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Ji Eun Kim(김지은),In Sik Hwang(황인식),Jun Seo Goo(구준서),So Hee Nam(남소희),Sun Il Choi(최선일),Hae Ryun Lee(이혜련),Young Ju Lee(이영주),Yoon Han Kim(김윤환),Se Jin Park(박세진),Nahm-Su Kim(김남수),Young Hwan Choi(최영환),Dae You 한국생명과학회 2012 생명과학회지 Vol.22 No.5
LP9M80-H는 맥문동(Liriope platyphylla)으로부터 메탄올과 헥산을 이용하여 추출한 새로운 추출물로서 ICR 마우스에서 인슐린분비를 촉진하며, 간과 뇌 조직에서 인슐린 신호경로를 활성화시키는 것으로 알려져 있다. 본 연구에 서는 LP9M80-H가 당뇨와 비만의 치료에 미치는 효과를 조사하기 위하여, OLETF 모델동물에 LP9M80-H를 2주간 투여한 후 당뇨와 비만과 관련된 주요인자의 변화를 관찰하였다. 비록 체중은 두 집단간에 차이가 없었으나 복부 지방량은 vehicle 투여군보다 LP9M80-H 투여군에서 적었다. 또한, 혈중 포도당농도는 LP9M80-H를 투여한 OLETF랫드가 대조군에 비하여 약간 낮았으나 인슐린의 농도는 유의적으로 크게 증가하였다. 혈청 내 3가지 주요 지질의 농도는 LP9M80-H를 투여한 OLETF 랫드에서 유의적으로 감소하였고, 지방의 산화를 촉진하는 아디포넥틴의 농도도 LP9M80-H를 투여한 OLETF 랫드에서 감소하였다. 더불어, 체내에 분비된 인슐린이 표적장기에 미치는 영향을 관찰하기 위하여 간조직에서 인슐린 수용체와 인슐린 수용체기질(IRS)의 발현을 관찰하였으며, 이러한 2가지 단백질은 LP9M80-H를 투여한 OLETF 랫드에서 vehicle 투여군에 비해 유의미하게 감소하였다. 또한, 인슐린 신호경로의 다운스트림에 위치하는 포도당 수송체 중에서 Glut-2와 Glut-3 발현은 LP9M80-H를 투여한 OLETF 랫드에서 유의미하게 감소하는 반면에, Glut-4 발현은 일정하게 유지되었다. 따라서 이러한 결과는 LP9M80-H는 포도당항상성과 지질농도의 조절을 통하여 당뇨와 비만의 증상을 완화시키는데 기여할 것으로 사료된다. It was reported that the novel compounds (LP9M80-H) of Liriope platyphylla regulate glucose transporter (Glut) biosynthesis by activating the insulin-signaling pathway in the liver and brain of ICR mice. To investigate the therapeutic effects of LP9M80-H on the pathology of diabetes and obesity, alterations of key factors related to symptoms were analyzed in the Otsuka Long Evans Tokushima Fatty (OLETF) rats treated with LP9M80-H for 2 weeks. The abdominal fat masses in the LP9M80-H-treated group were lower than the vehicle-treated group, although there was no difference in body weight between the two groups. Additionally, when compared to the vehicle-treated group, LP9M80-H treatment induced a significant decrease in glucose levels and an increase in the insulin concentration in the blood of OLETF rats. A high level of insulin protein was also detected in pancreatic β cells of LP9M80-H-treated OLETF rats. A significant reduction in the concentration of lipids and adiponectin was detected only in LP9M80-H-treated OLETF rats. Furthermore, the expression of insulin receptor β and the insulin receptor substrate (IRS) was dramatically decreased in LP9M80-H-treated OLETF rats compared to the vehicle-treated group. Of the glucose transporters located downstream of the insulin-signaling pathway, glucose transporters (Glut) -2 and -3 were significantly decreased in LP9M80-H-treated OLETF rats, while the level of Glut-4 was maintained under all conditions. Therefore, these results suggest that LP9M80-H may contribute to relieving symptoms of diabetes and obesity through glucose homeostasis and regulation of lipid concentration.
연구보문 : 자연과학 ; 베트남 하노이지역 작기에 따른 국내 토마토 품종의 수확량 및 과실 특성
이택종 ( Taek Jong Lee ),쩌우후앙민 ( Hoang Minh Chau ),하또투 ( To Thi Thu Ha ),이기환 ( Gi Hwan Yi ),박동진 ( Dong Jin Park ),김현순 ( Hyun-soon Kim ),김남수 ( Nahm Su Kim ),박춘근 ( Choon Keun Park ),조원대 ( Weon Dae Cho ) 한국국제농업개발학회 2012 韓國國際農業開發學會誌 Vol.24 No.3
This study was conducted to investigate the yield and fruit characteristics of Korean tomato (Lycopersicon esculentum Mill.) cultivars in two different cropping seasons (February 2011 to February 2012) in Hanoi, Vietnam. The experiment was arranged in a completely randomized block design, with three replications. Eight Korean cultivars, specifically, ``Pink Top``, ``Kyupirang``, ``Super Dotaerang``,``Sun Red``, ``Sun Glove``, ``TP-7 Plus``, ``Lovely 250``, and ``Gwangbok``, and one Vietnamese cultivar, ``FM 120``, were transplanted in an open field in March (spring-summer) and October (fall-winter) of 2011. The cropping season significantly affected the plant height (cm), stem diameter (mm), fruit (no.) and total yield (kg) per plant, fruit length (cm) and width (cm), fruit weight (g) per plant, and total soluble solids (TSSs, °Brix). However, the dry weight (%) and vitamin C (mg/100 g) content showed no significant differences in the different cropping seasons. The highest values for the growth and fruit characters of tomato appeared during the fall-winter season, whereas the highest TSSs (4.8 oBrix) was observed in the fruit harvested during the spring-summer season. The Vietnamese cultivar ``FM 120`` showed highest values of fruit per plant (33.8), total yield (3.6 kg), and vitamin c content (13.9 mg/100 g) for both cropping seasons. However, the highest values for the plant height, fruit length, fruit width, and fruit weight were observed in the Korean cultivars. Therefore, the fall-winter cropping season is recommended as the optimum season for enhancing the fruit yield and characteristics of Korean tomato cultivars under the environmental conditions of Hanoi in Vietnam.