한국 전통공간에서 타자(他者)로서 심적 가치의 역할에 관한 연구

문대성 ( Dae Sung Moon ) 한국기초조형학회 2008 기초조형학연구 Vol.9 No.4

호흡기 ; 여성 폐암 환자에서 Gefitinib과 Erlotinib 치료 성적 비교

문대성 ( Dae Sung Moon ),장태원 ( Tae Won Jang ),옥철호 ( Chul Ho Oak ),정만홍 ( Maan Hong Jung ),김도현 ( Do Hyun Kim ),최인수 ( In Soo Choi ) 대한내과학회 2009 대한내과학회지 Vol.76 No.2

목적: 우리나라에서 비소세포폐암의 발생 빈도는 증가하는 추세에 있다. 여성 폐암은 대부분이 비흡연자이고 선암이 주로 발병하는 것으로 알려지고 있으며 표피성장인자수용체의 티록신 키나아제 억제제가 동양인 여성에서 더 효과가 있다는 것이 알려져 있다. 본 연구는 gefitinib과 eroltinib은 작용기전은 비슷하나 용량의 차이가 있어 각각의 치료 성적이 보고자 마다 조금씩 달라 두 약제의 치료 성적을 비교하여 보고자 하였다. 방법: 2004년 2월 2007년 4월까지 고신대학교 복음병원에서 진단 및 치료받은 여성 폐암 환자들을 의무기록을 통해 후향적으로 조사했다. 한달 이상 gefitinib, erlotinib을 복용하고 치료 평가가 가능한 환자를 대상으로 생존기간, 약물투여 기간, 독성의 발생빈도를 비교 분석하였다. 결과: 전체 환자는 42명이었고, gefitinib 치료군은 26명, erlotinib 치료군은 16명이었다. 나이의 중간값은 58세였고, 85%가 비흡연가, 83%가 선암이었으며, 병기는 IIIb가 13명(24.0%), IV가 16명(76%)이고, 생존일 중앙값은 793일이었다. gefitinib으로 치료한 군이 26명(62%)이었고, 이 중 18명(69.2%)이 3차 화학요법으로 이 약제를 사용하였고, erlotinib을 사용한 16명 중 12명(87.5%)이 2차약으로 사용하였다. 전체적인 치료 반응율은 14명에서 부분 관해를 보여 33.3%의 반응율을 보였고, 안정성 병변을 포함한 질병 조절율은 76.2%이었다. gefitinib군의 치료 반응율은 39%, erlotinib군 31%이었으며 양군 간의 통계적 차이는 없었고, 평균 생존 기간이 각각 651일, 510일이었으나 통계적 차이는 없었다. 약제 투여 기간의 중앙값은 gefitinib군에서 186일, erlotinib군이 262일로 erlotinib군에서 길었으나 역시 통계적 유의성은 없었다. 피부 독성은 gefitinib군이 27%, erlotinib군 75%로 erlotinib군에서 많이 나타났다. 결론: Gefitinib군과 erlotinib군의 치료 반응율과 생존기간 및 약제 투여기간의 차이는 없었다. Erlotinib군에서 피부 발진 빈도가 더 높게 나타났다. Background/Aims: Lung cancer is the leading cause of cancer death worldwide. There are significant gender differences in lung cancer: most females with lung cancer are non-smokers and they are diagnosed with adenocarcinoma. Epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKIs) are more effective in female lung cancer patients, but the results with gefitinib and erlotinib differ. This study compared the therapeutic response and toxicity of gefitinib and erlotinib in female lung cancer patients. Method: We retrospectively reviewed the clinical information on patients treated with gefitinib or erlotinib for more than one month at Kosin University Gospel Hospital from February 2004 to November 2007. Results: Forty-two patients (26 gefitinib vs. 16 erlotinib) were enrolled during this period. Their median age was 58 years. Thirty-six patients (85%) were non-smokers and 35 patients (83%) had adenocarcinoma. There were 24% at stage IIIb and 76% at stage IV. The median survival time was 793 days. In the gefitinib group, 69% of the patients received 3rd-line chemotherapy, while 12 of 16 (87.5%) in the erlotinib group received 2nd-line chemotherapy. There were no significant differences in the overall response rate (gefitinib 39% vs. erlotinib 31%, p=0.524), median survival time (gefitinib 605 days vs. erlotinib 510 days, p=0.455), and time to progression (gefitinib 186 days vs. erlotinib 262 days, p=0.660). Rashes were more common in the erlotinib group (73.3% vs. 27%, p<0.001). Conclusions: There were no significant differences in the response rate, overall survival, and time to progression between the two groups. Rashes were more common in the erlotinib group. (Korean J Med 76:179-185, 2009)

태권도 운동이 허약 고령자의 건강체력과 인지능력 및 치매유발인자에 미치는 영향

문대성(Moon Dae-Sung),권유찬(Kwon Yoo-Chan) 한국체육과학회 2010 한국체육과학회지 Vol.19 No.1

As a result of performing an experiment three times a week during 12 weeks with random assignment dividing the elderly women subjects into the taekwondo exercise group and control group, the body composition and health-related physical fitness were improved by the significantly decrease of weight and BMI and the increase of LBM in taekwondo group. Also, all the dangerous factors of dementia were significantly reduced thanks to the significantly improvement of LDL-cholesterol and HDL-cholesterol, which have positive effects on β -amyloid and homocysteine as dementia-causing factors. Therefore, for the elderly women, regular teakwondo exercise influences positively on body composition, health-related physical fitness and dementia-induced factors so it is expected to prevent dementia whose risk is high in elderly women in advance and eventually to help not only save the medical expenses but also improve their and their family's life satisfaction.

