남성 유방암 폐전이 환자의 폐절제술 후 한의기반 통합암치료로 증상 호전에 대한 증례보고

고은주,하수정,박지혜,박소정,이연월,조종관,유화승,Ko, Eun ju,Ha, Su-jeong,Park, Ji-hye,Park, So-jung,Lee, Yeon-weol,Cho, Chong-kwan,Yoo, Hwa-seung 대한암한의학회 2020 大韓癌韓醫學會誌 Vol.25 No.1

Objective: The purpose of this study is to report improvement of symptoms after lobectomy of male breast cancer lung metastasis treated with Korean Medicine based Integrative Cancer Treatment (ICT). Methods: A male left breast cancer patient diagnosed with metastasis on lung at July 2019. After Video assisted thoracic surgery (VATS) left lower lobe (LLL) lobectomy and En bloc wedge resection the patient visited the Daejeon korean medicine hospital of Daejeon university East West Cancer Center (EWCC) to treat operation-site (op-site) pain, dysphagia, anorexia with Korean Medicine Treatment. The patient was treated with Korean Medicine based ICT for an approximately 20 days. The clinical outcomes were measured by National Cancer Institute Common Terminology Criteria for Adverse Event (NCI-CTCAE), Numeral rating scale (NRS) and Eastern Cooperative Oncology Group (ECOG). The safety of treatment was verified by blood tests. Results: After treatment, op-site pain was improved from NRS 9 to 6, dysphagia and anorexia were relieved from NRS 9 to 2. And ECOG score of the patient was improved from grade 2 to 1. Conclusion: This case study suggests that Korean Medicine based ICT may help to improve post operative sequelae in metastatic lung cancer patient.

5-Fluorouracil, Mitomycin C 및 Acriflavine-Guanosine 복합제가 Ehrlich 암세포를 이식한 생쥐 위점막 점액상피세포의 미세구조에 미치는 영향

고은주,박경호,박대균,김덕수,고정식,Ko, Eun-Ju,Park, Kyung-Ho,Park, Dae-Kyoon,Kim, Duk-Soo,Ko, Jeong-Sik 한국현미경학회 2011 Applied microscopy Vol.41 No.1

