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유구한(Koo Han Yoo),이형래(Hyung-Lae Lee) 대한비뇨기종양학회 2010 대한비뇨기종양학회지 Vol.8 No.3
Life expectancy increases in worldwide countries. Subclinical prostate cancer is important to old aged population because many prostate cancers pose little risk to life or health. Old patients with localized prostate cancer are commonly treated with conservative managements, however, they should be considered to treat with definite therapy. Watchful waiting is a suitable option in patients with a life expectancy of less than 10 years and clinically localized, well or moderately well differentiated prostate cancer. Active surveillance with selective delayed definite therapy has close monitoring using prostate-specific antigen, digital rectal examination, and prostate biopsy. Radical prostatectomy or radiation therapy in old aged man revealed longer cancer-specific survival rates and lower biochemical progression rate than conservative treatments. Critical points to decide screening or treatment are life expectancy, co-morbidity, characteristics of primary tumor, complication of treatment and patient uses rather than chronological age.
투명세포신세포암에서 NF-κB의 발현과 임상병리인자에 관한 분석
이영(Young Lee),최정혁(Jeonghyouk Choi),이동기(Dong-Gi Lee),유구한(Koo Han Yoo),민경은(Gyeong Eun Min),이형래(Hyung-Lae Lee),원규연(Kyu Yeoun Won),임성직(Sung-Jig Lim) 대한비뇨기종양학회 2016 대한비뇨기종양학회지 Vol.14 No.2
Purpose: A multi-subunit transcription factor NF-κB is associated with anti-apoptotic signals in several cancers including renal cell carcinoma (RCC). In this study, we investigated whether the expression levels of the NF-κB were related to the clinical properties of human renal cell carcinoma such as nuclear grade, TNM stage, and recurrence free survival. Materials and Methods: Patients who were diagnosed with clear cell RCC between January 2006 and February 2013 were included. Clinicopathological data and survival were investigated. The expressions of NF-κB were investigated by performing immunohistochemical staining on 61 clear cell RCC. The expression levels of NF-κB were divided two groups by the expression levels. Results: Results on the expression of NF-κB were not significant. Analysis of NF-κB expressions is not associated with any of the clinical properties including age, nuclear grade and TNM stage (p=0.613, p=0.059, p=0.107, p=0.570, and p=0.760, respectively). Also, a statistically correlation was not observed between recurrence free survival and NF-κB expression levels (p=0.573). Conclusions: The expressions of the NF-κB were not associated with the clinical properties of clear cell RCC such as age, nuclear grade, TNM stage, and recurrence free survival.
Prognostic Significance of Immunohistochemical MSH2 Expression in Prostate Cancer
Young Bin Kim(김영빈),Dong-Gi Lee(이동기),Koo Han Yoo(유구한),Hyung-Lae Lee(이형래),Seung-Kwon Choi(최승권) 대한비뇨기종양학회 2018 대한비뇨기종양학회지 Vol.16 No.2
Purpose: There are numerous prostate cancer-related genes that involve in carcinogenesis and tumor progression. Among the genes, DNA mismatch repair genes recognize and repair misincorporated nucleotides during DNA replication. In this analysis, we evaluated the association of hMSH2 which is one of the mismatch repair genes, with risk of aggressive prostate cancer and prostate cancer recurrence. Materials and Methods: Immunohistochemistry was performed in 46 patients who diagnosed prostate cancer and underwent radical prostatectomy between January 2006 and December 2012 at Kyung Hee University Hospital at Gangdong. We evaluated an association between the degree of hMSH2 immunohistochemical staining and various clinical variables including prostate-specific antigen (PSA), Gleason score, pathological stage, and biochemical recurrence. The intensity of immunostaining for hMSH2 was divided into 2 groups: low expression group (immunostaining score <2) and high expression group (immunostaining score ≥2). Results: Although seminal vesicle invasion was marginally associated with the degree of hMSH2 immunohistochemical staining, PSA, Gleason score, lymph node metastasis, presence of lymphatic, perineural, vascular invasion, and extracapsular extension were not associated with the degree of hMSH2 immunohistochemical staining. Furthermore, the association of biochemical recurrence free survival with hMSH2 expression was not statistically significant. Conclusions: The hMSH2 expression was marginally associated with risk of aggressive prostate cancer such as seminal vesicle invasion. Further evaluation with a larger number of cases is needed to verify these results.
한국 남성의 비만과 전립선 비대증, 발기부전과의 연관성
서준상(Jun Sang Suh),조중훈(Jung Hoon Cho),정원식(Won Sik Jeong),하유신(U-Syn Ha),배재현(Jae Hyun Bae),김태효(Tae Hyo Kim),김재헌(Jae Heon Kim),이승환(Seung Hwan Lee),조희주(Hee Ju Cho),유구한(Koo Han Yoo),이형래(Hyung-Lae Lee),장인호(I 대한비뇨기종양학회 2015 대한비뇨기종양학회지 Vol.13 No.3
Purpose: Pathogenically, both erectile dysfunction (ED) and benign prostatic hyperplasia (BPH) are closely related to vascular problems, and vascular problems are closely associated with obesity. This study evaluated the relationships between obesity, BPH, and ED. Materials and Methods: The medical history of male patients, aged ≥40 years, evaluated at urology outpatient clinics of 11 university hospitals in Korea with chief complaints of lower urinary tract symptoms (LUTS)/BPH and ED were retrospectively evaluated. The correlations of medical history, body mass index (BMI), international prostate symptom score (IPSS), prostate volume, International Index of Erectile Function -5 (IIEF-5), and serum testosterone level were assessed. Results: Body mass index showed significant correlations with IPSS (r=0.087, p=0.003), prostate volume (r=0.384, p<0.001), IIEF (r=-0.072, p=0.015), and serum testosterone concentration (r=-0.303, p<0.001). Conclusions: Body mass index correlates with testosterone concentration, prostate volume, and markers of LUTS and ED in men with the latter conditions.
방광경부 현수술후 봉합사에 의해 발생된 재발성 방광결석
유구한,안규일,장성구 경희대학교 2006 慶熙醫學 Vol.22 No.1
Stress urinary incontinence is a common problem which can be corrected surgically. Burch colposuspension is one of successful operation performed for stress urinary incontinence. We report a patient who presented urgency, tenesmus, frequency, dysuria after Burch colposuspension. Any patients with unexplained lower urinary tract symptoms following Burch colposuspension must be evaluated radiologically and urologically to find iatrogenic bladder stone.