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      • 반추가축의 단백질원으로서 Lysine 발효부산물의 이용에 관한 연구 : 2 . Lysine 발효부산물의 첨가수준별 면양의 반추위내 발효특성 및 in vivo 영양소 소화율과 한우의 사양성적에 미치는 영향 2 . EFFECTS OF DIFFERENT LEVELS OF LYSINE FERMENTATION BY - PRODUCT ON THE NUTRIENT DIGESTIBILITY AND RUMEN FERMENTATION IN SHEEP AND ON THE PERFORMANCE OF KOREAN NATIVE BULLS

        한인규,이성실,김홍대,하종규,곽병오,김완영,고영곤,심성수,이지훈 한국영양사료학회 1998 韓國營養飼料學會誌 Vol.22 No.6

        Lysine 발효부산물을 0, 2, 4% 수준으로 첨가하여 면양에게 급여한 후 반추위내 발효 특성과 in vivo 영양소 소화율 및 질소 축적율에 미치는 효과를 규명하고자 평균체중 40㎏이며 반추위에 fistula를 부착한 재래숫면양 12두를 처리당 4반복, 반복당 1두를 완전임의배치하여 대사 실험을 실시하였으며, 한우의 사양성적과 경제성에 미치는 효과를 규명하기 위해서 평균체중 350㎏ 되는 한우수컷 24두를 공시하여 처리당 8반복, 반복당 1두씩 완전 임의배치하여 10주간의 사양시험을 실시하였으며, 그 결과는 다음과 같다. 1. 건물, 조단백질, 조섬유, 조회분 및 NFE의 소화율은 lysine 발효부산물을 2% 첨가했을 때에 높게 나타났으며 처리간에 유의성은 없었고, 조지방의 소화율은 4% 첨가구에서 가장 높았다 (P<.05). 2. 질소 축적율은 처리구간에 유의적인 차이가 없었다. 3. 반추위내 pH는 lysine 발효부산물의 첨가수준과 사료급여 후 시간 경과에 따라서 처리구간에 유의한 차이를 보이지 않았다. 4. 반추위내 암모니아태 질소의 농도는 Iysine 발효부산물의 첨가수준간에 유의성은 없었으나, 첨가수준이 증가할수록 증가하는 경향이었다. 반추위내 pretease 농도와 순단백질 함량은 2% 처리구에서 높았다 (P<.05). 5. 반추위내 총 휘발성지방산 생성량은 lysine 발효부산물의 첨가수준간에 유의적인 차이가 없었으며, acetic acid와 propionic acid의 농도도 일정한 경향이 없었다. 6. 한우의 사양시험에 있어 일당 증체량은 Iysine 발효부산물의 첨가수준이 0, 2 또는 4%일 때 각각 0.99, 1.04, 1.10㎏/일로서 첨가수준이 증가함에 따라서 증가하였다. 7. Lysine 발효부산물의 첨가수준이 증가함에 따라서 사료섭취량은 다소 감소하였으나 사료효율은 개선되는 경향을 나타내었다. 8. 경제성 분석에 있어서도 lysine 발효부산물 첨가구의 경제성이 높았다. 이상의 결과로 보아 lysine 발효 부산물은 반추동물의 단백질원으로서 효과적으로 이용될 수 있는 가능성을 보여준다고 하겠으며, 앞으로 이에 대한 보다 많은 연구가 필요할 것으로 생각된다. Two experiments were carried out to investigate the effects of different levels of lysine fermentation by-product on the nutrient digestibility and rumen fermentation in sheep and on the performance of Korean native bulls. In experiment I, twelve sheep(average body weight 40㎏) fistulated in the rumen were grouped and randomly assigned to three rations for this study. Lysine fermentation by-product was added at the rate of 0, 2, 4% to each concentrate portion of diet including raw straw as a roughage source. Rumen protease and protein soluble concentration were the highest at the rate of 2% of lysine fermentation by-product (P< .05). Rumen VFA and ammonia N concentration were not affected by lysine fermentation by-product levels. Addition of lysine fermentation by-product has a tendency to increase digestibilites of DM and increased crude fat digestibility (P< .05). Nitrogen retention was not affected by the addition of lysine fermentation by-product. In experiment 2, twenty four heads of Korean native bulls, weighed about 350㎏, were randomly assinged to 3 treatments (0, 2, 4% lysine fermentation by-product supplementation to concentrate) with 8 heads per treatment and one replicate. After 2 weeks of preliminary period, bulls were subjected to 10 weeks of collection period. Average daily gain of steers tended to increase with increasing lysine fermentation by-product levels. Dry matter intake and feed/gain had a tendency to increase with increasing lysine fermentation by-product levels. Economic evaluation indicates that adding lysine fermentation by-products was more economical than for the control group.

