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창출(蒼朮)이 천식 관련 Th1/Th2 세포 분비 cytokine에 미치는 영향
이정우,이형구,정희재,Lee, Jeong-Woo,Rhee, Hyung-Koo,Jung, Hee-Jae 대한한방내과학회 2007 大韓韓方內科學會誌 Vol.28 No.4
Background and Objective : Atractylodes japonica (AJ) is a commonly-used herbal medicine in Asian countries such as Korea, China and Japan. The present study was designated to evaluate the direct effects of AJ on helper T cell activities and on Th1/Th2 lineage development in vitro. Materials and Methods : Spleen cells from 8-week BALB/c mice were cultured in CR extracts containing medium without activation for 24 hours and with activation for 48 hours. CD4+ T cells were isolated and analyzed for mRNA expression levels of INF-$\gamma$, IL-4, T-bet and GATA-3 by RT-PCR and secretion cytokines levels of INF-$\gamma$, IL-2, IL-4, IL-5 and IL-10 by ELISA. Results : The results demonstrated that AJ had no mitogenic effects on unstimulated CD4+ T cells, but augmented CD4+T-cell proliferation upon activation with anti-CD3/anti-CD28 antibodies in a dose-dependent manner. AJ treatment significantly increased CD4+ T cell population and IFN-$\gamma$ expression was significantly enhanced, while IL-4 expression significantly decreased. In addition, in vitro Th1/Th2 polarization experiments revealed that AJ enhanced IFN-$\gamma$ secretion in Th1 cells, but reduced the IL-4 in Th2 cells in dose-dependent manner. Conclusion : These results suggest that AJ treatment could be a desirable alternative therapy for the prevention or correction of Th2 dominant pathological disorders, such as allergy and asthma.
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휴리스틱에 의하여 개선된 반딧불이 알고리즘의 설계와 분석
이현숙,이정우,오경환,Rhee, Hyun-Sook,Lee, Jung-Woo,Oh, Kyung-Whan 한국정보처리학회 2011 정보처리학회논문지B Vol.18 No.1
본 논문에서는 최근 Xin-She Yang에 의해 소개된 반딧불이 알고리즘(FA)에 휴리스틱을 적용하여 개선하는 방안을 제안한다. 또한 이를 위하여 기존의 FA를 이와 유사한 문제영역의 알고리즘인 Particle Swarm Optimization(PSO)와 정확도 측면, 수렴 시간 측면, 각 입자의 움직임 측면에서 비교 분석한다. 비교 실험 결과, FA의 정확도는 PSO보다 나쁘지 않았지만, 수렴 속도는 느린 것으로 나타났다. 본 논문은 이에 대한 직관적인 원인을 고찰하고, 이를 극복하기 위해, 기존의 FA에 부분 돌연변이 휴리스틱을 적용하여 개선된 FA(Improved FA)를 제안한다. 벤치마크 함수들을 최적화 하는 비교 실험 결과, 개선된 FA가 PSO와 기존의 FA보다 정확도와 수렴속도 측면에서 우수함을 보이고자 한다. In this paper, we propose a method to improve the Firefly Algorithm(FA) introduced by Xin-She Yang, recently. We design and analyze the improved firefly algorithm based on the heuristic. We compare the FA with the Particle Swarm Optimization (PSO) which the problem domain is similar with the FA in terms of accuracy, algorithm convergence time, the motion of each particle. The compare experiments show that the accuracy of FA is not worse than PSO's, but the convergence time of FA is slower than PSO's. In this paper, we consider intuitive reasons of slow convergence time problem of FA, and propose the improved version of FA using a partial mutation heuristic based on the consideration. The experiments using benchmark functions show the accuracy and convergence time of the improved FA are better than them of PSO and original FA.
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이정우,김태성,임영진,김국기,이봉암,임언 대한신경외과학회 1994 Journal of Korean neurosurgical society Vol.23 No.1
Hydrocephalus is one of the important complication of subarachnoid hemorrhage. The incidence of significant symptomatic hydrocephalus secondart to spontaneous subarachnoid hemorrhage was 7.9%. We analyzed several factors possibly related to hydrocephalus following subarachnoid hemorrhage in 439 patients between 1990 and 1992. The development of hydrocephalus after subarachnoid hemorrhage is multifactorial. We found the following factors were significnatly related with the development of hydrocephalus after subarachnoid hemorrhage : intraventricular hemorrhage, level of consciousness on admission, increasing age, hypertension history before subarachnoid hemorrhage, subarachnoid blood noted on CT scan, posterior circulation site of aneurysm.
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