치료 감호중인 조현병 환자에서 정신병질 성격과 대인관계문제

왕성근,권지현,이재우,지익성,Wang, Seung-Keun,Kwon, JeeHyun,Lee, Jae-Woo,Chee, Ik-Seung 대한불안의학회 2014 대한불안의학회지 Vol.10 No.2

Objective : This study was conducted to evaluate the validity of the Korean Inventory of Interpersonal Problems (K-IIP) with Psychopathic Personality Inventory-Revised (PPI-R) to assess interpersonal problems in Korean criminal offenders with schizophrenia. Methods : The sample consisted of 187 inpatients with schizophrenia who had committed crimes. All participants filled out self-report questionnaires ofPPI-R and K-IIP. Results : The result showed that all scales of K-IIP were correlated highly with the PPI-R total score (r range=0.25-0.65). Correlations with K-IIP scales were highest for Blame Externalization, Rebellious Nonconformity, and Machiavellian Egocentricity scales (r range=0.50-0.66, 0.43-0.64, 0.39-0.58, respectively). All scales of K-IIP exhibited a negative correlation with Social Influences, Stress Immunity, Coldheartedness (C) scale ofPPI-R. Cold/Distant scale ofK-IIP was not correlated with C scale of PPI-R. All scales of K-IIP was highly correlated with PPI-R-factor-2 (r range=0.44-0.71) and negatively correlated with PPI-R-factor-l (r range=-0.03-0.38). Conclusions : Despite of strong correlation between PPI-R total score and K-IIP total score, K-IIP was not correlated with PPI-R-I that represents affective and interpersonal deficits. It suggests K-IIP may not proper for measuring the interpersonal problems of criminal offenders with schizophrenia. It will be needed other assessment scale for measuring the interpersonal problems of psychopathy in criminal schizophrenia.

T102C Polymorphism of the 5-HT<SUB>2A</SUB> Receptor Gene is not Associated with Homicide in Male Schizophrenics

Ik-Seung Chee(지익성),Seung-Keun Wang(왕성근),Sun-Woo Lee(이선우),Jeong-Lan Kim(김정란),Young-Ho Lee(이영호),Sang-Sup Choi(최상섭),Chung-Suk Lee(이충숙) 대한생물치료정신의학회 2007 생물치료정신의학 Vol.13 No.2

목적:세로토닌체계의 변화가 정신분열병이나 폭력행동과 관련이 있다고 알려져 있다. 저자 등은 5-HT2A 수용체 유전자 다형성(T102C)이 살인을 범한 남성 정신분열병과 관련이 있는지 알아보기 위하여 본 연구를 시행하였다. 방법:살인을 범한 정신분열병 환자 105명, 비폭력 정신분열병 환자 102명, 정상 대조군 104명을 대상으로 중합효소 연쇄반응을 이용하여 5-HT<SUB>2A</SUB> 수용체 유전자 다형성(T102C)의 유전자형과 대립유전자의 빈도를 비교하였다. 모든 대상은 한국인 남자였다. 결과:살인을 범한 정신분열병군, 비폭력 정신분열병군, 정상대조군을 비교한 결과 세군간에 유전자형(χ²=8.090, df=4, p=0.088)이나 대립유전자(χ²=2.880, df=2, p=0.237)에서 통계적인 차이가 없었다. 또한 살인을 범한 정신분열병군과 비폭력 정신분열병군, 살인을 범한 정신분열병군과 정상 대조군, 그리고 비폭력 정신분열병군과 정상 대조군을 각각 비교하였을 때도 유전자형과 대립유전자에서 통계적인 차이가 없었다. 결론:이러한 결과는 5-HT<SUB>2A</SUB> 수용체 유전자 다형성(T102C)이 남성 정신분열병환자의 살인행동과는 관련이 없음을 제시한다. 향후 살인을 범한 여성정신분열병환자와 살인을 범한 일반 범죄인을 포함한 연구가 필요할 것으로 사료된다.

