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A. Divsalar,A. A. Saboury*,H. Mansoori-Torshizi,B. Hemmatinejad 대한화학회 2006 Bulletin of the Korean Chemical Society Vol.27 No.11
The interaction between whey carrier protein b-lactoglobulin type A and B (BLG-A and -B) and 2,2'-bipyridin n-hexyl dithiocarbamato Pd(II) nitrate (BPHDC-Pd(II)), a new heavy metal complex designed for anticancer property, was investigated by fluorescence spectroscopy combined with chemometry and circular dichroism (CD) techniques. A strong fluorescence quenching reaction of BPHDC-Pd(II) to BLG-A and -B was observed. Hence, BPHDC-Pd(II) complex can be bound to both BLG-A and -B, and quench the fluorescence spectra of the proteins. The quenching constant was determined using the modified Stern-Volmer equation. The binding parameters were evaluated by fluorescence quenching method. The results of binding study provided evidences presence of two and three sets of binding sites on the BLG-B and -A, respectively, for BPHDC-Pd(II) complex. Using fluorescence spectroscopy and chemometry, the ability of BLG-A and -B to form an intermediate upon interaction with BPHDC-Pd(II) complex was assessed. CD studies displayed that under influence of different concentrations of BPHDC-Pd(II) complex, the regular secondary structure of BLG-B had no significant changes, whereas for BLG-A a transition from a-helix to b-structure was appeared. The results for both of BLG-A and -B displayed that BPHDC-Pd(II) complex can induce a conformational transition from the native form to an intermediate state with a slightly opened conformation, which is detectable with chemometry analyses.
Markelov, A.,Valikov, A.,Chepikov, V.,Petrzhik, A.,Massalimov, B.,Degtyarenko, P.,Uzkih, R.,Soldatenko, A.,Molodyk, A.,Sim, Kideok,Hwang, Soon The Korea Institute of Applied Superconductivity a 2019 한국초전도저온공학회논문지 Vol.21 No.4
2G HTS wire with high engineering current density is desired for applications where compact, high power density superconducting equipment is important. We have succeeded in enhancing engineering current density of commercial SuperOx 2G HTS wire based on GdBCO by increasing the HTS layer thickness without fast degradation of the HTS film microstructure. This was possible after improving the temperature uniformity along the HTS film deposition zone. In particular, the wire engineering current density was increased from 700-770 A/㎟ (for a 65 ㎛-thick wire without stabilisation) or 430-480 A/㎟ (for a 105 ㎛-thick stabilised wire) at the beginning of this study to almost 1200 A/㎟ (for a 67 ㎛-thick wire without stabilisation) or 770 A/㎟ (for a 107 ㎛-thick stabilised wire) at completion of this study.
Electrical properties and deep traps spectra of a-plane GaN films grown on r-plane sapphire
Polyakov, A.Y.,Smirnov, N.B.,Govorkov, A.V.,Markov, A.V.,Sun, Q.,Zhang, Y.,Yerino, C.D.,Ko, T.S.,Lee, I.H.,Han, J. Elsevier 2010 Materials science & engineering. B, Advanced funct Vol.166 No.3
Electrical properties, deep traps spectra and luminescence spectra were studied for two undoped a-plane GaN (a-GaN) films grown on r-plane sapphire using metalorganic chemical vapor deposition and differing by structural perfection. For sample A, the a-GaN film was directly deposited on AlN buffer. A two-step growth scheme was implemented for sample B, including an initial islanding growth stage and a subsequent enhanced lateral growth. Preliminary detailed X-ray analysis showed that the stacking faults density was 8x10<SUP>5</SUP>cm<SUP>-1</SUP> for sample A and 1.7x10<SUP>5</SUP>cm<SUP>-1</SUP> for sample B. Electrical properties of a-GaN films were largely determined by deep traps with a level near E<SUB>c</SUB> -0.6eV, with other prominent traps having the activation energy of 0.25eV. The Fermi level was pinned by the E<SUB>c</SUB> -0.6eV deep traps for sample A, but shifted to the vicinity of the shallower 0.25eV traps for sample B, most likely due to the reduced density of the 0.6eV traps. This decrease of deep traps density is accompanied by a very pronounced improvement in the overall luminescence intensity. A correlation of the observed improvement in deep traps spectra and luminescence efficiency with the improved crystalline quality of the films is discussed.
