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배양 자궁경부암 세포주에서 Cis - platinum 의 세포독성에 대한 Glutatione 의 영향
안태규(Tae Gyu Ahn),한세준(Sei Jun Han) 대한산부인과학회 2002 Obstetrics & Gynecology Science Vol.45 No.8
목적 : 본 연구는 자궁경부암 세포주에서 cisptatin의 세포독성에 미치는 glutathione의 영향을 관찰하고자 하였다. 방법 : 자궁경부암세포주 (SiHa cell, CaSki cell)를 배양하여 cisplatin, glutathione 합성효소 (γ-glutamyl-cysteine synthetase)의 억제제인 buthionine sulfoximine (BSO), glutathione 및 glutathione 합성 전구체인 2-oxo 4-thiazolidine carboxylic acid (OTC)을 첨가하여 배양한 후 생존한 세포수를 MTT법으로 측정하었다. 결과 : cisplatin과 섞인 배양세포는 cisplatin농도가 증가함에 따라 세포 생존율이 감소되었다. BSO 첨가로 자궁경부암세포주에서 cisplatin에 의한 독성 차이를 나타내지 않았고, GSH와 OTC 첨가로 cisplatin에 의한 MTT 환원율이 증가되었는데 GSH가 OTC보다 더 크게 MTT 환원율을 증가시켰다. 결론 : Glutathione 합성효소인 γ-glutamylcysteine synthetase 활성 억제는 cisplatin독성에 미치는 영향이 적고 GSH와 OTC는 cisplatin에 의한 독성감소 효과가 있는 것으로 나타나서, cisplatin 독성에 미치는 glutathione의 영향은 glutathione 합성효소의 활성보다는 glutathione이나 gtutathione 전구체 (OTC) 공급이 더 큰 영향이 있는 것으로 추측된다. Objective : The purpose of this study is to determine the effects of glutathione on cisplatin-induced cytotoxicity of human cervical carcinoma cell lines (SiHa: squamous cell carcinoma cell, CaSki: epidermoid metastatic carcinoma cell). Methods : Human cervical carcinoma cells (SiHa, CaSki) were incubated with culture media (RPMI1640) in the presence of cisplatin and/or buthionine sulfoximine (BSO), as a inhibitor of 7-glutamylcysteine synthetase, and/or glutathione (GSH) and/or 2-oxo 4-thiazolidine carboxylic acid (OTC). The viable cells were examined by using 3-[4,5-dirnethylthiazol-2-yll-2,5-diphenyl tetrazolium bromide (MTT) and was determined by spectrophotometer at 570 nm. Results : The incubation of cervical cells with cisplatin resulted in an decreasing cells viability by dose response. The MTT reduction rate were not different by BSO (5 mM) treatment in cervical cell lines. The viable cells were increased significantly by glutathione (5 mM) or OTC (5 mM) in cisplatin-treated cell lines. Conclusion : y -glutamylcysteine synthetase inhibitor had no effect on cisplatin toxicity. GSH and OTC had effect on cisplatin cytotoxicity. So, These result suggested that cervical cancer line cells were more susceptive to protective effects of glutathione and OTC than BSO on cisplatin induced-toxicity.
안태규 ( Tae Gyu Ahn ),이향아 ( Hyang Ah Lee ),황종윤 ( Jong Yun Hwang ),조준식 ( Jun Sik Cho ),이동헌 ( Dong Heon Lee ) 대한산부인과학회 2006 Obstetrics & Gynecology Science Vol.49 No.9
Adnexal torsion in the third trimester is very rare. Because of changes in uterine size and anatomical position of abdominal organs, the diagnosis of adnexal torsion during pregnancy is difficult to establish on the basis of symptoms, physical findings, or radiologic technique. Delayed diagnosis and management can lead to serious complications, so a rapid, reliable, and accurate imaging is needed to evaluate pregnant women with acute abdomen. Ultrasonography has been the initial imaging modality of choice in evaluation of obstetric patient, but it is technically difficult in the third trimester. MR imaging can provide a broad evaluation of the pelvic organs and enables diagnosis of many causes of acute abdomen, especially in the third trimester. We have experienced a case of Parovarian cyst torsion at pregnancy 29(+4) wks and reviewed it briefly.
