A Prospective Study of Benign Breast Disease and the Risk of Breast Cancer

London, Stephanie J.,Connolly, James l.,Schnitt, Stuart J.,Colditz, Graham A. MediMedia Korea 1992 JAMA-Korea Vol.7 No.6

세속적 홀리스틱 평화교육에서 정신적 관점 통합하기

Robert (Bob) London 한국홀리스틱융합교육학회 2019 한국홀리스틱융합교육학회 학술발표대회논문집 Vol.2019 No.10

Peripheral Defocus and Myopia Management: A Mini-Review

Nir Erdinest(Nir Erdinest ),Naomi London(Naomi London ),Itay Lavy(Itay Lavy ),David Berkow(David Berkow ),David Landau(David Landau ),Yair Morad(Yair Morad ),Nadav Levinger(Nadav Levinger ) 대한안과학회 2023 Korean Journal of Ophthalmology Vol.37 No.1

Myopia is the most common refractive error in the world, and its’ prevalence continually increases. The potential pathological and visual complications of progressive myopia have inspired researchers to study the sources of myopia, axial elongation, and explore modalities to arrest progression. Considerable attention has been given over the past few years to the myopia risk factor known as hyperopic peripheral blur, the focus of this review. The primary theories currently believed to be the cause of myopia, the parameters considered to contribute and influence the effect of peripheral blur, such as the surface retinal area or depth of blur will be discussed. The currently available optical devices designed to provide peripheral myopic defocus will be discussed, including bifocal and progressive addition ophthalmic lenses, peripheral defocus single vision ophthalmic lenses, orthokeratology lenses, and bifocal or multifocal center distance soft lenses, as well as their effectivity as mentioned in the literature to date.

Predictors of Obesity and Physical Health Complaints Among 911 Telecommunicators

Lilly, Michelle M.,London, Melissa J.,Mercer, Mary C. Occupational Safety and Health Research Institute 2016 Safety and health at work Vol.7 No.1

Background: This study aims to: (1) examine rates of obesity and physical health complaints among 911 telecommunicators; and (2) document the role of emotion dysregulation, psychological inflexibility, duty-related distress and dissociation, and psychopathology in predicting obesity and physical health complaints in this population. Methods: The sample consisted of 911 telecommunicators from across the country (N = 758). Participants completed an online survey assessing their mental and physical health functioning. Results: A total of 82.5% of the sample reported a body mass index that fell within the overweight or obese category and an average of 17 physical health complaints within the past month. Peritraumatic reactions (distress and dissociation), emotion dysregulation, and psychological inflexibility had effects on physical health largely through psychopathology (alcohol abuse, post-traumatic stress disorder, and depression). Conclusion: Development of adapted prevention and intervention efforts with this population is needed.

B型肝炎 바이러스가 絲毬體腎炎에 미치는 疫學的 病因論的 硏究

朴漢喆,姜鍾鳴,金箕洪,London,Thomas W.,Hann,Hie Won L.,Blumberg,Baruch S. 한양대학교 의과대학 1982 한양의대 학술지 Vol.2 No.1

