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Chung, Woo Jin,Simmonds, Adam G.,Griebel, Jared J.,Kim, Eui Tae,Suh, Hyo Seon,Shim, In‐,Bo,Glass, Richard S.,Loy, Douglas A.,Theato, Patrick,Sung, Yung‐,Eun,Char, Kookheon,Pyun, Jeffrey WILEY‐VCH Verlag 2011 Angewandte Chemie Vol.123 No.48
<P><B><I>Der Einsatz von elementarem Schwefel</I></B> als Reaktionsmedium für die Herstellung von Goldnanopartikeln und vulkanisierten Nanokompositen wird in der Zuschrift von J. Pyun et al. auf Seite 11 611 ff. beschrieben. Flüssiger Schwefel dient in diesem System als Lösungsmittel, Reduktionsmittel und Stabilisator für die Herstellung von Goldkolloiden. Potenziell nutzbarer elementarer Schwefel fällt in riesigen Mengen beim Raffinieren von Erdöl an.</P>
박우진,장영원,이성학,김낙준,이창길,권동일 대한금속재료학회(대한금속학회) 1994 대한금속·재료학회지 Vol.32 No.6
An investigation was conducted to examine the effects of microstructural parameters on the cracking behavior, often occurred in the top parts of the deep drawn cups of hot rolled formable steel. Particular emphasis was placed on the role of grain boundary carbides in the carcking phenomenon. Detailed microstructural analyses of the cracked region showed that a number of voids initiated at grain boundary carbides were observed to form intergranular cracks. These grain boundary carbides were identified as Mn-containing Fe₃C carbides which might be associated with the formation of the band structure. In the microstucture of the hot rolled steel, film or bulk-type carbides along grain boundaries, together with banded ferrite-pearlite structures, were commonly observed, and were thought to initiate cracks during deep drawing process. Thus the formation of grain boundary carbides and band structures must be minimized to prevent cracking. A1 killing process, homogenization treatment and low temperature coiling treatment are suggested as possible methods for minimizing the amount of grain boundary carbides.
M. S. Sidhu,Suk-Yi Woo,Wan Kee Kim,Heung Soon Lee,J. S. Yahng,Kyu Jin Kim,Sae Chae Jeoung,Hyun Kyu Lee 한국물리학회 2011 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.58 No.6
Femtosecond (fs) laser microsurgery is a powerful method for its potential to treat various retinal diseases, as well as to study the sub-cellular functions, because of its capability to selectively ablate a specific target (in vitro and in vivo) with minimal damage to the surrounding tissues. Here, we develop an fs-laser based microsurgery system, along with ophthalmoscope-assisted dynamic optical imaging system, for retinopathy treatment. The system is equipped with a galvano-scanner and a real-time imaging system. The laser system used for the current study consists of a regenerative amplified Ti-sapphire (λ = 810 nm) laser, delivering a 150-fs pulse at a repetition rate of 1 kHz. The illumination light from a white light-emitting diode (LED) was optically filtered to be maximally absorbed by blood, which allowed us to effectively differentiate the blood vessels from the retina surface. The estimated threshold fluences for inner limiting membrane (ILM) ablation and the primary blood vessel wall perforations within an intact porcine eye were found to be 2.6 ± 0.2 J/cm^2 and 5.0 ± 0.1 J/cm^2, respectively. The present work should be an important step in ongoing exploration of the use of femtosecond lasers for the purpose of treating retinal blood vessels.
