신경아교세포와 알츠하이머 병

김정란,Kim, Jeong Lan 대한생물정신의학회 2015 생물정신의학 Vol.22 No.2

Neuroglial cells are fundamental for brain homeostasis and defense to intrinsic or extrinsic changes. Loss of their function and over-reactivity to stimuli contribute to the aging of brain. Alzheimer's disease (AD) could be caused by more dramatic response in neuroglia associated with various chemokines and cytokines. Neuroglia of the AD brain shares some phenotypes with aging neuroglia. In addition, neuroglial activation and neuroinflammation are commonly showed in neurodegeneration. Thus neuroglia would be a promising target for therapeutics of AD.

섬망의 역학

김정란,Kim, Jeong-Lan 한국정신신체의학회 2008 정신신체의학 Vol.16 No.2

섬망은 자연적으로 발생하는 상태는 아니며 더욱이 내인성 질환은 아니다. 그러나, 섬망은 일부 특정인구 집단에서 발생하는 데, 노인 또는 내과적 상태가 악화된 환자들에서 흔히 발생된다. 이것은 체계적인 섬망역학 연구의 제한점으로 작용한다. 일반 인구 집단에서는 그 발생이 상대적으로 적기 때문에 섬망에 대한 많은 역학 연구들은 노인에 집중되었다. 그리고, 연구에 사용된 섬망 평가도구들의 민감도와 특이도도 매우 다양하다. 노령, 남자, 불량한 인지 및 기능 상태, 그리고 알코올 남용이 잘 알려진 섬망의 위험 인자들이다. 저자는 노인, 치매 환자, 고관적 골절 환자, 중환자실 입원 환자, 말기 암 환자, 그리고 뇌졸중 환자에서의 섬마의 역학에 대하여 다루게 될 것이다. Delirium is not developed naturally and is not an endogenous disease. However, delirium has occurred in some specific populations, such as the elderly or medically compromised patients. These become limitations on the systematic study of the epidemiology of delirium. Many epidemiologic studies of delirium have been focused on the elderly due to the fact there are relatively few in the general population. In addition, assessment tools with various sensitivity and specificity have been used. Advanced age, male, poorer cognitive and functional status, and alcohol abuse are well known risk factors of delirium. the epidemiological data will be reviewed in the elderly, patients with dementia, hip fractures, patients hospitalized in intensive care units, terminal cancer and patients with stroke.

