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전립선암으로 근치적 전립선적출술을 받은 한국인의 특징과 예후
김대성(Dae Sung Kim),변석수(Seok-Soo Byun),이상은(Sang Eun Lee),이은식(Eunsik Lee),최한용(Han Yong Choi),정병하(Byung Ha Chung),최영득(Young Deuk Choi),안한종(Hanjong Ahn),황태곤(Tae-Kon Hwang),이강현(Kang Hyun Lee),김원재(Wun-Jae Ki 대한비뇨기종양학회 2010 대한비뇨기종양학회지 Vol.8 No.1
Purpose: There is a great difference between the prostate cancer in Asian men compared to Western men. We evaluated the clinicopathologic features and prognosis of Korean men with prostate cancer who underwent radical prostatectomy. Materials and Methods: We reviewed retrospectively the clinicopathologic parameters including age, preoperative PSA, stage, Gleason score and so on in 2,783 men underwent radical prostatectomy in 14 institutions. Of 2,783 men, patients with prior radiotherapy, neoadjuvant treatment, suspicious lymph node invasion, distant metastasis and treatment failure were excluded. We evaluated recent change in clinical parameters. 2,081 men with localized prostate cancer were analyzed for the biochemical recurrence-free survival rates. Results: Proportion of patients with serum PSA of less than 10ng/ml were 38.9% in 1999. However the proportion were 68.6% in 2008. The 5-year overall biochemical recurrence-free survival rate (BCR-FS) was 48%. The 5-year BCR-FS according to the preoperative serum PSA, biopsy Gleason score, pathologic T stage, margin positivity had the lower level than Western series. Conclusions: The proportion of patients with serum PSA <10ng/ml were increased in Korean men with prostate cancer. However, the BCR-FS had the lower level than Western men. Therefore, we must consider that the prostate cancer in Korean men have a unfavorable prognosis compared with Western men.
정창욱(Chang Wook Jeong),변석수(Seok-Soo Byun),이은식(Eunsik Lee),이상은(Sang Eun Lee),정병하(Byung Ha Chung),최영득(Young Deuk Choi),최한용(Han Yong Choi),이현무(Hyun Moo Lee),안한종(Hanjong Ahn),황태곤(Tae-Kon Hwang),이강현(Kang Hy 대한비뇨기종양학회 2013 대한비뇨기종양학회지 Vol.11 No.3
Purpose: Previously, Seoul National University (SNU) prostate cancer (PC) stage calculator was developed to predict the pathological stage of clinically localized PC after radical prostatectomy (RP) in Korean men. We evaluated its generalizability and compared their clinical values with 2013 Partin tables by Korean multicenter cohort. Materials and Methods: Evaluated cohort consisted of 2,607 patients who had clinical stages T1c-T3a PC and were treated with RP at 14 institutions in Korea. After excluding 262 cases with prior hormone or radiation therapy and 604 cases with missing data, 1,741 cases were analyzed. Predictive accuracy was evaluated using the area under the receiver operating characteristic curve (AUC). The agreement between the predicted values with observed outcome was assessed with calibration plot. SNU PC stage calculator was compared with 2013 Partin tables applying to this cohort using DeLong method and decision curve analysis. Results: The accuracies of SNU PC stage calculator was all higher than those of 2013 Partin tables to predict organ-confined disease (0.755 vs. 0.711, p<0.001), extraprostatic extension (0.743 vs. 0.665, p<0.001), seminal vesicle invasion (0.833 vs. 0.764, p<0.001), and lymph node metastasis (0.842 vs 0.760, p=0.019). The observed outcomes were well calibrated with their predicted values by the calculator. Decision curve analyses demonstrated higher net benefits of SNU PC stage calculator compared with 2013 Partin tables.
신완식,송호철,김훈교,김양리,강진형,강문원,박연준,김선무,황태곤 대한감염학회 1992 감염 Vol.24 No.3
Carumonam is a new monocyclic β-lactam antibiotic which has a potent antimicrobial activity against a number of gram-negative bacteria. The in vitro antibacterial activity of carumonam against gram-negative clinical isolates was studied in comparison with that of aztreonam and other drugs by the agar dilution method. The clinical efficacy was evaluated in 27 patient with infection; 10 cases of urinary tract infection, 14 cases of respiratory tract infection and 3 cases of bacteremia. 1) In vitro study, carumonam has an excellent antibacterial activity like aztreonam against aerobic gram-negative bacilli, especially S. Marcescens and K. Pneumoniae. 2) Carumonam was effective in 9 out of 10 cases with urinary tract infection. The organisms were eradicated in 7 out of 8 cases from which microorganisms were isolated and one patients had superinfection with X. maltophilia. 3) It was effective in 11 out of 14 cases with a rate of effectiveness of 73% in respiratory tract infection and 2 out of 3 cases in bacteremia. 4) The adverse effect was observed in 1 case with transient elevation of SGOT and SGPT.