks. Changes in Hb and RET-HE after intervention were analyzed. Results: Receiver operating characteristic (ROC) curve analysis for RET-HE revealed values of the area under the curve for RET-HE was 0.818 (p <0.0001) and at cutoff level 31.65 pg the sensitivity was 81.5% and specifi city was 61.1%. Serum ferritin (r =0.499, p <0.0001) and TSAT (r = 0.592, p <0.0001) correlated to RET-HE. Hb and RET-HE before intervention were 8.65±1.09 g/dl and 29.98±3.85 pg, respectively. After intervention they were 9.98±1.77 g/dl and 32.6±3.24 pg, respectively. Signifi cant improvement in Hb and RET-HE were found (p =0.023 and p =0.019). Conclusions: RET-HE is a useful marker of iron defi ciency in regular haemodialysis patients. RET-HE can also be used to monitor responses to intravenous iron supplementation.

Plasma Levels of Matrix Metalloproteinase-9 in Children With Chronic Spontaneous Urticaria

Fatih Dilek,Deniz Ozceker,Emin Ozkaya,Zeynep Tamay,Mebrure Yazici,Siddika Kesgin,Abdurrahim Kocyigit,Nermin Guler 대한천식알레르기학회 2016 Allergy, Asthma & Immunology Research Vol.8 No.6

Purpose: Chronic spontaneous urticaria (CSU) is a disease that is primarily seen in adults and is comparatively rare in children. Consequently, only a few studies have focused on the pathogenesis of the disease in children. This study investigated the possible role of metalloproteinase-9 (MMP-9) in the pathogenesis of CSU in children. Methods: The study group was composed of 54 children with CSU; 34 healthy children comprised the control group. The demographic and clinical features of the study group were extensively evaluated, and laboratory assessments were also performed. An enzyme-linked immunosorbent assay was used to evaluate levels of plasma MMP-9. Disease activity was quantified using the urticaria activity score (UAS). Results: The median value of plasma MMP-9 was 108.9 ng/mL (interquartile range, 93.3-124.1) in the CSU group and 87.8 ng/mL (69.4-103.0) in the control group. The difference between the 2 groups was statistically significant (P<0.001). Also, MMP-9 levels showed a significant positive correlation with UAS (rho=0.57, P<0.001). Twenty-six percent of patients had positive autologous serum skin test (ASST) results. Neither UAS nor plasma MMP-9 levels were significantly different between ASST-positive and -negative patients (P>0.05). Conclusions: Plasma MMP-9 levels were elevated in children with CSU and were positively correlated with disease activity. MMP-9 may be both a good biomarker of disease activity and a potential therapeutic target in CSU.

microRNA Expression Profile in Patients with Stage II Colorectal Cancer: A Turkish Referral Center Study

Tanoglu, Alpaslan,Balta, Ahmet Ziya,Berber, Ufuk,Ozdemir, Yavuz,Emirzeoglu, Levent,Sayilir, Abdurrahim,Sucullu, Ilker Asian Pacific Journal of Cancer Prevention 2015 Asian Pacific journal of cancer prevention Vol.16 No.5

Background: There are increasing data about microRNAs (miRNA) in the literature, providing abundant evidence that they play important roles in pathogenesis and development of colorectal cancer. In this study, we aimed to investigate the miRNA expression profiles in surgically resected specimens of patients with recurrent and non-recurrent colorectal cancer. Materials and Methods: The study population included 40 patients with stage II colorectal cancer (20 patients with recurrent tumors, and 20 sex and age matched patients without recurrence), who underwent curative colectomy between 2004 and 2011 without adjuvant therapy. Expression of 16 miRNAs (miRNA-9, 21, 30d, 31, 106a, 127, 133a, 133b, 135b, 143, 145, 155, 182, 200a, 200c, 362) was verified by quantitative real-time polymerase chain reaction (qRT-PCR) in all resected colon cancer tissue samples and in corresponding normal colonic tissues. Data analyses were carried out using SPSS 15 software. Values were statistically significantly changed in 40 cancer tissues when compared to the corresponding 40 normal colonic tissues (p<0.001). MiR-30d, miR-133a, miR-143, miR-145 and miR-362 expression was statistically significantly downregulated in 40 resected colorectal cancer tissue samples (p<0.001). When we compared subgroups, miRNA expression profiles of 20 recurrent cancer tissues were similar to all 40 cancer tissues. However in 20 non-recurrent cancer tissues, miR-133a expression was not significantly downregulated, moreover miR-133b expression was significantly upregulated (p<0.05). Conclusions: Our study revealed dysregulation of expression of ten miRNAs in Turkish colon cancer patients. These miRNAs may be used as potential biomarkers for early detection, screening and surveillance of colorectal cancer, with functional effects on tumor cell behavior.

Is the Neutrophil-Lymphocyte Ratio an Indicator of Progression in Patients with Benign Prostatic Hyperplasia?

