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Chicken embryo toxic effects of 1,3,7-TriBDD, a naturally produced dioxin
Jae Gon Park(박재곤),Hisato Iwata(이와타 히사토),Nguyen Minh Tue(투 엔구옌 민),Tatsuya Kunisue(쿠니스 타스야),Eun-Young Kim(김은영) 환경독성보건학회 2021 한국독성학회 심포지움 및 학술발표회 Vol.2021 No.5
Dioxins are known to induce a variety of toxic effects and biological alterations as chemical pollutants. Until now, most of dioxins have been reported that they are derived from human activities such as industrial, combustion, and incineration sources. However, recent researches have shown that naturally produced dioxins were detected. 1,3,7-tribromodibenzo-p-dioxin (1,3,7-TriBDD) is one of the natural occurred dioxins by algal species and abundant polybrominated dibenzo-p-dioxins in marine ecosystem. 1,3,7-TriBDD is assimilated in mussels, and ingested by water birds with tons of mussels. Thus, it is possible that 1,3,7-TriBDD could effect on bird species. But, despite this possibility, the effects of biological exposure on vertebrates such as birds are not well known. Therefore, we performed in ovo exposure test and hepatic transcriptomic analysis with chicken embryos to understand effect of 1,3,7-TriBDD exposure. Chicken embryos treated with 27μM and 137μM of 1,3,7-TriBDD and sacrificed after 21 day incubation. Treated chicken embryos showed decreased glucose level in 1,3,7-TriBDD treated embryos. In transcriptomic analysis, 733 and 596 genes were identified as differentially expressed genes (DEGs) from 6520 sequences in 27 and 137μM of 1,3,7-TriBDD-treated groups, respectively. Pathway analysis with DEGs (differentially expressed genes) suggested that 1,3,7-TriBDD possibly induces cancerous effects and alteration of metabolism. And these results were similar with results of TCDD, the representative dioxin, treated chicken embryos. Collectively, this study suggests the necessity to further investigate the effects of 1,3,7-TriBDD exposure in animals, considering a possibility of increased production of 1,3,7-TriBDD due to climate change such as global warming.