Aaltonen, T.,Amerio, S.,Amidei, D.,Anastassov, A.,Annovi, A.,Antos, J.,Apollinari, G.,Appel, J. A.,Arisawa, T.,Artikov, A.,Asaadi, J.,Ashmanskas, W.,Auerbach, B.,Aurisano, A.,Azfar, F.,Badgett, W.,Bae American Physical Society 2016 Physical Review D Vol.93 No.11
<P>We report a measurement of the forward-backward asymmetry, A(FB), in b (b) over bar pairs produced in proton-antiproton collisions and identified by muons from semileptonic b-hadron decays. The event sample is collected at a center-of-mass energy of root s = 1.96 TeV with the CDF II detector and corresponds to 6.9 fb(-1) of integrated luminosity. We obtain an integrated asymmetry of A(FB)(b (b) over bar) = (1.2 +/- 0.7)% at the particle level for b-quark pairs with invariant mass, m(b (b) over bar), down to 40 GeV/c(2) and measure the dependence of A(FB)(b (b) over bar) on m(b (b) over bar). The results are compatible with expectations from the standard model.</P>
LHCb Collaboration,Aaij, R.,Abellan Beteta, C.,Adeva, B.,Adinolfi, M.,Adrover, C.,Affolder, A.,Ajaltouni, Z.,Albrecht, J.,Alessio, F.,Alexander, M.,Alkhazov, G.,Alvarez Cartelle, P.,Alves, A.A.,Amato, North-Holland Pub. Co 2011 Physics letters: B Vol.706 No.1
The first observation of the decay B@?<SUB>s</SUB><SUP>0</SUP>→D<SUP>0</SUP>K<SUP>@?0</SUP> using pp data collected by the LHCb detector at a centre-of-mass energy of 7 TeV, corresponding to an integrated luminosity of 36 pb<SUP>-1</SUP>, is reported. A signal of 34.4+/-6.8 events is obtained and the absence of signal is rejected with a statistical significance of more than nine standard deviations. The B@?<SUB>s</SUB><SUP>0</SUP>→D<SUP>0</SUP>K<SUP>@?0</SUP> branching fraction is measured relative to that of B@?<SUP>0</SUP>→D<SUP>0</SUP>ρ<SUP>0</SUP>: B(B@?<SUB>s</SUB><SUP>0</SUP>→D<SUP>0</SUP>K<SUP>@?0</SUP>)B(B@?<SUP>0</SUP>→D<SUP>0</SUP>ρ<SUP>0</SUP>)=1.48+/-0.34+/-0.15+/-0.12, where the first uncertainty is statistical, the second systematic and the third is due to the uncertainty on the ratio of the B<SUP>0</SUP> and B<SUB>s</SUB><SUP>0</SUP> hadronisation fractions.
Galal El-Shemi, A,Mohammed Ashshi, A,Oh, E,Jung, B-K,Basalamah, M,Alsaegh, A,Yun, C-O Nature Publishing Group 2018 Gene Therapy Vol.25 No.1
<P>Current treatments of hepatocellular carcinoma (HCC) are ineffective and unsatisfactory in many aspects. Cancer-targeting gene virotherapy using oncolytic adenoviruses (OAds) armed with anticancer genes has shown efficacy and safety in clinical trials. Nowadays, both inhibitor of growth 4 (ING4), as a multimodal tumor suppressor gene, and tumor necrosis factor-related apoptosis-inducing ligand (TRAIL), as a potent apoptosis-inducing gene, are experiencing a renaissance in cancer gene therapy. Herein we investigated the antitumor activity and safety of mono- and combined therapy with OAds armed with ING4 (Ad-ΔB/ING4) and TRAIL (Ad-ΔB/TRAIL) gene, respectively, on preclinical models of human HCC. OAd-mediated expression of ING4 or TRAIL transgene was confirmed. Ad-ΔB/TRAIL and/or Ad-ΔB/ING4 exhibited potent killing effect on human HCC cells (HuH7 and Hep3B) but not on normal liver cells. Most importantly, systemic therapy with Ad-ΔB/ING4 plus Ad-ΔB/TRAIL elicited more eradicative effect on an orthotopic mouse model of human HCC than their monotherapy, without causing obvious overlapping toxicity. Mechanistically, Ad-ΔB/ING4 and Ad-ΔB/TRAIL were remarkably cooperated to induce antitumor apoptosis and immune response, and to repress tumor angiogenesis. This is the first study showing that concomitant therapy with Ad-ΔB/ING4 and Ad-ΔB/TRAIL may provide a potential strategy for HCC therapy and merits further investigations to realize its possible clinical translation.</P>
Lee, N.R.,Park, B.S.,Kim, S.Y.,Gu, A.,Kim, D.H.,Lee, J.S.,Kim, I.S. Saunders Scientific Publications, W.B. Saunders ; 2016 Cytokine Vol.86 No.-
