급성 천식발작시 혈장 및 요중 Endothelin 농도 변동

장중현 ( Jung Hyun Chang ),신태림 ( Tae Rim Shin ),우가은 ( Ga Eun Woo ),김종선 ( Jong Seon Kim ),홍은순 ( Eun Soon Hong ),서기열 ( Gi Yeoul Seo ),차주현 ( Joo Hyun Cha ),김미선 ( Mi Seon Kim ),김영선 ( Yeung Seon Kim ),조영주 ( Y 대한결핵 및 호흡기학회 1997 Tuberculosis and Respiratory Diseases Vol.44 No.4

경구유발시험으로 확진된 메밀알레르기 1례

홍은순,박진아,신태림,서기열,우가은,이나영,김미선,맹선희,조영주 梨花女子大學校 醫科大學 醫科學硏究所 1997 EMJ (Ewha medical journal) Vol.20 No.1

Buckwheat belongs to the Polygonacea or buckwheat family and is not a true cereral since it does not belong to the Graminiae, or grain family. Its products have long been considered excellent foods for both human and animal consumption. The earlist reference to case of buckwheat sensitivity was a report by Smith in 1909. He accurately described a case of angionerotic edema and urticaria in a young man upon ingestion accurately described a case of angionerotic edema and urticaria in a young man upon ingestion of small amounts of buckwheat, and violent asthma on the ingestion of moderate quantities of buckwheat. The authors have experienced one case of buckwheat allergy. The chief complaints were wheezing and dyspnea for several years. The skin tests showed positive reaction to the extracts of buckwheat flour and buckwheat husk. The buckwheat allergy is considered to be the model of the typeⅠallergy(that is lgE dependent type) proposed by Cooms and Gell. The antigenicity of buckwheat is extremely string, so oral provocation test must not easily be applied for fear of severe and dangerous reaction.

성인에서 혈중 렙틴 농도와 경동맥 내막중막 두께의 관계

이혜진,홍은순,홍영선,성연아 대한내분비학회 2002 Endocrinology and metabolism Vol.17 No.1

Background: Many studies have recently shown that leptin can promote angiogenesis via endothelial leptin receptors and induce oxidative stress in endothelial cells; These findings suggest the relationship between cardiovascular risk and blood leptin concentration. In the present study, we investigated the relationship between leptin concentration and carotid intima-medial thickness (CIMT) as an indicator of early atherosclerosis in adults. Methods: The study subjects comprised 138 (45 men and 93 women; mean age 42.4±7.5 years; mean BMI 24.0±2.7 ㎏/㎡) without history of diabetes, hypertension or cardiovascular disease. We measured CIMT by high resolution ultrasonography and plasma leptin levels by radioimmunoassay. Results: 1) No significant differences in age, BMI or CIMT between male and female subjects were noted, but the leptin levels in female were significantly higher than those in males. (8.42±5.90 ng/mL vs. 3.08±1.00 ng/mL, p<0.001) 2) CIMT showed a significant positive correlation with age (r=0.31, p < 0.001), BMI (r=0.25, p<0.01) and level (r=0.42, p<0.05) in simple regression analysis. 3) When male and female subjects were each divided into 3 groups by leptin concentration, no significant difference in CIMT among female subjects was found. In male subjects, CIMT was significantly higher in the highest tertile of leptin level than in the other 2 groups (0.65±0.03 ㎜ vs. 0.56±0.07 ㎜ and 0.53±0.07 ㎜, p<0.01) after adjustment for BMI and age. However, this difference was not significant after adjustment for smoking. 4) CIMT (0.61±0.05 ㎜ vs. 0.53±0.07 ㎜, p<0.01) and leptin concentrations (3.57±2.13 ng/mL vs. 2.20±1.39 ng/mL, p<0.05) were significantly higher in male smokers than in male non-smokers. Conclusion: Our results demonstrated significant correlation of CIMT to plasma leptin level before adjustment for smoking. A possible explanation is the permissive action of smoking on the atherogenic effect of leptin. However, further studies to elucidate the relationships and interactions among smoking, leptin level and the development of atherosclerosis will be needed