      • 해외 부존 사료자원의 개발 및 이용성 연구 : 2 . 해외 부존 사료자원의 광물질과 항영양인자 분석 결과

        이성실,김홍대,하종규,곽병오,한인규,고영곤,감동근,전현식,박장희 한국영양사료학회 1998 韓國營養飼料學會誌 Vol.22 No.5

        본 연구는 해외 부존자원의 개발을 위하여 동남아시아 5개국과 중국에서 수집한 시료의 광물질, 중금속 및 항영양 인자 수준을 분석하여 원료가치를 판단하는 기초 자료를 제공하고자 실시되었다. 성분 분석 결과를 요약하면, 1. 본 시험에 공시한 부존사료자원들의 광물질 함량은 현재 우리나라에서 사용중인 원료사료와 비교 하였을 때 그 수준이 비슷하거나 높았다. 2. Bio-v-pro (India)에서 크롬 함량이 높게 나타났고, 대두박 (China)에서 납 함량이 높게 나타난 것을 제외하고는 대부분의 부존 사료자원의 중금속 함량은 안정권내에 있었다. 3. Cassava waste (Thailand)에서 HCN의 함량이 높게 나타났고, mustard cake (India)에서 tannic aicd 함량이 비교적 높게 나타난 것을 제외하고는, 아플라톡신, gossypol, nitrate 등을 포함하는 항영양성 인자들의 함량이 대부분의 부존사료자원들에서 낮은 것으로 조사되었다. This study was conducted to evaluate nutritional value of non-conventional feeds of foreign-origin. Samples collected from South-Asian countries and China were analyzed for minerals, heavy metals and anti-nutritional factors. 1. Most non-conventional feed resources obtained from 6 countries was similar or higher mineral contents in some cases than conventional feeds which used in Korea. Particularly, calcium and phosphorus were high in bone meal and fish meal from Vietnam. 2. Heavy metal contents of most non-conventional feed resources in this study was below safety level. But exceptions were bio-v-pro (India) containing higher chrome and soybean meal (China) containing higher Pb than in conventional feeds. 3. HCN was high in cassava waste (Thailand), and tannic acid was high in mustard cake (India). But in most non-conventional feed resources, the level of anti- nutritional factors was low enough to be used as feed resources.

      • 반추가축의 단백질원으로서 Lysine 발효부산물의 이용에 관한 연구 : 1 . Lysine 발효부산물의 화학조성 , 반추위액내 발효특성 , in vitro 건물 소화율과 젖소의 생산성에 미치는 영향 1 . CHEMICAL COMPOSITION AND EFFECTS OF DIFFERENT LEVELS OF LYSINE FERMENTATION BY - PRODUCT ON IN VITRO NUTRIENT DIGESTIBILITY AND RUMEN