Fernando, I.P. Shanura,Jayawardena, Thilina U.,Kim, Hyun-Soo,Lee, Won Woo,Vaas, A.P.J.P.,De Silva, H.I.C.,Abayaweera, G.S.,Nanayakkara, C.M.,Abeytunga, D.T.U.,Lee, Dae-Sung,Jeon, You-Jin Academic Press 2019 Environmental research Vol.172 No.-
<P><B>Abstract</B></P> <P>Particulate matter (PM) air pollution has gradually become a widespread problem in East Asia. PM may cause unfamiliar inflammatory responses, oxidative stress, and pulmonary tissue damage, and a comprehensive understanding of the underlying mechanisms is required in order to develop effective anti-inflammatory agents. In this study, fine dust collected from Beijing, China (CPM) (size < PM13 with majority < PM2.5) was evaluated for its oxidative stress- and inflammation-inducing effects, which cause cell damage, in A459 human lung epithelial cells. Oxidative stress was marked by an increase in intracellular ROS levels and the production of antioxidant enzymes such as superoxide dismutase (SOD), catalase (CAT), and heme oxygenase-1 (HO-1). Upon induction of oxidative stress, a marked increase was observed in the expression of key inflammatory mediators such as COX-2 and PGE<SUB>2</SUB> and the pro-inflammatory cytokines TNF-α and IL-6 via NF-kB and MAPK pathways. Cellular damage was marked by a reduction in viability, increased lactate dehydrogenase (LDH) release, formation of apoptotic and necrotic bodies, accumulation of sub-G1 phase cells, and DNA damage. Apoptosis was found to be mediated via the activation of caspases through the mitochondria-mediated pathway. Fucosterol, purified from the brown alga <I>Sargassum binderi</I> (Sonder ex J. Agardh) by bio-assay-guided fractionation and purification, exhibited potential therapeutic effects against CPM-induced detrimental effects. Further studies could focus on developing fucosterol, in forms such as steroidal inhalers, against PM-induced pulmonary tissue inflammation.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Fine dust air pollution is a major reason of pulmonary complications in East Asia. </LI> <LI> Dust particles induce oxidative stress and inflammation damaging the lung epithelial cells. </LI> <LI> Fucosterol suppressed the dust induced cell damage by inhibiting oxidative stress and inflammation. </LI> <LI> Fucosterol may have beneficial effects in alleviating adverse respiratory effects of air pollution. </LI> </UL> </P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>
TXNIP potentiates Redd1-induced mTOR suppression through stabilization of Redd1
Jin, H-O,Seo, S-K,Kim, Y-S,Woo, S-H,Lee, K-H,Yi, J-Y,Lee, S-J,Choe, T-B,Lee, J-H,An, S,Hong, S-I,Park, I-C Macmillan Publishers Limited 2011 Oncogene Vol.30 No.35
The mammalian target of rapamycin (mTOR) is a highly conserved serine–threonine kinase activated in response to growth factors and nutrients. Because of frequent dysregulation of the mTOR signaling pathway in diverse human cancers, this kinase is a key therapeutic target. Redd1 is a negative regulator of mTOR, mediating dissociation of 14-3-3 from tuberous sclerosis complex (TSC)2, which allows formation of a TSC–TSC2 complex. In the present study, we identify TXNIP that inhibits mTOR activity by binding to and stabilizing Redd1 protein. Redd1 and TXNIP expression was induced by a synthetic glucose analog, 2-deoxyglucose (2-DG). Moreover, Redd1 expression in response to 2-DG was regulated by activating transcription factor 4 (ATF4). Overexpression of TXNIP was associated with reduced mTOR activity mediated by an increase in Redd1 level, whereas knockdown of TXNIP using small interfering RNA resulted in recovery of mTOR activity via downregulation of Redd1 during treatment with 2-DG. Interestingly, Redd1 was additionally stabilized via interactions with N-terminal-truncated TXNIP, leading to suppression of mTOR activity. Our results collectively demonstrate that TXNIP stabilizes Redd1 protein induced by ATF4 in response to 2-DG, resulting in potentiation of mTOR suppression. To the best of our knowledge, this is the first study to identify TXNIP as a novel member of the mTOR upstream that acts as a negative regulator in response to stress signals.
