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여드름 환자에서 Propionibacterium acnes에 대한 항생제의 최저발육저지농도에 관한 연구
임연순(Yeon Soon Lim),명기범(Ki Bum Myung),정낙은(Nak Eun Chung),정화순(Wha Soon Chung) 대한피부과학회 1995 대한피부과학회지 Vol.33 No.3
Background : Propioriacterium acnes plays an importantol in the development of inflammatory acne, and inflarnmatory lesions are improved by oralnc topical antibiotics. But as Pacnes frequently develop resistance to antibiotics in patients neing long term systemic antibiotic therapy, the theravuti effects diminish, and eventually thay fails. Objective : The purpose of this study is to evaluate theerral susceptability of P. acnes to antibiotics and the difference in the MIC depending on the of oral and/or topical antibiotics, therapeutic effects and disease duration in patients with acie ulgaris. Methods : We used twenty six strains of P. acnes which were obtained from patients with acne and performcd suseptibility testing for antibiotics usir the E test procedure. Results : 1. The growth of P. acnes was completely inhibited by e ythromycin and chloramphenicol at concentrations of 0.023ug/ml and 0.064ug/ml, respectively cefoxitin at 0.094ug/ml, and by tetracycline and clindarnycin at 0.190 ug/ml. 2. P. acnes was mot susceptible to erythromycin, and olwed by chloramphenicol, cefoxitin, tetracycline, clindamycin in order of decreasing susceptibilit . 3. There were no significant differences in the MIC in reat in to previous antibiotic treatment. 4. For tetracycline, The MIC was significantly lower(p<0.01) in patients who improved after treatment. 5, For tetracycline and chloramphenicol, the MIC was grficantly lower(p<0.05) in patients with less than 2 years disease duration. Conclusion : The susptibility of antibiotics for P. acneias highest in erythromycin. There were no significant differences in the MIC in relation to prvious antibiotic treatment, and for some antibiotics the suseptibility was low in patients who dill not show clinical improvement or who had long disease duration. (Kor J Dermatol 1995;33(3): 437-444)
Development of database programs for facial 3D reconstruction.
Kyung-moo Yang(양경무),Yi-suk Kim(김이석),Gil-ro Han(한길로),Han-young Lee(이한영),Nak-eun Chung(정낙은),Young-sik Choi(최영식),Won-tae Lee(이태원),Yong-suk You(유용석),Dae-soon Kwak(곽대순),Chang-hoon Lee(이창훈),Seung-ho Han(한승호 한국법과학회 2005 한국법과학회 학술대회 Vol.2005 No.1
심승철(Seung Cheol Shim),전재범(Jae Bum Jun),정성수(Sung Soo Jung),이인홍(In Hong Lee),배상철(Sang Cheol Bae),유대현(Dae Hyun Yoo),김성윤(Seong Yoon Kim),정화순(Wha Soon Chung),정낙은(Nak Eun Chung) 대한내과학회 1994 대한내과학회지 Vol.47 No.6
N/A Objectives : Anemia is the most common extra-articular manifestation of rheumatoid arthritis (RA). However neither the frequency of anemia in the patients of RA nor the role of erythroid abnormalities in various types of anemia have been reported previously in Korean population. Methods : To establish the frequency of anemia and the role of erythropoietin in the pathophysiology of anemia, 500 patients with RA were selected randomly from the patients who were diagnosed at Rheumatism center of Hanyang university hospital from January 1993. Results : 1) In the series of 500 RA patients, 196 patients (39.2%) had anemia, and 127 of 196 patients with anemia had mild anemia (Hb more than 10.0 g/dl), the other 69 patients (35%) had moderate to severe anemia. 2) 92 (77.3%) of 120 patients with anemia had anemia of chronic disease (ACD) and iron deficiency anemia (IDA) was observed in 26 patients (22.7%). Other types of anemia were also found: one case had vitamin B12 deficiency anemia, the other case had autoimmune hemolytic anemia. 3) 17 patients with ferritin between 20~100 ng/ml were examined bone marrow aspiration and biopsy. The results of bone marrow biopsy were identical with that of Iron index (=-0.00446×TIBC+1.22765×Log ferritin-0.07824) except one case, 4) ACD had higher value of Ritchie index, ESR, functional class than IDA (p<0.01), Serum iron had no significant differences between ACD and IDA, but TIBC and ferritin had significant differences between two groups (p<0.01). 5) Ritchie index versus Hb (r=-0.38. p<0.01)'and ESR versus Hb (r=-0.53, p<0.01) were negatively related but there were no significant differences in disease duration. 6) Serum erythropoietin was 17.27±1.3 mu/ml in ACD and 35.64±1.7 mu/ml in IDA, and there were significant differences between these two groups (p<0.01). Conclusions : Iron index is a useful method for differential diagnosis between ACD and IDA. In ACD, erythropoietin may be effective in rheumatoid arthritis with moderate to severe anemia.