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박시경(Si Kyung Park),오갑진(Gab Jin Oh),배춘일(Choon Il Bae),김종현(Hyun Jong Kim),환완식(Wan Sik Han),정순간(Sun Gan Chung),조의환(Eui Whan Cho) 대한약학회 1997 약학회지 Vol.41 No.6
In our search for bioactive natural products with antitumor activity, we have valuated various extracts of Saururi Herba (Saururaceae), which has been used in traditional medicine for edema, beriberi, jaundice, turbid urine, carbuncle and furuncle. The hexane extract of the aerial part of this plant was found to show a potent cytotoxicity against several kinds of cultured human solid tumor cell lines (AGS, A549, HCT15, SKOV3, HEP-3B) in vitro. Using cytotoxicity-guided chromatographic separation of the hexane extract, cytotoxic constituent: 10-aminomethyl-3-hydroxy-4-methoxyphenanthrene-carboxylic acid lactam, was isolated and structurally identified by physico-chemical properties and spectroscopic evidences.