넙치 (Paralichthys olivaceus)에 대한 포르말린의 급성독성 효과

박인석,김형배,김민석,박철원,Park, In-Seok,Kim, Hyung-Bae,Kim, Min-Suk,Park, Chul-Won 한국어병학회 1995 한국어병학회지 Vol.8 No.1

평균 전장 $6.1{\pm}0.5cm$ 의 양식산 넙치, Paralichthys olivaceus 치어에 대한 포르말린의 1시간 2 시간, 4 시간 및 24 시간 급성독성 효과를 조사한 결과, 각 처리구간의 대조군은 모두 생존하였으며 포르말린에 대한 1 시간 $LC_{50}$ 값은 2,520 ppm 이며 95% 신뢰한계의 상한치는 2,540 ppm, 하한치는 2,490 ppm 이었다. 2 시간 $LC_{50}$ 값은 1,610 ppm 이며 95% 신뢰한계의 상한치는 1,630 ppm, 하한치는 1,590 ppm 이었다. 4 시간 $LC_{50}$ 값은 868 ppm 이며 95% 신뢰한계의 상한치는 885 ppm, 하한치는 851 ppm 이었다. 그리고 24 시간 $LC_{50}$ 값은 141 ppm 이며 95% 신뢰한계의 상한치는 147 ppm, 하한치는 136 ppm 이었다. 각 처리시간에서 독성실험 종료 후 죽은 개체들은 아가미덮개 및 입이 열리고 몸통이 유안측으로 만곡되었고 표피 점액질에 손상을 입은 독성증후를 나타내었다. 포르말린에 대한 24 시간 급성독성 실험 후 죽은 개체들의 아가미, 신장, 간 및 심장 조직을 대조군과 조직학적 비교를 한 결과 대조군은 모두 정상이었으나 24 시간 급성독성 실험군에서는 아가미세엽 (혈관 확장, 점액세포 파괴, 상피세포의 확장 및 괴사를 동반하는 퇴행성 병변), 신장 (쇄뇨관 상피세포 확장, 괴사 및 초자적의 퇴행), 간 (염색질의 핵막침착, 핵크기 감소 및 부분 혹은 전반적인 괴사) 및 심장 (핵의축, 심장근 확장 및 괴사) 조직에서 손상 등을 확인할 수 있었다. 현재 넙치의 세균성, 기생충성 질병의 구제에 포르말린 약욕이 실시되고 있어 해당 약제에 대한 넙치 치어의 독성실험 결과는 포르말린의 그 정확한 처리시간 및 처리농도를 결정하는데 중요한 자료로 판단된다. Twenty-four hours, acute toxicity and the histopathological effect of formaline to flounder, Paralichthys olivaceus larvae were examined. The $LC_{50}$ values obtained to farmaline were 2,520 ppm in 1 hour treatment. 1.610 ppm in 2 hours treatment, 868 ppm in 4 hours treatment and 141 ppm in 24 hours treatment. Many pathological features such as hypertrophy of mucous and epithelial cells in secondary gill lamella, hyaline droplet degeneration of tubular epithelial cells in the proximal convoluted segment of renal tubules, focal or massive necrosis in liver cells and pycnotic nucleus in heart cells were recognized. The above results were discussed in relation to the application of formaline as therapeutic agent in flounder disease.

PNF 하지 패턴이 반대측 중둔근의 활성도에 미치는 영향

박인석,이상열,Park, In-Suk,Lee, Sang-Yeol 대한고유수용성신경근촉진법학회 2016 PNF and Movement Vol.14 No.3

Purpose: This study investigates the influence of applying proprioceptive neuromuscular facilitation (PNF) leg patterns on the activation of three types of mesogluteal fibers at the opposite side. Methods: The target subjects of this study were 19 healthy men who voluntarily agreed to participate in the program. For all subjects, the following four PNF leg patterns were applied while they were in a standing position, and then, the activation of the gluteus medius at the opposite side was measured: (1) flexion abduction internal rotation pattern, (2) flexion adduction external rotation pattern, (3) extension abduction internal rotation pattern, and (4) extension adduction external rotation pattern. In each position, a pattern was executed three times in 5 s, and the average of each measurement was used for the statistics. Results: Among the PNF leg patterns, the activation of the mesogluteal fibers at the opposite side was most significant under the application of the extension abduction internal rotation pattern. The activation of the back muscular fiber was significantly high under the application of the flexion abduction internal rotation pattern. Conclusion: Selective application of PNF leg patterns can improve the functional activity of each mesogluteal fiber.