이 실험은 Ehrlich 종양세포를 이식한 후 5-fluorouracil, mitomycin 및 acriflavine-guanosin 복합제(AG60)을 투여하였을 때, 위점막 점액상피세포의 미세구조적 변화를 연구하고자 시행하였다. 실험동물로는 ICR생쥐를 사용하였으며 정상대조군 이외의 종양대조군, 5-fluorouracil, mitomycin C 및 AG60 투여군의 동물들은 샅부위 피부밑조직에 각각 $1{\times}10^7$의 Ehrlich 종양세포를 이식하였다. 각각의 실험군은 종양세포를 이식한 다음날부터 5-fluorouracil (30 mg/kg), mitomycin C ($400{\mu}g/kg$) 및 AG60 (30 mg/kg)을 격일 간격으로 한번씩 피부밑조직에 주사하였다. 종양대조군은 종양세포이식 후에 0.2 mL의 생리식염수를 피부밑조직에 주사하였고 정상대조군은 종양세포를 이식하지 않은 동물을 사용하였다. 종양대조군을 비롯한 실험군은 생리식염수 또는 각각의 약제를 격일 간격으로 7회씩 투여한 다음날, 에테르(ether) 마취하에 앞배벽을 열어 위조직을 절취하였다. 절취한 조직은 2.5% 글루타르알데히드(glutaraldehyde)-1.5% 파라포름알데히드(paraformaldehyde) 혼합액에 고정한 후, 1% 오스뮴사산화물(osmium tetroxide)용액에 다시 고정한 후 탈수과정을 거쳐 애럴다이트(araldite) 혼합액에 포매하였다. 포매된 위점막 조직은 얇은 절편을 만들었으며, 각 절편은 우라닐아세테이트(uranyl acetate)용액과 구연산납(lead citrate)용액으로 대조염색한 후, 전자현미경으로 비교 관찰하였다. 5-fluorouracil 투여군은 종양대조군에 비해 점액상피세포에 수초구조(myelin figure)가 자주 관찰되고, 분비과립이 세포질을 포함한 막성구조에 싸여 속공간으로 함께 분비되는 부분분비현상이 보일 정도로 손상을 받았다. 그리고 mitomycin C 역시 수초구조가 자주 관찰되고 분비과립을 함유한 세포질이 속공간으로 돌출되는 등의 미세구조적 변화를 보였다. 그러나 AG60의 경우는 수초구조와 다소포체가 비교적 자주 관찰되는 외에는 별다른 미세구조적 변화를 관찰할 수 없었다. 이상의 결과를 종합해보면 mitomycin C, 5-fluorouracil 및 AG60을 반복 투여 하면 위점막 점액상피세포의 분비기능이 억제되었음을 시사하는 미세구조적 변화를 보였다. 그러나 세포의 손상 정도가 mitomycin C와 5-fluorouracil 투여군에 비해 AG60 투여군에서 매우 경미하였으므로 AG60은 위점막 점액상피세포의 분비기능에 큰 손상을 주지 않는 약제라고 생각된다. This experiment was performed to evaluate the morphological responses of the gastric epithelial cells of the mouse, inoculated with Ehrlich carcinoma cells in the inguinal area, following administration of 5-fluorouracil, mitomycin C or Acriflavine-Guanosine compound (AG60). In this study, each mouse was inoculated with $1{\times}10^7$ Ehrlich carcinoma cells subcutaneously in the inguinal area. From next day after inoculations, 0.2 mL of saline, 5-fluorouracil (30 mg/kg), mitomycin C ($400{\mu}g/kg$) or AG60 (30 mg/kg) were injected to the animals every other day, respectively. Each animals were sacrificed after 7th injection and tissue were taken from the gastric mucosa. Thereafter, the ultrathin sections were stained with uranyl acetate and lead citrate. In the 5-fluorouracil-, mitomycin C- or AG60-treated mice, myelin figures and multivesicular bodies within the gastric mucous epithelial cells were observed more frequently than those of the normal control. In the 5-fluorouracil-treated mice, membrane structures containing a few mucous granules in the luminal space were observed. Indeed, bulging cytoplasmic process containing mucous granules protruding into the gastric lumen were observed in the mitomycin Ctreated mice. Therefore, this study suggested that AG60 as compared with 5-fluorourail and mitomycin C may effective medicine without damage to the secretion ability of gastric mucous epithelial cells.

췌장암 간전이 환자의 통합 암 치료에 대한 증례보고

고은주,명지수,김종희,박지혜,박소정,이연월,유화승,Ko, Eun-ju,Myong, Ji-soo,Kim, Jong-hee,Park, Ji-hye,Park, So-jung,Lee, Yeon-weol,Yoo, Hwa-seung 대한암한의학회 2021 大韓癌韓醫學會誌 Vol.26 No.1

Objective: The purpose of this study is to report effects and potential of Integrative Cancer Treatment (ICT) on metastatic pancreatic cancer patient. Methods: A 79-year-old pancreatic cancer patient diagnosed with metastasis on liver visited the Daejeon Korean medicine hospital of Daejeon university East West Cancer Center (EWCC) on May 2021. The patient has been received chemotherapy (gemcitabine plus abraxane) and concurrently treated with ICT since May 2021. The clinical outcomes were measured by computed tomography, laboratory findings including tumor markers (CEA, CA19-9) and numeric rating scales (NRS). Laboratory analysis and National Cancer Institute Common Terminology Criteria for Adverse Events (NCI-CTCAE), version 5.0 were used to evaluate the safety of ICT. Results: After treatment, constipation was relieved from NRS 5-6 to 2, both leg numbness was improved from NRS 9 to 2. Tumor size was generally decreased accompanying by reducing the levels of tumor markers. There were no severe adverse events induced by ICT based on NCI CTCAE version 5.0. Conclusion: This case study suggests that ICT in combination with chemotherapy may help in the treatment of patients with metastatic pancreatic cancer.