        한인규,이성실,김홍대,하종규,곽병오,김완영,고영곤,심성수,이지훈 한국영양사료학회 1998 韓國營養飼料學會誌 Vol.22 No.6

        본 실험은 lysine 제조과정에서 다량으로 발생되는 발효부산물의 화학적 특성을 규명하고, 이들 발효부산물을 0, 1, 2, 4, 6% 수준으로 농후사료와 조사료에 첨가하여 이들 발효부산물의 첨가수준에 따른 반추위액의 성상과 건물소화율에 미치는 효과를 평가하고자 in vitro 소화시험을 실시하였으며, 또한 젖소에게 lysine 발효부산물을 0, 3% 첨가하여 단백질과 에너지의 수준을 동일하게 설계한 시험사료를 급여하여 젖소의 사료섭취량, 산유량 및 유성분의 변화와 사료적 가치를 규명하기 위해서 Hostein 착유우 18두 (평균체중 593㎏, 평균 산차수 2.4, 평균 비유일수 185일)를 선발하여 처리구마다 9두씩의 젖소를 완전 임의배치법에 의해 할당하여 2주간의 예비시험과 7주간의 본 시험을 실시하였다. 그 결과는 다음과 같다. 1. Lysine 발효부산물은 건물 함량 70.0%, 조단백질 함량 45.0%, 조회분 3.0%이고, 조지방과 조섬유는 거의 존재하지 않았으며, 아미노산의 조성은 glutamic acid 1.90%와 lysine 1.3%로서 가장 높았다. 2. Lysine 발효부산물의 첨가수준 (0, 1, 2, 4, 6%)에 따라서 반추위액내 pH는 영향받지 않았다. NH₃생성량은 lysine 발효부산물의 첨가수준이 높을수록 증가하는 경향을 보였으나 유의성은 없었다. 3. 총 VFA 생성량은 lysine 발효부산물의 첨가수준에 따라서 유의성이 없었으나 조사료를 기질로 사용한 4% 첨가구에서는 propionic acid의 생성량이 높았다 (P$lt;.05). 4. Lysine 발효부산물의 첨가수준에 따른 농후사료 및 조사료의 in vitro 건물소화율은 유의적인 차이를 나타내지 않았다. 5. 젖소의 사양시험에서 사료섭취량은 대조구와 lysine 발효부산물 3% 첨가구에서 각각 21.21, 21.93㎏/day로서 첨가구에서 다소 높았으나 통계적인 유의차는 없었다. 6. 산유량은 대조구에 비해서 lysine 발효부산물 3% 첨가구에서 높았으나 유의성은 없었다. 7. Lysine발효 부산물 첨가에 따른 젖소의 유성분 변화는 관찰되지 않았다. Experiments were conducted to evaluate the nutritive value of lysine fermentation by-product. Its effects on chemical composition, rumen fermentation, in vitro dry matter degradability, feed intake, milk production and milk composition of lactating Holstein cows were assessed in these experiments. In experiment I, lysine fermentation by-product (0, 1, 2, 4, 6%) was added to concentrate and roughage, respectively, to determine changes of characteristics in rumen fluid and in vitro dry matter degradability. Incubation times for concentrate were 12 and 24 hours, and for roughage were 24 and 48hours. Addition of lysine fermentation by-product did not affect pH and VFA concentration in the rumen, but NH₃concentration in the rumen tended to increase with the increasing level of lysine fermentation by-product. In vitro DM degradability of concentrate and roughage was not affected by the addition of lysine fermentation by-product. In experiment II, eighteen heads of lactating Holstein cows were randomly assigned to 2 treatments (0 and 3% lysine fermentation by-product supplementation with concentrate) with 9 heads per treatment. After 2 weeks of preliminary period, milk cow were subjected to 7 weeks of collection period. Feed intake, milk production and milk composition was not affected by supplementation of 3% lysine fermentation by-product.

