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Plasma zinc's alter ego is a low-molecular-weight humoral factor
Ou, Ou,Allen-Redpath, Keith,Urgast, Dagmar,Gordon, Margaret-Jane,Campbell, Gill,Feldmann, Jö,rg,Nixon, Graeme F.,Mayer, Claus-Dieter,Kwun, In-Sook,Beattie, John H. The Federation of American Societies for Experimen 2013 The FASEB Journal Vol.27 No.9
<P>Mild dietary zinc deprivation in humans and rodents has little effect on blood plasma zinc levels, and yet cellular consequences of zinc depletion can be detected in vascular and other tissues. We proposed that a zinc-regulated humoral factor might mediate the effects of zinc deprivation. Using a novel approach, primary rat vascular smooth muscle cells (VSMCs) were treated with plasma from zinc-deficient (<1 mg Zn/kg) or zinc-adequate (35 mg Zn/kg, pair-fed) adult male rats, and zinc levels were manipulated to distinguish direct and indirect effects of plasma zinc. Gene expression changes were analyzed by microarray and qPCR, and incubation of VSMCs with blood plasma from zinc-deficient rats strongly changed the expression of >2500 genes, compared to incubation of cells with zinc-adequate rat plasma. We demonstrated that this effect was caused by a low-molecular-weight (∼2-kDa) zinc-regulated humoral factor but that changes in gene expression were mostly reversed by adding zinc back to zinc-deficient plasma. Strongly regulated genes were overrepresented in pathways associated with immune function and development. We conclude that zinc deficiency induces the production of a low-molecular-weight humoral factor whose influence on VSMC gene expression is blocked by plasma zinc. This factor is therefore under dual control by zinc.—Ou, O., Allen-Redpath, K., Urgast, D., Gordon, M.-J., Campbell, G., Feldmann, J., Nixon, G. F., Mayer, C.-D., Kwun, I.-S., and Beattie, J. H. Plasma zinc's alter ego is a low-molecular-weight humoral factor.</P>
보건관리자의 직능별 직업 및 조직 헌신도에 대한 비교 연구
이경용,이기범,Natalie j.Allen,조영숙 한국직업건강간호학회 1998 한국직업건강간호학회지 Vol.7 No.1
This study was carried out in order to confirm the reliability and validity of the commitment inventor developed by Meyer and Allen, and to investigate commitment level of health manager, to compare two different professionals of health manager such industrial health nurse and industrial hygienist to find out some characteristics that have effect on commitment. This survey was done by self -administered questionnaire to 227 respondents as the trainees of Industrial Safety Training Center, KISCO from June to December 1996. Authors classified commitment into two categories : professional commitment and organizational commitment, and these two types of commitments have three different aspects affective, continuance, and normative commitment based on Meyer's inventory. The results were as follows: 1. Items of whole scales of the both type of commitments have three factors that represent three aspects of commitment ; affective, continuance, and normative commitment. This means that each type of commitment was reliable to use as measurement tool of three different aspects of commitment. Classification of items by factor analysis was more consistent in professional commitment than organizational commitment, Among 16 items of organizational commitment, four items were classified into different aspects of commitment with similar factor loading. 2. Commitment level of industrial health nurse was higher than that of industrial hygienist in affective, continuance professional commitment controlled by other characteristics. These differences can be due to other characteristics of specific task and background of health managers that were not used in this study. 3. The level of affective professional commitment was statistically different in age, sex, education level, and that of organizational commitment was statistically different in only two variables such as age, and job tenure. The level of continuance professional and organizational commitments were different in sex group, but past history of employ went have effect on continuance organizational commitment. The level of normative organizational commitment was affected by only age. As the above results, the tools of measurement of commitment developed by Meyer and Allen can be useful to measure the level of commitment of health manager. Three aspects of two types of commitments were influenced by different characteristics of health manager. Authors suggested future study on the affecting variables to the commitment such as background, task of health manager and organizational characteristics.
Solar Lighting System for Barangay Abulalas & Barangay Carillo Bridge
Allen N. Maroma,Dolly P. Maroma ASCONS 2019 IJASC Vol.1 No.4
The Bulacan State University had an agreement between Local Government Units of Brangays Abulalas & Carillo both in the town of Hagonoy, Bualacan, Philippines to develop and install a much needed Solar Powered Street Lighting system for the bridge that connects the two barangays. The system is composed of two solar powered lighting units capable of illuminating up to 100watts of illumination within a span of 10-12 hours during night time. On the as a result of all these research activities , it was concluded by the researchers that the system is composed with the appropriate components to maximize the peculiarities of the area; the project was deemed by the recipient barangays as highly acceptable, and in terms of the service rendered by the proponents of the project, the recipient barangays rated the service to be very highly acceptable. Qualitative data also indicate that positive progressive developments have occurred due to the installation of the system such as: perceived increased traffic activity during night time and reduced undesirable incidences in the area.
Robust 1D inversion of large towed geo-electric array datasets used for hydrogeological studies
Allen, David,Merrick, Noel Korean Society of Earth and Exploration Geophysici 2007 지구물리와 물리탐사 Vol.10 No.1
The advent of towed geo-electrical array surveying on water and land has resulted in datasets of magnitude approaching that of airborne electromagnetic surveying and most suited to 1D inversion. Robustness and complete automation is essential if processing and reliable interpretation of such data is to be viable. Sharp boundaries such as river beds and the top of saline aquifers must be resolved so use of smoothness constraints must be minimised. Suitable inversion algorithms must intelligently handle low signal-to-noise ratio data if conductive basement, that attenuates signal, is not to be misrepresented. A noise-level aware inversion algorithm that operates with one elastic thickness layer per electrode configuration has been coded. The noise-level aware inversion identifies if conductive basement has attenuated signal levels so that they are below noise level, and models conductive basement where appropriate. Layers in the initial models are distributed to span the effective depths of each of the geo-electric array quadrupoles. The algorithm works optimally on data collected using geo-electric arrays with an approximately exponential distribution of quadrupole effective depths. Inversion of data from arrays with linear electrodes, used to reduce contact resistance, and capacitive-line antennae is plausible. This paper demonstrates the effectiveness of the algorithm using theoretical examples and an example from a salt interception scheme on the Murray River, Australia.