미산부 여성에서 발생한 초기 자궁 내막암의 고용량 Megestrol Acetate와 광역동 요법 (photodynamic therapy)을 이용한 치료
안태규 ( Tae Gyu Ahn ),강민창 ( Min Chang Kang ),박준선 ( Jun Sun Park ),조영신 ( Young Shin Cho ),최범채 ( Bum Chae Choi ),김동원 ( Dong Won Kim ),한세준 ( Sei Jun Han ),( Victor Sokolov ) 대한산부인과학회 2005 Obstetrics & Gynecology Science Vol.48 No.4
안태규 ( Tae Gyu Ahn ),정혁 ( Hyuk Jung ),송창훈 ( Chang Hun Song ),최상준 ( Sang Joon Choi ),이병래 ( Byoung Rai Lee ),한세준 ( Sei Jun Han ) 대한산부인과학회 2003 Obstetrics & Gynecology Science Vol.46 No.6
목적 : 자간전증 환자의 태반조직 손상 기전에 관한 실험의 일환으로 태반 SOD isozymes 활성도 변화를 관찰하고자 하였다. 연구 방법 : 35명의 자간전증 환자와 35명의 정상 혈압 환자의 적혈구와 태반에서 항산화 효소 [superoxide dismutase (SOD), catalase, glutathione peroxidase (GSHPx)]의 활성도와 유리기에 의한 산화산물인 thiobarbituric acid reactive substanc Objective : The aim of this article was investigated whether changes of superoxide dismutase isozymes in the placenta of patients with preeclampsia contribute to radical-induced tissue injury. Methods : The activities of antioxidant enzymes (superoxide di
임신 제3삼분기 혈청 페리틴과 조산 및 저체중아와의 연관성
안태규 ( Tae Gyu Ahn ),이란 ( Lan Li ),이세진 ( Se Jin Lee ),허윤현 ( Yoon Hyeon ),김초롱 ( Chorong Kim ),황종윤 ( Jong Yun Hwang ) 한국모자보건학회 2021 한국모자보건학회지 Vol.25 No.1
Objective: Although serum ferritin is considered the best measure of total body iron, with low levels indicating iron deficiency, recent studies have shown that high levels are associated with gestational diabetes, premature birth, and low birth weight. This study aimed to analyze the association between serum ferritin levels in the third trimester of pregnancy and low birth weight and preterm birth. Methods: This study included pregnant women who delivered a single fetus at Kangwon National University Hospital between January 2009 and December 2013 and in whom serum ferritin levels were measured between 28 and 34 weeks of gestation. The association between serum ferritin levels measured in the early third trimester of pregnancy and preterm birth and low birth weight infants was analyzed. Results: A total of 1,079 women fulfilled the study criteria and had their serum ferritin level measured during the third trimester (28-33.9 weeks of gestation) and later delivered at Kangwon National University Hospital. Comparison of the group with serum ferritin levels above the 75th percentile and those below the 25th percentile at the beginning of the third trimester revealed that the incidence of preterm births (<34 weeks of gestation, <37 weeks of gestation) and low birth weight were significantly higher in the group with serum ferritin levels above the 75th percentile than those below the 25th percentile (p<0.05). When variable factors were controlled through multiple regression analysis, the group whose serum ferritin levels were above the 75th percentile at 30-31.9 weeks of gestation had the highest risk of preterm birth before 34 weeks of gestation (adjusted odds ratio [OR], 7.85; 95% confidence interval [CI], 1.32-29.9) and low birth weight (adjusted OR, 6.49; 95% CI, 2.10-20.0). Conclusion: In this study, when serum ferritin was high in the third trimester of pregnancy, it was significantly increased with preterm birth (<34 and 37 weeks) and low birth weight. In particular, when serum ferritin levels were high at 30-31.9 weeks of gestation, the risk of premature birth before 34 weeks and low birth weight was statistically highest.
국내 산과 전문의의 임신 중 고혈압성 질환 임상진료패턴 분석
안태규 ( Tae Gyu Ahn ),김연희 ( Yeon Hee Kim ),김윤숙 ( Yun Sook Kim ),신재은 ( Jae Eun Shin ),오영림 ( Young-Lim Oh ),이순애 ( Soon Ae Lee ),이민아 ( Mina Lee ),이귀세라 ( Gui Se Ra Lee ),김석영 ( Suk Young Kim ),김수미 ( Su-Mi Ki 한국모자보건학회 2021 한국모자보건학회지 Vol.25 No.3
Purpose: The purpose of this study was to investigate the clinical practice patterns of Korean obstetricians and gynecologists the diagnosis and management of hypertensive disease in pregnant women. Methods: From April 2015 to October 2015, questionnaire was distributed via email to obstetricians who were members of the Society for Maternal and Fetal Medicine. The survey consisted of 37 questions in 6 categories. Responses to the questions on the management of hypertensive disorders of pregnancy, from diagnosis to treatment, were evaluated. Results: A total of 93 obstetricians and gynecologists responded to the survey. High blood pressure was allocated the highest priority as an index mainly used when deciding to hospitalize patients with hypertensive disease during pregnancy, followed by pregnancy symptoms, proteinuria, and blood test results. Calcium channel blocker (CCB) for oral administration and hydralazine for injection were preferred as antihypertensive drugs mainly used to control severe hypertension. Regarding the delivery method for hypertensive disease during pregnancy, in cases of preeclampsia, 63% of the respondents chose the delivery method according to the cervical status, and in cases of hemolysis, elevated liver enzymes and low platelets (HELLP) syndrome and eclampsia, which increased in severity, 52% and 31% responded that the delivery method was determined according to the cervical status, respectively. In cases of mild preeclampsia, the 70% of respondents preferred 37-38 weeks of gestation for the delivery time. Regarding the use of aspirin in patient with hypertension during pregnancy, 52% of the respondents occasionally administered aspirin, and in patients with a history of hypertensive disease during pregnancy, only 43% were administered prophylactic aspirin. Conclusion: Domestic obstetricians regarded blood pressure as the most meaningful factor when treating women with hypertension during pregnancy and considered blood pressure control as important. The preferred antihypertensive agents were oral CCB and hydralazine injections, and the choice of delivery method was determined according to the condition of the cervix and severity of the disease. Even in women with high risk factors for preeclampsia, prophylactic aspirin was administered in as low as 50%, of patients, possibly may due to the absence of domestic guidelines for aspirin use during pregnancy. Korean guidelines for prophylactic aspirin administration during pregnancy is needed based on additional research on the efficacy of aspirin for domestic women in the future.