겹쳐 쓰기 또는 사이에 쓰기 -마르그리트 뒤라스의 〈근원 소설〉들에 나타난 자전적 요소들의 변용-

김정란 ( Kim Jeong Lan ) 한국불어불문학회 2003 불어불문학연구 Vol.0 No.54

Les expe´riences autobiographiques de Marguerite Duras sont approche´es diffe´remment dans trois <romans des origines>: Un Barrage contre le Pacifique(l950). L`Amant(1984), L`Amant de la Chine du Nord(1991). La premie`re e´tape du cycle, Un Barrage contre le Pacifique, refoule les faits personnels, surtout les faits sexuels. Nous pensons que la raison de ce refoulement, c`est la culpabilite´ e´thique de l`auteur a` l`e´gard de la mise`re de 1`Indochine qu`elle a vue dans son adolescence, bien qu`elle soit aussi une victime du syste`me pourri du colonialisme. Les codes sexuels refoule´s montrent l`aspect de la disse´mination se´miotique, en attribuant au texte plusieurs de´cors de camouflage. Mais la de´nonciation sociale du colonialisme est d`autant plus e´vidente et virulente, que les codes individuels-sexuels sont refoule´s. Au bout d`une trentaine d`anne´es, nous rencontrons l`auteur qui confesse dans l`Amant, que le cache´ principal de la premie`re oeuvre autobiographique e´tait l`origine chinoise de son amant, et qui assume, implicitement, que cet amour avait un caracte`re de prostitution. Cette confession courageuse semble e^tre focalise´e au fait me^me de la confession : la re´alite´ de 1`Indochine n`apparai^t presque pas. En 1991, l`auteur revient a` ces matie`res autobiographiques, avec plus de pre´cisions, dans l`Amant de la Chine du Nord. L`auteur assume entie`rement, cette fois-ci, le fait de la prostitution, mais en me^me temps, elle plaide la since´rite´ de son amour avec l`amant chinois. Dans cette oeuvre, l`auteur met l`accent sur le de´sir du me´tissage, en ide´alisant l`amant chinois, et en corrigeant des fautes commises par sa famille a` ce dernier. Nous constatons qu`un autre de´sir apparai^t clairement dans cette oeuvre : le de´sir incestueux esquisse´ dans deux oeuvres pre´ce´dentes. L`Indochine y perd son aspect concret pour devenir une idylle, et la mise`re coloniaie sont enfouie dans l`expression de l`aventure sexuelle. Mais dans une cetrtaine mesure, cette fin est impose´e : l`auteur dilue la prostitution, en l`assumant, et en le reliant au de´sir du metissage, dans le plan ontologique de la subjectivite´ ouverte, qui conduit le de´part de l`Indochine concret ou divise´ vers l`univers-le tout. Donc, l`identite´ ultime recherche´e dans cettte oeuvre, est celle d`un homme ou d`une femme qui aime <dans la rue>. Elle est, sans doute, celle d`un autre moi de l`humanite´ qui est en train de nai^ttre.

불어 알파벳 연구 (1) - 알파벳 기원과 형태의 변천 -

김정란(Jeong Lan Kim) 건국대학교 동화와번역연구소(구 건국대학교 중원인문연구소) 1999 중원인문논총 (구 논문집) Vol.18 No.-

페로와 안데르센의 동화관

김정란 ( Jeong Lan Kim ) 건국대학교 동화와번역연구소(구 건국대학교 중원인문연구소) 2009 동화와 번역 Vol.18 No.-

뻬로의 「도가머리 리케 Riquet a La Houppe」는 왜 창작일까?

김정란 ( Jeong Lan Kim ) 건국대학교 동화와번역연구소(구 건국대학교 중원인문연구소) 2005 동화와 번역 Vol.10 No.-

가정폭력노출 실태분석을 통한 피해아동의 심리사회적 적응력 향상방안 연구

김정란 ( Kim Jeong Lan ) 한국가족관계학회 2003 한국가족관계학회지 Vol.8 No.2

This study is a research on the psycho­social maladjustment of children who are exposed to domestic violence. It attempts to find out how children`s experience of domestic violence influences on their psycho­social maladjustment, and to present plans for improvement in adjustment. The SPSS 10.0 for Windows was used to analyze data obtained through 519 children who live in Gwangju·Chonnam area. Major findings are as follows: 1. Prevalence rates of exposure to domestic violence are considerably serious; 80.2% child abuse by parents, 46.2% witness of father­to­mother abuse. 2. Child abuse and wife abuse have close relationship in their occurrence and severity. 3. Internalizing problems, externalizing problems, and social competence of children are different by the child abuse, the wife abuse, and the style of exposure to domestic violence. 4. Child abuse have the strongest impact on the children`s psycho­social adjustment. As the result of the study, it concludes that the exposure to domestic violence has a negative effect on the children`s psycho­social adjustment. In order to improve psycho­social adjustment of children exposed to domestic violence, various plans are suggested in this study.