원산지효과, 상표자산 및 상표충성 간의 관계에 관한 연구: 미국, 중국, 한국의 비교분석

고은주,김경훈,김숙현,이구봉,추붕,장호,Ko, Eun-Ju,Kim, Kyung-Hoon,Kim, Sook-Hyun,Li, Guo-Feng,Zou, Peng,Zhang, Hao 한국마케팅과학회 2009 마케팅과학연구 Vol.19 No.1

The marketing environment has become competitive to an extent that requires firms to target their products at markets that span national boundaries. However, competitive clout cannot be achieved in global consumer markets unless firms thoroughly understand and adequately respond to the core values and needs of those consumers. Brand equity is one of the most important assets to a company. Especially in sportswear markets, brand equity is the crucial value added to a product by its brand name. Factors such as country of origin also influence customer's attitude towards brand equity. Therefore, this paper discusses the relationship between country of origin effect and brand equity, and how they influence consumers' loyalty for respective brands. This paper focused on the sports shoes market, because it is an increasing area of opportunity for world manufacturers. The objectives of this study were the following. (1) Test the effect of country of origin on brand equity. (2) Test how brand equity influences consumers' brand loyalty. (3) Find whether there are differences in the effects of country of origin and brand equity among the three countries. (4) Find whether there are differences in the effects of country of origin and brand equity among the different lifestyles. Based on the review of literature results, the hypotheses are concluded as the following: H1-a: Country image has positive influence on country of origin. H1-b: Product perception has positive influence on country of origin. H2-a: Perceived quality has positive effect on brand equity. H2-b: Perceived price has positive effect on brand equity. H3: Country of origin has positive effect on brand equity. H4: Brand equity has a positive impact on brand loyalty. Research model was constructed (see Fig. 1). After data analysis, the following results were concluded: sports shoes purchase behavior showed significant differences among Korean, Chinese, and American consumers for favorite brand, purchased brand, purchased place, information usage, and favorite sports games. The results of this study also extend the research of the relationship among country of origin, brand equity and brand loyalty to the sports shoes market. Brand equity was proven to have a significant relationship with brand loyalty for all countries. The factors which can influence brand equity are different for different countries. The third finding of this paper is that we identified different three lifestyles, adventurer, follower, and laggard, for Korean, Chinese and American consumers. Without the nationality boundary, seeing the emergence of a new group of consumers who have similar preferences and buy similar brands is more important. All of the consumers consider brand equity to keep their brand loyalty. Perceived price is the only factor which can influence brand equity for adventurers; brand is more important for them. The laggards were not influenced by any factor. All of the factors expect perceived price are important for the followers. Marketing managers should consider brand equity when introducing their brand into a new market. Also localization is the basic strategy that all the sports shoes companies should understand. But as a global brand, understanding the same characteristics for each country is more important to build global strategy.

