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정용태 ( Yong Tae Jeong ),강민주 ( Min Ju Kang ),김진희 ( Jin Hee Kim ) 대한화장품학회 2015 대한화장품학회지 Vol.41 No.3
본 연구는 오디씨 에탄올 추출물(MSE)의 멜라닌 합성 저해 효과를 밝히는 것이다. 먼저 MSE의 melan-a 세포를 이용한 멜라닌 합성 저해 실험결과, 독성을 보이지 않는 10 μ g/mL의 농도까지 멜라닌 합성 저해 효과를 나타내었다. 또한 tyrosinase, tyrosinase-related protein-1 (TRP-1) 단백질의 발현이 저해되었으며, extracelluar signal-regulated protein kinase (ERK)의 발현을 농도 의존적으로 증가시키는 MSE의 기전을 확인하였다. 뿐만 아니라, 제브라피쉬를 이용한 in vivo 모델의 실험에서도 색소 발생이 저해됨을 관찰하였다. 따라서 오디씨로 부터 획득한 에탄올 추출물이 ERK 단백질의 발현으로 인해 멜라닌 생합성을 억제할 수 있음을 밝혔다. The purpose of this study was to investigate anti-melanogenesis effects of mulberry seed extracts (MSE). MSE inhibited melanogenesis in melan-a cells at 10 μ g/mL without cytotoxicity. Also, MSE decreased tyrosinase, tyrosinase-related protein-1 (TRP-1) protein expression in the melan-a cells. To identify the signaling pathway of MSE, the ability of MSE to influence extracellular signal-regulated protein kinase (ERK) activation was investigated. MSE induced ERK protein expression in a dose-dependent manner. In addition, MSE presented inhibition of the body pigmentation in vivo zebrafish model. These results suggest that MSE may be an effective anti-melanogenesis agent regulating the expression of ERK protein and melanogenic enzymes.
동해 강도다리(Platichthys stellatus) 2개체군의 형태 및 분자변이
정용태 ( Yong Tae Jeong ),백혜자 ( Hea Ja Baek ),김진구 ( Jin Koo Kim ) 한국수산과학회 2014 한국수산과학회지 Vol.47 No.1
Morphological and genetic variation of two populations of Platichthys stellatus were investigated based on 30 in-dividuals each, collected from Uljin (seedling release area) and Pohang (control) in Korea. Morphological analyses demonstrated that the two populations of P. stellatus were well distinguishable in body color of the blind side and fin shape. Mitochondrial DNA control region analysis indicated no significant differences between the two popula- tions (F ST = -0.00849, P >0.05). We also analyzed microsatellite DNA loci of the two populations using six markers. Observed heterozygosity (H O) and expected heterozygosity(HE) were 0.550 and 0.592, respectively, in P. stellatus from Uljin, but 0.700 and 0.737 in P. stellatus from Pohang. An index of differentiation in genetic structure revealed significant differences between the two populations (F ST = 0.0208, P <0.05). Our results suggest that the Uljin popula-tion may be comprised of released P. stellatus, whereas the Pohang population may be wild P. stellatus, highlighting the necessity of continuous monitoring of the two populations.
정용태(Yong-Tae Jung),정봉주(Bong Joo Jeong),․,최봉완(Bong-Wan Choi),임동순(Dong-Soon Yim) 한국산업경영시스템학회 2019 한국산업경영시스템학회지 Vol.42 No.1
The Cooperative Engagement Capability (CEC) System produces a synergy between the sensors and shooters that are used on various platforms by integrating them. Even the US Navy has been recently adopting the CEC system that maximizes the effectiveness of the air defense operations by efficiently coordinating the dispersed air defense assets. The Navy of other countries are conducting research studies on the theory and application methods for the CEC system. The ROK Navy has limited air defense capabilities due to its independent weapons systems on battle ships. Therefore, the ROK Navy is currently going through a phase where research on proving the validity of building the CEC system because it will provide a way to overcome the limit of the platform based air defense capability. In this study, our goal is to propose methods that maximize the air defense capability of ROK Navy, identify the available assets for constructing the CEC system, and estimate effects of the CEC system when it is applied to the naval operations. In addition, we will provide a simple model that was developed to estimate these effects and a case study with virtual data to demonstrate the effects of the system when it is applied to the naval operations. The research result of this study will provide a way for building the basis of the Korean CEC system.
