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Jee-hyun, Hwang(황지현),Kyung-Min Lim(임경민) 환경독성보건학회 2021 한국독성학회 심포지움 및 학술발표회 Vol.2021 No.5
Biocides are widely used in household products. Humans are exposed to biocides through dermal, inhalational, and oral routes. However, information on the dermal and inhalational toxicity of biocides is limited. We evaluated the effects of biocides on the skin and airways using the reconstructed human epidermis model KeraSkin™ and the airway model SoluAirway™. We determined the irritancy of 11 commonly used biocides in the KeraSkin™ and SoluAirway™ by viability and histological examinations. BIT and CC were found to cause skin irritation at the approved concentrations or at the concentration close to approved limit while the others were non-irritants within the approved concentration. These results were confirmed via histology, wherein skin irritants induced erosion, vacuolation, and necrosis of the tissue. In the SoluAirway™, most of the biocides decreased cell viability even within the approved limits, except for PE, IPBC, and deltamethrin, suggesting that the airway may be more vulnerable to biocides than the skin. Taken together, our result indicates that some biocides can induce toxicity in skin and airway. Further studies on the dermal and inhalational toxicity of biocides are warranted.
Glucan 처리 당근에서 Phenylalanine Ammonia - Lyase 의 활성에 미치는 에틸렌 및 Ca2+ 의 효과
황지현(Jee Hyun Hwang),김명원(Myoung Won Kim),강영희(Young Hee Kang) 한국식물학회 1994 Journal of Plant Biology Vol.37 No.3
Involvement of ethylene and Ca^2+ on the induction of pheaylalanine ammonis-lyase (PAL) was investigated in Daucus carota L. suspension culture system. Ethylene production started to increase about 3 h after glucan treatment. And the maximal induction of ethylene was preceded by PAL induction by 30 min. After the treatment of ethrel, PAL activity was increased. When calls were treated with glucan and Co^2+, PAL activity was simutaneously reduced. Ethylene production was reduced dramatically in calcium-free medium, even though glucan was treated. PAL activity and ethylene production was inhibited conspicuously when ethylene glycolbis(β-aminoethyl ether) N_+N_+N^-_+N^+ - tetraacetic acid (EGTA) was treated with glucan. Verapamil and trifluoperazine also inhibited PAL activity. When cells were treated with calcium ionophore A23187, PAL activity was increased in nontreated medium. We report here PAL activity is increased in related to ethylene production and involvement of Ca^2+ in glucan-treated carrot suspension cells.
김지현 ( Ji Hyun Kim ),김승진 ( Seung Jin Kim ),황지현 ( Jee Hyun Hwang ),유수민 ( Su Min Yoo ),박용덕 ( Yong Duk Park ) 대한예방치과·구강보건학회 2012 大韓口腔保健學會誌 Vol.36 No.3
Objectives: The aim of this study was to examine and analyze the awareness of dentists of the problems of elderly life, and to provide direction for a desirable retirement plan, according to individual awareness. Methods: A stratified sampling method was used in proportion to the number of dental clinic and dental hospitals practicing in the Seoul metropolitan area, Incheon city, and Gyeonggi province. The data was verified by the Korea Dental Association`s 2010 list of dentists, and for stratified random sampling, was stratified according to the number of regional dental clinics. Dentists from 855 dental clinics and dental hospitals were selected between May and Sept. 2010 for a self-administered survey questionnaire, by mail, fax or interview. 484 valid questionnaires (56.7%) were collected from respondents for data analysis. The study used SPSS (ver. 18.0) to analyze Chi-square tests, one-way ANOVA, and independent t-tests on the collected survey data. Results: The responders pointed out that ``health related problems``, ``financial problems``, and ``isolation from society``, were, in order, the main problems of the elderly stage of life. Dentists showed the highest response to their own suitable retirement age of ``60- under 70``. The more that responders recognized his or her own good personal health status, the lower the subjective degree of anxiety for financing after retirement (P<0.001). Responders who had monthly net income of ``under 1,500 ten thousand won`` showed the highest degree of anxiety, and those who had ``over 2,500 ten thousand won`` showed the lowest degree of anxiety, which showed statistical significance (P<0.001). Conclusions: In conclusion, ``health related problems`` was the highest predicted problem for elderly dentists. Therefore, dentists should actively engage in a healthy living style to prepare for a healthy old age. Furthermore, early preparation and establishment of countermeasures to actively manage predictable problems in elderly living is needed.