여성에서 Dehydroepiandrosterone sulfate와 인슐린저항성증후군의 연관성

김효정,홍은순,오지영,홍영선,성연아 대한내분비학회 2002 Endocrinology and metabolism Vol.17 No.5

연구배경: DHEA는 안드로겐 전구체로서 연령 증가에 따라 감소한다. 남성에서 DHEA는 인슐린저항성 및 심혈관질환에 대한 보호 작용을 하는 것으로 알려져 있으나 여성에서는 인슐린저항성과 심혈관질환에 대한 DHEA의 역할은 정립되어 있지 않다. 본 연구는 여성에서 인슐린저항성과 심혈관질환에서 DHEA의 역할을 규명하고자 시행하였다. 방법: 지역사회에서 무작위 추출된 471명의 여성을 대상으로 DHEA보다 반감기가 길고 일중 변동이 적은 것으로 알려져 있는 DHEAS의 농도를 방사면역측정법으로 측정하였다. DHEAS 농도와 인슐린저항성증후군 및 이 증후군을 구성하는 인자들과의 연관성을 관찰하였다. 결과: 1. 인슐린저항성증후군 인자의 빈도는 비만 25.3%, 내당능장애 8.5%, 고혈압 21.9%, 이상지질혈증 6.2%이었으며 인슐린저항성증후군의 빈도는 16.5%이었다. 2. DHEAS는 연령(r=-0.47, p<0.001), 수축기혈압(r=-0.18, p<0.001), 이완기혈압(r=-0.10, p<0.05), 공복혈당(r=-0.10, p<0.05), 포도당부하 2시간 혈당(r=-0.12, p<0.01), 및 중성지방(r=-0.16, p<0.01)과 의미있는 음의 상관관계가 있었다. 3. DHEAS 농도를 사분위수로 나눈 후 연령을 보정한 후 인슐린 저항성증후군 구성요소의 빈도를 관찰하였을 때 DHEAS 농도 감소에 따라 고혈압의 빈도가 유의하게 증가하였다.(p<0.05). 4. 연령(p<0.0001) 및 체질량지수(p<0.05)가 DHEAS에 영향을 주는 인자로 작용하였다. 5. 연령을 보정한 후 낮은 DHEAS농도는 인슐린저항성증후군의 위험인자로 작용하지 않았다. 결론: 여성에서 혈청 DHEAS 농도는 혈압, 혈당 및 혈청 지질 농도와 음의 상관관계가 있었으며, 연령을 보정한 후 DHEAS 농도가 감소함에 따라 고혈압의 빈도가 증가하는 것으로 보아 최소한 DHEAS는 인슐린저항성증후군에 대해 위해 작용을 가지지는 않는 것으로 생각된다. 그러나 DHEAS의 인슐린저항성증후군 및 심혈관질환에 대한 보호 작용을 증명하기 위해서는 이들 대상자를 전향적으로 추적 관찰하여 인슐린저항성증후군 및 심혈관질환의 발생과 DHEAS의 관계를 규명해야 할 것이다. Background: Dehydroepiandosterone (DHEA) is an androgen precursor, and is known to be decreased by the aging process. DHEA has been known to have a protective effect on insulin resistance and cardiovascular disease in men, but remains controversial in women. The aim of this study was to elucidate the role of DHEA on insulin resistance, and the risk for cardiovascular disease, in women. Methods: We analyzed the relationship between DHEA sulfate (DHEAS), known to have a longer half-life and less diurnal variation than DHEA, and insulin resistance syndrome (IRS) in 471 non-diabetic women from an urban community diabetes prevalence study. Serum DHEAS concentrations were measured using a commercially available radioimmunoassay kit. Results: 1. the frequencies of obesity, impaired glucose tolerance, hypertension and dyslipidemia were 25.3, 8.5, 21.9 and 6.2%, respectively, and the frequency of IRS was 16.5%. 2. DHEAS was significantly inversely correlated with age (r=-0.47, p<0.001), systolic blood pressure (r=-0.18, p<0.001), diastolic blood pressure (r=-0.10, p<0.05), fasting serum glucose (r=-0.10, p<0.05), postchllenge 2 hour glucose (r=-0.12, p<0.01) and triglycerides (r=-0.16, p<0.01). 3. As serum DHEAS concentrations, by quartiles, were decreased, the age-adjusted frequency of hypertension was significantly increase (p<0.05). 4. A Multiple linear regression analysis revealed that DHEAS was significantly associated with age (p<0.0001) and BMI (p<0.05). 5. A Logistic regression analysis showed that DHEAS was not associated with IRS after adjustment for age. Conclusion: DHEAS is inversely associated with age. DHEAS has no harmful effect, and may even have a protective role, on insulin resistance syndrome. Prospective examinations of DHEAS and insulin resistance syndrome in women are needed to confirm the mechanism for the association between DHEAS and the development of cardiovascular disease (J Kor Soc Endocrinol 17:675∼684, 2002).

Thiazide 계 이뇨제에 의한 호중구 침윤이 현저한 급성 간질성 신염 1 예

김미선,이은영,성순희,홍은순,윤견일,신태림,강덕희,최규복 대한내과학회 1998 대한내과학회지 Vol.54 No.2

Drug-induced acute interstitial nephritis, induced by unknown immunologic mechanisms, is inflammatory lesions of the tub3ointerstitial area due to several kinds of drugs as hapten and a rare, but increasingly recognized cause of acute renal failure. Drugs implicated include not only methicillin and other penicillins but also diuretics and nonsteroidal anti-imflammatory agents. Diagnosis of acute interstitial nephritis is important, because withdrawal of the offending agent will usually result in rapid improvement in renal function, and steroid therapy may reduce residual chronic renal damage. We are reporting a case of diuretic-induced acute interstitial nephritis in a 49 year-old female patient, who was given hydrochlomthiazide to treat hypertension. A percutaneous biopsy showed tubulointerstitial nephritis accopanying prominent neutrophil infiltration without glomerulitis. Withdrawal of the drug and use of corticosteroid led to remarkable improvement with renal function returning to normal.

대동맥 안장 색전증을 유발한 승모판 우종 1예

김종선,이진화,차주현,홍은순,신태림,이나영,이현경,서기열,조홍근,박성훈,한재열,한재진,안재호 대한순환기학회 1998 Korean Circulation Journal Vol.28 No.1