협동적 수학활동을 통한 바깥놀이가 유아의 수학개념과 친사회적 행동에 미치는 영향

고은주(Ko Eun Ju),이경민(Lee Kyung Min) 학습자중심교과교육학회 2017 학습자중심교과교육연구 Vol.17 No.1

본 연구의 목적은 협동적 수학활동을 통한 바깥놀이가 유아의 수학개념과 친사회적 행동에 미치는 영향을 알아보는 것이다. 이를 위해 만 5세 유아 52명(실험집단 26명, 비교집단 26명)을 연구대상으로 선정하였다. 연구과정은 교사훈련, 예비검사, 사전검사, 실험처치, 사후검사의 절차로 진행하였으며 실험처치는 12주 동안 실시하였다. 연구도구는 유아그림수학능력검사 도구와 친사회적 행동검사 도구를 사용하였으며, 자료 분석은 SPSS 20.0 프로그램을 이용하여 공변량 분석(ANCOVA)을 실시하였다. 연구결과 첫째, 실험집단은 비교집단 유아들보다 수학개념이 유의미하게 높게 나타났으며 하위요인인 대수, 수와연산, 기하에서도 유의미한 향상이 나타났다. 이는 협동적 수학활동을 통한 바깥놀이가 유아의 수학개념에 긍정적인 영향을 미쳤다고 할 수 있다. 둘째, 실험집단은 비교집단보다 친사회적 행동에서 유의미한 향상을 보였으며 하위요인인 개인정서 조절능력, 대인관계 형성능력, 유치원 적응능력에서도 유의미한 차이가 나타나 협동적 수학활동을 통한 바깥놀이가 유아의 친사회적 행동에 긍정적인 영향을 미쳤다고 할 수 있다. 이상의 연구결과를 통해 협동적 수학활동을 통한 바깥놀이는 유아의 수학개념과 친사회적 행동향상에 효과가 있음을 알수 있다. The purpose of this study was to analyze the effects of outdoor play through cooperative mathematics activities on young children’s mathematical concept and prosocial behavior. A total 52 children of five years old(26 children in experimental group, 26 children in comparative group) participated in this study. The experiment was conducted 12times for 12weeks. The experimental group participated in outdoor play through cooperative mathematics activities and in the comparative group common outdoor play on the Nuri curriculum were carried out. Data analysis was conducted using ANCOVA.. The results of this study was follows. First, the effects of outdoor play through cooperative mathematics activities on children’s mathematical concept was statistically meaningful. There were meaningful differences on children’s mathematical concept such as algebra, number and operation, and geometry. In other words, outdoor play through cooperative mathematics activities have positive effects on improving children’s mathematical concept. Second, the effects of outdoor play through cooperative mathematics activities on children’s prosocial behavior was statistically meaningful. There were meaningful differences on children’s prosocial behavior such as ability of controlling private emotion, ability of conducting relationships, and ability of adjusting in kindergarten. In other words, outdoor play through cooperative mathematics activities have positive effects on improving children’s prosocial behavior. In conclusion, it is revealed that outdoor play through cooperative mathematics activities is more positive effective on children’s mathematical concept and prosocial behavior.

보문 : 새로운 유통으로의 모바일 패션 쇼핑몰 도입에 관한 연구 -브랜드 특성(복종, 가격, 타겟, 매출액)을 중심으로

고은주 ( Eun Ju Ko ),김경희 ( Kyeung Hee Kim ),김선숙 ( Seon Sook Kim ) 韓國衣類學會 2009 한국의류학회지 Vol.33 No.7