Tanik, Serhat,Albayrak, Sebahattin,Zengin, Kursad,Borekci, Hasan,Bakirtas, Hasan,Imamoglu, M. Abdurrahim,Gurdal, Mesut Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.15

Purpose: The aim of this study was to evaluate inflammation parameters and assess the utility of the neutrophil-lymphocyte ratio (NLR) as a simple and readily available predictor for clinical disease activity in patients with nenign prostate hyperplasia BPH. We also aimed to investigate the relationship between inflammatory parameters with ${\alpha}$-blocker therapy response, and evaluate the potential association between NLR and the progression of benign prostatic hyperplasia (BPH). Materials and Methods: We examined 320 consecutive patients (July 2013-December 2013) admitted to our outpatient clinic with symptoms of the lower urinary tract at Bozok University. The mean age was 60 (range, 51-75) years. Complete blood count (CBC), prostate-specific antigen (PSA), erythrocyte sedimentation rate (ESR), and C-reactive protein (CRP) were assessed. Correlations between PSA, CRP, ESR, prostate volume, International Prostate Symptom Score (IPPS), maximum urinary flow rate (Qmax), and NLR were assessed statistically. Patients were divided into two groups: high and low risk of progression. Results: NLR was positively correlated with IPSS (p=0.001, r=0.265), PSA (p=0.001, r=0.194), and negatively correlated with Qmax (p<0.001, r=-0.236). High-risk patients a had a higher NLR compared with low-risk patients, based on IPSS (p<0.001), PSA (p=0.013), and Qmax (p<0.001); however, there were no significant differences between the groups in terms of age (p>0.05), and prostate volume (p>0.05). Conclusions: NLR can predict BPH progression. We propose that increased inflammation is negatively associated with clinical status in BPH patients and suggest that NLR can give information along with LUTS severity which may be used as a readikly accessible marker for patient follow-up.

Red Cell Distribution Width as a Predictor of Prostate Cancer Progression

Albayrak, Sebahattin,Zengin, Kursad,Tanik, Serhat,Bakirtas, Hasan,Imamoglu, Abdurrahim,Gurdal, Mesut Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.18

Background: The aims of this study were to investigate the utility of red blood cell distribution width (RDW) as a simple and readily available marker in prostate cancer, as well as to evaluate RDW as a predictor of progression in prostate cancer patients. Materials and Methods: We evaluated 62 newly diagnosed prostate cancer patients who underwent transrectal ultrasound (TRUS)-guided biopsy and 62 healthy controls of mean age 64 (range, 45-75) years at the Urology Clinic of Bozok University Hospital. Data collection was performed using our laboratory information system database to retrieve findings regarding RDW, hemoglobin, prostatespecific antigen (PSA), and age. The RDW values were compared between the healthy control group and prostate cancer patients. A high risk of progression as defined as a Gleason score (GS) >6, total number of cores positive for cancer >33%, each core containing >50% cancer cells, and a prostate-specific antigen (PSA) level >10 ng/mL. Patients were classified according to risk of progression, as well as divided into subgroups according to the RDW quartile. Results: The mean RDW value of prostate cancer patients was 14.6, compared with 13.7 in the healthy control group (p=0.001). A higher RDW was associated with an increased risk of progression, whereas a lower RDW value was correlated with a low risk of progression. Conclusions: RDW is an easily derived measure that might, in combination with other markers, help predict prostate cancer risk and progression. We suggest that RDW may be used in combination with other parameters in the assessment of prostate cancer.

Left Atrial Thrombus in a Patient with Mitral Bioprosthetic Valve

Muhammed Hakan Tas,Ziya Simsek,Husnu Degirmenci,Hayri Ogul,Abdurrahim Colak,Huseyin Senocak 대한심장학회 2013 Korean Circulation Journal Vol.43 No.6

Genetic relationships of salep orchid species and gene flow among Serapias vomeracea × Anacamptis morio hybrids

Palaz Esra Bulunuz,Demirel Fatih,Adali Sümeyye,Demirel Serap,Yilmaz Abdurrahim 한국식물생명공학회 2023 Plant biotechnology reports Vol.17 No.2

Orchids are naturally grown in many countries of the Eastern Mediterranean. Salep, produced from orchid tubers via grinding and used as a hot drink, is an essential ingredient of ice cream. Salep orchid species are in danger of extinction due to the absence of cultivation and over-harvesting from nature. In this study, the genetic diversity and population structure between salep orchid species, their hybrids, and commercial species of Phalenopsis sp. were first investigated using inter-Primer Binding Site (iPBS) Retrotransposon markers. A total of 854 bands were scored with a 100% polymorphism rate. Neighbor-joining, model-based structure, and PCoA (Principal Coordinate Analysis) algorithms clustered the 30 salep orchids into three main populations. The analysis of molecular variance revealed variations within and among the populations as 71% and 29%, respectively. Anacamptis morio and Serapias vomeracea had the furthest genetic distances, and F1 hybrids of S. vomeracea and A. morio had great genetic diversity. The study results will provide helpful information for orchid breeding by eliciting the genetic distances of salep orchids.