홍성갑,정용태,천경호,백순영,Hong, Seong-Gap,Jeong, Yong-Tae,Cheon, Gyeong-Ho,Baek, Sun-Yeong 한국미생물학회 2003 미생물학회지 Vol.39 No.4
본 연구에서는 에어컨 내에서 서식하는 세균을 분리하여 동정하였고 이들 에어컨에 대한 위생 관리에 대하여 조사하였다. 20개의 에어컨 냉각기에서 8종의 세균이 분리, 동정되었는데 그것들은 가장 많이 분리 동정된 Pantoea sp.를 비롯하여 Bacillus circulans, Bacillus pumilus, Corynebacterium, Flavimonas oryzihabitans, Ochrobacterum anthropi, Micrococcus sp., non fermented bacilli (NFB)이었다. 한편 에어컨 사용자 1,322명을 대상으로 에어컨의 위생관리 상태에 대하여 조사하였는데 설문자의 1,138명(86%)이 에어컨 사용시 환기를 하는 것으로 나타났다. 에어컨 청소에 있어서 1,128명(85%)이 청소를 하는 것으로 나타났지만 에어컨의 오염원들이 되는 에어컨의 필터 청소는 864명(66%)이 하지 않는 것으로 나타났고 에어컨의 열교환기는 1089명(82%)이 하지 않는 것으로 나타났다. 이런 결과로 상기에서 언급된 세균들과 같은 에어컨 오염원이 증가하면 호흡기 질환과 같은 인간의 질병을 초래할 수 있다는 것을 알 수 있었고 따라서 에어컨 사용시 에어컨의 오염원제거와 위생관리는 에어컨내 세균으로부터 발생되는 인간의 질병을 예방할 수 있을 것이다. This study was performed to identify the microorganisms from air conditioners and to investigate hygiene management on air conditioners. Eight species of bacteria were isolated and identified from twenty samples of coolers in air conditioners; Pantoea sp., Bacillus circulans, Bacillus pumilus, Corynebacterium, Flavimonas oryzihabitans, Ochrobacterum anthropi, Micrococcus sp., and non fermented bacilli (NFB). One thousand and three hundreds twenty-two persons who used air conditioners in their houses were investigated about the state of hygiene management in their air conditioners. One thousand and one hundred thirty eight persons (86%) of the total investigated persons ventilated their air conditioners and 1,128 persons (85%) of them cleaned their air conditioners. However, 864 persons (66%) of them did not clean filters and 1,089 persons (82%) did not clean the heat exchangers, both of which air conditioners could be easily contaminated by microorganisms. From these results, we could conclude that the contaminants, bacteria as mentioned the above, in air conditioners could cause human disease such as respiratory infections if the number of bacteria increase in air conditioners. Thus, the removal of contaminants and the improved hygiene of the air conditioners can prevent human diseases caused by the released bacteria during the use of air conditioners.
포도막 흑색종에 대한 감마나이프 방사선수술 - 증례보고 -
김병욱,김무성,심홍보,정영균,이선일,정용태,김수천,심재홍,윤일한,김영일,백광욱,Kim, Byung Wook,Kim, Moo Seong,Sim, Hong Bo,Jeong, Yeong Gyun,Lee, Sun Il,Jung, Yong Tae,Kim, Soo Chun,Sim, Jae Hong,Youn, Il Han,Kim, Young Il,Paik, Koang 대한신경외과학회 2001 Journal of Korean neurosurgical society Vol.30 No.5
Uveal melanoma is uncommon but life-threatening intraocular malignancy and has been treated by irradiation, local excision and enucleation. Gamma-Knife radiosurgery allows a high dose of radiation to be delivered to an intracranial target with a very high spatial accuracy and has been used for the treatment of ocular melanomas. We have treated two cases of uveal melanoma between October 1994 and December 1999. They include one man and one woman(34, 62 years, respectively). They were followed up for 12 momths. Mean maximal dose was 65Gy. In one case, the tumor disappeared 7 months after gamma-knife radiosurgery. In another case, multiple tumors (uveal, suprasellar and cerebellar tumor) had decreased in size. These results show that single and high dose gamma-knife radiosurgery is may be an option in the local control of uveal melanoma which can spare the eyeball and vision.
