심낭 삼출액으로 인한 심장 탐폰과 거대결장증을 주 증상으로한 갑상선기능저하증과 병합된 임신 1례

이기헌 ( Ki Heon Lee ),유증배 ( Jung Bae Yoo ),김경태 ( Kyung Tai Kim ),황윤영 ( Youn Yeoung Hwang ),이재억 ( Jai Auk Lee ),안유헌 ( You Hern Ahn ) 대한주산의학회 1993 Perinatology Vol.4 No.3

한국형 출혈열과 합병된 임신 1례

김종호 ( Chong Ho Kim ),라명재 ( Myung Jae Ra ),문영진 ( Young Jin Moon ),황정혜 ( Jeong Hyae Hwang ),김승룡 ( Seung Ryong Kim ),황윤영 ( Youn Yeoung Hwang ) 대한산부인과학회 1997 Obstetrics & Gynecology Science Vol.40 No.12

Korean hemorrhagic fever complicated during pregnancy are rare. Korean hemorrhagic fever is a disease characterized by fevers, capillary dilatation, leakage of blood leading to hemorrhagic manifestations, and in severe cases, shock and renal tubular disease or acute respiratory failure. We experienced one case of pregnancy complicated with Korean hemorrhagic fever, so we report the case with brief review of the literatures.

사람 태반조직 Peroxidase의 부분정제 및 특성에 관한 연구

황윤영,차인돈,이희성 중앙대학교 의과대학 의과학연구소 1987 中央醫大誌 Vol.12 No.1

The purification and some properties of peroxidase of human term placenta was made in this study. The activity of peroxidase was measured by the method of Pu‥tter(1974). The results were summarized as follows; 1. The activity of peroxidase in cytosolic fraction of human term placenta was found to be 31.09 units per g wet tissue. 2. The peroxidase from human term placenta was purified about 22-fold by ammonium sulface precopitation and DEAE-cellulose column chromatography. 3. The most rapidly oxidized substrate was o-dianisidine. Benzidine, ascordic acid and guaiacol were oxidized with decreasing order of rats, while oxidation of dihydrooxyphenols and trihydrooxyphenol were very slow. 4. The partially purified peroxidase was strongly inhibited by i.omM of sulfhydryl reagents and cyanide. 5. The optimal tempreature for enzyme astivity was 40℃ and the optimal pH was 5.5. 6. The half life of the enzyme astivity was 30 min. at 60℃. 7. the Km values for hydrogen peroxid and guaiacol of peroxidase were 0.50mM and 0.44mM, respectively. 8. The purified enzyme was a typical hemoprotein.

난소암 환자의 복수내 인슐린양 성장인자 및 인슐린양 성장인자 결합단백의 농도에 관한 연구

김경태,이기헌,황윤영 대한부인종양 콜포스코피학회 1998 Journal of Gynecologic Oncology Vol.9 No.1

Based on the facts that expression of insulin-like growth factors(IGFs), their receptors, and insulin-like growth factor binding proteins(IGFBPs) have been found in many different types of malignancies including human ovarian cancer and their potent mitogenic effects in vitro, a role for IGFs mediated autocrine loop in oncogenesis and growth regulation of human malignancies was suggested. Since ascites support the biological environment for advanced ovarian cancer, it seemed to be resonable to measure the level of growth factors or cytokines in ascites for understanding precise mechanism of those factors in tumor biology. To investigate their roles and to evaluate prognostic significance in ovarian cancer, the IGFs/IGFBPs system were studied in the ascites, not in sera or cystic fluids, from 22 patients with ovarian cancer, who underwent surgical staging and subsequent cis-platinum based systemic chemotherapyery at the Department of Obstetrics and Gnecology, Hanyang University Hospital from Jan. 1989 through Dec. 1994. Ascites from 7 patients with benign disease were used as the control. IGF-Ⅰ, Ⅱ, IGFBP-1, and 3 were measured by immunoradiometric assay. The IGF-Ⅰ level was significantly higher in ascites with ovarian cancer compared with those of benign disease(63.3 11.1 vs 17.9 6.2ng/ml, p=0.0098), but the level of IGF-Ⅱ was not significantly different(70.5 13.9 vs 70.8 31.5 ng/ml, p=0.2827). IGFBP-1 levels were tend to be lower in ascites of patients with ovarian cancer than that of control(25.2 9.5 vs 58.6 28.2ng/ml, p=0.0637). However, IGFBP-3 levels had no statistically significant difference between two groups(779.7 110.6 vs 674.7 175.1ng/ml, p=0.8328). Although growth hormone levels were significantly higher in ascites with metastatic ovarian cancer than those of primary epithelial ovarian cancer, the levels of IGF-Ⅰ, Ⅱ, IGFBP-1 and 3 in ascites were not significantly different between two groups. IGF-Ⅰ levels were correlated with the levels of IGFBP-3 in ascites with ovarian cancer(Y=8.83X-2.0, r=0.745, p=0.0000). High level of IGF-Ⅰ in ascites of patients with ovarian cancer in this study was suggested that IGF-Ⅰ had an important role on growth regulation of ovarian cancer. As majority of ascites were obtained from advanced and poorly differentiated ovarian cancer patients, IGF-Ⅰ in ascites seemed to be related with intraperitoneal metastasis. Further large number of study including data from sera or cystic fluid will be needed to elucidate the role of the IGFs and IGFBPs in ascites of patients with ovarian cancer.

