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한국인 전립선비대증 환자에서 두타스테리드의 안전성 평가를 위한 시판 후 조사
김준형,배지영,오신영,이일섭,Kim, Joon-Hyung,Bae, Ji-Young,Oh, Shin-Young,Lee, Yil-Seob 대한임상약리학회 2012 臨床藥理學會誌 Vol.20 No.1
Background: Dutasteride is an inhibitor of both types I and II 5 alpha-reductase and was approved in Korea in April 2004. This post-marketing surveillance was to assess the safety of dutasteride in Korean patients with benign prostate hyperplasia in real life and to elucidate the risk factors related adverse events. Methods: From December 2004 to January 2010, 3,977 patients were enrolled by 184 urologists. According to post-marketing surveillance regulation, patients were enrolled consecutively. Patients administered dutasteride at least once were included in safety assessment. The incidences of any adverse events and serious adverse events were evaluated. Multiple logistic regression method was used to identify risk factors related to adverse events. Results: The safety assessment included 3,870 patients with the mean age of 67.3 years. The incidence of adverse events was 3.8%. The most frequent adverse event was impotence (75 cases, 1.9%), libido decrease (49 cases, 1.3%), ejaculation disorder (30 cases, 0.8%), and gynecomastia (5 cases, 0.1%). The incidence of unexpected adverse events was 0.5% and cerebral infarction, lung cancer, pulmonary embolism, and diarrhea were reported as serious adverse events. Conclusion: In this survey, impotence was the most frequently reported adverse events. Dutasteride was well tolerated in Korean patients with benign prostate hyperplasia. These results updated the safety information and would provide important additional information for prescribers.
AC-PDP용 인산염 결정화 유리의 유전적 특성에 관한 연구
김준형,연석주,Kim, Joon-Hyung,Yon, Seog-Joo 한국결정성장학회 2007 韓國結晶成長學會誌 Vol.17 No.3
인산염계 유리를 사용하여 PDP 소자의 하판유전체 후막을 제작하였다. 유전체 후막의 제조는 soda-lime glass위에 silk screen printing 법을 사용하였다. 기판과 유전체후막의 열팽창계수를 맞추기 위하여 $TiO_2$와 $Al_2O_3$를 충진제로 사용하였다. 유전체의 결정화 거동은 DTA, XRD를 사용하였으며 광학적 열적 전기적인 특성을 알아보기 위하여 UV-spectrometer, Dilatometer, Impedance Analyser를 사용하였다. 실험결과 주 결정상은 메타인산아연과 피로인산아연으로 나타났다. $TiO_2$의 첨가로 인하여 반사율은 높아졌으나 상대적으로 유전상수는 높아졌다. 또한 $Al_2O_3$를 첨가한 경우 반사율은 크게 변화가 없었으나 유전상수 값은 낮아졌다. 또한 열팽창 계수는 약 $62{\times}10^{-7}/^{\circ}C$ 정도였다. Dielectric layer of phosphate glass for plasma display panel (PDP) device made by silk screen printing on soda-lime glass. For regulate thermal expansion coefficient (CTE) of between substrate glass and dielectric layer use addition of $Al_2O_3$ and $TiO_2$. The crystallization process of glass-ceramics for dielectric layer have been examined by DTA, XRD some of optical, electrical properties of the dielectric layer were evaluated by UV-spectrometer, dilatometer, impedance analyser. The principal crystalline phase was identified as zinc metaphosphate [$Zn(PO_3)_2$] and zinc pyrophosphate [$Zn_2P_2O_7$]. Reflectance and dielectric constance increased with the addition of $TiO_2$ filler, dielectric constant lower the out side reflectance unchanging of the adding of $Al_2O_3$ filler. Besides CTE was at about $62{\times}10^{-7}/^{\circ}C$.
김준형(Joon-Hyung Kim),최영석(Young-Seok Choi),윤준용(Joon-Yong Yoon),박성관(Sung-Kwan Park),현석호(Seok-Ho Hyun) 한국유체기계학회 2010 유체기계 연구개발 발표회 논문집 Vol.2010 No.12
The kimchi refrigerator is the electronic home appliance which is used for the maturing and a custody of the kimchi. In this paper, performance improvement of fan and duct system for kimchi refrigerator has been studied by using a commercial CFD code. In order to achieve a improved fan performance, three-dimensional computational fluid dynamics and the Design of Experiments method have been applied. Additionally, to know the optimized duct inlet shape with the optimized fan. the overall performances were calculated with various duct inlet shapes. The final fan and duct system for kimchi refrigerator showed improved performance in efficiency and total head compared with the existing model.
입구부 형상이 수중 카고 펌프의 흡입 성능에 미치는 영향
김준형(Joon-Hyung Kim),최영석(Young-Seok Choi),이경용(Kyoung-Yong Lee) 한국유체기계학회 2007 유체기계 연구개발 발표회 논문집 Vol.- No.-
In this paper, effects of inlet shape on the performance of a submerged cargo pump were numerically studied using a commercial CFD code CFX. The inlet shape, especially the gap between pump and suction well, is an important parameter in a point of view of performances of submerged cargo pump due to its effects on the residual and also hydraulic performance of the pump, respectively. To know the optimized gap, the overall performance degradations were calculated with the gap. In addition to that, the flow field through the gap was investigated to explain the effect of velocity non-uniformity on the performance of the pump impeller.
내시경적 실리콘관 삽입술의 코눈물관 저항에 따른 임상적 결과
김준형(Joon Hyung Kim),유인천(In Cheon You),안민(Min Ahn) 대한안과학회 2016 대한안과학회지 Vol.57 No.1
Purpose: To evaluate the clinical result of silicone tube intubation through Hasner’s valve according to nasolacrimal duct resistance under intranasal endoscopic guidance in partial acquired nasolacrimal duct obstruction patients. Methods: The present study enrolled a total of 50 eyes from 31 patients diagnosed with partial acquired nasolacrimal duct obstruction in the Department of Ophthalmology, Chonbuk National University Hospital from 2012 January to 2012 December. Silicone tube intubation was done through the Hasner’s valve and confirmed by intranasal endoscopy and the nasolacrimal duct resistance was measured. Success was defined as the disappearance of epiphora, and failure was defined as the maintenance of epiphora after silicone tube intubation. Results: There were 8 male patients and 23 female patients, ages between 32 to 80 and the average age was 61.4 years old. 3eyes of 3 patients (6%) had no resistance, 26 eyes of 17 patients (52%) had mild resistance, 17 eyes of 15 patients (34%) had moderate resistance and 4 eyes of 3 patients (8%) had severe resistance. The success was 44 eyes (88%) and the failure was 6 eyes (12%). In the no resistance and mild resistance groups the success rates were both 100%, while an 82% of success rate in the moderate resistance group and 25% success rate in the severe resistance group were observed. The success rates showed clear distinction between severe, moderate and mild resistance patients. Conclusions: Ensuring the passage of a silicone tube through Hasner’s valve increases the success rate in the functional aspect; however, the resistance of the nasolacrimal duct can highly influence the success rate. Therefore, if a patient has severe nasolacrimal duct resistance, dacryocystorhinostomy should be considered earlier.