보문 : 스포츠 의류브랜드의 고객자산과 고객만족과의 관계연구

고은주 ( Eun Ju Ko ),이현주 ( Hyun Ju Lee ) 한국의류학회 2009 한국의류학회지 Vol.33 No.5

패션브랜드개성이 브랜드 선호도 및 구매의도에 미치는 영향 연구-정장, 캐주얼, 스포츠 브랜드의 비교-

고은주(Ko Eun Ju),윤선영(Sun Young Yun) 한국마케팅과학회 2004 마케팅과학연구 Vol.14 No.-

본 연구는 패션 제품은 사회심리적 속성이 강하다는 특징을 가지고 있기 때문에 Aaker의 일반적인 제품에 적용한 브랜드 개성 차원과는 다른 차별화된 개성을 나타낼 수 있는 연구가 필요하다는 생각에서 출발하였다. 패션 브랜드 이미지에서 추출한 브랜드 개성을 나타낼 수 있는 어휘들을 포함하여, 패션 브랜드 개성 차원을 도출하여 전체적 패션브랜드 개성 차원을 밝혔으며, 또한 패션 제품의 세분화 기준중의 하나인 복종별 (정장, 캐주얼웨어, 스포츠웨어)에 따라 패션 브랜드 개성요인은 어떻게 다르게 도출되는 지를 알아보았다. 이는 패션 제품 카테고리에 맞는 패션브랜드개성 차원을 개발함으로써 차별적 브랜드 마케팅 전략 수립 및 활용을 위한 자료로 사용될 수 있는다는 것에 의의를 가질 수 있다. 또한 소비자들에게 있어 브랜드 개성차원의 중요성을 알아보기 위하여 각각의 개성 차원들이 브랜드의 선호도 및 구매의도에 어떠한 영향을 미치는지를 살펴보았다. 분석 결과 첫째, 패션 브랜드 개성 차원은 유행/혁신성, 성실성, 보편/안정성, 전문성의 4가지 차원으로 도출되었다. 둘째, 복종에 따라 정장에서는 혁신/활동성, 안정성, 전문성, 보편성이, 캐주얼웨어에서는 유행/혁신성, 활동성, 성실성, 안정성으로, 스포츠웨어에서는 혁신성, 사교성, 성실성의 개성 차원이 도출되었다. 셋째, 패션 브랜드 개성 요인에 따라 소비자의 브랜드 선호와 구매의도의 영향략은 다르게 나타났다. 패션 브랜드 개성 차원 중에서는 성실성, 보편성, 전문성이 선호도에 유의한 영향을 미쳤고, 정장 브랜드 개성 차원 중에서는 전문성, 캐주얼웨어 브랜드 개성 차원 중에서는 활동성, 스포츠웨어 브랜드 개성 차원 중에서는 성실성이 선호도에 각각 유의한 영향을 미쳤다. 또한 전반적인 패션브랜드 개성과 정장 브랜드 개성에서는 선호도와 동일한 차원들이 각각 구매의도에 유의한 영향을 미치는 것으로 나타났으며, 캐주얼웨어 브랜드 개성 차원에서는 유행/혁신성, 진실성, 안정성이 스포츠 브랜드 개성 차원에서는 혁신성이 각각 구매의도에 영향을 미치는 것으로 나타났다. As industrial development standardized the quality of products, people are increasingly attracted by a certain brand with intangible value. Consumers, surrounded by a variety of brand in a market, want to have relationships with specific brands reflected by their personality. Especially in fashion, brand personality is more important since products are highly involved in terms of personal emotion. The purpose of the study is to identify the dimension of overall fashion brand personality, to specify the 'Dimension of Fashion Brand Personality' according to fashion product categories(i.e., formal wear, casual wear, sports wear), and to investigate the effect of each dimension of fashion brand personality on brand preference and purchase intention. The results were as follows: Firstly, based on Aaker(1997)'s 'Big five factors' and selection fashion brand personality factors form our pretest, the fashion brand personality factors were verified as 'Fashionable/Innovative', 'Sincere', 'Universal/Stable', 'Professional'. Secondly, according to fashion product categories, brand personality was defined as below. Brand personality for formal wear included 'Innovative/ Active', 'Stable', 'Professional', and 'Universal'. Brand personality for casual wear included 'Fashionable/Innovative', 'Active', 'Sincere'. and 'Stable'. Brand personality for sports wear included 'Innovative', 'Social', 'and 'Sincere'. Finally, overall fashion brand personality factors ('Sincere', 'Universal/Stable', 'Professional') influenced on brand preference and purchase intention. In formal wear, 'Professional' influenced on brand preference and purchase intention. In casual wear, 'Active' influenced on brand preference, but 'Fashionable' and 'Sincere' influenced on purchase intention. In sports wear, 'Sincere' influenced on brand preference and 'Innovative' influenced on purchase intention.

보문 : 여성잡지광고에 나타난 소비가치의 변화와 광고소구방법 및 문장표현방법 분석연구 -1955~2008년 여성잡지광고내용 분석을 중심으로-

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