한국인 일반 여성의 HPV 감염 유병율 -부산지역 일반 여성에서의 HPV DNA 및 항 VLPs 항체 양성 빈도 -

홍숙희,이덕희,신해림,Hong, Sook-Hee,Lee, Duk-Hee,Shin, Hai-Rim 대한세포병리학회 2004 대한세포병리학회지 Vol.15 No.1

To investigate a population-based survey of the prevalence of human papillomavirus (HPV) infection in South Korea, we performed Papanicolaou smears and tests for HPV DNA and anti-HPV antibody detection in 909 sexually active general women (age range; 20-74 years, median 44 years) who were randomly selected residents from S district of Busan City. The presence of DNA of 36 different HPV types was detected by means of a GP 5+/6+ primer-mediated PCR enzyme immunoassay in cervical exfoliated cells, and IgG antibodies against L1 virus-like particles (anti-VLPs) of 5 HPV types 16, 18, 31, 33, and 58 were tested by means of enzyme linked immunoassay. The incidence of cytologic abnormality was 5.2% in Pap smear. The positive rate of HPV DNA was 10.4%, high in young women younger than 35 years old and proportionally increased according to the cytologic grades. The most often found HPV type was HPV 70, followed by HPV 16 and 33, and high-risk HPV types were more frequent in women younger than 35 years old. The most common HPV type in abnormal cytologic smears was HPV 16, followed by HPV 58 and 66. Anti-VLPs was positive in 19.7% and the frequent anti-VLPs type was against HPV 18, followed by HPV 31 and 16. The concordance between the markers for each specific HPV type was noted in 10 women and HPV 16 was the most frequent one. The incidence of multiple HPV infection was 18.9% and that of multiple anti-VLPs antibodies was 31%. Among 103 self-reported virgins, 4.9% had anti-VLP antibodies.

위암의 (胃癌) 통계학적 관찰과 병리조직학적 (病理組織學的) 분류의 문제점에 대하여

홍숙희(Sook Hee Hong),석동수(Dong soo Suk),주종은(Jong Eun Joo),임인숙(In Sook Lim) 대한소화기학회 1987 대한소화기학회지 Vol.19 No.1

N/A Total 211 lesions of stomach cancer were collected from the pathology department of the Pusan Paik Hospital during 1979 and 1985. Statistical analysis was carried out showing the following findings; 1) Among the total 211 cancers, male 139 and female 72. The male-female ratio is 2:1. 2) Average age is 52 years, male 54.7 and female 47.5 years old. These figures are 7 years lower than Japanese, and 4 years lower than Americans, clearly suggesting higher carcinogenic agents present in the Korean environment (food). 3) The size of the gastric cancer is 2-5 cm in diameter in the majority of the cases. Those of female are 0.6 cm larger in the average diameter than those of male. 4) The site of the cancer is antrum in half of all cases, the next is body and pylorus. 5) Depth of cancer invasion into the gastric wall shows the serosa the most frequent, 37.4%, the next is subserosa, 28.4%. There was the Early Gastric Cancer in 11% among all cancers of the stomach. 6) Metastasis of the regional lymph nodes was found in 66.8%. The frequency of the metastasis is increasing proportionally with the size of the cancer and the depth of the cancer invasion in the gastric wall. 7) Histopathology of the stomach cancer shows in the following order; poorly differentiated(38.4 %), moderately differentiated(22.7%) and well differentiated(18.5%). Together of these three types consist of 80% of total lesions. There is a distinct difference between male and female on the histological types, for there are 52% in undifferentiated and 48% in differentiated types among male while 72% and 28% among female groups. In average, they are 60% and 40%, respectively. 8) Prominent infiltration of lymphocytes in the stroma is found 2-5% of the cancers. Promenent proliferation of fibrous connective tissue of the stroma is found in 3-9% of the cancers. 9) The distinct difference in female group such as lower age group and more frequent association with undifferentiated form, will be elucidated by genetic disposition, and should be tested by tissue typing. 10) The histopathological classification should be as those of the traditional detailed description of the histopathological types. It will be much benefitcial having a standard classicfication adopted by all institutes of Korea such as the currently adopted method of japanese institutes