Dysregulation of neutrophil apoptosis causes pathogenesis and aggravation of allergy. S100A9 exists as one of the proteins in the neutrophils, triggering inflammatory responses by activating the immune cells. In this study, we investigated whether S100A9 affects constitutive neutrophil apoptosis by activating the monocytes in normal and allergic subjects. Supernatant from human monocytic THP-1 cells after treatment with S100A9 suppressed normal neutrophil apoptosis by inhibiting the activations of caspase 9 and caspase 3. S100A9 upregulated the release of MCP-1, IL-6, and IL-8 in THP-1 cells. An increase in cytokine was suppressed by CLI-095, a Toll-like receptor (TLR) 4 inhibitor, PP2, a Src inhibitor, rottlerin, a PKCδ inhibitor, MAP kinase inhibitors, including PD98059, SB202190, and SP600125, and BAY-11-7085, an NF-κB inhibitor. Src, PKCδ, ERK½, p38 MAPK, and JNK were phosphorylated by S100A9. The phosphorylation of Src and PKCδ was suppressed by CLI-095, and the activation of ERK½, p38 MAPK, and JNK was inhibited by CLI-095, PP2, and rottlerin. S100A9 induced NF-κB activity, and the activation was suppressed by CLI-095, PP2, rottlerin, and MAPK kinase inhibitors. In normal and allergic subjects, supernatant from normal and allergic monocytes after stimulation with S100A9 suppressed normal and allergic neutrophil apoptosis, respectively; MCP-1, IL-6, and IL-8 in the supernatant was increased by S100A9. The cytokine secretion induced by S100A9 is related to TLR4, Src, PKCδ, ERK½, p38 MAPK, JNK, and NF-κB. Taken together, S100A9 induces anti-apoptotic effect on normal and allergic neutrophils by increasing cytokine secretion of monocytes. These findings may help us to better understand neutrophil apoptosis regulated by S100A9 and pathogenesis of allergic diseases.
V994 Herculis: the multiple system with a quadruple-lined spectrum and a double eclipsing feature
Lee, C.-U.,Kim, S.-L.,Lee, J. W.,Kim, C.-H.,Jeon, Y.-B.,Kim, H.-I.,Yoon, J.-N.,Humphrey, A. Blackwell Publishing Ltd 2008 MONTHLY NOTICES- ROYAL ASTRONOMICAL SOCIETY Vol.389 No.4
<P>ABSTRACT</P><P>We report the discovery of a multiple system with a quadruple-lined spectrum and a double eclipsing feature. Our photometric and high-resolution spectroscopic data show that V994 Herculis (V994 Her; ADS 11373 AB) is composed of two pairs of double-lined eclipsing binaries, which we designate as A and B. System A consists of a B8V+A0V binary with an orbital period of 2.083 264 d and system B of a A2V+A4V binary with 1.420 033 d. Our light curves show that both of them have a detached binary configuration. We derive masses and radii of four components (Aa, Ab, Ba and Bb) from the synthetic analyses of light curves and radial velocity curves. The masses of systems A and B are <I>M</I><SUB>Aa</SUB>= 2.83 ± 0.20 M<SUB>⊙</SUB>, <I>M</I><SUB>Ab</SUB>= 2.30 ± 0.16 M<SUB>⊙</SUB>, <I>M</I><SUB>Ba</SUB>= 1.87 ± 0.12 M<SUB>⊙</SUB> and <I>M</I><SUB>Bb</SUB>= 1.86 ± 0.12 M<SUB>⊙</SUB>, with radii <I>R</I><SUB>Aa</SUB>= 2.15 ± 0.05 R<SUB>⊙</SUB>, <I>R</I><SUB>Ab</SUB>= 1.71 ± 0.04 R<SUB>⊙</SUB>, <I>R</I><SUB>Ba</SUB>= 1.59 ± 0.08 R<SUB>⊙</SUB> and <I>R</I><SUB>Bb</SUB>= 1.50 ± 0.08 R<SUB>⊙</SUB>, respectively. These masses and radii are well consistent with the empirical relation for double-lined eclipsing binaries.</P>
Transcriptomes of major renal collecting duct cell types in mouse identified by single-cell RNA-seq
Chen, Lihe,Lee, Jae Wook,Chou, Chung-Lin,Nair, Anil V.,Battistone, Maria A.,Pă,unescu, Teodor G.,Merkulova, Maria,Breton, Sylvie,Verlander, Jill W.,Wall, Susan M.,Brown, Dennis,Burg, Maurice B. National Academy of Sciences 2017 PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF Vol.114 No.46