젊은 성인에서 대인관계문제 및 신체불만족이 자살사고에 미치는 영향

이재민,김정란,왕성근,지익성,Lee, Jae-Min,Kim, Jeong-Lan,Wang, Seong-Keun,Chee, Ik-Seung 대한불안의학회 2014 대한불안의학회지 Vol.10 No.2

Objective : The aim of this study was to investigate the relationship between interpersonal problems, body dissatisfaction, and suicidal idea. Methods : Two hundred ninety-four participants filled out the self-reporting questionnaires : Body dissatisfaction was measured with Body Dysmorphic Disorder Examination-Self Report (BDDE-SR) ; Interpersonal problems was measured with Korean Inventory of Interpersonal Problem (KIIP) ; Suicidal Ideation Questionnaire (SIQ) was used to assess suicidal idea. A path analysis was conducted to identify the impact of interpersonal problems and body dissatisfaction on the suicidal ideas. Results : 'Socially inhibited (KIIP_C4)', 'overly-accommodating (KIIP_C6)', age, and gender had a direct effect on their body dissatisfaction, and those factors had a indirect effect on the suicidal ideas. Also, 'cold (KIIP_C3)' and body dissatisfaction had a direct effect on the suicidal ideas. Conclusions : These findings can help to identify how interpersonal problems and body dissatisfaction influence the suicidal ideas of people. It would be useful to consider and assess suicidal ideas in the patients with 'cold (KIIP_C3)', 'socially inhibited (KIIP_C4)', 'overly-accommodating (KIIP_C6)'.

젊은 성인에서 신체 불만족과 성격 특성 및 스트레스와의 관계

김재헌,김정란,왕성근,지익성,Kim, Jae-Heon,Kim, Jeong-Lan,Wang, Seong-Keun,Chee, Ik-Seung 대한불안의학회 2014 대한불안의학회지 Vol.10 No.2

Objective : The aims of this study was to evaluate relationship between body dissatisfaction, personality characteristic, and stress in young adults. Methods : One hundred and ninety five young, healthy, and normal participants filled out all 3 types of self-reported questionnaire, the Body Dysmorphic Disorder Examination-Self Report (Korean version of BDDE-SR ; K-BDDE-SR), Neuroticism, Extraversion, Openness-Five Factor Inventory (NEO-FFI) and Stress Scale of Korean version of the Depression Anxiety Stress Scale (K-DASS-21). Results : Out of the 195 participants, 30% (n=59) was male and 70% (n=136) was female. There was no statistical difference between high K-BDDE-SR group (K-BDDE-SR score 75 percentile or higher, n=50) and low K-BDDE-SR group (K-BDDE-SR score below than 75 percentile, n=145) in terms of weight, height, and BMI. In high K-BDDE-SR group, neuroticism was significantly higher than low K-BDDE-SR group, and extraversion, agreeableness, conscientiousness were significantly lower than low K-BDDE-SR group. Also, level of stress in high K-BDDE-SR group was significantly higher than low K-BDDE-SR group. Conclusion : Our study revealed that individual's with more body dissatisfaction were more neurotic and stressful. Thus, body dissatisfaction and diverse psychiatric diseases should be considered in treating neurotic and stressful young adults.

한국인 조현병 환자와 도파민 D2 수용체 유전자 다형성과의 관련연구

김태성,차승민,왕성근,김정란,이영호,최혜인,지익성,Kim, Tae-Sung,Cha, Seung-Min,Wang, Seong-Keun,Kim, Jeong-Lan,Lee, Young-Ho,Choi, Hye-In,Chee, Ik-Seung 대한생물정신의학회 2012 생물정신의학 Vol.19 No.1

Objectives : This study was designed to investigate the association between the dopamine D2 receptor (DRD2) genetic polymorphism [TaqIB (rs17294542) and TaqID (rs1800498)] and patients with schizophrenia. Methods : TaqIB (rs17294542) and TaqID (rs1800498) polymorphism of the DRD2 gene were typed in 100 patients with schizophrenia and 109 normal controls. Results : There were no statistical differences in genotype and allele distribution of TaqIB (rs17294542) and TaqID (rs1800498) genetic polymorphism between patients with schizophrenia and normal controls. Conclusions : These results suggest that the TaqIB (rs17294542) and TaqID (rs1800498) polymorphisms of the DRD2 gene may not be associated with schizophrenia in the Korean population.