평생교육 기반으로서의 지역사회교육 논의의 역사적 변천 과정 탐색

홍숙희(Hong, Sook Hee) 한국평생교육학회 2010 평생교육학연구 Vol.16 No.1

본 연구는 지역 평생교육의 활성화가 강조되고 있는 우리사회에서 지역평생교육의 일환으로 이미 적용되어온 지역사회교육 논의를 중심으로 그 역사적 변천 과정을 고찰하고, 이를 기반으로 평생교육의 방향성을 모색해보고자 하였다. 이를 위해 본 연구는 지역사회교육의 전개과정을 검토하고, 지역사회교육 논의의 역사적 변천과정을 탐색하여 쟁점들을 검토함으로써 지역 평생교육으로서의 지역사회교육 논의의 방향을 분석하였다. 이를 바탕으로 한국 평생교육학의 발전을 위한 지역사회교육의 발전과제를 제시하였다. 첫째, 지역사회교육은 문제해결을 위한 프로그램뿐만 아니라 공동체 형성 지향의 과정으로서 초점이 맞추어져야할 것이며, 둘째, 특별한 정책이나 제도로서가 아니라 지역사회 구성원들과 교육서비스로서 관계를 맺는 전체를 대상으로 총체적이고, 체제적으로 접근되어야할 것이다. 셋째, 지역사회에서 진행되고 있는 교육․문화․복지․환경 등 전 방위적인 영역과의 관계성을 확립해 나가야할 것이며, 넷째, 지역사회교육의 특성을 반영한 연구방법론의 모색과 정립을 통해 지역사회교육학의 체계화를 모색해 나가야 할 것이다. This study attempted to explore the directivity of Lifelong Education based on examining the historical change process of Community Education discourses which had been applied as the part of Community Lifelong Education in our society. The goal of this paper is to examine the developmental process of Community Education and exploring the historical change process and issues of Community Education discourses, it analyzes the directivity of discourses of Community Education which are performed in our society. The research suggests the issues for improving Community Education to develop Life Education in Korea. First, Community Education will concentrate on the community-oriented process rather than the problem-solving programs. Second , Community Education should not be a specific policy or system, but should be arranged as a holistic and systematic approach on educational service which relates community members and the whole area. Third, it must try to establish the relationships among the omni-directional areas such as the education, culture, welfare, environment which are on the move in the community. Finally, Community Education needs to devise its systemization through constituting and seeking research methodology reflected in the characteristic of Community Education.

결직장 선종 및 선암종에서 Glutathione S-transferase , P53 및 CEA 발현에 관한 연구 - 면역조직 화학적방법에 의한 대장암 표지자에 관한 연구 ( Study on the Immunogistochemical Expression of Placental From Glutathione S-transferase, P53 and CEA in Colorectal Adenomas and Adenocarcinomad - Tumor Marker Study in Colon Cancer Tissues by Immunohistochemical Methods -

홍숙희(Sook Hee Hong),최석렬(Seok Reyol Choi),김두형(Du Hyeong Kim),한상영(Sang Young Han),노명환(Myung Hwan Roh),허기영(Gi Yeong Huh),신우원(Woo Won Shin),김종성(Jong Seong Kim) 대한소화기학회 1997 대한소화기학회지 Vol.29 No.5

