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Samir Abdelmalek,Ahmad Taher Azar,Djalel Dib 제어·로봇·시스템학회 2018 International Journal of Control, Automation, and Vol.16 No.3
In this paper, a new combined fuzzy observer-based fault-tolerant tracking control scheme is proposed for a doubly fed induction generator (DFIG) based wind turbine (WT) subject to actuator faults. The main contribution consists of the proposal of a novel fault-tolerant fuzzy tracking controller combined with a nominal control law. The control objective is to ensure good state references tracking regardless of the actuator faults effects and simultaneous system state and faults estimation. This later requires the knowledge of the occurrence of actuator faults which are estimated from a Takagi-Sugeno Fuzzy Proportional Integral Observer (T-S FPIO). Within this control scheme, a T-S FPIO has been developed to provide stability tracking error dynamics even the system is subjected to different actuator faults. A compensation term is appended to the composite controller and to ensure robustness against actuator faults. Stability and tracking analysis properties are demonstrated through a quadratic Lyapunov function, which are formulated in terms of Linear Matrix Inequalities (LMIs). The observer gains are determined based on the proposed LMIs stability conditions. A numerical simulation is carried out on a typical 1.5 MW DFIG based WT system to access the effectiveness of the proposed control scheme in comparison to the existing results.
Pharmacologic Therapy for the Treatment of NASH
( Manal Abdelmalek ) 대한간학회 2020 춘·추계 학술대회 (KASL) Vol.2020 No.1
Nonalcoholic steatohepatitis is a leading cause of chronic liver disease worldwide. Although lifestyle modification remains the primary recommendation NAFLD/NASH, sustaining lifestyle changes is challenging for the majority of patients. There are currently no FDA approved drugs for the treatment of NASH, many pharmacologic approaches are being evaluated to prevent the developed of progressive hepatic fibrosis, cirrhosis and its associated complications. While there are a vast number of targets in preclinical and early clinical development, few have progressed to late phase clinical trials. Focus in this presentation will be paid only on the primary mechanisms of action of specific drugs entering or currently in phase 3 clinical studies. Of note, NASH is likely a heterogeneous disease, with patients arriving at a common phenotype by different mechanisms. In the future, there may be an era of personalized medicine and/or use of combination therapy by which clinicians can select specific therapies based on a patient’s genetic, histologic or clinical phenotype. Currently available pharmacotherapy for treatment of NASH include pioglitazone and vitamin E. Both pioglitazone can improve NASH. Based on these data, the AASLD and the EASL guidelines on NASH state that pioglitazone can be considered in patients with biopsy-proven NASH, taking into account the risks of weight gain, loss of bone density, and bladder cancer. Two placebo-controlled studies, one in children and one in adults, did show a benefit of vitamin E, although only in some patients in both groups. However, using therapeutic doses of vitamin E may not be completely benign, as studies have suggested an increased risk of cardiovascular disease. The society guidelines recommend that vitamin E be considered in noncirrhotic, nondiabetic patients with biopsy- proven NASH at a dose of 800 IU of the natural form (i.e, rrr-α-tocopherol).
Kachbi, Abdelmalek,Abdelfettah-Kara, Dalila,Benamor, Mohamed,Senhadji-Kebiche, Ounissa Korean Chemical Society 2021 대한화학회지 Vol.65 No.4
The purpose of this work is the development of a method for an effective, less expensive, rapid, and simultaneous determination of three phenolic compounds (caffeic acid, gallic acid, and quercetin) widely present in food resources and known for their antioxidant powers. The method relies on partial least squares (PLS) calibration of UV-visible spectroscopic data. This model was applied to simultaneously determine, the concentrations of caffeic acid (CA), gallic acid (GA), and quercetin (Q) in six herb infusion extracts: basil, chive, laurel, mint, parsley, and thyme. A wavelength range (250-400) nm, and an experimental calibration matrix with 21 samples of ternary mixtures composed of CA (6.0-21.0 mg/L), GA (10.0-35.2 mg/L), and Q (6.4-17.5 mg/L) were chosen. Spectroscopic data were mean-centered before calibration. Two latent variables were determined using the contiguous block cross-validation procedure after calculating the root mean square error cross-validation RMSECV. Other statistic parameters: RMSEP, R<sup>2</sup>, and Recovery (%) were used to determine the predictive ability of the model. The results obtained demonstrated that UV-visible spectrometry and PLS regression were successfully applied to simultaneously quantify the three phenolic compounds in synthetic ternary mixtures. Moreover, the concentrations of CA, GA and Q in herb infusion extracts were easily predicted and found to be 3.918-18.055, 9.014-23.825, and 9.040-13.350 mg/g of dry sample, respectively.