팽성화,김무성,심홍보,정영균,이선일,정용태,김수천,심재홍,Paeng, Sung Hwa,Kim, Moo Seong,Sim, Hong Bo,Jeong, Yeong Gyun,Lee, Sun Il,Jung, Yong Tae,Kim, Soo Chun,Sim, Jae Hong 대한신경외과학회 2001 Journal of Korean neurosurgical society Vol.30 No.11
Object : The goals of radiosurgery include preservation of neurological function and prevention of tumor growth. We document the results of gamma-knife radio-surgery for vestibular schwannoma. Method & Object : Eighty-two patients underwent stereotactic radiosurgery for an vestibular schwannoma from October, 1994 to December, 2000. Sixty-five of these patients were followed up for radiological and clinical evaluation. As pregamma-knife modality, surgical resection were done in 23 patients,and V-P shunt in 2 patients. Initial symptoms were headache(n=45), dizziness(n=16), tinnitus(n=17). While normal facial function(House-Brackmann grade 1) was present in 48 patients(73.8%), other patients showed grade 2 function in 8, grade 3 function in 7,and grade 4 function in 2. The Gardner/Robertson scale was used to code hearing function. Male to female ratio was 1:3. Mean tumor volume was $7.98cm^3$. Mean dose delivered to the tumor margin was 14.2Gy,and mean maximal dose was 28.3Gy. Results : Mean follow-up duration of 19.9 months. Thirty-five showed decrease(53.8%) in size, 19 patients(29.2%) stationary, 3(4.6%) initial decrease follow up increase, 5(7.6%) initial increase follow up decrease,and 59 patients (90.8%) were well controlled. Two patients experienced transient facial neuropathy, one transient trigeminal neuropathy, and one transient hearing deterioration. After gamma-knife radiosurgery, ventriculoperitoneal shunt was done in 4 patients. Conclusions : Gamma-knife radiosurgery can be used to treat postoperative residual tumors as well as in patients with concomitant medical problems in patients with preserved hearing function. Gamma-knife radiosurgery is safe and effective method to treat small, medium sized(less than 3cm in extracanalicular diameter), intracanalicular vestibular schwannoma, associated with low rate of cranial neuropathy.
LPS로 유도된 RAW 264.7 대식세포의 염증반응에서 MAPK 신호경로 조절을 통한 지칭개 에탄올 추출물의 항염증 효과
김철환(Chul Hwan Kim),이영경(Young-Kyung Lee),정진우(Jin-Woo Jeong),황병수(Buyng Su Hwang),정용태(Yong Tae Jeong),오영택(Yong Taek Oh),조표연(Pyo Yun Cho),강창희(Chang-Hee Kang) 한국자원식물학회 2021 한국자원식물학회지 Vol.34 No.1
Hemistepta lyrata Bunge (HL) has been used as a folk remedy to treat cancer, inflammation, bleeding, hemorrhoids and fever, and leaves and young shoots have been used as famine food. Nevertheless, the biological activities and underlying mechanisms of the anti-inflammatory effects remain unclear. In this study, it was undertaken to explore the functions of the aerial part of HL as a suppressor of inflammation by using RAW 264.7 cells. As immune response parameters, the productions of as nitric oxide (NO) and prostaglandin E2 (PGE2), cytokines such tumor necrotic factor (TNF)-α and interleukin (IL)-6 were evaluated. Although the release of TNF-α remained unchanged in HL-treated RAW 264.7 cells, the productions of NO, PGE2 and IL-6 were significantly increased at concentrations with no cytotoxicity. Furthermore, HL significantly attenuated the mitogen-activated protein kinases (MAPK) pathway including decreasing the phosphorylation of the extracellular signal-regulated kinase (ERK1/2) and p38 mitogen-activated protein kinases. Collectively, this study provides evidence that HL inhibits the production of major pro-inflammatory molecules in LPS-stimulated RAW 264.7 cells via suppression of ERK and P38 MAPK signaling pathways. These findings suggest that the beneficial therapeutic effects of HL may be attributed partly to its ability to modulate immune functions in macrophages.