HBV와 관계된 抗原,抗體의 複合體가 絲毬體腎炎을 일으키는데 있어 그 寄與度를 알아보기 위하여 소白尿를 동반한 腎疾患患者 116名과 肝疾患을 가진 患者 115名, 그외의 여러疾患患者 127名, 그리고 對照群으로서 建康한 女子 60名과 男子 17名에 대하여 HBsAg, antiHBs 및 antiHBc를 검사하고, 臨床所見을 종합하여 相互의 連關性을 比較하였다. 腎疾患에 있어서 23例에서 腎生檢을 施行하였다. 1. 建康人에 있어서 HBsAg는 7.8%의 陽性率을 보였고, antiHBs는 67.5%, antiHBc는 77.9%에서 陽性이었다. 2. 對象者 全部에 對하여 年齡的으로 볼때, HBsAg의 陽性率은 年齡이 增加함에 따라 차차 減小하지만 antiHBs와 antiHBc는 年齡이 많을수록 增加하여 40歲 以上이면 antiHBs는 70%이상, antiHBc는 90% 이상에서 陽性이 되었다. 3. 腎疾患患者군에 있어서 HBV의 標識, 즉 HBsAg,antiHBs,antiHBc의 陽性率은 建康人群이나 基他疾患群과 다름이 없었고, 肝疾患群에 있어서는 다른 어떤 群보다도 HBsAG와 antiHBc의 陽性이 현저히많았다. 4. 腎生檢한 患者中에서 微少變化性 腎症候群을 除外하고 絲毬體腎炎으로 確定된 12名中 3例, 즉 25%에 있어 HBsAG가 陽性이었고, 이는 對照群 7.8%보다 많으나 統計的으로 意味를 갖기 위하여는 더 많은 標本例가 必要하다. 要컨데 HBV感染으로 絲毬體腎炎이 誘發되는 頻度는 成人에서는 많지 않고, 小兒에서는 좀 더 많을 듯하나 이는 좀더 調査해 보아야 알수 있겠다. 5. 慢性腎不全이 있는 患者群에서 이것이 없는 患者群보다 antiHBs의 陽性率이 높고 感染받지 않은 例가 적었다. 이것은 慢性腎不全患者들이 病院에 出入하면서 HBV에 露出되었고 免疫力도 低下되었기 때문으로 풀이된다. 6. 附隨的으로 HBsAg(+)群에 있어서 尿의 比重이 낮았다. 仔細한 理由는 모르겠으나 HBV가 腎細尿管의 機能에 變化를 준 것이 아닌가 추측된다. A number of reports are now present in which glomerulonephritis is associated with hepatitis B virus(HBV) infection. In persons who carry HBV, HBV antigens and antibodies wax and wane in the blood and form antigen-antibody complex, detectable in the cryoprecipitate or polyethylene glycol precipetate. The antigens and/or antibodies were detectable in the glomerular basement membrane by immunofluorescent studies and were extractable from the basement membrane. It is therefore increasingly evident that HBV infection can cause immune complex mediated glomerulon ephritis. HBV infection is now prevalent in Korea with 7 to 8% positive rate of HBsAg in healthy adults. The purpose of this study is to show the role of HBV antigens in the formation of glomerulonephritis. Patients with significant proteinuria and/or increased levels of SGPT were randon selected and from clinical assessment and biopsies the patients were divided into four groups: 116 cases of patients with glomerulopathy, 115 cases of patients with hepatic diseases, 127 cases with other diseases, and 77 healthy normal control. Sera were separated, stored in -20 degree C. and sent frozen in dry-ice to the Institute for Cancer Reserch, Philadelphia, U.S.A. and were measured for HBsAg, ant i-HBs, and anti-HBc. Results: 1) In healthy normal control group, the HBsAg was positove in 12% of males, 6.7% of females, and 7.8% of both sexes. Anti-HBs was positove in 65% of the male and 68% of the female group. Anti-HBc was positove in 76% of the male and 78% of the female group. 2) As a whole study group, HBsAg positive rate tended to decline as age increased. The positive rates of anti-HBs and anti-HBc were conversely increased. 3) The positive rates of the three HBV markers were statistically not significant between the renal and healthy groups, of between the renal and other disease group. 4) Renal biopsies were performed in 24patients with glomerulonephritis, 3 cases athies were excluded from the study. Of 12 patients with glomerulonephritis, 3cases or 25% were positive for HBsAg. More statistically significant differenences might have been obtained if there were more biopsy samples or if pediatric ages were included 5) Of renal disease group, positive rate of antiHBs was significantly higher in patients with chronic renal failure than those without (77.8% vs 48.5%). Uninfected rate was lower in patients with renal failure than those without (4.4% vs 39.4%). 6) Urinary specific gravity was significantly lower in HBsAg positive group (1.015) than the unifected group (1.020, p less than 0.005). It is specluated that HBV alter the renal concentrating function.

Predictors of Obesity and Physical Health Complaints Among 911 Telecommunicators

Michelle M. Lilly,Melissa J. London,Mary C. Mercer 한국산업안전보건공단 산업안전보건연구원 2016 Safety and health at work Vol.7 No.1

Background: This study aims to: (1) examine rates of obesity and physical health complaints among 911 telecommunicators; and (2) document the role of emotion dysregulation, psychological inflexibility, duty-related distress and dissociation, and psychopathology in predicting obesity and physical health complaints in this population. Methods: The sample consisted of 911 telecommunicators from across the country (N ¼ 758). Participants completed an online survey assessing their mental and physical health functioning. Results: A total of 82.5% of the sample reported a body mass index that fell within the overweight or obese category and an average of 17 physical health complaints within the past month. Peritraumatic reactions (distress and dissociation), emotion dysregulation, and psychological inflexibility had effects on physical health largely through psychopathology (alcohol abuse, post-traumatic stress disorder, and depression). Conclusion: Development of adapted prevention and intervention efforts with this population is needed.