N/A Background/Aims: This study is aimed to observe the expression of GST-z in colorectal adenomas and adenocarcinomas according to the risk and prognostic factors, and investigate the role during carcinogenesis and the possibility of clinical application as a tumor marker of colorectal neoplasm, in cornparision with the expression of p53 protein and CEA. Methods: Immuno- histochemical stain was performed in 15 cases of normal colon, 31 adenomas and 63 adenocarci- nomas. Results: The incidence of GST- expression was higher in adenocarcinoma (95.2%) than normal colon(40%), adenoma(87.1%) and adjacent norrnal mucosa to adenocarcinoma(63.5%) and the degree of the expression was also significantly different among them. In adenomas, the higher the degree of dysplasia, the higher the expression of GST-z. In adenocarcinomas, the expression was significantly decreased in relation with progression to lower histologic grade. The incidence of p53 expression was higher in adenocarcinomas(54.0%) than normal colon(0%), adenoma(25.8%) and adjacent normal mucosa to adenocarcinoma(0%) and the degree of the expression was also significantly different among them. In adenomas, the higher the degree of dysplasia, the higher the expression of p53. In adenocarcinoma, there was no sifnificant difference in relation with the histologic grade and stage. The incidence of CEA expression was higher in adenocarcinoma (96.8%) than normal colon(33.3%), adenoma(64.5%) and adjacent normal mucosa to adenocarci- norna(95.2%) and the degree of the expression was also significantly different among them. In adenomas, there was no significant difference in relation with size, amount of villous component and degree of dysplasia. In adenocarcinomas, the expression was increased in relation with progression to higher stage. The incidence of intense co-expression of GST-z and p53 in adenocarcinoma showed a tendency to be increasing in relation with progression to higher stage. But there was no statistically significant. Conclusions: It has been found from the above results that the expression of GST-z is progressively increased during colorectal carcinogenesiser. (Korean J Gastroenterol 1997;29:632-644)

각막 Amyloidosis 의 1예

이송희(Song Hee Lee),엄부섭(Boo Seop Oum),정의홍(Ui Hong Chung),홍숙희(Sook Hee Hong) 대한안과학회 1983 대한안과학회지 Vol.24 No.2

폐과오종 치험 3례

조광현,박동식,홍숙희,Cho, Kwang-Hyun,Park, Dong-Sick,Hong, Sook-Hee 대한흉부심장혈관외과학회 1982 Journal of Chest Surgery (J Chest Surg) Vol.15 No.2

The term hamartoma was first used by Albrecht to describe what he considered to be localized errors of development involving one or more tissue native to the organ of origin. The definition was meant to encompass not only abnormal local growth rate, but also the spatial arrangement, relative proportions and degree of the component tissue. But lately the major conclusions are that this group of lesion is neoplastic than developmental in origin. The Importance of pulmonary hamartoma is that they are relatively common among the benign tumor of the lung, but they usually present as asymptomatic coin lesion on chest x-ray film and were find out In routine check up and frequently mimic clinically the more common lung tumor such as cancer. Recently, we have experienced three cases of pulmonary hamartoma which were all discovered during routine chest film check up for certificate of health and evaluation of other disease. All of these were surgically resected with good result. Among the operations, one of these was mass enucleation and the others were lobectomy of lung involved by the mass.

