Comparison of controlled ovarian stimulation outcomes for fertility preservation in women with breast cancer according to KI-67, histologic grade, pathologic type, and cancer stage

( Eun Ji Oh ),( Yeon Hee Hong ),( Seul Ki Kim ),( Jung Ryeol Lee ),( Byung Chul Jee ),( Chang Suk Suh ),( Seok Hyun Kim ) 대한산부인과학회 2020 대한산부인과학회 학술대회 Vol.106 No.-

Objective: This study aims to analyze that specific prognostic factors such as Ki-67 value, histologic grade, pathology type, and cancer stage can affect controlled ovarian stimulation outcomes(COS) for fertility preservation in women with breast cancer. Methods: This retrospective cohort study included 92 patients with breast cancer aged 21-44 who underwent COS from August 2012 to April 2020, excluding patients with previous gonadotoxic therapy history. All COS cycles were conducted letrozole-combined random start GnRH antagonist protocol. COS outcomes were compared according to prognostic factors;Ki-67 (< 30% vs. ≥ 30%), histologic grade (low vs. high), and pathologic type (intraductal carcinoma(IDC) vs. triple-negative breast cancer(TNBC)), and cancer stage (early (I, II) vs. advanced (III, IV)). Multivariate analysis was also conducted to find any parameter that can impact over 10 mature oocytes acquisition. Results: Among the 92 patients, 42 were Ki-67≥30% compared to 49 of Ki-67<30%. The number of oocytes, and initial mature oocytes were comparable between Ki-67<30% and ≥30 group. The maturation rate was significantly higher in Ki-67≥30% group than Ki-67<30% group (57.4±36.8% vs. 44.8±28.3%, p=0.041). The same results were drawn when divided according to IDC or TNBC. The maturation rate was significantly higher in TNBC than the IDC group (73.0±17.6% vs. 47.0±28.1% p=0.001). However, the histologic grade or stage did not show any difference in COS outcomes between high and low grade or early and advanced stages. With multivariate analysis, age and AMH are parameters associated with the acquisition of over 10 mature oocytes (OR 0.863, 95% CI [0.755-0.987], OR 1.408, 95% CI [1.145-1.732], respectively). Conclusion: Either Ki-67 or pathologic type can be a potential reliable marker for predicting COS outcome, especially maturation rate. Further study with larger sample size with specific conditions is necessary to clarify the correlation between breast cancer prognostic factors and COS outcomes.

보리순의 영양성분 조성

서혜지,최용민,김상천,이준수,이기택,정명근,천지연,황진봉,남진식,서우덕,황영,김행란,김세나 忠北大學校 農業科學硏究所 2015 農業科學硏究 Vol.31 No.2

The influence of obesity on pediatric conscious sedation

Park, Ki-Tae,Kim, Ji-Yeon,Park, Sung-Dong 大韓小兒齒科學會 2006 大韓小兒齒科學會誌 Vol.33 No.1

Objective: This study was conducted to investigate as to whether obesity have any effects on conscious sedation outcomes. Methods: Forty children (mean age 30.5 months, mean height and weight were 91.3 cm, 14.3 kg respectively) were sedated with chloral hydrate (60 mg/kg) and hydroxyzine (25 mg). The relative obesity rate of the patients was obtained by the proportion of height to weight and the tonsil size of the patients was classified by Brodsky's scale. The overall sedation outcomes were evaluated by Houpt's scale. The pulse and respiratory rates during sedation were also evaluated. Results: The obesity of the patients had no statistically significant effects on movement, crying during sedation. However, an increase in obesity had negative effects on the overall conscious sedation outcomes. Conclusion: This investigation demonstrated that increased obesity may cause detrimental effects on pediatric conscious sedation outcomes. 본 연구의 목적은 소아의 비만도가 진정요법의 효과에 미치는 영향을 알아보는 것이다. 삼성서울병원 소아치과에 내원한 환자 중 ASA Ⅰ또는Ⅱ에 해당하는 40명의 환아 (평균연령 30.5개월, 평균신장 91.3cm, 평균체중 14.3kg)를 대상으로 chloral hydrate(60mg/kg) 및 hydroxyzine(25mg)을 사용하여 진정요법을 시행하였다. 환아의 체중과 신장을 이용하여 환아 각각의 비만도를 계산하였고 Broadsky's scale을 이용하여 편도선의 크기를 측정하였다. 진정요법에 대한 결과는 Houpt's scale(수면, 움직임, 울음, 전반적인 행동지수)을 이용하여 평가하였다. 환아의 비만도는 진정효과중 움직임과 울음에 대하여는 통계학적으로 유의한 차이를 만들지 않았으나 비만도가 증가 할수록 전반적인 행동지수가 유의하게 나빠지는 결과를 보였다.