<P><B>Significance</B></P><P>A long-term goal in mammalian biology is to identify the genes expressed in every cell type of the body. In the kidney, the expressed genes (i.e., transcriptome) of all epithelial cell types have already been identified with the exception of the cells that make up the renal collecting duct, which is responsible for regulation of blood pressure and body fluid composition. Here, single-cell RNA-sequencing was used in mouse to identify transcriptomes for the major collecting duct cell types: type A intercalated cells, type B intercalated cells, and principal cells. The information was used to create a publicly accessible online resource. The data allowed identification of genes that are selectively expressed in each cell type, which is informative for cell-level understanding of physiology and pathophysiology.</P><P>Prior RNA sequencing (RNA-seq) studies have identified complete transcriptomes for most renal epithelial cell types. The exceptions are the cell types that make up the renal collecting duct, namely intercalated cells (ICs) and principal cells (PCs), which account for only a small fraction of the kidney mass, but play critical physiological roles in the regulation of blood pressure, extracellular fluid volume, and extracellular fluid composition. To enrich these cell types, we used FACS that employed well-established lectin cell surface markers for PCs and type B ICs, as well as a newly identified cell surface marker for type A ICs, c-Kit. Single-cell RNA-seq using the IC- and PC-enriched populations as input enabled identification of complete transcriptomes of A-ICs, B-ICs, and PCs. The data were used to create a freely accessible online gene-expression database for collecting duct cells. This database allowed identification of genes that are selectively expressed in each cell type, including cell-surface receptors, transcription factors, transporters, and secreted proteins. The analysis also identified a small fraction of hybrid cells expressing aquaporin-2 and anion exchanger 1 or pendrin transcripts. In many cases, mRNAs for receptors and their ligands were identified in different cells (e.g., <I>Notch2</I> chiefly in PCs vs. <I>Jag1</I> chiefly in ICs), suggesting signaling cross-talk among the three cell types. The identified patterns of gene expression among the three types of collecting duct cells provide a foundation for understanding physiological regulation and pathophysiology in the renal collecting duct.</P>
Calderone, P.J.,Banerjee, D.,Plonka, A.M.,Kim, S.J.,Parise, J.B. Elsevier Sequoia [etc.] 2013 Inorganica chimica acta Vol.394 No.-
A series of three magnesium trimesate coordination networks was synthesized from identical reaction mixtures by varying synthetic temperature. Mg(HBTC)(DMF)<SUB>2</SUB>.[(CH<SUB>3</SUB>)<SUB>2</SUB>NH] (1; BTC=trimesate; space group P6<SUB>3</SUB>/m, a=16.596(4)A, c=14.351(8)A) crystallizes at 65<SUP>o</SUP>C, Mg<SUB>3</SUB>(BTC)(HCOO)<SUB>3</SUB>(DMF)<SUB>3</SUB> (2; space group P@?3, a=13.928(2)A, c=8.025(6)A) crystallizes at 100<SUP>o</SUP>C, and Mg<SUB>3</SUB>(BTC)<SUB>2</SUB>(DMF)<SUB>4</SUB> (3; space group P2<SUB>1</SUB>/c, a=17.490(4)A, b=11.940(2)A, c=18.460(4)A, β=116.87(3)<SUP>o</SUP>) crystallizes at a temperature of 180<SUP>o</SUP>C. Each network contains metal-coordinated solvent DMF molecules, but thermodynamics and solvent hydrolysis play major roles in structure formation. Compounds 1 and 2 are two-dimensional networks which incorporate hydrolysis byproducts. Compound 3 is a three-dimensional network and shows no inclusion of byproducts. The series follows the trend of increased network connectivity resulting from increased temperature. Each of the networks show a weak photoluminescence response, suggesting that coordinated solvent molecules and interlayer species play a role in quenching photoluminescence.