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Genome-Wide Association Study of Lung Cancer in Korean Non-Smoking Women
Kim, Jin Hee,Park, Kyunghee,Yim, Seon-Hee,Choi, Jin Eun,Sung, Jae Sook,Park, Ju-Yeon,Choi, Yi Young,Jeon, Hyo-Sung,Park, Jae Yong,Yoon, Hyoung Kyu,Kim, Yeul Hong,Yoo, Byung Su,Kim, Young Tae,Hu, Hae-J The Korean Academy of Medical Sciences 2013 JOURNAL OF KOREAN MEDICAL SCIENCE Vol.28 No.6
<P>Lung cancer in never-smokers ranks as the seventh most common cause of cancer death worldwide, and the incidence of lung cancer in non-smoking Korean women appears to be steadily increasing. To identify the effect of genetic polymorphisms on lung cancer risk in non-smoking Korean women, we conducted a genome-wide association study of Korean female non-smokers with lung cancer. We analyzed 440,794 genotype data of 285 cases and 1,455 controls, and nineteen SNPs were associated with lung cancer development (<I>P</I> < 0.001). For external validation, nineteen SNPs were replicated in another sample set composed of 293 cases and 495 controls, and only rs10187911 on 2p16.3 was significantly associated with lung cancer development (dominant model, OR of TG or GG, 1.58, <I>P</I> = 0.025). We confirmed this SNP again in another replication set composed of 546 cases and 744 controls (recessive model, OR of GG, 1.32, <I>P</I> = 0.027). OR and <I>P</I> value in combined set were 1.37 and < 0.001 in additive model, 1.51 and < 0.001 in dominant model, and 1.54 and < 0.001 in recessive model. The effect of this SNP was found to be consistent only in adenocarcinoma patients (1.36 and < 0.001 in additive model, 1.49 and < 0.001 in dominant model, and 1.54 and < 0.001 in recessive model). Furthermore, after imputation with HapMap data, we found regional significance near rs10187911, and five SNPs showed <I>P</I> value less than that of rs10187911 (rs12478012, rs4377361, rs13005521, rs12475464, and rs7564130). Therefore, we concluded that a region on chromosome 2 is significantly associated with lung cancer risk in Korean non-smoking women.</P>
Hye-Ryung Kim,Gyu-Tae Jeon,Jong-Min Kim,Ji-Su Baek,Yeun-Kyung Shin,Oh-Kyu Kwon,Hae-Eun Kang,Ho-Seong Cho,Doo-Sung Cheo,박최규 한국동물위생학회 2022 韓國家畜衛生學會誌 Vol.45 No.4
Bordetella (B .) bronchiseptica , Mycoplasma (M .) felis , and Chlamydia (C .) felis are considered as main bacterial pathogens of feline upper respiratory tract disease (URTD). In this study, a new triplex quantitative real-time polymerase chain reaction (tqPCR) assay was developed for the rapid and dif-ferential detection of these bacteria in a single reaction. The assay specifically amplified three bacte-rial genes with the detection limit of below 10 copies/reaction. The assay showed high repeatability and reproducibility, with coefficients of intra-assay and inter-assay variation of less than 1%. Based on the diagnostic results of the assay using 94 clinical samples obtained from cats with URTD signs, prevalence of B. bronchiseptica , M. felis , or C. felis was 10.6%, 36.2%, or 6.4%, respectively, indicat-ing that the diagnostic sensitivity was comparable to those of previously reported monoplex qPCR assays. The dual infection rates for B. bronchiseptica and M. felis or M. felis and C. felis was 2.1% or 3.2%, respectively. These results indicated that M. felis has been widely spread, and its co-infection with B. bronchiseptica or M. felis has been frequently occurred in Korean cat population. The devel-oped tqPCR assay will serve as a promising tool for etiological and epidemiological studies of these three bacterial pathogens and the prevalence data obtained in this study will contribute to expanding knowledge about the epidemiology of feline URTD in Korea.
Comparative proteomic analysis of human follicular dermal papilla cells and fibroblasts (초)
( Chong Hyun Won ),( Chae Hwa Kim ),( Oh Sang Kwon ),( Yong Jung Kang ),( Jeon Hae Chan ),( Hyeon Gyeong Yoo ),( Jin Ho Chung ),( Kyu Han Kim ),( Hee Chul Eun ),( Kun Cho ),( Jong Soon Choi ),( Won Se 대한피부과학회 2009 초록집 Vol.47 No.20
Comparative proteomic analysis of human follicular dermal papilla cells and fibroblasts
Chong Hyun Won,Chae Hwa Kim,Oh Sang Kwon,Yong Jung Kang,Jeon Hae Chan,Hyeon Gyeong Yoo,Jin Ho Chung,Kyu Han Kim,Hee Chul Eun,Kun Cho,Jong Soon Choi,Won Seok Park,Nok Hyun Park 대한피부과학회 2009 대한피부과학회 학술발표대회집 Vol.61 No.2