한국판 Cohen-Mansfield 초조 척도(K-CMAI)의 표준화 연구

김정란(Jeong-Lan Kim),왕성근(Seung-Keun Wang),김민구(Min-Goo Kim),김수영(Soo-Young Kim),김의준(Eui-Jun Kim) 대한생물치료정신의학회 2008 생물치료정신의학 Vol.14 No.1

Objectives: This study was conducted to standardize and develop the Korean version of Cohen-Mansfield Agitation Inventory(K-CMAI), which is a scale for assessing common agitated behaviors in elderly patients. Methods: After developing the K-CMAI, 166 patients, who met diagnostic criteria of dementia, were rated by it and Korean version of Neuropsychiatric Inventory(K-NPI). We tested internal consistency, interrater reliability, and factor analysis and correlation with K-CMAI and K-NPI. Results: Internal consistency of frequency of K-CMAI(Cronbach's a) in two raters were 0.889 and 0.893, respectively, and κ value of interrater reliability was 0.97 for frequency and was 0.95 for difficulties of caregivers. Factor analysis from Varimax Rotation of K-CMAI was found 4 factors, such as aggressive behaviors, physically non-aggressive behaviors, verbally agitated behaviors, and hiding and hoarding, and we could confirm those 4 factors with Amos. Irritability, Disinhibition, and aberrant behavior domains of K-NPI were highly correlated with K-CMAI. Conclusions: The K-CMAI was showed good reliability and validity for the assessment of agitated behavior in elderly. The K-CMAI is an useful tool to caregiver for detecting abnormal behavior of dementia patients.

뇌 Single Photon Emission Computer Tomography 영상을 이용한 정신분열병 환자의 초기 증상 차이에 대한 연구

이진구,김성민,서영덕,김기성,왕성근,지익성,김정란,Lee, Jin-Gu,Kim, Seong-Min,Seo, Young-Duk,Kim, Ki-Seong,Wang, Seong-Keun,Chee, Ik-Seung,Kim, Jeong-Lan 대한생물정신의학회 2010 생물정신의학 Vol.17 No.3

Objectives : This study was conducted to compare between hallucination group and delusion group in patient with schizophrenia, using Brain $^{99m}Tc$-ECD PECT. Methods : Among 16 patients with less than 3 schizophrenic episodes, 8 patients whose initial symptom was hallucination were assigned to the hallucination group, and other 8 patients with initial sumptom of delusion were assinged to the hallucination group. All of the patients clinically evaluated using the PANSS and BPRS. Both groups of patients and 8 healthy subjects underwent $^{99m}Tc$-ECD PECT. Results : Score of thinking disturbance subscale of BPRS were significantly lower in the hallucination group than the delusion group. In SPECT analysis, the hallucination group showed significantly increased perfusion in some areas of the right temporal lobe, bilateral limbic lobes and left parietal lobe compared to delusion group. Both group had a reduced rCBF in some areas of the frontal lobe. Conclusion : The hallucniation group, compared with the delusion group, showed significantly increased regional cerebral blood flow in some regions. Therefore, this data suggests that different neural substrates may affect the process of auditory hallucination and delusion.

의과 대학생의 신체부위 불만족과 성격특성에 대한 연구

김현진(Hyun-Jin Kim),차승민(Seung-Min Cha),김정란(Jeong-Lan Kim),왕성근(Seong-Keun Wang),지익성(Ik-Seung Chee) 대한생물치료정신의학회 2010 생물치료정신의학 Vol.16 No.2

