A novel two-step rating-based 'double-faced applicability' test. Part 2: Introducing a novel measure of affect magnitude (d'_A) for profiling consumers' product usage experience based on Signal Detection Theory

Kim, I.A.,Hopkinson, A.,van Hout, D.,Lee, H.S. Longman Scientific Technical ; Elsevier Science Pu 2017 Food quality and preference Vol.59 No.-

<P>To measure consumers' product usage experience throughout the various product usage stages, a novel two-step rating-based 'double-faced applicability' test has recently been proposed by Kim et al. (2017). In this method, a 'two-step' rating (forced-choice Yes/No questions followed by 3-point sureness ratings) and 'double-faced' descriptors (a pair of semantic-differential descriptors) are used for each attribute to improve the product discriminability by reducing consumers' response bias and variations. In this paper, we introduce a novel measure that can be computed from the data from the 'double-faced applicability' test to provide a new way to generate affective product usage experience profiles. The novel measure was a nonparametric estimate of affect magnitude, named as d-prime affect magnitude (d'A), computed by considering the response ratio of positivity to negativity as the ratio of signal to noise in the context of Signal Detection Theory (SDT). The advantage of using this new measure d'A was that it meaningfully reflected the consumers' affective product usage experience for each product independently (and how this affect valence changed through a usage process), yet it can still be used to compare between products. The practical application of using d'A was demonstrated in comparison to the more conventional SDT measure d'. (C) 2017 Elsevier Ltd. All rights reserved.</P>

Measurement of vector boson plusD*(2010)+meson production inp¯pcollisions ats=1.96 TeV

Aaltonen, T.,Amerio, S.,Amidei, D.,Anastassov, A.,Annovi, A.,Antos, J.,Apollinari, G.,Appel, J. A.,Arisawa, T.,Artikov, A.,Asaadi, J.,Ashmanskas, W.,Auerbach, B.,Aurisano, A.,Azfar, F.,Badgett, W.,Bae American Physical Society 2016 Physical Review D Vol.93 No.5

<P>A measurement of vector boson (V) production in conjunction with a D*(2010)(+) meson is presented. Using a data sample corresponding to 9.7 fb(-1) of proton-antiproton collisions at center-of-mass energy root s = 1.96 TeV produced by the Fermilab Tevatron, we reconstruct V + D*+ samples with the CDF II detector. The D*+ is fully reconstructed in the D*(2010)(+) -> D-0 (-> K-pi(+))pi(+) decay mode. This technique is sensitive to the associated production of vector boson plus charm or bottom mesons. We measure the ratio of production cross sections sigma(W + D*) = sigma(W) = [1.75 +/- 0.13(stat) +/- 0.09(stat)]% and sigma(Z + D*)/sigma(Z) = [1.5 +/- 0.4(stat) +/- 0.2(stat)]% and perform a differential measurement of d sigma(W + D*)/dp(T)(D*). Event properties are utilized to determine the fraction of V + D*(2010)(+) events originating from different production processes. The results are in agreement with the predictions obtained with the PYTHIA program, limiting possible contribution from non-standard-model physics processes.</P>

Fabrication of a three-dimensional bone marrow niche-like acute myeloid Leukemia disease model by an automated and controlled process using a robotic multicellular bioprinting system

Dana M. Alhattab,Ioannis Isaioglou,Salwa Alshehri,Zainab N. Khan,Hepi H. Susapto,Yanyan Li,Yara Marghani,Arwa A. Alghuneim,Rubén Díaz-Rúa,Sherin Abdelrahman,Shuroug AL-Bihani,Farid Ahmed,Raed I. Felim 한국생체재료학회 2023 생체재료학회지 Vol.27 No.00

Background Acute myeloid leukemia (AML) is a hematological malignancy that remains a therapeutic challenge due to the high incidence of disease relapse. To better understand resistance mechanisms and identify novel therapies, robust preclinical models mimicking the bone marrow (BM) microenvironment are needed. This study aimed to achieve an automated fabrication process of a three-dimensional (3D) AML disease model that recapitulates the 3D spatial structure of the BM microenvironment and applies to drug screening and investigational studies. Methods To build this model, we investigated a unique class of tetramer peptides with an innate ability to selfassemble into stable hydrogel. An automated robotic bioprinting process was established to fabricate a 3D BM (niche-like) multicellular AML disease model comprised of leukemia cells and the BM’s stromal and endothelial cellular fractions. In addition, monoculture and dual-culture models were also fabricated. Leukemia cell compatibility, functionalities (in vitro and in vivo), and drug assessment studies using our model were performed. In addition, RNAseq and gene expression analysis using TaqMan arrays were also performed on 3D cultured stromal cells and primary leukemia cells. Results The selected peptide hydrogel formed a highly porous network of nanofibers with mechanical properties similar to the BM extracellular matrix. The robotic bioprinter and the novel quadruple coaxial nozzle enabled the automated fabrication of a 3D BM niche-like AML disease model with controlled deposition of multiple cell types into the model. This model supported the viability and growth of primary leukemic, endothelial, and stromal cells and recapitulated cell-cell and cell-ECM interactions. In addition, AML cells in our model possessed quiescent characteristics with improved chemoresistance attributes, resembling more the native conditions as indicated by our in vivo results. Moreover, the whole transcriptome data demonstrated the effect of 3D culture on enhancing BM niche cell characteristics. We identified molecular pathways upregulated in AML cells in our 3D model that might contribute to AML drug resistance and disease relapse. Conclusions Our results demonstrate the importance of developing 3D biomimicry models that closely recapitulate the in vivo conditions to gain deeper insights into drug resistance mechanisms and novel therapy development. These models can also improve personalized medicine by testing patient-specific treatments.