매복 정도에 따른 대구치 이소맹출의 치험례

이지현,김지연,박기태 大韓小兒齒科學會 2010 大韓小兒齒科學會誌 Vol.37 No.1

이소맹출은 치아가 비정상적인 위치나 방향으로 맹출하는 것으로 정의되며 구치부에서는 근심측으로 맹출하여 인접치아의 치근 흡수나 조기 탈락을 야기하여 공간 상실을 일으킬 수 있고, 부분 맹출된 경우 치은 하방의 치아우식 위험성이 증가하고 농양을 형성할 수도 있다. 구치부의 이소맹출 가운데 66% 정도는 가역적인 경우로 특별한 치료 없이 자연적으로 정상적인 맹출이 일어나며, 비가역적인 이소맹출의 경우에는 치아의 맹출 상태, 인접치에 의해 매복된 양, 인접치의 동요도, 통증이나 감염 여부 등의 여러 요인을 고려하여 본격적인 치료가 필요하다. 본 논문에서는 비가역적으로 이소맹출된 상악 제1대구치와 하악 제2대구치를 치간이개 고무줄, modified Halterman appliance 그리고 외과적 노출 후 modified Halterman appliance를 이용한 방법 등으로 정상적인 맹출을 유도한 증례를 보고하는 바이다. Ectopic eruption is defined as the eruption of the tooth in an abnormal position or orientation. In the molar region, ectopic eruption may cause distal root resorption and premature exfoliation of the neighbor teeth and uncontrolled space loss is followed. Prolonged partial impaction of the permanent molar may also cause undetected caries or abscess formation of the neighbor teeth. While 66% of ectopically erupting permanent molars are corrected spontaneously without treatment, the treatment is necessary for the irreversible ectopic eruption cases. The optimal treatment approach depends on a number of factors including the clinical eruption status of the molar, amount of enamel ledge and the mobility of the neighbor tooth, and the presence of pain or infection. This case report presents the results of treatment of the ectopically erupting maxillary first permanent molars and mandibular second molars using elastic separators or modified Halterman appliance with or without surgical approach.

포타슘 술포네이트 폴리스타이렌 아이오노머의 기계적인 성질에 미치는 Crown ether의 영향

나연화,조규성,이법원,김준섭,유지강,박기주 조선대학교 생산기술연구소 1999 生産技術硏究 Vol.21 No.1

The effects of crown ether on the dynamic mechanical properties of potassium sulfonated polystyrene ionomer were investigated. As expected, it was found that when crown ether molecules were added to the ionomer, the crown ether molecules interacted with K^(+) cations and weakened the ionic interaction between K^(+)/sulfonate ion pairs of the ionomer significantly. Thus, no multiplets were present, and, in turn, no clustering was found. When the ether was added to interact with 50% of K^(+) cations, weak clustering was observed: the clustering was slightly stronger than that of a 50% neutralized ionomer. From this result, it was speculated that in the 50% neutralized sample H^(+) ⇔ K^(+) cation exchange occurs rapidly between -SO₃H and -S0₃K groups in multiplets. which weakens ionic interactions. In the 50% crown ether-added sample, however, -S0₃- group, instead of -S0₃H, is present, and thus no cation exchange is expected to occur.