주말 부부

박인석,Park, In-Suk 한국기술사회 2008 技術士 Vol.41 No.5

기술사마당: 수상 -추억으로 가는 물소리

박인석,Park, In-Suk 한국기술사회 2010 技術士 Vol.43 No.6

종양용해중후군에 의한 급성신부전증의 임상적 양상

박인석(In Seok Park),임규택(Gyu Taek Lim),김성수(Sung Soo Kim),장윤식(Yoon Sik Chang),윤영석(Young Suk Yoon),진종률(Jong Yul Jin),박종원(Jong Won Park),김춘추(Choon Choo Kim),방병기(Byung Kee Bang),김동집(Dong Jip Kim) 대한내과학회 1992 대한내과학회지 Vol.43 No.5

N/A Background: Tumor lysis syndrome (TLS) occurs as a result of the rapid release of intracellular ions and metabolites into the bloodstream which can overwhelm the reanl capacity to excrete and then increase to lifethreatening concentrations. The syndrome is characterized by hyperuricmia, hyperkalemia, hyperphos-phatemia and hypocalcemia. Recently, intensive chemotherapy for hematologic malignancy have introduced and tumor lysis syndorme occurred with increasing tendency. Methods: Renal and metabloic complications of tumor lysis of ten episodes are reviewed in nine patients with various hematologic malignancy during last 2 years. Results: The ten episodes of tumor lysis syndrome had developed in one of malignant lymphoma. five of acute lymphocytic leukemia and four of chronic myelocytic leukemia. The mean serum BUN and creatinine concentration was 68.0 and 4.4 mg/dl, respectively. The mean serum calcium was 5.2 mg/dl, phosphorus 11.5 mg/dl, uric acid 13.9mg/dl. Clinical manifestations of tumor lysis syndrome had developed abruptly within 24 hours after chemotherapy in all episodes. Prophylactic treatment including intravenous hydration, potent diuretics, alkalinization of urine and allopurinol were not always successful in preventing or aborting it. The two major clinical features of tumor lysis syndrome were oligoanuria (6/10) and neurologic symptoms such as carpopedal spasm (5/10). Conclusion: We had experienced ten episodes of tumor lysis syndrome from 9 patients. Except three patients who expired due to unrelated causes, the overall recovery was good. The mean recovery day in three conservative-treated patients and four hemodialysis- Bsekground: Tumor lysis syndrome (TLS) occurs as a result of the rapid release of intracellular ions and metabolites into the bloodstream which can overwhelm the reaol capacity to excrete and then increase to lifethreatening concentrations. The syndrome is characterized by hyperuricmia, hyperkalemia, hyperphos- phatemia and hypocalcemia. Recently, intensive chemotherapy for hematologic malignancy have introduced and tumor lysis syndorme occurred with increasing tendency. Methods: Renal and metabloic complications of tumor lysis of ten episodes are reviewed in nine patients with various hematologic malignancy during last 2 years. Results: The ten episodes of tumor lysis syndrome had developed in one of malignant lymphoma. five of acute lymphocytic leukemia and four of chronic myelocytic leukemia. The mean serum BUN and creatinine concentration was 68.0 and 4.4 mg/dl, respectively. The mean serum calcium was 5.2 mg/dl, phosphorus 11.5 mg/dl, uric acid 13.9mg/dl. Clinical manifestations of tumor lysis syndrome had developed abruptly within 24 hours after chemotherapy in all episodes. Prophylactic treatment including intravenous hydration, potent diuretics, alkalinization of urine and allopurinol were not always successful in preventing or aborting it. The two major clinical features of tumor lysis syndrome were oligoanuria (6/10) and neurologic symptoms such as carpopedal spasm (5/10). Conclusion: We had experienced ten episodes of tumor lysis syndrome from 9 patients. Except three patients who expired due to unrelated causes, the overall recovery was good. The mean recovery day in three conservative-treated patients and four hemodialysistreated patients was 10 and 16 days, respectively.

