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전호정(Hojeong Jeon),이용구(Yongkoo Lee),진송완(Songwan Jin),구상모(Sangmo Koo),이창수(Chang-Soo Lee),유정열(Jung Yul Yoo) 대한기계학회 2005 대한기계학회 춘추학술대회 Vol.2005 No.11
Bacterial chemotaxis may have a significant impact on the study of structure and function of bacteria. Quantification of chemotactic motion is necessary to identify chemoeffectors and to determine the bacterial transport parameters used in prediction models of chemotaxis. Although many studies have accumulated the knowledge about chemotaxis for many years, the motion of a single bacterium has not been studied yet. In this study we propose a device microfabricated by soft lithography and consisting of microfluidic channels, which can generate a gradient of chemoeffectors in the main channel so that a single bacterium is injected into this channel by hydrodynamic focusing. This microfluidic assay offers superior performance to measure a single cell or a group of cells and to quantify their motion, and it also builds a delicate gradient of chemoeffectors to raise accuracy of measuring the bacterial motion.
유체역학적 집속 효과를 이용한 단일 박테리아 주화성의 정량적 분석
전호정(Hojeong Jeon),이용구(Yongkoo Lee),진송완(Songwan Jin),구상모(Sangmo Koo),이창수(Chang-Soo Lee),유정열(Jung Yul Yoo) 대한기계학회 2006 대한기계학회 춘추학술대회 Vol.2006 No.6
Bacterial chemotaxis may have a significant impact on the study of structure and function of bacteria. Quantification of chemotactic motion is necessary to identify chemoattractant and to determine the bacterial transport parameters used in prediction models of chemotaxis. Although many studies have accumulated the knowledge about chemotaxis for many years, the motion of a single bacterium has not been studied yet. In this study we propose a device microfabricated by soft lithography and consisting of microfluidic channels, which can generate a gradient of chemoattractant in the main channel so that a single bacterium is injected into this channel by hydrodynamic focusing. Additionally, we measure and analyze the motility of bacteria through the concentration gradient of chemoattractant quantitatively and statistically by using this microfluidic assay.
초정밀 레이저 나노패터닝 기술을 이용한 세포 거동 제어
전호정(Hojeong Jeon) 대한기계학회 2012 대한기계학회 춘추학술대회 Vol.2012 No.11
Recent progress in developing techniques for micro/nano-fabrication of biomaterials helps recapitulate many extracellular matrix cues, making them progressively more useful for applications in biology and regenerative medicine. This talk presents a study of femtosecond laser assisted nanofabrication applicable for the biomaterials design aiming at achieving deliberate control of the cell behavior. We applied femtosecond laser induced multiphoton laser ablation lithography to fabricate precisely defined two-dimensional chemical and topographical patterned surface in nanometer to micrometer length scale to be used in studies addressing fundamental issues concerning control of cell adhesion, migration and stem cell differentiation.