A POSSIBLE BINARY SYSTEM OF A STELLAR REMNANT IN THE HIGH-MAGNIFICATION GRAVITATIONAL MICROLENSING EVENT OGLE-2007-BLG-514

Miyake, N.,Udalski, A.,Sumi, T.,Bennett, D. P.,Dong, S.,Street, R. A.,Greenhill, J.,Bond, I. A.,Gould, A.,Kubiak, M.,Szymań,ski, M. K.,Pietrzyń,ski, G.,Soszyń,ski, I.,Ulaczyk, K.,Wyrzyk IOP Publishing 2012 The Astrophysical journal Vol.752 No.2

<P>We report the extremely high-magnification (A > 1000) binary microlensing event OGLE-2007-BLG-514. We obtained good coverage around the double peak structure in the light curve via follow-up observations from different observatories. The binary lens model that includes the effects of parallax (known orbital motion of the Earth) and orbital motion of the lens yields a binary lens mass ratio of q = 0.321 +/- 0.007 and a projected separation of s = 0.072 +/- 0.001 in units of the Einstein radius. The parallax parameters allow us to determine the lens distance D-L = 3.11 +/- 0.39 kpc and total mass M-L = 1.40 +/- 0.18 M-circle dot; this leads to the primary and secondary components having masses of M-1 = 1.06 +/- 0.13 M-circle dot and M-2 = 0.34 +/- 0.04 M-circle dot, respectively. The parallax model indicates that the binary lens system is likely constructed by the main-sequence stars. On the other hand, we used a Bayesian analysis to estimate probability distributions by the model that includes the effects of xallarap (possible orbital motion of the source around a companion) and parallax (q = 0.270 +/- 0.005, s = 0.083 +/- 0.001). The primary component of the binary lens is relatively massive, with M-1 = 0.9(-0.3)(+4.6) M-circle dot and it is at a distance of D-L = 2.6(-0.9)(+3.8) kpc. Given the secure mass ratio measurement, the companion mass is therefore M-2 = 0.2(-0.1)(+1.2) M-circle dot. The xallarap model implies that the primary lens is likely a stellar remnant, such as a white dwarf, a neutron star, or a black hole.</P>

D_s⁺ meson production at central rapidity in proton-proton collisions at s=7 TeV

ALICE Collaboration,Abelev, B.,Adam, J.,Adamova, D.,Adare, A.M.,Aggarwal, M.M.,Aglieri Rinella, G.,Agocs, A.G.,Agostinelli, A.,Aguilar Salazar, S.,Ahammed, Z.,Ahmad, N.,Ahmad Masoodi, A.,Ahn, S.A.,Ahn North-Holland Pub. Co 2012 Physics letters: B Vol.718 No.2

The p<SUB>T</SUB>-differential inclusive production cross section of the prompt charm-strange meson D<SUB>s</SUB><SUP>+</SUP> in the rapidity range |y|<0.5 was measured in proton-proton collisions at s=7 TeV at the LHC using the ALICE detector. The analysis was performed on a data sample of 2.98x10<SUP>8</SUP> events collected with a minimum-bias trigger. The corresponding integrated luminosity is L<SUB>int</SUB>=4.8 nb<SUP>-1</SUP>. Reconstructing the decay D<SUB>s</SUB><SUP>+</SUP>→φπ<SUP>+</SUP>, with φ→K<SUP>-</SUP>K<SUP>+</SUP>, and its charge conjugate, about 480 D<SUB>s</SUB><SUP>+/-</SUP> mesons were counted, after selection cuts, in the transverse momentum range 2<p<SUB>T</SUB><12 GeV/c. The results are compared with predictions from models based on perturbative QCD. The ratios of the cross sections of four D meson species (namely D<SUP>0</SUP>, D<SUP>+</SUP>, D<SUP>@?+</SUP> and D<SUB>s</SUB><SUP>+</SUP>) were determined both as a function of p<SUB>T</SUB> and integrated over p<SUB>T</SUB> after extrapolating to full p<SUB>T</SUB> range, together with the strangeness suppression factor in charm fragmentation. The obtained values are found to be compatible within uncertainties with those measured by other experiments in e<SUP>+</SUP>e<SUP>-</SUP>, ep and pp interactions at various centre-of-mass energies.