      • 해외 부존 사료자원의 개발 및 이용성 연구 : 1 . 해외 부존 사료자원의 일반성분과 아미노산 분석결과 1 . PROXIMATE ANALYSIS AMINO ACIDS COMPOSITION OF FOREIGN NON - CONVENTIONAL FEED RESOURCES

        신형태,이성실,김홍대,하종규,한인규,곽병오,고영곤,감동근,전현식,박장희 한국영양사료학회 1998 韓國營養飼料學會誌 Vol.22 No.5

        본 연구는 해외 부존자원의 개발을 위하여 동남아시아 4개국과 중국에서 수집한 시료의 일반성분과 아미노산 함량을 분석하여 원료가치를 판단하는 기초 자료를 제공하고자 실시되었다. 성분 분석 결과를 요약하면, 1. 대부분의 종실류와 유박류는 조지방 함량이 높아 에너지 수준이 높았다. 2. 중국산 채종박과 면실박은 조단백질 함량이 높았다. 3. 섬유질 공급 원료로 양초, OPF와 leucaena 잎등이 이용가능할 것으로 판단되었다. 4. 대부분의 원료사료는 아미노산 함량이 낮은 경향을 보였다. This study was conducted to evaluate nutritive values of non-conventional feed resources from South-Asian countries and China. Proximate and amino acid composition of feed samples were determined, and the results are as follows. 1. Gross energy of some oil seeds and oil seed meals was high because of their high oil contents. 2. Crude protein content was very high in rapeseed meal and cottonseed meal from China compared to other feedstuffs. 3. Chinese wild hay, oil palm fronds and leucaena leaf can be potential fiber sources. 4. Most of samples showed big variations in nutrients content by their origins. 5. Most of samples showed low amino acids composition compared with regularity used feedstuffs.

      • KCI등재

        가성 장폐쇄로 발현한 부신경절종 1 예

        김용태,이기업,박건춘,송영기,이문호,유은실,이준호,진태선 대한내과학회 1991 대한내과학회지 Vol.40 No.5

        Phenochromocytoma is a catecholamine-secreting tumor, most of which grow at the adrenal gland. About 109p Of pheochromocytomas are detected at the extra-adrenal chromaffine tissues and are called paraganglioma. The main symptoms of pheochromacytoma include hypertension, headache, palpitation, and sweating. Gastrointestinal symptoms such as abdominal pain, constipation, and vomiting are found in 20∼40% of patients with pheochromocytoma, but these are usually overlooked because of the severe, prominant cardiovascular symptoms. Intestinal pseudo-obstruction without hypertension in pheochromocytoma is very rarely found. It is caused by the decreased motility of the intestine and the over-contraction of the intestinal sphincter, which are caused by the unbalanced activation of α-and β-adrenal receptors. It can be hypothesized that catecholamine receptors in the cardiovascular system are down-regulated or desensitized, but those in the intestine remain intact. We report herein a case of pheochromocytoma in which intestinal pseudo-obstruction was the main presenting clinical manifestation. Symptoms of intestinal pseudo-obstruction were completely relieved by administration of phenoxybenzamine, an α-receptor blocker, and excisional surgery.

      • SCOPUSKCI등재
      • KCI등재

        운동후 측복통과 함께 발생한 급성 신부전 1 예

        김종순,박영주,조종태,이정임,신민호,구천희,박태용,한승수,강진화 대한내과학회 1996 대한내과학회지 Vol.50 No.6

        We report a case of acute renal failure with severe loin pain and patchy renal vasoconstriction after exercise. An immediate postcontrast computed tomogram of this case shows multiple patchy areas of poor contrast enhancement in the cortex of the both kidneys. A 24-hours delayed scan without further injection of contrast dye shows multiple wedge-shaped contrast enhancement in the coincident areas of poor enhancement in the immediate scan. The 2 and 5 days delayed scans show that wedge-shaped contrast enhancement becomes disappeared gradually to the renal cortex, and the 8 days delayed scan shows complete disappearance of contrast enhancement. The renal scintigrams with technetium-99m-methylene diphosphonate and dimercaptosuccinic acid show diffuse increased uptakes and multiple patchy photon deficient areas in the both kidneys respectively. The follow-up renal scintigrams show nearly normal findings, This patient had an uneventful hospital course and recovered completely without dialysis.

