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GPX1 및 hOGG1 유전자다형성에 따른 유전자의 산화적 손상 및 폐암 발생 위험도 평가
이철호,이계영,최강현,홍윤철,노성일,엄상용,고영준,장연위,임동혁,강종원,김헌,김용대,Lee, Chul-Ho,Lee, Kye-Young,Choe, Kang-Hyeon,Hong, Yun-Chul,Noh, Sung-Il,Eom, Sang-Yong,Ko, Young-Jun,Zhang, Yan-Wei,Yim, Dong-Hyuk,Kang, Jong-Won,Kim, H 대한예방의학회 2006 예방의학회지 Vol.39 No.2
Objectives : Oxidative DNA damage is a known risk factor of lung cancer. The glutathione peroxidase (GPX) antioxidant enzyme that reduces hydrogen peroxide and lipid peroxides plays a significant role in protecting cells from the oxidative stress induced by reactive oxygen species. The aim of this case-control study was to investigate effects of oxidative stress and genetic polymorphisms of the GPX1 genes and the interaction between them in the carcinogenesis of lung cancer. Methods : Two hundreds patients with lung cancer and 200 age- and sex-matched controls were enrolled in this study. Every subject was asked to complete a questionnaire concerning their smoking habits and their environmental exposure to PAHs. The genotypes of the GPX1 and 8-oxoguanine glycosylase 1 (hOGG1) genes were examined and the concentrations of urinary hydroxypyrene (1-OHP), 2-naphthol and 8-hydroxydeoxyguanosine (8-OH-dG) were measured. Results : Cigarette smoking was a significant risk factor for lung cancer. The levels of urinary 8-OH-dG were higher in the patients (p<0.001), whereas the urinary 1-OHP and 2-naphthol levels were higher in the controls. The GPX1 codon 198 polymorphism was associated with an increased risk of lung cancer. Individuals carrying the Pro/Leu or Leu/Leu genotype of GPX1 were at a higher risk for lung cancer (adjusted OR=2.29). In addition, these individuals were shown to have high urinary 8-OH-dG concentrations compared to the individuals with the GPX1 Pro/Pro genotype. On the other hand, the polymorphism of the hOGG1 gene did not affect the lung cancer risk and the oxidative DNA damage. Conclusions : These results lead to a conclusion that individuals with the GPX1 Pro/Leu or Leu/Leu genotype would be more susceptible to the lung cancer induced by oxidative stress than those individuals with the Pro/Pro genotype.
김선재 ( Seon J. Kim ),윤영채 ( Young C. Yoon ),김범환 ( Bum H. Kim ),김정숙 ( Jeong S. Kim ),이철호 ( Chul H. Lee ) 한국지역개발학회 2004 韓國地域開發學會誌 Vol.16 No.2
The purpose of this study is to examine the impact of the new administrative capital transfer on rental housing demand in Daejon, Korea through the estimation of rental housing demand equation. The study focuses on the statistical estimation issues encountered in calibrating rental housing demand: selectivity bias, estimation of hedonic prices, and application of the permanent income hypothesis. The results show a tenant has a higher marginal probability of being a tenant household than of being a homeowner and less demand for housing services after the announcement of the new administrative capital transfer.
단섬유로 강화된 Nylon 6.6/Ionomer 복합재료의 물리적 특성
서광석,박광석,이철호 고려대학교 공학기술연구소 1999 공학논문집 Vol.37 No.1
Physical properties of short glass fiber-reinforced nylon 6,6 and ionomer (Surlyn 9020) composites were studied. While ionomer content was increased from 0 to 30phr, tensile strength and flexural strength were decreased, whereas impact strength had maximum value at 20phr. Permittivity, tans, and volume resistivity had no remarkable difference with the variation of ionomer content, In PEA (Pulsed electroacoustic) experiments, for moisture-free specimens, homocharges were accumulated near electrodes and increased with the increase of ionomer content up to 20phr. It was found that moisture uptake rate of nylon 6,6 was declined due to hydrophobicity of ionomer. For moisture-contained specimens, homocharges were increased with moisture content at first, and then decreased while moisture content saturated. Moisture-ionomer interaction was a major mechanism of homocharge formation.