Pyrazinamide에 의한 전격성 간부전

문대성 ( Dae Sung Moon ),장태원 ( Tae Won Jang ),옥철호 ( Chul Ho Oak ),정만홍 ( Maan Hong Jung ),유찬희 ( Chan Hui Yoo ),송준영 ( Jun Young Song ),김성은 ( Sung Eun Kim ),김자경 ( Ja Kyung Kim ),장리라 ( Lee La Jang ),이은영 ( Eu 대한결핵 및 호흡기학회 2007 Tuberculosis and Respiratory Diseases Vol.63 No.5

Standard antituberculous therapy, including isoniazid (INH), rifampin, ethambutol, and pyrazinamide (PZA), is widely used to treat active tuberculosis. The most important side effect is hepatotoxicity. In a standard four-drug regimen, PZA was the most common cause of drug-induced hepatitis and was dose-related. The incidence of drug-induced hepatitis is high at doses of 40∼70 mg/kg per day but has fallen significantly since the recommended dose was reduced. Liver toxicity induced by PZA is rare at doses of 25 mg/kg per day or less. PZA-induced fulminant hepatic failure is also rare but fatal. We report a case of fulminant hepatic failure caused by a re-challenge of PZA. (Tuberc Respir Dis 2007;63:435-439)

전통적 공간구성에서 나타나는 심적 가치(心的 價値)의 적용에 관한 연구 : 아동을 위한 자람 공간의 형태화(形態化)를 중심으로

문대성 ( Dae Sung Moon ),김유림 ( Yoo Rim Kim ) 한국기초조형학회 2006 기초조형학연구 Vol.7 No.4

태권도 수련이 초경 후 여학생의 체력과 성장인자 및 여성호르몬에 미치는 영향

문대성 ( Dae Sung Moon ),서동균 ( Dong Kyun Seo ),김태일 ( Tae Il Kim ),김우규 ( Woo Kyu Kim ),신중달 ( Jung Dal Shin ) 대한무도학회 2009 대한무도학회지 Vol.11 No.2

본 연구는 초경 후 여학생을 대상으로 태권도 수련이 체격과 체력 그리고 혈중 성장인자와 여성호르몬에 어떤 영향을 미치는지를 알아보기 위하여 초경을 경험한 여학생(11~13세), 18명을 대상으로 운동군(9명), 대조군(9명)으로 나누어 1일 60분, 주 5회, 12주간 운동강도 60~70%HRmax로 태권도 수련 후 다음과 같은 결과를 얻었다. 태권도 수련군에서 신장(p<.05)이 유의하게 증가하였고 체중, 체질량지수, 체지방률은 유의한(p<.01, p<.01, p<.05) 감소가 나타났다. 반면 대조군에서는 체중과 체질량지수가 유의한(p<.05) 증가를 나타내었다. 그리고 그룹간에서는 체중, 체질량지수, 체지방량에서 유의한(p<.001) 차이를 나타내었다. 체력은 태권도 수련군에서 모든 체력요소들이 유의하게 개선된 것으로 나타났으며 대조군에서는 체전굴과 사이드스텝이 유의한(p<.05) 증가를 나타내었다. 그리고 그룹간에서는 악력, 제자리멀리뛰기, 눈감고외발서기, 50m 달리기가 유의한(p<.001) 차이를 나타내었으며, 체전굴, 윗몸일으키기, 10m왕복달리기에서도 유의한(p<.01) 차이를 나타내었다. 호흡순환기능의 변화에서는 태권도 수련군에서 최대산소섭취량, 체중당최대산소섭취량이 유의하게(p<.01, p<.05) 증가하였으며 그룹간에서도 최대산소섭취량, 체중당최대산소섭취량이(p<.05, p<.01) 차이를 나타내었다. 성장인자의 변화에서 태권도 수련군은 IGF-I과 성장호르몬가 유의하게(p<.05, p<.01) 증가하였으며 그룹간에서는 IGF-I과 성장호르몬가 유의한(p<.01) 차이를 나타내었다. 여성호르몬의 변화로 태권도 수련군과 대조군 모두 유의한 차이가 나타나지 않았다. 이상과 같이 12주간의 초경 후 여학생의 태권도 수련이 체격과 체력 그리고 성장인자에 긍정적인 영향을 미치므로 품새 위주의 태권도 수련이 여학생에게 바람직한 운동프로그램이라는 것을 시사하고 있다. The purpose of the study was to investigate the effect of Taekwondo training on physical fitness, estrogen and growth factor in men after menarche. The control group was composed of 9 men healthy students who not taking any particular physical training, and did menarche at 11~13 years. Subjects as taekwondo group were 9 men who had trained taekwondo training for 12week(60min/day, 5 days/week, 60~70%HRmax). The results of this study are as follows: The height significantly(p<.05) increased, the body weight increased. %fat significantly(p<.01) decreased in taekwondo groups, and increased in control group, but no significant. The physical fitnesses (VO2max, grip and back strength, trunk flexion, standing broad jump, closed eyes standing with a leg, 50m running, 10m shuttle run, side step test) significantly(p<.05) increased at taekwondo groups, they increased but no significant at control groups. After taekwondo training, growth hormone and IGF-1 significantly(p.05) increased at both groups. Estrogen, estradiol decreased but no significant at taekwondo groups, progesterone increased but no significant at control groups. In conclusion, taekwondo training positively effect the height, physical fitness and growth hormone and IGF-I but not significantly to the body weight, %fat, estrogen, estradiol and progesterone.