      • 사료의 pH 및 단백질 수준이 자돈의 성장 및 영양소 소화율에 미치는 영향

        김지훈,한인규,김진동,조원탁,현충남,이지훈 한국영양사료학회 1999 韓國營養飼料學會誌 Vol.23 No.4

        자돈사료내 pH와 단백질 수준의 효과를 알아보기 위하여 2개의 시험을 수행하였다. 시험 1에서는 pH 수준이 자돈의 성장과 영양소 소화율에 미치는 영향을 총 150두의 자돈(L×D×LW ; 8.82㎏ BW 30 ± 2일령)을 이용하여 1) pH 4.7, 2) pH 5.2, 3) pH 5.7 (basal diet), 4) pH 6.2, 5) pH 6.7의 다섯처리를 두었고, 시험 2에서는 pH와 단백질 수준의 효과를 알아보기 위하여 150두의 자돈을 (L×D×LW ; 5.46㎏ BW) 2×3 요인법으로 배치하였다. (조단백질 = 21.5, 24.5%, 사료 pH = 4.5, 5.5, 6.5). 또한 소화율의 측정을 위하여 시험 1에는 25두, 시험 2에는 24두의 자돈에 T-cannular를 설치하였다. 시험 1에서 pH는 자돈의 성장에 아무런 영향이 없는 것으로 나타났다. 낮은 pH사료를 급이한 구에서 사료효율이 약간 좋은 경향이 있었으나, 유의적인 차이는 발견되지 않았다. 회장 및 분소화율도 처리에 의한 효과가 발견되지 않았다. 시험 2에서는 낮은 pH 사료를 급이한 구에서 성장 및 사료효율이 개선되는 경향이 있었다 (P = 0.16). 사료효율은 단백질 수준에 의한 영향이 있었으며 (P<0.05), pH와 단백질 수준간의 상호작용이나 다른 효과는 발견되지 않았다. 회장 소화율도 단백질 수준에 의한 영향은 있었으나, pH의 효과는 methionine의 소화율에만 영향이 있는 것으로 나타났다. 전체적으로 소화율은 pH에 의한 일정한 경향이 발견되지 않았다. 본 시험의 결과는 사료의 pH 조절효과는 자돈의 나이나 사료의 종류에 따라 영향을 받는다는 것을 암시하며, 일반적으로 통용되고 있는 자돈사료는 특별한 산성화 처리가 필요하지 않은 것으로 나타났다. Two experiments were conducted to investigate the effect of diet pH and protein levels on the growth performance and nutrients digestibility in young piglets. In Exp. 1, a total of 150 piglets (Landrace × Duroc × Large White ; 8.82㎏ B W, 30 ± 2 days of age) were allotted into 5 treatments. Treatments were 1) pH 4.7, 2) pH 5.2, 3) pH 5.7 (basal diet), 4) pH 6.2 and 5) pH 6.7. In Exp. 2, the effect of dietary protein and diet pH levels on the growth performance and nutrient digestibility was examined with 150 crossbreds Landrace × Duroc × Large White ; 5.46㎏ BW) piglets in 2 × 3 factorial arrangement. (21.5 and 24.5% CP and diet pH (4.5, 5.5 and 6.5)). Each treatment has 5 replications, 5 heads per replicate. For the digestibility determination, 25 pigs for Exp 1. and 24 pigs for Exp. 2. were fitted with simple T-cannula and individually fed the experimental diet. In Exp. 1, no significant difference was found in any of the criteria measured. Pigs fed low pH diets showed slightly better feed efficiency, but the difference was not significant. Both ileal and fecal nutrient digestibility were not different. A small difference was found in major amino acids digestibility, but there was no constant trend detected. In Exp. 2, pigs fed low pH diet showed a trend (P = 0.16) to grow faster than those fed high pH diet. Feed efficiency was affected by protein level (P<0.05). No other main effect was detected. Protein level affected the ileal digestibility of energy, dry matter, crude fat, methionine and threonine. The effect of pH was found only in methionine digestibility. No other main effect was found in ileal digestibility. It appeared that age of pigs and type of diet could greatly influence the effect of diet pH manipulation. Acidification of commercially available diets might have minimal effect when diet contained high portion of high quality feed ingredients.