공인(公人)이었던 저자의 관점으로 본 페로동화 -「도가머리 리케」(Riquet a La Houppe)를 중심으로-

김정란 ( Jeong Lan Kim ) 건국대학교 동화와번역연구소(구 건국대학교 중원인문연구소) 2008 동화와 번역 Vol.16 No.-

Les contes de Perrault sont la rencontre de ≪la culture savante et des traditions populaires≫. C’est pourquoi contrairement aux contes populaires, ils refletent le point de vue de l’auteur, poete et chancelier de l’Academie Francaise sous le regime de Louis XIV. Pourtant jusqu’a aujourd’hui les etudes concernant les contes de Perrault restent centrees sur leur dimension populaire. L’objet de notre etude est donc de decrire et d’analyser les principaux traits de Riquet a la houppe que l’auteur a decrit de son point de vue d’homme d’Etat. Par dela le texte, cette etude se base egalement sur la mise en perspective de l’auteur dans son epoque. Au 17eme siecle, la bourgeoisie cherche a s’affirmer tandis que Perrault se passionne pour le mythe de Psyche et les fables qui consititueront les fondements de ses ecrits. Ainsi, l’influence de ces recits se retrouve dans l’histoire de Riquet a la houppe. Par exemple, le mariage de Riquet et de la princesse montre que les opposes peuvent coexister pacifiquement Quelques traits particuliers a la version de Riquet a la houppe composee par Perrault distinguent ce recit des contes populaires: ? En ajoutant ≪a la houppe≫au nom de Riquet. Perrault en souligne la difformite bien qu’il soit de sang royale. ? Tout en insistant sur l’egalite des valeurs de l’esprit et de la beaute, Perrault en souligne le caractere inne et predetermine. Selon Perrault, ces qualites sont neamoins transmissibles. En conclusion, Perrault nous montre que la rencontre de l’amour ne vient ni de l’activite sociale ni du pouvoir decisionnel de l’etre humain. En fait, seule la reconnaissance de la valeur d’autrui dans un etre surnaturel, la fee, permet de s’aborder sur un pied d’egalite, prealable necessaire a toute relation sincere. Dans ce recit, Perrault valorise la fonction de leader a travers ses heros qui sortent grandis de leurs epreuves. L’amour est la recompense pour Riquet dont la patience a permis de surmonter les souffrances psychologiques et de se defaire de sa ‘houppe’.

설화의 동화화에 대한 연구 ( 2 ) - 뻬로의 「 잠자는 숲 속의 미녀 La Belle Au bois Dormant 」

김정란(Jeong Lan Kim) 건국대학교 동화와번역연구소(구 건국대학교 중원인문연구소) 2002 동화와 번역 Vol.3 No.-

한국판 Cohen-Mansfield 초조 척도(K-CMAI)의 표준화 연구

김정란(Jeong-Lan Kim),왕성근(Seung-Keun Wang),김민구(Min-Goo Kim),김수영(Soo-Young Kim),김의준(Eui-Jun Kim) 대한생물치료정신의학회 2008 생물치료정신의학 Vol.14 No.1

Objectives: This study was conducted to standardize and develop the Korean version of Cohen-Mansfield Agitation Inventory(K-CMAI), which is a scale for assessing common agitated behaviors in elderly patients. Methods: After developing the K-CMAI, 166 patients, who met diagnostic criteria of dementia, were rated by it and Korean version of Neuropsychiatric Inventory(K-NPI). We tested internal consistency, interrater reliability, and factor analysis and correlation with K-CMAI and K-NPI. Results: Internal consistency of frequency of K-CMAI(Cronbach's a) in two raters were 0.889 and 0.893, respectively, and κ value of interrater reliability was 0.97 for frequency and was 0.95 for difficulties of caregivers. Factor analysis from Varimax Rotation of K-CMAI was found 4 factors, such as aggressive behaviors, physically non-aggressive behaviors, verbally agitated behaviors, and hiding and hoarding, and we could confirm those 4 factors with Amos. Irritability, Disinhibition, and aberrant behavior domains of K-NPI were highly correlated with K-CMAI. Conclusions: The K-CMAI was showed good reliability and validity for the assessment of agitated behavior in elderly. The K-CMAI is an useful tool to caregiver for detecting abnormal behavior of dementia patients.