Objectives : This study investigated the relationship of the dissatisfied body parts, personality characteristics, depression, obsessive-compulsive disorder, social anxiety, and self-esteem in a Korean medical student sample. Methods : Three hundred and eighty six medical students completed the measures of Body Dysmorphic Disorder Examination-self report(BDDE-SR-Korean version), Eysenck Personality Questionnaire(EPQ-Korean version), Beck Depression Inventory(BDI-Korean version), Maudsley Obsessional-Compulsive Inventory(MOCI-Korean version), Liebowitz social anxiety scale(LSAS-Korean version), Rosenberg Self Esteem scale(SES-Korean version). Results : Out of the 386 students, 72.0%(N=278) were male and 28%(N=108) were female. The most dissatisfied body part of participants were waist-abdomen(10.0%), tooth(8.3%), head hair(7.8%), nose(6.8%) and thigh(5.3%). The gender difference in dissatisfied body parts, the body part in female student were breast, calves, thighs, nose and buttocks. Whereas, males were concerned about head hair, shoulder, genitals, chest, eyes, mouth. In Higher BDDE-SR score group, neuroticism, addiction, impulsivity, empathy and criminality personality traits were significantly higher than lower BDDE-SR score group. And, Higher BDDE-SR score were linked with high levels of MOCI, BDI, and LSAS score but with lower level of SES score. Conclusion : These findings indicate that the medical college students with higher level of body dissatisfied are highly associated with neuroticism, addiction, impulsivity empathy and criminality personality traits, and have higher score of depression, social anxiety, obsession and poor self-esteem.

정신과 외래 우울증 환자에서 분노 경험

안병훈(Byung-Hoon Ahn),지익성(Ik-Seung Chee),왕성근(Seong-Keun Wang),홍주봉(Joo-Bong Hong),박권수(Kwon-Soo Park),김영란(Young-Lan Kim),김정란(Jeong-Lan Kim) 대한생물치료정신의학회 2009 생물치료정신의학 Vol.15 No.2

Objectives: This study was conducted to evaluate the degree and type of anger experienced by patients with depressive disorders and to determine which type of anger is correlated with symptom severity. Methods: One hundred-six psychiatric outpatients with depressive disorders and ninety normal control subjects completed the Korean version of Aggression Questionnaire(AQ) and Korean version of Depression, Anxiety, and Stress Scale (DASS). Comparison between two groups was conducted to evaluate which type of anger are prominent in the depressed group. Therefore, correlation and partial correlation between the scores of 4 subscales(Anger, Hostility, Verbal aggression, and Physical aggression) of AQ and the scores of 3 subscales(Depression, Anxiety, and Stress) of DASS were assessed. A multiple regression analysis was performed to determine which type of anger predicted symptom severity. Results: Total AQ score, hostility, anger and physical aggression scores were significantly higher in patients with depressive disorders. After the score of Stress and Anxiety subscale of DASS were controlled; the depression score was significantly correlated with total AQ score, physical aggression and hostility score. The Hostility score was a major predictor of the depressive symptom severity. In addition, the Anger score was a major predictor of the anxiety and stress symptom severity. Conclusion: Anger is frequently found symptom in patients with depressive disorders. Therefore, it is important that clinicians routinely evaluate the degree and type of anger in patients with depressive disorders.

한국판 분노반응검사의 표준화 연구

조영우(Young-Woo Cho),김정란(Jeong-Lan Kim),김수영(Soo-Young Kim),왕성근(Seong-Keun Wang),지익성(Ik-Seung Chee) 대한생물치료정신의학회 2009 생물치료정신의학 Vol.15 No.2

Objectives: The purpose of this study was to standardize the Korean version of the Reaction Inventory(K-RI) for measuring an individual's propensity for anger arousal. Methods: After translating the Reaction Inventory into the K-RI, the K-RI, Korean version of the Aggression Questionnaire(K-AQ), and Korean version of the Depression Anxiety Stress Scale-21(K-DASS-21) were administered to 424 Korean medical college students. The re-test was conducted with a 2-week interval of 119 students. Results: 1) The internal consistency of K-RI was 0.96(Cronbach's α, p<0.01). The test-retest reliability of K-RI was 0.68(Pearson's correlation coefficiency, p<0.01). Convergent validity was examined by Pearson's correlation coefficient between K-RI and K-AQ, which was 0.48 (p<0.001). 2) Four factors from K-RI were extracted by factor analysis with Varimax Rotation. The factors of K-RI were "Unpredictable disruptions and disturbances factor", "Embarrassing circumstances factor", "Personal disrespect factor", and "Unpleasant encounters factor". Conclusion: These results indicate that the Korean version of Reaction Inventory is a reliable and valid instrument to assess anger reaction.