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전용현(Yong-Hyun Jeon),노정현(Jeong-Hyun Rho),장준석(Jun-Seok Jang) 한국산학기술학회 2017 한국산학기술학회논문지 Vol.18 No.6
교통수요 예측 결과는 교통계획 및 운영과 같은 의사결정 과정에서 매우 주요하게 작용되고 있다. 교통수요 예측시 적용되는 기존 교통수요 예측 4단계 모형은 지정된 기점과 종점 간의 통행만을 대상으로 하며 모형의 특성상 접근성 향상에 따라 유발되는 수요는 고려하지 못하고 있다. 따라서 본 연구는 기존 모형의 한계를 보완하고 모형의 추정력 및 신뢰성을 제고하기 위해 접근성을 반영한 전국 지역 간 통행발생 및 통행분포모형 개발에 목적을 두었다. 접근성을 반영한 통행발생 및 통행분포모형 정산 결과, 접근성 계수의 부호는 양(+)의 값으로 추정되었다. 통행목적 중 업무통행은 타 목적통행에 비해 외부요소의 제약에 가장 둔감한 것으로 나타났으며 여가통행은 통행비용에 가장 민감한 것으로 나타났다. 정산된 통행발생 및 통행분포모형을 관측자료 와의 비교를 통해 검증한 결과, 접근성을 반영한 모형의 가중평균(weighted average) 오차율(%), RMSE(Root Mean Square Error), 총 오차량(total error)등이 기존 모형에 비해 감소하는 것으로 나타남에 따라 모형의 추정력 및 신뢰성이 개선됨을 확인하였다. Traffic demand prediction result is a primary factor for decision making such as the traffic planning and operation. The existing traffic demand prediction 4-stepmodel only covers the trip between the origin and the destination, and not the demand followed by the accessibility improvement, due to the characteristic of this model. Therefore, the purpose of this research is to improve the limitations of the existing model by developing the inter-city trip generation and trip distribution model with more accessibility. After calculating of the trip generation and trip distribution model with more accessibility, the sign of the accessibility coefficient was positive. Commuting was the most insensitive indicator, affected by external factors among the other trip purposes. The leisure trip was the most sensitive, affected by the trip fee. According to the result of comparison with each of estimated model and observational data, it was certain that the reliability and assumption of the model have been improved by discovering the reduced weighted average error rate, Root Mean Square Error (RMSE) and total error through the model with more accessibility compared with the existing one.
조현석 ( Hyun Seok Cho ),한동수 ( Dong Soo Han ),박세우 ( Se Woo Park ),변태준 ( Tae Jun Byun ),김태엽 ( Tae Yeob Kim ),은창수 ( Chang Soo Eun ),전용철 ( Yong Cheol Jeon ),손주현 ( Joo Hyun Sohn ) 대한장연구학회 2007 Intestinal Research Vol.5 No.1
Endometriosis is one of the most common benign gynecologic conditions in women of childbearing age. Endometriosis involving the gastrointestinal tract occurs in 5.3-12% of women and the most commonly affected site is the rectum and the sigmoid colon. The reports of intestinal endometriosis in Korea are too few to obtain a rate of occurence, and in these cases, the depth of invasion was limited to the serosa, resulting in no significant symptoms or signs. Intestinal endometriosis can show up as a mass suggestive of malignant neoplasm on imaging studies, which can result in serious errors in diagnosis and treatment. In Korean studies, the masses were solitary, and there was no reported case of multiple endometriosis in the sigmoid colon, ascending and descending colon. We report a case of multiple deep infiltrating intestinal endometriosis presenting as an abdominal mass. (Intest Res 2007; 5:87-91
김웅준 ( Woong Jun Kim ),은창수 ( Chang Soo Eun ),이민규 ( Min Kyu Lee ),민승연 ( Seung Yeon Min ),유연화 ( Yeon Hwa Yoo ),한동수 ( Dong Soo Han ),전용철 ( Yong Cheol Jeon ),손주현 ( Joo Hyun Sohn ) 대한장연구학회 2012 Intestinal Research Vol.10 No.2