초음파를 이용한 형태학적 점수화 체제와 혈류학적 특징에 따른 부속기 종양의 진단 예측

박지수,이정한,조삼현,유중배,황윤영,문형,김경태 대한부인종양 콜포스코피학회 1999 Journal of Gynecologic Oncology Vol.10 No.3

Objects: The purpose of this study was to evaluate the relative usefulness of the morphologic scoring system and spectral doppler ultrasonographic analysis in differentiating between benign and malignant adnexal masses. Methods: All patients scanned between July 1995 and June 1998 with sonographically identified and pathologically confirmed adnexal masses formed the study group. The adnexal masses were scored as benign or malignant on the basis of their sonographic appearance. Specific categories included inner wall structure, wall thickness, septal structure, and echogenicity. Women whose morphologic findings were suspicious for malignancy underwent doppler sonography. A threshold pulsatility index of 1.0 and resistance index of 0.4 were used to differentiate benign from malignant lesions. The findings were correlated with the presence of malignancy. Results: Two hundred fifty one patients formed the study group; 215 patients were benign and 36 patients were malignant pathologically. Using the morphologic scoring system, 31 of the 36 malignant masses were classified as suggestive of malignant tumor, and 147 of the 215 benign masses were classified as not suggestive of malignant tumor (sensitivity, 86%; specificity, 68%; positive predictive value, 31%; negative predictive value, 97%). Doppler velocimetry was performed on a total of 62 patients, 19 patients with malignant tumors and 43 patients with benign tumors. A mean PI value of 0.85 and RI value of 0.52 for malignant tumors and mean PI value of 2.00 and RI value of 0.75 for benign tumors was shown. The PI value was significantly lower (p=0.001) in malignant than that of in benign masses, but RI value was not significant (p=0.184). The sensitivity and specificity in the detection of malignancy combined with doppler velocimetry was 86% and 67%, respectively. Conclusion: Doppler velocimetry studies did not add substantially to the prediction of malignancy using the morphologic scoring system.

자궁경부암 진단에 있어 세포진 검사의 정확도에 관한 연구

김승룡,조삼현,이재억,황윤영,문형,김경태,고승희 대한부인종양 콜포스코피학회 1999 Journal of Gynecologic Oncology Vol.10 No.2

Background: Carcinoma of the uterine cervix is a theoretically preventable disease because its precursor lesions can be detected by cervical Papanicolau smears and appropriately treated, Although cervical cytology screening programmes have resulted in the redution of cervical cancer incidence and mortality, Pap smear have been subjected to intense scrutiny and criticism in recent years. The focus of criticism has been the false-negative Pap smear, and the false-negative Pap smear is the major quality issue currently facing the physicians. To reduce the false-negative rate of Pap smear, it is essential to improve the accuracy of Pap smear. But false-negative rate of Pap smear has been reported variously. Objective: This study was undertaken to evaluate accuracy of Pap smear by study false-negative and false-positive rate of Pap smear and to determine whether false-negative and false-positive rate had any correlations with clinical factors. Study design: The study population was comprised of 346 women, who were undertaken gynecologic operation at the Department of Obstetrics & Gynecology at Hanyang University hospital between March, 1997 and April, 1998. All patients were taken Pap smear before operation. In 93 women of these, preoperative diagnosis were cervical intraepithelial neoplasia and carcinoma in situ of uterine cervix, and in 253 women of these, preoperative diagnosis were benign disease as uterine myoma or adenomyosis, etc. All of their surgical specimen were examined. Pap smear, pathology, medical charts of all patients were reviewed retrospectively, and false-negative rate and false-positive rate were calculated. Clinical factors that associated with false-negative and false-positive rate were evaluated. Fishers exact test and Pearson chi-square test were used of statistical analysis, Results: False-negative rate of Pap smear was 7.2%, false-positive rate was 4.6%, corresponding rate with histology was 88.2%. Sensitivity and specificity of PAP smear were 87.0% and 97.0% respctively. According to gross finding of uterine cervix, erosion was 46.6% in cervical intraepithelial neoplasia, 67.8% in carcinoma in situ, 66.6% in microinvasive carcinoma of uterine cervix and 55.3% of 103 erosion findings was cervical intraepithelial neoplasia, carcinoma in situ or microinvasive carcinoma. 23.1% of cervical lesion were normal gross finding. Menopause was associated with false-negative rate and previous vaginal infection history, previous cervical minor operation, delivery mode, contraception method, pelvic inflammatory disease history, vaginal bleeding at Pap smear and gross finding of cervix were not associated. There were no clinical factors that were associated with false-positive rate Conclusion: Compared with other reports, false-negative rate(7.2%) and false-positive rate(4.6%) of Pap smear was lower and corresponding rate(88.2%) was higher in Hanyang university hospital. Because of higher false-negative rate in menopausal women, it need more careful to take and interpretate Pap smear in these group.