3D 인공 피부모델을 이용한 화장품 안전성 및 효능 평가 연구
김규리 ( Kyuri Kim ),황지현 ( Jee-hyun Hwang ),임경민 ( Kyung-min Lim ) 한국동물실험대체법학회 2021 동물실험대체법학회지 Vol.15 No.1
Cosmetics and their raw materials must be safe for consumers under the conditions of use. Safety assessments for some toxicological endpoints and efficacy evaluation of raw materials have relied on animal studies for a long time. However, in addition to animal welfare concerns and regulatory measures, more human-relevant data without animal testing have led to a new approach to safety assessment. As animal testing for safety evaluation of cosmetics and its raw materials is prohibited, various alternative test methods have been developed and used. Recently, interest in efficacy evaluation and safety confirmation systems using artificial skin models as alternative for animal testing is increasing. In this study, latest research trends for alternative animal testing methods for cosmetic safety evaluation were reviewed, and the limitations and directions for improvement of the current alternative animal testing methods were investigated. In addition, the current status of cosmetic efficacy evaluation research using artificial skin model and guidelines for evaluating the functional efficacy of existing cosmetics were investigated.
성정민 ( Jeong Min Seong ),황지현 ( Jee Hyun Hwang ),이선경 ( Sun Kyoung Lee ),김지현 ( Ji Hyun Kim ),김응권 ( Eung Kwon Kim ),송귀숙 ( Kwui Sook Song ),김창희 ( Chang Hee Kim ),유수민 ( Su Min Yoo ),이영수 ( Young Soo Lee ),장종 대한예방치과·구강보건학회 2011 大韓口腔保健學會誌 Vol.35 No.1
Objectives. The purpose of this study was to examine the Professors, who teach the Dental Hygiene Program in Korea, on the awareness of the research ethics andcheck their educational backgrounds on research ethics during their past academic studies, in an attempt to provide and promote a basic foundation for future education and regulations in research ethics. Methods. The subjects in this study were total of one hundred and sixty fine full time professors and part time professors registered on Dental Hygiene Department professors association as of July 2010. Research materials were collected by mail, telephone call with the Department Dean and research assistant, fax, email, and walk in visitation from September 2010 to December 15th 2010. Results. 66.1% of respondents, which is more then majority, have never taken a research ethic education during their university years or continuing education courses provided by Korean Dental Hygienists Associations. Regarding the correlation between plagiarism in dissertation, citation styles, and redundant publication, plagiarism in dissertation and redundant publication had a statistically significant correlation of .370 which was the highest correlation factor (p<0.01). Conclusions. Education on research ethic should be provided and reinforced not only tothe current dental hygiene academic faculties, but also to the dental hygiene students who are the next future professors and researchers of this field. Also, rules and regulations on research ethic should be more publicized and educated through websites, educational institutions, and associations just like other foreign universities.
가전제품 설치수리기사가 인지하는 코로나19에 대한 감염 불안이 업무스트레스에 미치는 영향
권은중 ( Eun-jung Kwon ),황지현 ( Jee-hyun Hwang ),김희걸 ( Hee-gerl Kim ) 한국산업보건학회 2021 한국산업보건학회지 Vol.31 No.4
Objectives: The purpose of this study is to understand the effect of infection anxiety about COVID-19 perceived by home appliance installers and repair technicians on work stress. Methods: To collect data, the purpose of the study was explained through the labor union of domestic home appliance service companies, and a survey was conducted through mobile to 286 home appliance installers and repair technicians who agreed to the survey. Results: As a result of the analysis, it was found that age, fatigue, work satisfaction, visit time, and Corona 19 infection anxiety had a significant effect on work stress. In other words, the higher the age, the higher the fatigue, the lower the job satisfaction, the higher the work stress was when the visit time was more than 30 minutes, and the higher the Corona 19 infection anxiety, the higher the work stress. Conclusions: Based on the results of this study, the following suggestions are made. First, in order to prevent work stress, we propose the development of a workplace health care program that can solve fatigue. Second, it is necessary to prepare a working environment and provide institutional support to reduce work stress by increasing Job satisfaction. Third, a workplace quarantine measures is needed to prevent infection for essential-workers who do face-to-face work in preparation for possible infectious diseases in the future.
황지현,강봉구,최은,이양균 순천향의학연구소 1995 Journal of Soonchunhyang Medical Science Vol.1 No.1
The purpose of this study was to evaluate the analgesic effect of micro-TENS (Magicpulse) in patients with acute and chronic pain. We divided the pain of the subjects into two groups, such as acute pain(pain duration less than 3 months) and chronic pain(more than 3 months), and the analgesic effect was measured by VAS(Visual Analogue Scale) difference, VAS improvement ratio and thermographic change between pre-treatment and post-treatment. As a result, VAS difference was 4.59 ±2.75 in acute pain group and 4.00 ±1.96 in chronic pain group(p<0.01, respectively), and the patients with VAS improvement ratio(>50%) were 62.4% in acute pain group, 46.6% in chronic pain group. A significant increase in skin temperature was observed after treatment(p<0.05). We concluded that the micro-TENS has an analgesic effect on both acute and chronic pain, and the better effect is expected in acute pain than chronic pain.