Styrene-co-lithium methacrylate ionomer의 기계적인 성질에 미치는 LiCl의 영향

나연화,김준섭,유지강,박기주 조선대학교 생산기술연구소 1999 生産技術硏究 Vol.21 No.2

The effect of LiCl salt added to styrene-co-lithium methacrylate ionomer on the mechanical properties of ionomers was studied dynamic rnschanically. When the LiCl salt was added to a 100% Li-neutralized ionomer, the amount of added salt. in the range of 100-300% to ionic groups of the ionomer, did not change the mechanical properties of the ionomers, This implies that the added salt may form isolated LiCl salt aggregates in the polymer matrix. However, when LiCl was added to a 200% neutralized ionomer, the cluster T_(g) shifted to a low temperature and then the sample started to flow. This result suggests that in this case the LiCl salts reside in and near the multiplets, resulting the weakening of ionic interactions between ionic groups in multiplets.

뇌졸중 환자를 대상으로 한 KEPAD 손기능 작업표본검사와 Manual Function Test 간의 상관관계

김지연,장기연 한국장애인고용촉진공단 고용개발원 2009 장애와 고용 Vol.19 No.3

본 연구는 경증 뇌졸중 환자를 대상으로 KEPAD 손기능 작업표본검사와 뇌졸중 상지기능 평가 (Manual Function Test : MFT)의 상관성을 알아보고, 경증 뇌졸중 환자의 손기능을 평가하는데 KEPAD 검사가 효용성이 있는지 보고자 하였다. 브런스트롬 손의 회복단계(Brunnstrom recovery stage)가 5단계 이상인 경증 뇌졸중 환자 62명을 대상으로 KEPAD 손기능 작업표본 검사와 뇌졸중 상지기능평가(MFT)를 실시한 결과, 경증 뇌졸중 환자 전체 및 환측의 브런스트롬 손의 회복단계별 KEPAD 손기능 작업표본검사와 뇌졸중 상지기능검사(MFT)는 모든 영역에서 상관성을 나타내었다. 또한 경증 뇌졸중 환자 전체 및 환측의 브런스트롬 손의 회복단계별 KEPAD 손기능 작업표본검사의 하위 영역 간(대, 중, 소, 양손) 상관관계에서 높은 상관성을 보였다. 본 연구 결과는 KEPAD 손기능 작업표본검사가 뇌병변장애 중 하나인 뇌졸중 환자의 손기능을 평가하는데 유용하며, 이를 통해 환자의 초기 직업재활 계획을 세우는데 도움이 될 수 있음을 시사하고 있다. This study was designed to find out the effectiveness of KEPAD test on hand function assessment for mild Cerebrovascular Accident patients, by looking into the correlation between MFT and KEPAD hand function work sample test. When MFT and KEPAD hand function work sample test were conducted on 62 patients from Cerebrovascular Accident, who were taking hospital treatment for Cerebrovascular Accident and came under Stage 5 or higher of Brunnstrom recovery stage, significant correlation was shown in all areas of MFT and KEPAD hand function work sample test. Moreover, for each of the Brunnstrom recovery stage, significantly high correlation was shown in all areas(large, middle, small, both) of KEPAD hand function work sample test. As seen from the results of this study, it is found that KEPAD hand function work sample test was useful in hand function assessment for mild Cerebrovascular Accident patients as well as in establishment of initial vocational rehabilitation for patients by estimating hand function.