자궁경부암 원통형 및 거대내자궁병소에 대한 관해항암화학요법의 치료효과

조수현,이정한,김승룡,황정혜,조삼현,이재억,류기영,황윤영,공미숙,문형,김경태,이문휘 대한부인종양 콜포스코피학회 1999 Journal of Gynecologic Oncology Vol.10 No.2

Objectives: This retrospective study was conducted to analyze the hypothesis that with neoadjuvant chemotherapy of vinblastine, bleomycin, and cisplatin followed by radical hysterectomy or radiation therapy and concurrent chemoradiation with cisplatin based regimen would improve survival in patients with barrel-shaped or bulky-endophytic (Diameter $gt; 4cm) cervical carcinomas than those of radiation alone or combined radiation and surgery. Study design: Eighty-eight patients with barrel-shaped or bulky-endophytic cervical carcinomas, treated at the Hanyang University Hospital from 1983 to 1997, were the subjects of this investigation. Fifty-six of these patients were treated by neoadjuvant chemotherapy followed by radical hysterectomy with bilateral pelvic lymphadenectomy ( Stage I b2, 8; IIa, 15; IIb, 20; III- IV, 13), twelve patients were treated by neoadjuvant chemotherapy followed by radiation therapy ( Stage IIb, 4; III-IV, 8), and twenty patients were treated by concurrent chemo-radiotherapy ( Stage IIb, 2; III-IV, 18). Results: The incidence of parametrial extension and pelvic lymphnode metastases was higher in patients with barrel-shaped or bulky-endophytic cervical carcinomas than non-barrel-shaped cervix (p=.025 : .001). 5-years disease free survival rate was determined for patients treated by neoadjuvant chemotherapy followed by radical hysterectomy with bilateral pelvic lymphadenectomy was 73.3 %. For patients treated by neoadjuvant chemotherapy followed by radiation therapy it was 45.7%. For patients treated by concurrent chemo-radiotherapy it was 46.1%. Conclusion: These data support an improvement in survival of patients with barrel-shaped or bulky-endophytic cervical carcinomas treated by neoadjuvant chemotherapy followed by radical hysterectomy or radiation therapy and concurrent chemo-radiotherapy.

반복성 포상기태 3예

이윤영,김경태,이재억,유중배,김영오,황윤영 대한부인종양 콜포스코피학회 1993 Journal of Gynecologic Oncology Vol.4 No.2

Three patients(1%) with recurrent molar pregnancy were managed arnong 317 registered molar pregnancies at the department of Obstetrics and Gynecology, Hanyang University Hospital between 197S and 1991. Reeurrent molar pregnancy seemed to be oaiated with a worsening histology and an increased incidence of proliferative trophoblastic sequelae in the successive episodes of hydatidiform mole. The treatment of recurrent mole is discussed and the literature regardmg recurrent rnolar pregnancy is reviewed.

난소의 경계성 상피종양의 임상 및 병리학적 고찰

김승룡,문영진,조삼현,이재억,신중식,한동익,황윤영,문형,김경태 대한부인종양 콜포스코피학회 1999 Journal of Gynecologic Oncology Vol.10 No.2

Twenty six cases of borderline ovarian tumor(BOT) were treated between Jan. 1985 and Dec. 1997 at the Department of Obstetrics and Gynecology, Hanyang University. The clinical records were reviewed for all patients including histopathology, clinical features, and follow-up. The frequency of BOT was 12%(26/214) of epithelial ovarian malignancies, and patients with these tumors tend to present at a younger age(36 yrs) than those with invasive carcinomas. In terms of histologic type, mucinous type(21/26: 81%) were more prevalent than serous tumor(5/21: 19%) in this study. The positive rate of CA 125 was 20% in serous, and the positive rate of CA 19-9 was 24% in mucinous tumor. The size of mucinous was larger than that of serous tumors(17.1 cm vs 9,3 cm). Almost all of these tumor categorized as early stage(stage I: 96%), however, only one patient with serous tumor had advanced stage of disease(stage III: 4%), Therefore BOT tend to be diagnosed as earlier than invasive carcinoma. About 2/3 of patients were treated as conservative surgery(unilateral salpingooophorectomy or enuclation). Postoperative adjuvant chemotherapy was not given about half of cases(13/26). Median follow-up was 43 months and recurrent case was found only one in serous tumor. All patients in this study are still alive and free of disease except one, 5-year survival rate was 100%. But large number of study and long-term follow-up are needed to make a decision to treat and manage of BOT.

고위험 조산환자에서 Fetal Fibronectin의 측정

이재규,박문일,고은선,김대운,황정혜,정성로,이재억,황윤영 大韓周産醫學會 1996 大韓周産醫學會雜誌 Vol.7 No.4