‘학습’으로서의 네트워킹 - 부천 지역 교육안전망 사례연구

이지혜(Lee Ji-Hye),홍숙희(Hong Sook-Hee) 한국평생교육학회 2007 평생교육학연구 Vol.13 No.3

  이 글은 그간의 평생교육 분야에서 네트워크 논의가 정적인 측면에 초점을 맞추어 왔다고 보고, 네트워크 안에 담긴 역사성과 중층성, 그래서 형성된 ‘역동’을 이해하기 위하여 학습에 대한 사회문화적 관점을 도입한 분석을 시도하였다. 이론적 배경으로는 활동이론과 상황학습이론을 근간으로 하였고, 사례 분석 대상으로는 부천지역의 교육안전망을 채택하였다. 개인 면담 및 전문가협의회, 문헌분석 등에 의하여 수집한 자료를 분석한 결과, 부천지역의 교육안전망은 학습활동의 ‘도구(tools)’로써, 온-오프 매체를 통한, 공식 비공식, 민관-민민 협력 등의 다양한 ‘매개수단’을 확보하고 있었고, ‘네트워크’에 대한 신뢰와 함께 ‘민관 협력’에 대한 긍정적 인식, 그리고 네트워킹의 절차를 일종의 학습 ‘규칙(rules)’으로 내재화하고 있었다. 뿐만 아니라, ‘참여’를 통한 실천을 통해 지역공동체의 일원으로서의 정체성(identity)을 형성해 가는 특징을 보이고 있었다. 이러한 학습요소를 이끄는 목표는 개별 기관의 이해를 넘어 치열한 갈등과 조정을 거치며 ‘공공성’을 지향하는 공통 가치 준거 공유과정을 통해 형성 변화해 가는 특징을 보였다. 이와 같은 분석은 네트워킹에 대하여 새로운 관점을 제공하여 준다. 첫째, ‘네트워킹’을 곧 공동의 ‘정체성’ 형성과정이라는 시각에서 바라보게 하여 준다. 둘째로, 네트워크를 움직이는 것은 참여자 간의 ‘긴장’ 그리고 역사적으로 축적된 ‘모순’의 힘이다. 셋째로 네트워킹 활성화를 위해서는 중층적 입체적 ‘매개수단’을 확보할 필요가 있으며, 허브조직의 가장 주요한 역할은 네트워크 내의 학습을 촉진하는 것으로 이는 바로 ‘매개수단’의 공유 및 재생산으로 나타난다.   In the area of lifelong education, the discourse of ‘network’ has been focused on the static aspect. However, it needs to include the historicity, complexity and dynamics. This study aims to suggest an alternative perspective to understand ‘network’. Theoretically, it based on the situated learning theory and activity theory to interpret ‘network’ as a dynamic learning subject.<BR>  For the purpose of the study, ‘Education Safety Net’ in Bucheon is adopted as the case. The networking in Bucheon which is diverse and dynamic is highly estimated. To collect the data, in-depth interviews, practitioner meetings and literature review were used.<BR>  The results of the analysis show the following implications: At first, it provide a perspective to see networking as forming a common identity. In the process, ‘participation’ of the agents in the area is pivotal. Secondly, the driven forces to move a networking is originated from the tensions between agents and elements and contradictions accumulated in local history. The tensions results in the collective motives and tendency of object-oriented activity system. Thirdly, it needs to have diverse ‘tools’ to activate networking. The roles of hub organization are to facilitate and to regenerate the ‘tools’.

흉막폐모세포종의 압착도말 소견 - 1예 보고 -

노미숙,서지영,허기영,최필조,홍숙희,정진숙,Roh, Mee-Sook,Seo, Ji-Young,Huh, Gi-Yeong,Choi, Pill-Jo,Hong, Sook-Hee,Jeong, Jin-Sook 대한세포병리학회 2001 대한세포병리학회지 Vol.12 No.1

Pleuropulmonary blastoma (PPB) is an unusual intrathoracic blastoma presenting in childhood and charac-terized by a biphasic neoplastic population of undifferentiated, small round blastemal cells and larger spindle-shaped sarcomatous cells with entrapped benign epithelial-lined structures. We experienced the cytologic features of PPB in imprint smear from the pleural-based huge mass of the middle lobe of the right lung in a 4-year-old boy. The smears showed high cellularity composed of small ovoid blastemal elements and scattered spindle mesenchymal tumor cells. Lobectomy and pathologic investigation confirmed the diagnosis. PPB seems to be a tumor in which accurate diagnosis may be achieved by cytoiogy if appro-priate clinical information were given. Timely and accurate diagnosis of PPB by cytology paves the way for attempting preoperative treatment in future cases.

