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경증태아 빈맥에서의 심박동 각변수의 근사엔트로피 및 정준상관분석
황정혜(Jung Hye Hwang),윤상순(Sang Soon Yoon),문형(Hyung Moon),박영선(Young Sun Park),차경준(Kyung Joon Cha),박문일(Moon Il Park) 대한산부인과학회 2001 Obstetrics & Gynecology Science Vol.44 No.12
N/A Objective : This study was to determine differences of fetal heart rate (FHR) parameters, approximate entropy, canonical correlation coefficient and perinatal outcome between fetuses with mild baseline tachycardia (FHR range : 161-180 bpm) and fetuses with normal baseline FHR. Methods : Using our own software developed by Hanyang University Hospital in Korea, non-stress tests were performed for 20 minutes and cases were divided into two groups; mild tachycardia group (FHR range ; 161-180 bpm, 100 cases) and normal group (FHR ranges ; 120-160 bpm, 197 cases). And then, we analyzed various FHR parameters, approximate entropy, adjusted canonical correlation coefficient and perinatal outcome in each group. Results : Perinatal outcomes between two groups were not significant. However, mean minute range (MMR) was lower and the number of deceleration (15 bpm for 15 sec, more than one) was significantly higher in fetuses with mild tachycardia than normal group (p<0.05). The apprximate entropy and canonical correlation coefficient showed respectively 0.77±0.02, 0.45±0.06 in mild tachycardia group and 0.80±0.01, 0.43±0.07 in normal group, there were no significant differences. Conclusions : The results showed that mild baseline tachycardia in this range were not associated with an increase in the incidence of adverse perinatal outcome, although decreased MMR and increased number of deceleration in mild tachycardia group may suggest hidden subtle change of FHR parameters. Fetuses with mild tachycardia were not different irregularity of FHR quantified by approximate entropy from normal fetuses and were also similar tendency to correlation with perinatal outcome by adjusted canonical correlation coefficient, which is a multivariate extension of the univariate correlation analysis
초기 임신 탈락막에서의 TGF - β1 , β2 의 발현 ; 기저탈락막과 주변탈락막에서의 비교
황정혜(Jung Hye Hwang),고승희(Seung Hee Koh),한동익(Dong Ik Han),정성로(Sung Ro Chung),박문일(Moon Il Park),황윤영(Youn Young Hwang),장세진(Se Jin Jang) 대한산부인과학회 2001 Obstetrics & Gynecology Science Vol.44 No.6
N/A Objective: Implantation is a complex process between developing embryo and maternal endometrium, especially decidua. Decidua is a specialized endometrium during pregnancy and decidua basalis is the real implantation site infiltrated directly by trophoblast cells. The decidua parietalis lines the uterine cavity away from the implantation site, not real implantation site. TGF- β1 and TGF-β2 have known as multipotential cytokines and expression of TGF- p and TGF-/3. increased in decidua during pregnancy than secretory phase of endometrium. However, there is little known about their expression in decidua parietalis, compared with decidua basalis. The purpose of this study was to compare the expression of TGF-β1 and TGF-β2 in the decidua basalis and decidua parietalis during early pregnancy. Methods: The early pregnant 26 samples were obtained at hysterectomy, which underwent surgery for cervical carcinoma, ovarian cancer, etc. Immunohistochemical staining of TGF- β1 and TGF-β2 was performed and staining intensity was semiquantified by using HSCORE. Results: TGF-β1 was slight]y expressed in the decidua basalis and decidua parietalis and there were no differences among them. But the expressions of TGF-β2 of stroma and glandular cells were higher in the decidua basalis than parietalis (p < 0.005). And the expressions of TGF-β2 were stronger than that of TGF-β1 in the both decidua of ear]y pregnancy (p < 0.005). Conclusion: In decidua basalis, especially stromal cells, the expression of TGF-β2 was increased than in the decidua parietalis. This suggests that TGF-β2 may play an important role in decidua basalis that is directly invasion site by embryo and can be regulated by embryonic derived local factor. TGF- 2, compared with TGF- β1, was increased in both implantation site and suggest it may regulate implantation process during early pregnancy.
The expression of germ-Line related markers in human embryonic stem cells by BMP2 and BMP4
황정혜 ( Jung Hye Hwang ),( Yun Kyung Jang ),( Jung Han Lee ),( Seung Ryong Kim ),( Moon Il Park ),( Sung Ro Chung ),( Kyung Tae Kim ),( Hyung Moon ),( Youn Young Hwang ),( Kye Seong Kim ),( Woo Suk Hwan 대한산부인과학회 2004 대한산부인과학회 학술대회 Vol.90 No.-
원인불명의 불임환자에서의 Transforming Growth Factor-β1, β2의 발현
황정혜 ( Jung Hye Hwang ),이재억 ( Jae Auk Lee ),장세진 ( Se Jin Jang ) 대한산부인과학회 1997 Obstetrics & Gynecology Science Vol.40 No.12
Objectives: The purpose of this study was to determine the differences of immunohistochemical localization of TGF-β1 and TGF-β2 in the human endometrium of fertile and infertile patients. Methods: We have studied the expression of TGF-β1 and TGF-β2 in the human endometrium of fertile and infertile patients by immunohistochemical staining method. Results: In the women with unexplained infertility, TGF-β1 and TGF-β2 were not expressed in the epithelial and stromal cells during the whole menstrual phase. But in epithelial cells of the fertile women, TGF-β1 was moderately expressed in the secretory phase and TGF-β2 was moderately expressed in the proliferative and secretory phase. In stromal cells of the fertile women, TGF-β1 and TGF-β2 were not expressed in the proliferative and secretory phase, that are similar to the results of unexplained infertility. There are significant differences in the expression of TGF-β1 and TGF-β2 between infertile and fertile patients, especially in the secretory phase of epithelial cells. Conclusions: These findings suggest that the absence of expression of TGF-β1 and TGF-β2 during the menstrual phase in women with unexplained infertility may have a negative effect on implantation and cell differentiation, and could result in ``incomplete`` embryo-maternal recognition, a possible consequence of which may be implantation failure.
파종성 결핵 환자에서 interferon-γ 수용체의 부분결핍에 관한 연구
황정혜 ( Jung Hye Hwang ),고원중 ( Won Jung Koh ),이신혜 ( Shin Hye Lee ),김은주 ( Eun Joo Kim ),강은해 ( Eun Hae Kang ),서지영 ( Gee Young Suh ),정만표 ( Man Pyo Chung ),김호중 ( Ho Joong Kim ),권오정 ( O Jung Kwon ) 대한결핵 및 호흡기학회 2005 Tuberculosis and Respiratory Diseases Vol.58 No.1
연구배경 : 결핵의 발병에 유전적인 소인이 존재하며 숙주 면역 반응에 IFN-γ가 중요한 역할을 한다고 알려져 있다. 파종성 NTM 또는 BCG 감염증 환자에서 IFN-γ 수용체 유전자 돌연변이가 밝혀져 있는데, 결핵 환자에서 IFN-γ 수용체의 부분결핍 유무는 잘 알려져 있지 않았다. 방법 : 2개 이상의 장기를 침범한 파종성 결핵 환자 6명을 대상으로 염기순서분석을 통해 IFN-γ 수용체 1과 IFN-γ 수용체 2의 부분결핍을 초래하는 유전자 이상이 Background : Interferon-gamma (IFN-γ) is essential in the immune response to mycobacterial infections, and a complete or partial deficiency in the IFN-γ receptor 1 (IFNγR1) or the IFN-γ receptor 2 (IFNγR2) have been reported to confer susceptibility to a