http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
장기적인 Captopril 투여가 백서 소장 점막의 Angiotensin Converting Enzyme 활성도에 미치는 영향
김나영(Na Young Kim),김웅(Woong Kim),안준석(Zoon Seog Ahn),양석균(Suk Kyun Yang),이풍렬(Poong Lyul Rhee),정현채(Hyun Chae Jung),이효석(Hyo Suk Lee),윤용범(Yong Bum Yoon),송인성(In Sung Song),김정룡(Chung Yong Kim) 대한내과학회 1989 대한내과학회지 Vol.37 No.1
N/A Angiotensin-converting enzyme (ACE, c-terminal dipeptidyl carboxypeptidase) plays a key physiological role in the regulation of blood pressure through conversion of angiotensin I to angiotensin II and inactivation of bradykinin. Although this enzyme has been mainly found in vascular endothelial cells, recently it has been identified as a prominent mucosal brush border membrane bound enzyme in the small intestine and is estimated to take part in the digestion and absorption of dietary protein. The authors designed the following experiment to investigate the effect of long-term captopril administration, which is used broadly as an antihypertensive agent and is an active site specific ACE inhibitor, to mucosal ACE specific activity in rat small intestine. Twenty-three 215 g average weight rats were divided into three groups; the control group, consisting of 9 rats, was not fed with captopril; the second group, consisting of 9 rats, was fed with 2.5 mg/kg captopril dissolved in distilled water; and the third group, consisting of 5 rats, was fed with 12.5 mg/kg . The rats were killed by decapitation and the isolated small intestines were divided into three segments of equal length from the Treitz ligament to the terminal ileum, After the mucosal homogenate was obtained from each segment, ACE specific activities and the stable marker enzymes known for the brush border membrane (aminopeptidase N, dipeptidyl aminopeptidase IV, alkaline phosphatase) were assayed. The results were as follows; 1) ACE specific activities were highest in the middle segment and lowest in th distal segment, and there was no difference in ACE specific activities between the control group and 2.5 mg/kg or 12.5 mg/kg captopril treated groups (p>0.05). 2) There was no difference in aminopeptidase N, dipeptidyl aminopeptidase IV, and alkaline phosphatase specific activities between the control group and captopril treated groups (p>0.05). We concluded that mucosal ACE specific activities in rat small intestine were not inhibited by long-term captopril administration, and that the estimated role of rat intestinal ACE in the digestion and absorption of dietary protein would not be altered by long-term captopril administration.
위 점막하종양의 내시경적 소견과 상부위장관 조영술의 비교
송인성,김용일,김정룡,윤정환,이풍렬,최병인,안준석,정현채 대한소화기내시경학회 1989 Clinical Endoscopy Vol.9 No.2
Gastric submucosal tumors are occasionally symptomatic (bleeding) but usually found incidentally at endoscopy. To evaluate comparisons of gastric endoscopy and upper gastrointestinal series in the submucosal tumor, we studied 50 patients which were diagnosed as submucosal tumor at SNUH from 1985 to 1988. The results were as follow: 1) Gastric submucosal tumors occupied 2.2% of the stomach cancer. (continue...)
송인성,김용태,정현채,김용일,최규완,이건욱,이효석,김정룡,정영화,박재형,윤용범,양석균,안준석,조주희 대한내과학회 1989 대한내과학회지 Vol.36 No.2
In Korea, angiodysplasia has not been reported until now. We experienced a patient with angiodysplasia in acute massive lower gastrointestinal bleeding. A 62-year-old male patient was admitted to the hospital because of hematochezia. No abnormality was found on gastrofiberscopy, colon barium study, and colonoscopy, but anemia persisted despite transfusion. By selective angiography, multiple tortuous vascular tangles were identified in the cecal area in the later arterial phase. Awareness of angiodysplasia in acute massive lower gastrointestinal beding is needed.
송인성,정현채,윤병철,김정룡,이풍렬,박인애,윤용범,최상운,안준석,송치성,이재훈 대한내과학회 1989 대한내과학회지 Vol.37 No.3
Tuberculosis of the stomach is a very rare disease. It is very difficult to make correct diagnosis, and even more difficult for its early diagnosis due to its non-specific symptoms. We have recently experienced a case of gastric tuberculosis in 66-year old woman with only nonspecific symptom, intermittent epigastric discomfort. The diagnosis was made on the basis of the histological study of the endoscopic biopsy specimen. We have confirmed the healing of the gastric lesion by the follow-up endoscopy, after 9 months' treatment of antituberculous medication.