How to Act and Think from the Local to the Global Level
Ali AIT ABDELMALEK 부산대학교 한국민족문화연구소 2013 Localities Vol.- No.3
The globalization of markets and economies, technical change and technological innovation, migrations and international trade: everything seems to be calling for the encounter and exchange among cultures, and at the same time, the reinvention of local territories and “singular” identities. It seems that this movement is continuing, and even accelerating, resulting in contrasting trends, and a variety of transformations and changes… How are we to find a new form of social ties that would take into account the evolution of business practices and regional identities? Thus, the purpose of this communication is to investigate not only the “globalization” of world politics, but also the functioning of this so-called European “Community” as an economic, political and cultural institution having multiple effects on all citizens, located and professionally organized in micro-territories.
An Overview of Ocean Thermal and Geothermal Energy Conversion Technologies and Systems
Mohammed Faizal,Abdelmalek Bouazza,Rao M. Singh 대한설비공학회 2016 International Journal of Air-Conditioning and Refr Vol.24 No.3
The Earth and the oceans have a natural temperature gradient between the surface and given depths. The natural temperature gradient is used to operate renewable energy systems, such as power generation and space heating/cooling, which operate on similar thermodynamic concepts. For a given purpose, different technologies are used to extract heat from the two resources. Even though the concepts of the two systems are the same, their energy extracting performance is different. An overview of the similarities between the usages of the two thermal resources is presented in this paper. The energy balances at the surface of the Earth and the oceans, system performances, availabilities and economics are also presented.
Modeling the Effect of Temperature on the Nanotube Field Effect Transistors Using Neural Network
Menacer Farid,Kadri Abdelmalek 보안공학연구지원센터 2016 International Journal of Hybrid Information Techno Vol.9 No.10
In this article, we modelled and simulated Carbon Nanotube Field Effect Transistors (CNTFET); this transistor has a carbon nanotube channel. An Artificial Neural Networks (ANN) model was developed to reproduce accurately the behavior of CNTFET to predict its response for a wide range of temperature and voltage with focusing on the experimental data. The neural model is tested and validated; hence the ANN model is able to predict the CNTFET behavior with good accuracy. Finally, the proposed ANN model is integrated as a component in the library of simulation software of PSPICE electronic components.
Efficacy and Toxicity of Sunitinib in Metastatic Renal Cell Carcinoma Patients in Egypt
Edesa, Wael Abdelgawad,Abdelmalek, Raafat Ragaey Asian Pacific Journal of Cancer Prevention 2015 Asian Pacific journal of cancer prevention Vol.16 No.5
Background: To evaluate our results in terms of response, survival and toxicity profile of sunitinib among Egyptian patients with metastatic renal cell carcinoma. Materials and Methods: Between January 2010 and December 2013, 44 patients with metastatic renal cell carcinoma who received sunitinib at an oncology center of Cairo university hospitals were enrolled in this retrospective analysis. Results: The median age of the patients was 53 years, 22 (50%) having localized disease at presentation, while the remaining half of the patients presented with metastasis. At a median follow up of 19 months, 9 (21%) patients achieved partial remission, while disease was reported stable in 20 cases (45%) and progressive in 7 (16%), 4 (9%) being lost to follow up, and 4 (9%) had discontinued therapy due to toxicity. The median overall survival was 23 months (95%CI 15.2 - 30.9), while progression free survival was 12 months (95%CI 11.6 - 12.3). The most commonly reported non hematological grade 3 adverse events included mucositis (15.9%), hand-foot syndrome (13.6%), and fatigue (9%), while the predominant grade 3 or 4 laboratory abnormalities were neutropenia (6.8%), followed by anemia in 4.5% of patients. Conclusions: Our efficacy data were comparable to the published literature in terms of progression free survival and overall survival, while toxicity profile is different from Asian and western countries. However, sunitinib adverse events were manageable and tolerable in most of our Egyptian patients.