Urban patial restructuring, Event-led Development and Scalar Politics

전병유,신진욱,장지연,신현방,University of London),황규성 Urban Studies Foundation 2014 Urban Studies Vol.51 No.14

Minimally-invasive versus open enucleation for pancreatic tumours: A propensity-score adjusted analysis

Tousif Kabir,Zoe Z. X. Tan,Nicholas Syn,Alexander Y. F. Chung,London L. P. J. Ooi,Brian K. P. Goh 한국간담췌외과학회 2019 Annals of hepato-biliary-pancreatic surgery Vol.23 No.3

Backgrounds/Aims: This study aims to evaluate the perioperative outcomes of minimally-invasive enucleation (MIEn) of the pancreas versus open enucleation (OEn). Methods: This is a retrospective review of 20 consecutive patients who underwent pancreatic enucleation at a single institution. Results: Seven patients underwent MIEn, of which 3 were robotic and 4 were laparoscopic. After propensity-adjusted analysis, the only significant difference was a reduced rate of readmissions within 30 days in the MIEn group versus the OEn group [0 vs 4 (30.8%), p=0.0464]. There were no conversions to open in the MIEn group, and median operation time was similar in both groups. There was no difference in median EBL in both groups, and none of the patients in our series required blood transfusions. The overall morbidity rate was 45.0% and the major complication (Clavien-Dindo>2) rate was 15%; which was similar between both groups. Seven (35%) patients had a Grade B/C POPF, and there was no significant difference between the two groups for this. The MIEn group had a shorter median length of stay compared to OEn [5 days (range, 3-24) vs 8.5 days (range, 5-42)] this was not significant on propensity-adjusted analysis (p=0.3195). There was no post-operative 90-day/ in-hospital mortality in all 20 patients. Conclusions: Our experience demonstrates that MIEn was associated with similar perioperative outcomes and fewer readmissions compared to OEn.

DNA methylation and smoking in Korean adults: epigenome-wide association study

Lee, Mi Kyeong,Hong, Yoonki,Kim, Sun-Young,London, Stephanie J.,Kim, Woo Jin BioMed Central 2016 CLINICAL EPIGENETICS Vol.8 No.-

<P><B>Background</B></P><P>Exposure to cigarette smoking can increase the risk of cancers and cardiovascular and pulmonary diseases. However, the underlying mechanisms of how smoking contributes to disease risks are not completely understood. Epigenome-wide association studies (EWASs), mostly in non-Asian populations, have been conducted to identify smoking-associated methylation alterations at individual probes. There are few data on regional methylation changes in relation to smoking. Few data link differential methylation in blood to differential gene expression in lung tissue.</P><P><B>Results</B></P><P>We identified 108 significant (false discovery rate (FDR) < 0.05) differentially methylated probes (DMPs) and 87 significant differentially methylated regions (DMRs) (multiple-testing corrected <I>p</I> < 0.01) in current compared to never smokers from our EWAS of cotinine-validated smoking in blood DNA from a Korean chronic obstructive pulmonary disease cohort (<I>n</I> = 100 including 31 current, 30 former, and 39 never smokers) using Illumina HumanMethylation450 BeadChip. Of the 108 DMPs (FDR < 0.05), nine CpGs were statistically significant based on Bonferroni correction and 93 were novel including five that mapped to loci previously associated with smoking. Of the 87 DMRs, 66 were mapped to novel loci. Methylation correlated with urine cotinine levels in current smokers at six DMPs, with pack-years in current smokers at six DMPs, and with duration of smoking cessation in former smokers at eight DMPs. Of the 143 genes to which our significant DMPs or DMRs annotated, gene expression levels at 20 genes were associated with pack-years in lung tissue transcriptome data of smokers (Asan Biobank, <I>n</I> = 188).</P><P><B>Conclusions</B></P><P>Our study of differential methylation in Koreans confirmed previous findings from non-Asian populations and revealed novel loci in relation to smoking. Smoking-related differential methylation in blood is associated with gene expression in lung tissue, an important target of adverse health effects of smoking, supporting the potential functional importance of methylation in smoking-related disease.</P><P><B>Electronic supplementary material</B></P><P>The online version of this article (doi:10.1186/s13148-016-0266-6) contains supplementary material, which is available to authorized users.</P>

Simultaneous explanation of the R K and R D * $$ {R}_{D^{\left(*\right)}} $$ puzzles: a model analysis

Bhattacharya, Bhubanjyoti,Datta, Alakabha,Gué,vin, Jean-Pascal,London, David,Watanabe, Ryoutaro Institute of Physics Pub 2017 The journal of high energy physics Vol.2017 No.1