A SUB-SATURN MASS PLANET, MOA-2009-BLG-319Lb

Miyake, N.,Sumi, T.,Dong, Subo,Street, R.,Mancini, L.,Gould, A.,Bennett, D. P.,Tsapras, Y.,Yee, J. C.,Albrow, M. D.,Bond, I. A.,Fouqué,, P.,Browne, P.,Han, C.,Snodgrass, C.,Finet, F.,Furusawa, K IOP Publishing 2011 The Astrophysical journal Vol.728 No.2

<P>We report the gravitational microlensing discovery of a sub-Saturn mass planet, MOA-2009-BLG-319Lb, orbiting a K-or M-dwarf star in the inner Galactic disk or Galactic bulge. The high-cadence observations of the MOA-II survey discovered this microlensing event and enabled its identification as a high-magnification event approximately 24 hr prior to peak magnification. As a result, the planetary signal at the peak of this light curve was observed by 20 different telescopes, which is the largest number of telescopes to contribute to a planetary discovery to date. The microlensing model for this event indicates a planet-star mass ratio of q = (3.95 +/- 0.02) x 10(-4) and a separation of d = 0.97537 +/- 0.00007 in units of the Einstein radius. A Bayesian analysis based on the measured Einstein radius crossing time, t(E), and angular Einstein radius,theta(E), along with a standard Galactic model indicates a host star mass of M-L = 0.38(-0.18)(+0.34) M-circle dot and a planet mass of M-p = 50(-24)(+44)M(circle plus), which is half the mass of Saturn. This analysis also yields a planet-star three-dimensional separation of a = 2.4(-0.6)(+1.2) AU and a distance to the planetary system of D-L = 6.1(-1.2)(+1.1) kpc. This separation is similar to 2 times the distance of the snow line, a separation similar to most of the other planets discovered by microlensing.</P>

Structure-property relationship of D-A type copolymers based on thienylenevinylene for organic electronics

Kim, Y.A.,Jeon, Y.J.,Kang, M.,Jang, S.Y.,Kim, I.B.,Lim, D.H.,Heo, Y.J.,Kim, D.Y. Elsevier Science 2017 Organic electronics Vol.46 No.-

A series of D-A type conjugated polymers based on (E)-1,2-bis(3-dodecyllthiophen-2-yl)ethene (TV) as electron donor unit and with different repeating subunits, PTVBO8, PTVBT8, PTVTBO12, and PTVTBT12 were synthesized for use in organic field effect transistors and bulk heterojunction organic photovoltaics. Upon incorporation of alkoxy substituents in acceptor units, benzooxadiazole (BO) and benzothiadiazole (BT), polymer solubility improved and higher molecular weight polymers were obtained. In addition, all copolymers showed favorable thermal stability (T<SUB>d</SUB> > 300 <SUP>o</SUP>C), and low band gap properties (1.49-1.67 eV). The thiophene-flanked TV-TBX copolymers, PTVTBO12 and PTVTBT12, exhibited higher molecular weight and superior device performance in both OFETs and OPVs compared with the TV-BX copolymers. The electronic energy levels of copolymers were strongly influenced by the nature of acceptor units, while optical band gaps and shape of molecular orientation of polymer chains were affected by the presence or absence of thiophene spacer. Charge carrier mobilities in TV-TBX copolymers were 1 order of magnitude greater than in TV-BX copolymers. OFETs based on a PTVTBT12 with TG/BC configuration displayed the highest hole mobility of 0.48 cm<SUP>2</SUP> V<SUP>-1</SUP> s<SUP>-1</SUP>. The photovoltaic device containing a PTVTBO12:PC<SUB>71</SUB>BM (1:2 w/w) blend system exhibited best performance with a V<SUB>oc</SUB> of 0.56 V, a short-circuit current density (Jsc) of 13.1 mA cm<SUP>-2</SUP>, a fill factor (FF) of 69%, and a power conversion efficiency (PCE) of 5.0%.