유치열기 3급 부정교합 환아에서 facemask의 효과와 재발 양상

김지연,유승은,이지현,박기태 大韓小兒齒科學會 2009 大韓小兒齒科學會誌 Vol.36 No.3

본 연구의 목적은 유치열기 3급 부정 교합 환아에서 facemask를 이용한 악정형 치료 후 골격적 변화와 치료 후 나타나는 재발 양상을 평가하는 것이다. 유치열기 3급 부정교합 환아 15명을 대상으로 구내장치로 bonded expander, 구외장치로 facemask를 이용한 악정형 치료를 평균 12개월 동안 시행하였으며, 1년 간의 follow up 기간 동안 유지 장치는 사용되지 않았다. 치료 시작 전, 치료 직후, 치료 1년 후에 측면두부방사선사진을 촬영하고 전후방 및 수직적 골격관계와 연조직의 변화를 비교분석하였다. 모든 환아에서 치료 직후, 유의할 만한 골격적 전후방 관계의 변화를 보였고 1년 간의 follow-up 기간 동안 재발되는 경향을 보였으나 치료 시작 전과 비교하여 치료 효과는 유지되었다. 수직적 골격적 변화는 치료 직후 증가되었으나 1년 간의 follow up 기간 동안 다시 감소하여 치료 시작 전과 비교하여 차이를 보이지 않았다. 연조직의 변화는 facial convexity 및 상순의 위치가 치료 직후 개선됨을 보였고 1년 간의 follow-up 기간 동안에도 치료 전과 비교하여 치료효과는 유지되었다. 하순의 위치는 치료 직후에 유의할 만한 변화를 보이지 않았다. Facemask는 유치열기 3급 부정교합에 있어서 효과적인 치료 방법이며, 안정적인 치료 결과를 위해서는 적절한 형태의 유지장치가 고려되는 것이 바람직하다. The purpose of this study was to evaluate skeletal and soft tissue changes that occur after using a facemask for treatment of skeletal class Ⅲ malocclusion. and to assess the relapse pattern when no retention appliance was used. Fifteen skeletal class Ⅲ malocclusion patients were treated with a facemask for an average of 12 months. No retention appliance was used during the 1 year follow-up period. Cephalograms were taken during pretreatment, posttreatment, and the 1 year follow-up. Cephalograms were traced, analyzed, and the results were compared between cephalograms. All patients showed significant sagittal skeletal changes after treatment, but they also showed a significant relapse during the 1 year follow-up period when no retention appliance was used. Despite the relapse, the sagittal skeletal changes that remained were still significant. Vertical skeletal change was also significant after treatment, but the total change was not significant after a 1 year follow-up due to relapse. In soft tissue changes, facial convexity and upper lip position improved after treatment and this change remained significant after the 1 year follow-up period. Facemask therapy is therefore an effective method for treatment of skeletal class Ⅲ malocclusion, however, retention is imperative to maintain the treatment effect.

견운모 석분을 이용한 돌침대용 판재 개발

김기락,주명기,최동순,김남길,연규석 강원대학교 석재복합신소재제품연구센터 1998 석재연 논문집 Vol.3 No.-

이 연구의 목적은 견운모 석분을 포함하는 폴리머 복합체로 현재의 돌침대용 관재보다 고강도이며, 우수한 열적성질을 가진 상판을 개발하고 물리·역학적 성질을 실험적으로 구명하는데 있다. 실험결과 성능이 우수하고, 고강도이며, 높은 충격강도와 양호한 축열성능을 갖는 것으로 나타나 실용화가 충분히 가능한 것으로 판단된다. The objectives of this study were to develop an stone bed-panel that has higher strength, better thermal property than existing bedpamels by using polymer composite contained sericite powder and to experimentally test to describe the physical and mechanical properties of the stone bed-panel. Test results not only indicate that the bed-panel has a good performance, high strength, high impact resistance and good heat storage property but also has a good possibility to put into practical usage.

섬록암폐석을 이용한 폴리머 콘크리트의 특성 및 제품 개발

김기락,최동순,연규석,주명기,김남길 강원대학교 석재복합신소재제품연구센터 1997 석재연 논문집 Vol.2 No.-

우리나라에서는 각종 광산으로 부터 폐석이 다량으로 발생되고 있다. 이와같은 폐석의 부가가치를 높일 수 있는 방안의 모색이 절실한 실정이다. 따라서 본 연구에서는 강원도 춘천지역의 섬록암 광산에서 다량으로 발생되고 있는 폐석을 활용하여 고강도이며, 내구성이 우수한 폴리머 콘크리트를 제조하고, 이에 대한 물리·역학적 특성을 실험적으로 구명하였다. 또한 섬록암 폐석을 이용한 폴리머 콘크리트를 사용하여 플륨, 경계석, 보도블럭, 기와 등과 같은 공장제품을 제조하여 이에 대한 효율적 활용 방안을 제시하였다. Large amount of mine waste have been produced and acumulated from various mining works in korea. Mine wastes causes many adverse invironmental impacts and it is urgently required t develop methods to increase its value by resuing in construction materials and other products. The dbjectives of the study were to develop a high strength and durable high quality polymer concrete by using Diorite mine wastes that are produced from mines in Chunchon area, and to experimentally test the physical and mechanical properties of the concrete. Also, effective reuse methods for the Diorite mine wastes were suggested by developing flumes, curb stones, foot path blocks and roof tiles with the polymer concrete.