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박성학,박주현,신완식,김관형,한현복,김양리,강문원 대한감염학회 1990 감염 Vol.22 No.3
Clinical efficacy and safety of cefixime, a new oral cephem antibiotics, were evaluated in 30 patients with respiratory tract infection. Cefixime was administered to 30 cases consisting of 4 cases of acute tonsillitis, 16 cases of pneumonia (8/16 have underlying chronic lung disease) and 10 cases of acute exacerbation of chronic lung diseases (3 with bronchiectasis, 2 with bronchial asthma and 5 with chronic obstructive lung diseases), at daily dosis of 200~400㎎ for 5~21 days by oral route. Clinical efficacy was evaluated to be excellent in 11 cases, good in 13 cases, fair in 5 cases and poor in 1 case. Thus cefixime was effcetive in 24 of 30 cases in total with a rate of effectiveness of 80%. Effectiveness of cefixime was 100% (12/12) in acute disease, but 66.7%(12/18) in chronic or complicated disease. 16 microorganisms were isolated from 13 cases. 10 cases were eradicated, 2 cases were persisted and 1 case was superinfected with P. aeruginosa. Adverse resactions were found in 3 cases: 1 with eosinophilia, 1 with anorexia and 1 with eosinophilia and skin rash to whom cefixime was discontinued. In conclusion, cefixime is useful oral drug for the empirical treatment of mild to moderate respiratory tract infection.
무증상의 혈뇨와 무증상의 단백뇨를 보인 성인환자의 장기추적 조사
박정희,김용수,박주현,장윤식,오은숙,김형근,방병기,양철우 대한신장학회 1999 Kidney Research and Clinical Practice Vol.18 No.4
To determine the clinical outcome of patients with asymptomatic hematuria and/or proteinuria, the biochemical parameters and renal biopsies were reviewed. The patients with asymptomatic urinary abnormalities(n=193) were followed up in Kangnam St. Mary's hospital between 1981 and 1996 and their mean age was 38.8±14.0 years old, sex ratio of M:F 54:139, mean follow-up period 6.2±4.4 years. They were divided into three groups according to the first dipstick urinalysis findings:82 patients with isolated hematuria(H), 28 patients with isolated proteinuria(P), and 83 patients with concomitant hematuria and proteinuria(H+P). During the follow-up period, in the 82 patiets with H, 68.3% had persistent hematuria without proteinuria, hematuria disappeared in 23.2%, and 8.5% manifested proteinuria, none of the patients showed renal insufficiency. Of the 28 patients with P, 42.9% had persistent proteinuria, proteinuria disappeared in 39.3%, 10.7% manifested hematuria, and 7.1% showed renal insufficiency. Of the 83 patis with H?P, 51.8% had persistent hematuria and proteinuria, hematuria and proteinuria disappeared in 13.3%, 16.9% had persistent hematuria without proteinuria, 9.6% had persistent proteinuria without hematuria, and 8.4% showed renal insufficiency. Renal biopsy was performed in 79 patients. 75.9% of these patients had Ig A nephropathy, 11.4% had mesangial proliferative glomerulonephritis or mesangiopathy, and 8.9% had membranous proliferative glomerulonephritis. In conclusion, the most common cause of asymptomatic urinary abnormalities was Ig A nephropathy(75.9%) and all patients with isolated hematuria kept normal renal function, while some patients with proteinuria(7.1%) or concomitant hematuria and proteinuria(8.4%) progressed to chronic renal failure. Therefore, to monitor progressing to chronic renal failure, the patients with proteinuria(whether or not they showed concomitant hematuria) should be closely followed up.