Temperature dependent structure formation and photoluminescence studies of a series of magnesium-based coordination networks

Calderone, P.J.,Banerjee, D.,Plonka, A.M.,Kim, S.J.,Parise, J.B. Elsevier Sequoia [etc.] 2013 Inorganica chimica acta Vol.394 No.-

A series of three magnesium trimesate coordination networks was synthesized from identical reaction mixtures by varying synthetic temperature. Mg(HBTC)(DMF)<SUB>2</SUB>.[(CH<SUB>3</SUB>)<SUB>2</SUB>NH] (1; BTC=trimesate; space group P6<SUB>3</SUB>/m, a=16.596(4)A, c=14.351(8)A) crystallizes at 65<SUP>o</SUP>C, Mg<SUB>3</SUB>(BTC)(HCOO)<SUB>3</SUB>(DMF)<SUB>3</SUB> (2; space group P@?3, a=13.928(2)A, c=8.025(6)A) crystallizes at 100<SUP>o</SUP>C, and Mg<SUB>3</SUB>(BTC)<SUB>2</SUB>(DMF)<SUB>4</SUB> (3; space group P2<SUB>1</SUB>/c, a=17.490(4)A, b=11.940(2)A, c=18.460(4)A, β=116.87(3)<SUP>o</SUP>) crystallizes at a temperature of 180<SUP>o</SUP>C. Each network contains metal-coordinated solvent DMF molecules, but thermodynamics and solvent hydrolysis play major roles in structure formation. Compounds 1 and 2 are two-dimensional networks which incorporate hydrolysis byproducts. Compound 3 is a three-dimensional network and shows no inclusion of byproducts. The series follows the trend of increased network connectivity resulting from increased temperature. Each of the networks show a weak photoluminescence response, suggesting that coordinated solvent molecules and interlayer species play a role in quenching photoluminescence.

Peculiarities in the pseudogap behavior in optimally doped YBa2Cu3O7d single crystals under pressure up to 1 GPa

A.L. Solovjov,L.V. Omelchenko,R.V. Vovk,O.V. Dobrovolskiy,S.N. Kamchatnaya,D.M. Sergeev 한국물리학회 2016 Current Applied Physics Vol.16 No.9

The influence of the hydrostatic pressure P up to 0.95 GPa on the excess conductivity s0(T) and the pseudogap D*(T) in optimally doped YBa2Cu3O7d single crystals (Tc x 91.1 K at ambient pressure) is investigated by electrical resistivity measurements. A pronounced enhancement of the pseudogap under pressure of dlnD*/dP z 0.32, which is only a factor of 1.12 smaller than in slightly doped single crystals, is revealed for the first time. This implies a somewhat more moderate increase of the coupling strength in optimally doped cuprates with increasing pressure. Simultaneously, the ratio 2D*(Tc)/kBTc z 5 at P ¼ 0 GPa, which is typical for high-temperature superconductors with strong coupling, increases by 16% with increasing pressure. At the same time, the pressure effect on Tc is minor: dTc/dP z þ0.73 K GPa1, whereas dlnr/dP z (17 ± 0.2)% GPa1 is comparable with that in lightly doped YBCO single crystals. This suggests that the mechanisms of the pressure effect on r(T) and Tc are noticeably different. Independently of pressure, near Tc, s0(T) is well described by the Aslamazov-Larkin (3D-AL) and 2D Hikami- Larkin fluctuation theories, exhibiting a 3De2D crossover with increasing temperature. However, the temperature interval Tc < T < T01, in which s0(T) obeys the classical fluctuation theories, is exceptionally narrow (z1.16 K). Nevertheless, a peculiarity at the temperature T01, up to which the wave function phase stiffness in the superconductor is maintained, is clearly observed in the dependence D*(T). Below T01 a fast growth of D*(T) is revealed for the first time. It can be associated with a sudden increase of the superfluid density, ns, that is the density of fluctuating Cooper pairs (short-range phase correlations) forming in the sample when T approaches Tc.

Selective hydrogenation of d-glucose to d-sorbitol over HY zeolite supported ruthenium nanoparticles catalysts

Mishra, D.K.,Dabbawala, A.A.,Park, J.J.,Jhung, S.H.,Hwang, J.S. Elsevier Science Publishers 2014 CATALYSIS TODAY - Vol.232 No.-

HY zeolite (HYZ) supported ruthenium (Ru) nanoparticles catalyst (Ru/HYZ) is prepared by simple impregnation method and is characterized by using energy dispersive X-ray analysis (EDX), transmission electron microscopy (TEM), CO chemisorption and inductively coupled plasma (ICP) mass spectrometry. The catalyst Ru/HYZ is evaluated in hydrogenation of d-glucose and hydrogenation experiments to produce a selective product d-sorbitol were conducted batch wise in a three-phase laboratory scale reactor. The kinetics studies of d-glucose hydrogenation using the catalyst Ru/HYZ were carried out. In the operating regime studied the rate of reaction showed first orders dependency with respect to d-glucose and hydrogen. For affording maximum d-glucose conversion, yield and selectivity to d-sorbitol, the reaction conditions were also optimized.