각종 간질환에 있어서 간염 B 바이러스의 혈청학적 표식자들과 간조직의 HBsAg 에 관한 연구

김순호(Soon Ho Kim),홍숙희(Sook Hee Hong) 대한소화기학회 1985 대한소화기학회지 Vol.17 No.2

N/A The authors carried out to determine serological markers of hepatitis B virus (HBV) and to examine HBsAg in livor tissues in 14 cases of acute hepatitis (AH), 10 cases of chronic persistent hepatitis (CPH), 37 cases of chronic active hepatitis (CAH), 37 cases of liver cirrhosis (LC), and 24 cases of hepatocellular carcinoma (HC). Diagnosis were confirmed histopathologically in all patients. Blood samples and liver biopsy materials of a total 122 cases were obtained during the period from January, 1981 to May, 1984 in Pusan Paik Hospital, Inje College. Serum HBsAg and anti-HBs were tested by passive hemagglutination method. HBeAg, anti-HBe, and anti-HBc were tested by radioimmunoassay. HBsAg in liver tissues was histochemically examiined with Shikata's orcein method. The results obtained were as follows: 1. In AH and CAH, HBV serological markers could be detected anti-HBc, HBsAg, HBeAg, and anti-HBe and/or anti-HBs in descending order, and in CPH, LC, and HC, those could be detected anti-HBc, HBsAg, anti-Hbe, EiReAg, and anti-HBs in descending order. 100.% of AH and CPH, 94.6% of CAH and LC, and 95.8% of HC had the serological evidence cf either a current or past HBV infection. 3. The most common pattern of HBV serological markers was pattern III in AH, CAH, and LC, pattern VII in CPH, and pattern VI in HC. 4. HBsAg detecting rates in liver tissues were 21.4% in AH, 20.0% in CPH, 29.8% in CAH, 32.4% in LC, and 29.2% in HC. HBsAg in liver tissue was detected in about half of patients with srum HBsAg positive various livcr diseases. 6.HBsAg in liver tissues could be detected more frequently in pattern III in AH, CPH, and CAH and in pattern VI in LC and HC, as compared with other patterns. On the basis of these findings, it was suggested that HBV might play an important role in causation of most cases of various liver diseases in Korea and in order to investigate the relation of HBV infection to liver diseases, it is important to examine HBV markers in both serum and liver tissue.

신장외 악성 횡문양 종양 - 1예 보고 -

이상용,김대철,나서희,홍숙희,강태훈,이영호,남경진,정진숙,Lee, Sang-Yong,Kim, Dae-Cheol,Rha, Seo-Hee,Hong, Sook-Hee,Kang, Tae-Hun,Lee, Young-Ho,Nam, Kyoung-Jin,Jeong, Jin-Sook 대한세포병리학회 1996 대한세포병리학회지 Vol.7 No.1

Malignant rhabdold tumor is a distinct renal tumor in the pediatric age group. It was originally described as a rhabdomyosarcomatold variant of Wilms' tumor. However, subsequent studies fatted to confirm myogenous differentiation, so it is now considered to be a distinct and unique type of highly malignant tumor, histogenetically unrelated. Although extrarenal forms of this tumor are rare, several examples have been described in other sites, especially the liver, prostate, paravertebral area, urinary bladder and soft tissue. We experienced a case of malignant rhabdiod tumor located in the intraabdominal cavity in a 10 month-old boy. Smear of peritoneal fluid showed round, polygonal and irregular shaped cells with large nuclei, ample cytoplasm containing light pink to purple cytoplasmic inclusions, and one or a few prominent nucleoli. Immunocytochemistry revealed positivity to cytokeratin, epithelial membrane antigen and vimentin, and negativity to desmin and neuron-specific enolase. These distinct cytologic appearance and immunophenotypes were most consistent with a diagnosis of extrarenal malignant rhabdoid tumor. The cytoplasmic inclusions were correlated with eosinophilic inclusions seen in histologic section and electron microscopy confirmed this interpretation, showing filamentous aggregations in the cytoplasms of the tumor cells.