A chronic intestinal pseudo-obstruction is a rare disorder and a severe digestive syndrome. It is characterized by deranged gut propulsive motility that resembles a mechanical obstruction, but no obstructive process is present. An intestinal pseudo-obstruction may be classified as acute or chronic; the chronic form may also be classified as idiopathic or secondary to a variety of diseases. Treatment of intestinal pseudo-obstruction involves nutritional, pharmacological, and surgical therapies. Surgery should be limited to patients who are refractory to medical therapy and show a deteriorating course. Despite available medical and surgical interventions, the outcome remains poor. Here, we describe a case of a 54-year-old female with chronic constipation and abdominal distension, who was subsequently found to have segmental aganglionosis. The patient was treated with a subtotal colectomy and ileosigmoidostomy without sequelae. (Intest Res 2012;10:210-214)
박혜정 ( Hye Jeong Park ),전용철 ( Yong Cheol Jeon ),이경아 ( Kyeong A Lee ),변태준 ( Tae Jun Byun ),김태엽 ( Tae Yeob Kim ),은창수 ( Chang Soo Eun ),한동수 ( Dong Soo Han ),손주현 ( Joo Hyun Sohn ) 대한소화기학회 2008 대한소화기학회지 Vol.52 No.3
A psoas abscess (PA) is a rare clinical entity but is potentially serious condition which presents diagnostic and therapeutic challenges. The diagnosis is frequently delayed due to its variable and nonspecific features and occult clinical course. The delay in diagnosis and treatment of PA is the major poor prognostic factor. We describe herein a case of the sterile psoas abscess complicating Cronh`s disease which presented as hip flexion contracture. A 29-year-old man, at remission stage of CD involving ileocolic segment, was admitted due to pain from hip contracture. He had no bloody diarrhea and no abdominal pain. PA was confirmed by abdominal ultrasound. PA with hip contracture was completely treated with surgical excision, irrigation, drainage, and antibiotics. PA was sterile and there was no evidence of a fistulous communication from the bowel. Once suspected, aggressive diagnostic work up and definitive operative intervention is needed. (Korean J Gastroenterol 2008;52:188-191)
Dong-joon Kim(김동준),Yong-hyun Jun(전용현),Dong-hyun Kim(김동현),Jong-Joong Kim(김종중) 대한체질인류학회 2015 해부·생물인류학 (Anat Biol Anthropol) Vol.28 No.2
BMI1 유전자는 크로마틴 사일런서를 보존시켜 주며 정상 및 암 줄기세포의 단계를 유지하는 데 필수적인 polycomb-repressive complex 1 (PRC1) 단백질의 한 종류이다. 이번 실험에서, siRNA를 이용한 BMI1 유전자 발현 억제가 사람신경교종세포주인 U251에서 종양세포의 침투, 이동 및 세포사멸과 같은 종양작용과 종양진행과 관련된 세포 신호에 어떠한 영향을 미치는지에 대해 알아보았다. 그 결과, BMI1 유전자 발현 억제는 cleaved PARP와 caspase-3의 활성화와 항세포사멸 단백질, survivin, XIAP, Bcl-xL, Mcl1 단백질들의 발현감소를 통해 세포사멸을 증가시켰다. 또한 BMI1 발현억제는 세포 침투 및 이동 능력을 현저히 감소시켰으며 Akt/FOXO1/3a 신호단백질들의 인산화작용의 감소 역시 관찰되었다. 이상의 연구 결과는 BMI1 유전자의 발현억제가 U251 신경교종세포의 세포사멸을 증가시키고, 침투 및 이동을 감소시켰으며 이러한 현상들은 사람 신경교종세포의 진행에 영향을 미치는 Akt신호체계와 연관이 있음을 시사한다. BMI1 belongs to the polycomb-repressive complex 1 (PRC1) family of genes that are conserved chromatin silencers. These are essential for maintaining both the normal and cancerous stem cell state. In this study, we evaluated the effect of siRNA-mediated BMI1 knockdown on tumor cell properties such as invasion, migration, and apoptosis, as well as on cell signaling pathways responsible for tumor progression in the human glioma cell line, U251. Knockdown of BMI1 induced apoptosis by activating cleavage of PARP and caspase-3. It also decreased the expression of anti-apoptotic proteins, survivin, XIAP, Bcl-xL, and Mcl1. Additionally, BMI1 knockdown significantly decreased cell invasion and cell migration ability. BMI1 knockdown also decreased the phosphorylation of Akt/FOXO1/3a signaling proteins. Our results suggest that BMI1 knockdown induces apoptosis and decreases cell invasion and cell migration. Moreover, we believe these phenomenona are associated with decreased phoshorylation of Akt signaling proteins, which contributes to cancer progression.