골프연습자의 연습실태와 운동상해에 관한 연구

문대성(Moon Dae-Sung),김현권(Kim Hyeon-Kwon),천인호(Chun In-Ho) 한국체육과학회 2000 한국체육과학회지 Vol.9 No.2

The purpose of this study that was to investigate the practice state and sports injury women golfer. Following conclusion was obtaied from the analysis of the practice state and sports injury through questionaring of 200 female golf practicers : 1. The practice state of golf practicers. This study showed that practice times(per week) have trained five days and practice hour (per day) investigated two hour below 2. The sports injury of golf practicers. This study showed that 47% of the golf practicers had an sports injury during the exercise. especially they were injury on the elblow(48%), the shoulder(23%), the rib-bone(21%), and the waist(17%) with high percentage. first. The pattern of injury was highest in during exercise as 48.0%. secund. Warming up period was mostly minutes as 53.0% third. An important of warming up was high percentage. four. he most injury reason were negligence 38.0% irregular pracice 21.0% over training 17.0%.

초등학교 고학년 학생의 체육교과에 대한 태도 분석

문대성 ( Dae Sung Moon ) 한국스포츠리서치 2007 한국 스포츠 리서치 Vol.18 No.4

Higher-grade student attitude to physical education has been investigated statistically to provide the basic reference for teaching the subject education in the elementary school. The objective is to study the Student Attitudes toward the subject of Physical Education and toward the method of teaching in the class. For the statistical measurement, the population has been chosen as the fifth and sixth grade 319 Student (160 male; 159 female) from four different elementary school in Seoul, Korea. The Questionnaire in this study has been selected from Luke & Cope (1994) and the chi-square test has been applied to determine statistical significance of the data, accepting level for all significances was above α=.05. Concerning the Physical Education Class, the results show that the student have a positive attitude to Physical activities in class, the class organization, skill level, fitness development, and evaluation for their behaviors, where as they take a negative attitude to new skill drill, new activities, skill practice time, and fitness tests. In addition, the results show that students enjoy playing team games rather than individual ones; cooperation rather than competition. this study clearly indicates that the students want more affirmative and cooperative class environment and they expect to be evaluated not only by skill itself, but also by class participation and activity in their Physical Education Class. The attitude and preference toward the class between male and female students did not show any difference in this study.

지문 인증을 이용한 보안 토큰 시스템 구현

문대성(Dae-Sung Moon),길연희(Youn-Hee Gil),안도성(Do-Sung Ahn),반성범(Sung-Bum Pan),정용화(Yong-Wha Chung),정교일(Kyo-Il Chung) 한국정보보호학회 2003 정보보호학회논문지 Vol.13 No.4

상업 스포츠 센터 관리자의 거래적 리더십과 조직시민행동의 관계

문대성(Moon Dae-Sung) 한국체육과학회 2006 한국체육과학회지 Vol.15 No.3

The transformational leadership refers to the process of influencing major change in the attitudes and assumptions of organization members and building commitment for the organization's mission or objectives. In order to achieve the aforementioned purposes, the relevant data were gathered from 274 male/female employees who worked at the commercial sport centers which were located in Seoul and Incheon City. They were selected by the systematic cluster random sampling method. The statistical methods used for the analysis of this study were one-way ANOVA, simple regression analysis. The results of this study are described as follows. Firstly, it was found out that male is higher than female and In addition to this, less than one year appeared highly compared with the career person. in transactional leadership. Secondly, it was appeared that male is higher than female and 6-10 years experienced man than other experienced man in organizational citizenship behavior. Thirdly, the contingent reward are the most influential variables on the organizational citizenship behavior among the transactional leadership of the managers.