The Long Term Clinical Outcome of Drug Eluting Stent Fractures (초)
( Jin Joo Park ),( Kyung Woo Park ),( In Ho Chae ),( Jae Bin Seo ),( Han Mo Yang ),( Hae Young Lee ),( Hyun Jae Kang ),( Young Seok Cho ),( Tae Jin Yeon ),( Woo Young Chung ),( Bon Kwon Koo ),( Dong J 대한내과학회 2010 대한내과학회 추계학술대회 Vol.2010 No.-
Jin, Mi-Jin,Um, Doo-Seung,Ogbeide, Osarenkhoe,Kim, Chang-Il,Yoo, Jung-Woo,Robinson, J. W. A. Techno-Press 2022 Advances in nano research Vol.13 No.3
Two-dimensional (2D) transition metal carbides/nitrides or "MXenes" belong to a diverse-class of layered compounds, which offer composition- and electric-field-tunable electrical and physical properties. Although the majority of the MXenes, including Ti<sub>3</sub>C<sub>2</sub>T<sub>x</sub>, are metallic, they typically show semiconductor-like behaviour in their percolated thin-film structure; this is also the most common structure used for fundamental studies and prototype device development of MXene. Magnetoconductance studies of thin-film MXenes are central to understanding their electronic transport properties and charge carrier dynamics, and also to evaluate their potential for spin-tronics and magnetoelectronics. Since MXenes are produced through solution processing, it is desirable to develop deposition strategies such as inkjet-printing to enable scale-up production with intricate structures/networks. Here, we systematically investigate the extrinsic negative magnetoconductance of inkjetprinted Ti<sub>3</sub>C<sub>2</sub>T<sub>x</sub> MXene thin-films and report a crossover from weak anti-localization (WAL) to weak localization (WL) near 2.5K. The crossover from WAL to WL is consistent with strong, extrinsic, spin-orbit coupling, a key property for active control of spin currents in spin-orbitronic devices. From WAL/WL magnetoconductance analysis, we estimate that the printed MXene thin-film has a spin orbit coupling field of up to 0.84 T at 1.9 K. Our results and analyses offer a deeper understanding into microscopic charge carrier transport in Ti<sub>3</sub>C<sub>2</sub>T<sub>x</sub>, revealing promising properties for printed, flexible, electronic and spinorbitronic device applications.
Influence of <i>CYP2D6*10</i> on the pharmacokinetics of metoprolol in healthy Korean volunteers
Jin, S. K.,Chung, H. J.,Chung, M. W.,Kim, J.-I.,Kang, J.-H.,Woo, S. W.,Bang, S.,Lee, S. H.,Lee, H. J.,Roh, J. Blackwell Publishing Ltd 2008 Journal of clinical pharmacy and therapeutics Vol.33 No.5
<P>Summary</P><P>Background and objective: </P><P>Genetic polymorphism of <I>CYP2D6</I> leads to differences in pharmacokinetics of CYP2D6 substrates. The <I>CYP2D6*10</I> allele is clinically important in Koreans because of its high frequency in Asians. We investigated whether the pharmacokinetics of metoprolol was altered by the presence of the <I>CYP2D6*10</I> allele in Korean subjects.</P><P>Methods: </P><P>One hundred and seven volunteers were recruited and grouped as <I>CYP2D6*1/*1</I>, <I>CYP2D6*1/*10</I> and <I>CYP2D6*10/*10</I> according to their genotypes. Metoprolol tartrate 100 mg (Betaloc<SUP>®</SUP>) was administered orally once to each subject in these three groups (<I>n</I> = 6, 7 and 5, respectively). The pharmacokinetic parameters of metoprolol and its metabolite, &agr;-hydroxymetoprolol, and the metabolic ratio for the three groups were estimated and compared.</P><P>Results and discussion: </P><P>The area under the plasma concentration–time curve (AUC<SUB>0→∞</SUB>), the maximum plasma concentration (<I>C</I><SUB>max</SUB>) and the elimination half-life (<I>T</I><SUB>1/2</SUB>) of metoprolol and &agr;-hydroxymetoprolol for the <I>CYP2D6*10/*10</I> group were all significantly different from those of the <I>CYP2D6*1/*1</I> group (<I>P</I> < 0·05). The AUC<SUB>0→∞</SUB>s of metoprolol were 443·7 ± 168·1, 995·6 ± 321·4 and 2545·3 ± 632·0 ng·h/mL, and the AUC<SUB>0→∞</SUB>s of &agr;-hydroxymetoprolol were 1232·0 ± 311·2, 1344·0 ± 288·1 and 877·4 ± 103·4 ng·h/mL for groups <I>CYP2D6*1/*1</I>, <I>*1/*10</I> and <I>*10/*10</I>, respectively. The corresponding <I>T</I><SUB>1/2</SUB> values of metoprolol were 2·7 ± 0·5, 3·2 ± 1·3 and 5·0 ± 1·1 h, while those of &agr;-hydroxymetoprolol were 5·4±1·5, 6·0 ± 1·4 and 10·5 ± 4·2 h, respectively. The metabolic ratios of the three groups were significantly different (<I>P</I> < 0·05).</P><P>Conclusion: </P><P>The <I>CYP2D6*10</I> allele altered the pharmacokinetics of metoprolol in Korean subjects and is likely to affect other drugs metabolized by the CYP2D6 enzyme, similarly.</P>