호흡부전과 신경학적 이상을 동반한 Acute Intermittent Porphyria
전대원(Dae Won Jun),최춘식(Choon Shik Choi),최호순(Ho Soon Choi),전용철(Yong Chul Jung),손주현(Joo Hyun Sohn),한동수(Dong Soo Han),윤병철(Byung Chul Yoon),함준수(Joon Soo Hahm),이민호(Min Ho Lee),이동후(Dong Hoo Lee),기춘석(Choon Shu 대한소화기학회 2000 대한소화기학회지 Vol.36 No.3
The acute intermittent porphyria (AIP) is characterized biochemically by increased excretion of porphyrins and porphyrin precursors, S-aminolevulinic acid (ALA) and porphobilinogen (PBG). AIP presents with abdominal pain, mental disturbances and neurologic dysfunction. A 24-year-old woman with a medical history of AIP was admitted to our hospital because of abdominal pain and proximal muscle weakness. She was treated by carbohydrate loading with intravenous glucose. Twenty five days later, she developed tachycardia, fluctuation of blood pressure and syndrome of inappropriate secretion of antidiuretic hormore (SIADH). On 90th day, intubation was required to control her breathing. Complete flaccid paralysis developed, and the patient became comatose. The neurologic effects of acute porphyria are generally reversible, but the clinical course of severe case is complicated with respiratory failure, fluid electrolyte imbalance. AIP should be considered in differential diagnosis of patient with unexplained respiratory failure. (Kor J Gastroenterol 2000;36:413 - 418)
대량 출혈을 동반한 공장의 Dieulafoy 병변 1 예
이항락(Hang Lak Lee),윤병철(Byung Chul Yoon),변태준(Tae Jun Byun),한호(Ho Han),전운현(Woon Hyun Jun),박준용(Joon Yong Park),이숭환(Soong Hwan Lee),은창수(Chang Soo Eun),이오영(Oh Young Lee),전용철(Yong Chul Jun),한동수(Dong Soo Han) 대한소화기학회 2002 대한소화기학회지 Vol.39 No.2
Dieulafoy's lesion is an uncommon cause of gastrointestinal bleeding. However, it is clinically important in that it can be associated with recurrent and massive gastrointestinal bleeding. The bleeding results from an abnormal large submucosal artery. On endoscopy, a small mucosal defect with a protruding vessel or fresh clot may be visualized if the patient is actively bleeding. In most cases, the lesion is encountered in the proximal stomach within 6 cm of the gastroesophageal junction, but similar lesions have been described in the antrum, duodenum, colon, and rectum. In particular, jejunal Dieulafoy's lesion is extremely rare. We experienced one case of recurrent and massive bleeding from a proximal jejunal Dieulafoy's lesion, which was confirmed by the pathologic examination of the resected specimen. (Korean J Gastroenterol 2002;39:123-127)
이건화 ( Gun Hwa Lee ),은창수 ( Chang Soo Eun ),송준석 ( June Seok Song ),오일환 ( Il Hwan Oh ),정석현 ( Suk Hyun Jung ),박혜선 ( Hye Sun Park ),전용철 ( Yong Chul Jun ),손주현 ( Ju Hyun Sohn ),한동수 ( Dong Soo Han ) 대한장연구학회 2012 Intestinal Research Vol.10 No.3
Systemic lupus erythematosus (SLE) is a multisystem inflammatory disease that manifests various symptoms. Mesenteric vasculitis (MV) is one of the serious complications of SLE and carries a high mortality rate. Although MV is the main cause for acute abdominal pain in patients with SLE, it is very rare for the pain to be the first clinical manifestation of the disease. A 34-year old female presented with sudden onset abdominal pain accompanied by small intestinal bowel edema observed on abdominal computed tomography. We performed a diagnostic laparoscopy, as vital signs were becoming unstable and the diffuse abdominal tenderness was worsening rapidly. The examination showed a severe jejunal infarction; thus, the patient underwent a small bowel segmental resection. A histological examination revealed multiple, hemorrhagic, small-vessel vasculitis, and later serologic autoimmune markers were consistent with SLE. We suggest that SLE be considered in the differential diagnosis of young females presenting with an acute abdomen and unexplained enteropathy. A surgical approach such as exploratory laparoscopy could be an option in search for the cause. (Intest Res 2012;10:305-308)
한성희 ( Sung Hee Han ),이오영 ( Oh Young Lee ),양선영 ( Sun Young Yang ),전대원 ( Dae Won Jun ),이항락 ( Hang Lak Lee ),전용철 ( Yong Cheol Jeon ),한동수 ( Dong Soo Han ),손주현 ( Joo Hyun Sohn ),윤병철 ( Byung Chul Yoon ),최호순 대한소화기학회 2006 대한소화기학회지 Vol.48 No.1
In Crohn`s disease, neurologic complications such as cerebrovascular accident, headache, peripheral neuropathy have been reported sporadically. The pathogenesis of these neurologic complications is still unknown and controversial. We experienced a 22-year-old man, with Crohn`s disease accompanied by optic neuritis. Loss of visual acuity was developed during the worsening course of enterocutaneous fistula. After high dose steroid treatment, his visual acuity and neurologic symptoms improved immediately. (Korean J Gastroenterol 2006;48:42-45)