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전용준(Yong Joon Jeon),윤재석(Jae Suk Yun),임화경(Hwa Kyung Lim),박기숙(Ki Suk Park),나한광(Han Kang Na),김동섭(Dong Sup Kim),김주일(Joo Il Kim),윤여창(Yea Chang Yoon),최기환(Ki Hwan Choi) 대한약학회 2005 약학회지 Vol.49 No.5
Lactoferrin is a multifunctional protein that is found in milk, neutrophils, and other biological fluids, and its receptors have also been identified in the central nervous system. Recently, it was reported that bovine milk-derived lactoferrin (BLF) produced analgesia via a μ-opioid receptor-mediated response in the spinal cord. However the precise mechanism of this analgesic effect is remains unclear. In Randall-Selitto paw pressure study, each single administration of morphine (10 mg/kg) and BLF (50, 100 and 200 mg/kg) induced analgesia, however, NMDA receptor antagonist MK-801 (0.1, 0.2 and 0.3 mg/kg), inhibited analgesia induced by BLF(100mg/kg). Intracerebroventricular infusion (I.C.V) of N-methyl-D-aspartic acid (NMDA) (0.3 μg/8.0 μl/hr/day), as a NMDA receptor agonist, reversed inhibition of MK-801 (0.3mg/kg) on analgesia induced by BLF (100mg/kg). These results suggest that BLF have analgesic effect, through NMDA receptor activation.
Population Dose Assessment for Radiation Emergency in Complex Terrain
Yoon, Yea-Chang,Ha, Chung-Woo 대한방사선 방어학회 1987 방사선방어학회지 Vol.12 No.2
원자력 시설에서 대기중으로 방출되는 방사성 구름에 의한 환경선량계산에는 Gaussian plume model이 주로 사용되고 있으나, 바람의 분포나 대기의 흐트러짐이 공간적으로 일정하지 않은 복잡 지형에의 적용에는 문제가 있다. 복잡 지형을 고려한 기류계산에는 MATTEW, WIND04 코드가 그 타당성을 인정받고 있다. 이러한 코드의 원리를 기초로 하여, 질량보존법칙을 만족하는 이류 확산 방정식을 유한차분법으로 계산하고 풍속장을 구하였다. 입자 농도와 피폭선량은 방사성 구름을 입자군으로 근사시키는 PIC model을 이용하여 계산하였으며, 입자의 대기 확산은 Random Walk법을 이용하였다. 계산 결과, 지형에 의한 풍속, 풍향의 변화를 알 수 있었으며, 피폭선량분포를 구할 수 있었다. Gaussian plume model is used to assess environmental dose for abnormal radioactive release in nuclear facility, but there has a problem to use it for complex terrain. In this report. MATTEW and WIND04 Codes which had been verified were used to calculate wind Held in the complex terrain. Under the base of these codes principle, wind fields were obtained from the calculation of the finite difference approximation for advection-diffusion equations which satisfy the mass-conservative law. Particle concentrations and external doses were calculated by using PIC model which approximate the particle to radioactive cloud, and atmospheric diffusion of (he particles from the random walk method. The results show that the adjusted wind fields and the distributions of the exposure dose vary with the topography of the complex terrain.