본태성 고혈압 환자에서 혈소판내 유리칼슘의 변화

윤영석(Young Suk Yoon),구완서(Wan Suh Koo),박인석(In Suk Park),김석영(Suk Young Kim),최의진(Euy Jin Choi),방병기(Byung Kee Bang) 대한내과학회 1991 대한내과학회지 Vol.41 No.2

N/A To investigate a possible association between intracellular free calcium and blood pressure in normotensive subjects and patients with essential hypertension, intraplatelet free calcium was measured with intracellularly trapped fluorescent indicator Fura 2-AM. The results were as follows: 1) Intraplatelet free calcium levels were significantly higher in patients with essential hypertension than in normotensive subjects (222.4±58.0 vs. 119.6±10.9 nM; p < 0.0001). 2) There was a close correlation between the intraplatelet free calcium levels and the systolic, diastolic and mean blood pressure (n=45; r=0.817 for SBP, 0.728 for DBP, 0.800 for MBP; p<0.0001, respectively). 3) Antihypertensive treatment with calcium channel blookers or beta-blockers resulted in a reduction in both blood pressure and intraplatelet free calcium(p<0.0001). 4) There was a significant correlation between intraplatelet free calcium and serum cholesterol concentration (r=0.462, p<0.05). Based on the above findings, there was a close correlation between the free calcium level in platelets and blood pressure, and the serum cholesterol concentrations. Antihypertensive treatment with calcium channel blockers or beta blockers resulted in a reduction in free calcium, which correlated with the fall in blood pressure.

유자(柚子) 수확

박인석(In-Suk Park) 대한토목학회 2007 대한토목학회지 Vol.55 No.4

흡연 및 음주 여자청소년에서의 정신병리와 식이행

박인석(In-Suk Park),신정호(Jong-Ho Shin),안정숙(Joung-Sook Ahn),김춘배(Chun-Bae Kim),허혜경(Hea-Kyung Huh) 한국중독정신의학회 2003 중독정신의학 Vol.7 No.2

Objective:Female adolescents with drinking and smoking problems have shown a sharp increase, and they are liable to show abnormal eating behaviors. The objects of this research are 1) to estimate the rate of smoking and drinking among female adolescents, and 2) to study their association with psychopatholoy and eating behavior. Method:We conducted a survey of 864 girls at one junior high school (n=405) and one high school (n= 459) with questionnaires of the general information related to smoking and drinking behaviors, the SDQ (Strengths and Difficulties Questionnaire) for psychopathology, and the TFEQ (Three Factor Eating Questionnaire) for eating patterns. In addition, the BMI and the discrepancy of perceived-ideal body image were calculated. Result:The prevalence of drinking and smoking were 35.1% and 11.5%, respectively. Hyperactivity and conduct problems were found in smoking and drinking female adolescents. Smoking girls at high school got a low disinhibition score and high BMI, and showed considerable discrepancy between perceived and ideal body image. Drinking girls at high school got a high score in both disinhibition and hunger of eating patterns and a low score in dietary restraint. For the junior high schoolgirls, the lower disinhibition score was, the higher the risk of smoking and drinking was, but for the high schoolgirls, the lower dietary restraint score was, the higher the risk of drinking was. And, disinhibition/hunger measures and psychopathology were positively correlated. Conclusion:Smoking and drinking in female adolescents is closely associated with externalizing beha-vioral problems, and eating pattern is mainly related to drinking rather than smoking.

금호강의 명물 사장교

박인석(IN-SUK PARK) 대한토목학회 2008 대한토목학회지 Vol.56 No.6

서울의 개천(開川)

박인석(In-Suk Park) 대한토목학회 2006 대한토목학회지 Vol.54 No.1