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사람의 기저막성 신중에서 신사구체 기저막의 비후 기전에 관한 연구
김태숙,이현순,홍혜경,김정연 대한신장학회 2000 Kidney Research and Clinical Practice Vol.19 No.5
Membranous nephropathy is the most common cause of nephrotic syndrome in adult. To investigate the molecular mechanisms which underlie thickening of glomerular basement membrane, we analyzed α 1(IV) collagen, α 4(IV) collagen, laminin A, laminin Bl, laminin B2, s-laminin, fibronectin, TGF-β1 and TGF-β2 mRNA expression in 21 renal biopsies with membranous nephropathy using in situ hybridization. In addition, 7 renal biopsies with no detectable abnormalities were used as control. In membranous nephropathy, the numbers of glomerular visceral epithelial cells expressing α1(IV) collagen, α4(IV) collagen, s-laminin and TGF-β1 mRNA were significantly larger than in controls(p$lt;0.05). Laminin A, laminin B1, larninin B2, fibronectin, and TGF-β2 mRNA were rarely expressed in membranous nephropathy and in control group. The number of TGFβ-1 mRNA expressing cells/glomerular cross-section correlated to that of α1(IV) collagen mRNA expressing cells (p$lt;0.05). These results indicate that increased presence of glomerent membrane proteins in spikes of membranous nephropathy is associated with enhanced mRNA expression of those proteins in the glomerular visceral epithelial cells. Subepithelial deposits in membranous nephropathy stimulate glomerular visceral epithelial cells to produce TGF-β1, which in turn could mediate the expression of glomerular basement membrane protein genes by glomerular visceral epithelial cells.
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