      • KCI등재

        위암의 침윤과 전이에 관여하는 단백분해 효소(uPA, PAI-1 및 Type 4 Collagenase)에 관한 연구

        이종인,김병수,김주항,강진경,노성훈,민진식,김호근,조재용,정현철,박준오,유내춘,노재경 대한내과학회 1997 대한내과학회지 Vol.52 No.1

        Objectives: Prognosis of gastric cancer is related to invasion and metastasis. Evidence has accumulated that invasion and metastasis in solid tumors require the action of tumor associated proteases, which promote the dissolution of the surrounding tumor matrix and the basement membrane. The serine protease [(urokinase-type plasminogen activator and plasminogen activator inhibitor-1 (PAI-1)] and type IV collagenase(MMP-9 and MMP- 2) appear to play a key role in these processes. Recent reports have demonstrated that expression of these proteolytic enzymes are elevated in breast and colon cancer and that it can be associated with invasiveness and poor prognosis. We therefore evaluated whether the expression and activation of uPA, PAI-1 and type IV collagenase might be of clinical value in gastric cancer as a tumor/biologically defined risk factor. Methods: In a consecutive series of 160 gastric cancer patients who were enrolled in the Yonsei Cancer Center Study Group, the expression of uPA, PAI-1 and type IV collagenase was determined by ELISA, zymography and mmunohistochemical method. The results were as follows. Results: 1) Both uPA and PAI-1 levels were significantly higher in cancer tissues than no rmal (uPA; 9.4±8.7vs 5.3±3.1 ng/mg protein cytosol, PAI-1;10.9±9.1vs 5.8± 2.9 ng/mg protein cytosol), (p$lt;0.001 respectively). Both high uPA and PAI-1 levels were associated with differentiation of the tumor(p=0.04, p=0.004), and a high PAI-1 level was associated with lymph nodes metastasis at an advanced stage (p=0.003, p=0.04). There was a correlation between the levels of uPA and PAI-1 expression in cancer tissues(r=0.57). 2) The activation ratio of MMP-9 and MMP-2 in cancer tissues 0.32±0.25, 0.27±0.34 were significantly higher than in normal tissue 0.19±0,27, 0.06± 0.16(p$lt;0.001). The MMP-9 activation was associated with lymphnode metastasis and the MMP-2 activation was associated with distant metastasis(p=0.011, p=0.041). 3) In univariate analysis all of the proteolytic enzymes were associated with short relapse free survival, but in multivariate analysis only the high uPA expression was an independent prognostic parameter for short relapse free survival of the gastric cancer patients. Conclusion: These data indicate that uPA, PAI-1 and type IV collagenase were involved in the progression of gastric cancer at different points of time by different mechanisms. The combined expression and activation of these proteolytic enzymes were poor prognostic factors in gastric cancer patients, so new therapy based on these biologic behavior of the tumor in the same stage are clinically applicable. In particular, uPA is a new independent variable for the identification of patients at high risk, therefore therapy targetting uPA can be applied as a new treatment modality for gastric cancer.

      • KCI등재

        Vinca Alkaloids 투여방법에 따른 난치성 특발성 혈소판 감소성 자반증(ITP)의 치료 효과

        이재훈,김승택,이홍복,김병국,이문호,박선양,김노경,이종석 대한내과학회 1987 대한내과학회지 Vol.33 No.2

        Treatment with vinca alkaloids which consisted of infusion of vincristine-loaded platelets, or slow infusion of vinca alkaloids or both were done in 9 patients of idiopathic thrombocytopenic purpura refractory to glucocorticoids with or without splenectomy. 2 (22%) of them showed excellent response, 5 (56%), good response, 2 (22%), poor response. However one patient of excellent response and all of good response needed repeated treatment to maintain response. The toxicity of this treatment was mininal, only mild peripheral neuropathy was observed in 2 patients. It can be concluded that the treatment with vinca alkaloids is one of the useful therapeutic modalities to manage refrectory ITP.

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